Geoffrey Gottlieb

Summary

Affiliation: University of Washington
Country: USA

Publications

  1. pmc Susceptibility of the human retrovirus XMRV to antiretroviral inhibitors
    Robert A Smith
    Department of Pathology, University of Washington, Seattle, USA
    Retrovirology 7:70. 2010
  2. ncbi request reprint Candida dubliniensis fungemia in a solid organ transplant patient: case report and review of the literature
    G S Gottlieb
    Department of Medicine, University of Washington Medical Center, Seattle 981 95, USA
    Med Mycol 39:483-5. 2001
  3. pmc Emergence of multiclass drug-resistance in HIV-2 in antiretroviral-treated individuals in Senegal: implications for HIV-2 treatment in resouce-limited West Africa
    Geoffrey S Gottlieb
    Department of Medicine, School of Medicine, University of Washington, Seattle, WA 98195, USA
    Clin Infect Dis 48:476-83. 2009
  4. pmc HIV type 2 protease, reverse transcriptase, and envelope viral variation in the PBMC and genital tract of ARV-naive women in Senegal
    Geoffrey S Gottlieb
    Department of Medicine, School of Medicine, University of Washington, Seattle, Washington 98195, USA
    AIDS Res Hum Retroviruses 24:857-64. 2008
  5. pmc HIV-1 variation before seroconversion in men who have sex with men: analysis of acute/early HIV infection in the multicenter AIDS cohort study
    Geoffrey S Gottlieb
    Division of Allergy and Infectious Diseases, Department of Medicine, School of Medicine, University of Washington, Seattle 98195, USA
    J Infect Dis 197:1011-5. 2008
  6. ncbi request reprint HIV type 1 superinfection with a dual-tropic virus and rapid progression to AIDS: a case report
    Geoffrey S Gottlieb
    Division of Allergy and Infectious Diseases, School of Medicine, University of Washington, Seattle, WA 98195, USA
    Clin Infect Dis 45:501-9. 2007
  7. pmc Lower levels of HIV RNA in semen in HIV-2 compared with HIV-1 infection: implications for differences in transmission
    Geoffrey S Gottlieb
    Department of Medicine, School of Medicine, University of Washington, Seattle, Washington 98195, USA
    AIDS 20:895-900. 2006
  8. ncbi request reprint Molecular epidemiology of dual HIV-1/HIV-2 seropositive adults from Senegal, West Africa
    Geoffrey S Gottlieb
    Division of Allergy and Infectious Diseases, Department of Medicine, University of Washington, Seattle, Washington 98195, USA
    AIDS Res Hum Retroviruses 19:575-84. 2003
  9. ncbi request reprint Dual HIV-1 infection associated with rapid disease progression
    Geoffrey S Gottlieb
    Department of Microbiology, School of Medicine, University of Washington, Seattle, WA 98195 8070, USA
    Lancet 363:619-22. 2004
  10. ncbi request reprint Disseminated sporotrichosis associated with treatment with immunosuppressants and tumor necrosis factor-alpha antagonists
    Geoffrey S Gottlieb
    Division of Allergy and Infectious Diseases, Department of Medicine, University of Washington, Seattle, WA 98195, USA
    Clin Infect Dis 37:838-40. 2003

Research Grants

  1. Epidemiology of HIV-1/HIV-2 Dual Infection
    Geoffrey Gottlieb; Fiscal Year: 2005
  2. Antiretroviral Therapy for HIV-2 Infection in Senegal
    Geoffrey Gottlieb; Fiscal Year: 2007
  3. Antiretroviral Therapy for HIV-2 Infection in Senegal
    Geoffrey Gottlieb; Fiscal Year: 2009
  4. Antiretroviral Therapy for HIV-2 Infection in Senegal
    GEOFFREY SCOTT GOTTLIEB; Fiscal Year: 2010

