Research Topics
Species | Geoffrey GottliebSummaryAffiliation: University of Washington Country: USA Publications
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Publications
Susceptibility of the human retrovirus XMRV to antiretroviral inhibitorsRobert A Smith
Department of Pathology, University of Washington, Seattle, USA
Retrovirology 7:70. 2010..In the present study, we used a novel marker transfer assay to directly compare the antiviral drug sensitivities of XMRV and HIV-1 under identical conditions in the same host cell type...
Candida dubliniensis fungemia in a solid organ transplant patient: case report and review of the literatureG S Gottlieb
Department of Medicine, University of Washington Medical Center, Seattle 981 95, USA
Med Mycol 39:483-5. 2001..This case illustrates the need to be aware of emerging pathogens in new host populations and that new techniques used to identify yeast species may provide more accurate identification...
Emergence of multiclass drug-resistance in HIV-2 in antiretroviral-treated individuals in Senegal: implications for HIV-2 treatment in resouce-limited West AfricaGeoffrey S Gottlieb
Department of Medicine, School of Medicine, University of Washington, Seattle, WA 98195, USA
Clin Infect Dis 48:476-83. 2009..However, the mutations in HIV-2 that confer ARV resistance are not well characterized...- HIV type 2 protease, reverse transcriptase, and envelope viral variation in the PBMC and genital tract of ARV-naive women in SenegalGeoffrey S Gottlieb
Department of Medicine, School of Medicine, University of Washington, Seattle, Washington 98195, USA
AIDS Res Hum Retroviruses 24:857-64. 2008..We found no significant difference in ENV variants between PBMCs and the genital tract. HIV-2 RT and PR mutations in the genital tract of ARV-naive females may have implications for transmitted HIV-2 resistance and ARV therapy... - HIV-1 variation before seroconversion in men who have sex with men: analysis of acute/early HIV infection in the multicenter AIDS cohort studyGeoffrey S Gottlieb
Division of Allergy and Infectious Diseases, Department of Medicine, School of Medicine, University of Washington, Seattle 98195, USA
J Infect Dis 197:1011-5. 2008..Nearly all variants were predicted to be CCR5 tropic. We found no correlation between these viral characteristics and the HIV outcomes of time to clinical AIDS or death and/or a CD4 cell count <