Detail Information

Publications30

  1. pmc Susceptibility of the human retrovirus XMRV to antiretroviral inhibitors
    Robert A Smith
    Department of Pathology, University of Washington, Seattle, USA
    Retrovirology 7:70. 2010
    ..In the present study, we used a novel marker transfer assay to directly compare the antiviral drug sensitivities of XMRV and HIV-1 under identical conditions in the same host cell type...
  2. ncbi request reprint Candida dubliniensis fungemia in a solid organ transplant patient: case report and review of the literature
    G S Gottlieb
    Department of Medicine, University of Washington Medical Center, Seattle 981 95, USA
    Med Mycol 39:483-5. 2001
    ..This case illustrates the need to be aware of emerging pathogens in new host populations and that new techniques used to identify yeast species may provide more accurate identification...
  3. pmc Emergence of multiclass drug-resistance in HIV-2 in antiretroviral-treated individuals in Senegal: implications for HIV-2 treatment in resouce-limited West Africa
    Geoffrey S Gottlieb
    Department of Medicine, School of Medicine, University of Washington, Seattle, WA 98195, USA
    Clin Infect Dis 48:476-83. 2009
    ..However, the mutations in HIV-2 that confer ARV resistance are not well characterized...
  4. pmc HIV type 2 protease, reverse transcriptase, and envelope viral variation in the PBMC and genital tract of ARV-naive women in Senegal
    Geoffrey S Gottlieb
    Department of Medicine, School of Medicine, University of Washington, Seattle, Washington 98195, USA
    AIDS Res Hum Retroviruses 24:857-64. 2008
    ..We found no significant difference in ENV variants between PBMCs and the genital tract. HIV-2 RT and PR mutations in the genital tract of ARV-naive females may have implications for transmitted HIV-2 resistance and ARV therapy...
  5. pmc HIV-1 variation before seroconversion in men who have sex with men: analysis of acute/early HIV infection in the multicenter AIDS cohort study
    Geoffrey S Gottlieb
    Division of Allergy and Infectious Diseases, Department of Medicine, School of Medicine, University of Washington, Seattle 98195, USA
    J Infect Dis 197:1011-5. 2008
    ..Nearly all variants were predicted to be CCR5 tropic. We found no correlation between these viral characteristics and the HIV outcomes of time to clinical AIDS or death and/or a CD4 cell count <200 cells/microL...
  6. ncbi request reprint HIV type 1 superinfection with a dual-tropic virus and rapid progression to AIDS: a case report
    Geoffrey S Gottlieb
    Division of Allergy and Infectious Diseases, School of Medicine, University of Washington, Seattle, WA 98195, USA
    Clin Infect Dis 45:501-9. 2007
    ..The occurrence of human immunodeficiency virus type 1 (HIV-1) superinfection has implications for vaccine development and our understanding of HIV pathogenesis and transmission...
  7. pmc Lower levels of HIV RNA in semen in HIV-2 compared with HIV-1 infection: implications for differences in transmission
    Geoffrey S Gottlieb
    Department of Medicine, School of Medicine, University of Washington, Seattle, Washington 98195, USA
    AIDS 20:895-900. 2006
    ..To gain further insight into why HIV-1 is more readily transmitted as compared with HIV-2, we analyzed semen and plasma HIV RNA levels in HIV-1 and HIV-2-positive men from Senegal...
  8. ncbi request reprint Molecular epidemiology of dual HIV-1/HIV-2 seropositive adults from Senegal, West Africa
    Geoffrey S Gottlieb
    Division of Allergy and Infectious Diseases, Department of Medicine, University of Washington, Seattle, Washington 98195, USA
    AIDS Res Hum Retroviruses 19:575-84. 2003
    ..The common HIV-1 subtypes prevalent in West Africa (CRF-02 and subtype A) have a similar distribution to those found in our cohort of dually infected and dually seropositive subjects...
  9. ncbi request reprint Dual HIV-1 infection associated with rapid disease progression
    Geoffrey S Gottlieb
    Department of Microbiology, School of Medicine, University of Washington, Seattle, WA 98195 8070, USA
    Lancet 363:619-22. 2004
    ..4 and <3.1 years, respectively). Our findings should prompt larger studies to assess the effect of dual infection at the population level...
  10. ncbi request reprint Disseminated sporotrichosis associated with treatment with immunosuppressants and tumor necrosis factor-alpha antagonists
    Geoffrey S Gottlieb
    Division of Allergy and Infectious Diseases, Department of Medicine, University of Washington, Seattle, WA 98195, USA
    Clin Infect Dis 37:838-40. 2003
    ..This case illustrates the potential for infectious complications related to the use of cytotoxic immunosuppressants and anticytokine agents, such as TNF-alpha antagonists...
  11. ncbi request reprint Unusual appendicitis
    Geoffrey S Gottlieb
    Division of Allergy and Infectious Diseases, Department of Medicine, Harborview Medical Center, University of Washington, Seattle 98195, USA
    Clin Infect Dis 37:1334, 1378-9. 2003
  12. pmc Transmission cluster of multiclass highly drug-resistant HIV-1 among 9 men who have sex with men in Seattle/King County, WA, 2005-2007
    Susan E Buskin
    HIV AIDS Epidemiology Unit, HIV AIDS Program, Public Health Seattle and King County, 400 Yesler Way, Seattle, WA 98104, USA
    J Acquir Immune Defic Syndr 49:205-11. 2008
    ..Through surveillance activities and genetic analysis, the local Health Department and the University of Washington identified phylogenetically linked cases among ARV treatment-naive and -experienced individuals...
  13. ncbi request reprint Equal plasma viral loads predict a similar rate of CD4+ T cell decline in human immunodeficiency virus (HIV) type 1- and HIV-2-infected individuals from Senegal, West Africa
    Geoffrey S Gottlieb
    Division of Allergy and Infectious Diseases, Department of Medicine, School of Medicine, University of Washington, Seattle, Washington 98103, USA
    J Infect Dis 185:905-14. 2002
    ....
  14. pmc Lack of evidence for changing virulence of HIV-1 in North America
    Joshua T Herbeck
    University of Washington School of Medicine, Seattle, Washington, USA
    PLoS ONE 3:e1525. 2008
    ....
  15. pmc Role of human immunodeficiency virus (HIV)-specific T-cell immunity in control of dual HIV-1 and HIV-2 infection
    Natalie N Zheng
    Department of Pathology, University of Washington, Seattle, WA 98195, USA
    J Virol 81:9061-71. 2007
    ..In conclusion, the T-cell memory responses associated with containment of single HIV-1 and HIV-2 infection play a similar significant role in the immune control of dual HIV-1 and HIV-2 infection...
  16. ncbi request reprint No evidence for recombination between HIV type 1 and HIV type 2 within the envelope region in dually seropositive individuals from Senegal
    Marcel E Curlin
    Department of Medicine, University of Washington School of Medicine, Seattle, Washington 98104, USA
    AIDS Res Hum Retroviruses 20:958-63. 2004
    ..Although genetic recombination between HIV-1 and HIV-2 may occur, we conclude that any such events within env are exceedingly rare, and do not result in the outgrowth of recombinant strains...
  17. pmc Human immunodeficiency virus types 1 and 2 exhibit comparable sensitivities to Zidovudine and other nucleoside analog inhibitors in vitro
    Robert A Smith
    University of Washington, Department of Pathology, K 046 HSB, Box 357705, 1959 NE Pacific St, Seattle, WA 98195, USA
    Antimicrob Agents Chemother 52:329-32. 2008
    ..These data support the use of nucleoside analogs for antiviral therapy of HIV-2 infection...
  18. pmc Antiretroviral drug resistance in HIV-2: three amino acid changes are sufficient for classwide nucleoside analogue resistance
    Robert A Smith
    Department of Pathology, Division of Allergy and Infectious Diseases, University of Washington, Seattle, WA 98133, USA
    J Infect Dis 199:1323-6. 2009
    ..These data suggest that current NRTI-based regimens are suboptimal for treating HIV-2 infection...
  19. pmc HIV-1 superinfection in the antiretroviral therapy era: are seroconcordant sexual partners at risk?
    Mary S Campbell
    Department of Medicine, School of Medicine, University of Washington, Seattle, Washington, United States of America
    PLoS ONE 4:e5690. 2009
    ..In this study, we evaluated a longitudinal cohort of chronically HIV-infected men who were sexual partners to determine if individuals acquired their partners' viral strains...
  20. pmc Human immunodeficiency virus type 1 env evolves toward ancestral states upon transmission to a new host
    Joshua T Herbeck
    Department of Microbiology, SC 42, University of Washington, Seattle, WA 98195, USA
    J Virol 80:1637-44. 2006
    ..These results have important implications for the study of HIV population genetics and rational vaccine design, including favoring the inclusion of viral gene sequences taken early in infection...
  21. pmc Fidelity of SNP array genotyping using Epstein Barr virus-transformed B-lymphocyte cell lines: implications for genome-wide association studies
    Joshua T Herbeck
    University of Washington School of Medicine, Seattle, Washington, United States of America
    PLoS ONE 4:e6915. 2009
    ..LCL are created in a transformation process that entails in vitro infection of human B-lymphocytes with the Epstein-Barr Virus (EBV)...
  22. pmc Multistage genomewide association study identifies a locus at 1q41 associated with rate of HIV-1 disease progression to clinical AIDS
    Joshua T Herbeck
    Department of Microbiology, University of Washington School of Medicine, Seattle, WA 98195 8070, USA
    J Infect Dis 201:618-26. 2010
    ..To investigate host genetic determinants of the rate of progression to clinical AIDS, we performed a multistage genomewide association study...
  23. pmc Lower levels of HIV-2 than HIV-1 in the female genital tract: correlates and longitudinal assessment of viral shedding
    Stephen E Hawes
    Department of Epidemiology, School of Public Health and Community Medicine, University of Washington, Seattle, Washington 98103, USA
    AIDS 22:2517-25. 2008
    ..Thus, understanding patterns of, and risk factors for HIV genital tract shedding is critical to effective control of HIV transmission...
  24. pmc HIV-1 envelope subregion length variation during disease progression
    Marcel E Curlin
    Department of Medicine, University of Washington School of Medicine, Seattle, Washington, United States of America
    PLoS Pathog 6:e1001228. 2010
    ..V1V2 shortening during early and late-stage infection may reflect ineffective host immunity. Transmission from donors with chronic illness may have caused the modest increase in V1V2 length observed during the course of the pandemic...
  25. pmc Differences in proviral DNA load between HIV-1-infected and HIV-2-infected patients
    Geoffrey S Gottlieb
    AIDS 22:1379-80. 2008
  26. ncbi request reprint Presenting plasma HIV RNA level and rate of CD4 T-cell decline
    Geoffrey S Gottlieb
    JAMA 297:805; author reply 806-7. 2007
  27. ncbi request reprint Multidrug-resistant, dual-tropic HIV-1 and rapid progression
    Geoffrey S Gottlieb
    Lancet 365:1923-4; author reply 1924. 2005
  28. ncbi request reprint Characteristics and presenting complaints of outpatients with undiagnosed HIV infection: potential utility in selecting subjects for HIV testing
    Papa Salif Sow
    Department of Infectious Diseases, University of Dakar, Senegal
    J Acquir Immune Defic Syndr 37:1520-8. 2004
    ..This study suggests that this method might provide a cost-effective approach that permits limited screening resources to be spent in a way that maximizes individual and societal benefit...
  29. ncbi request reprint Consensus and ancestral state HIV vaccines
    David C Nickle
    Science 299:1515-8; author reply 1515-8. 2003
  30. ncbi request reprint HIV-1 over time: fitness loss or robustness gain?
    Morgane Rolland
    Nat Rev Microbiol 5:C1. 2007

Research Grants7

  1. Epidemiology of HIV-1/HIV-2 Dual Infection
    Geoffrey Gottlieb; Fiscal Year: 2005
    ....
  2. Antiretroviral Therapy for HIV-2 Infection in Senegal
    Geoffrey Gottlieb; Fiscal Year: 2007
    ..abstract_text> ..
  3. Antiretroviral Therapy for HIV-2 Infection in Senegal
    Geoffrey Gottlieb; Fiscal Year: 2009
    ..abstract_text> ..
  4. Antiretroviral Therapy for HIV-2 Infection in Senegal
    GEOFFREY SCOTT GOTTLIEB; Fiscal Year: 2010
    ..Understanding how to better treat HIV-2 and dual HIV-1/HIV-2 infection is an import public health priority in West Africa. ..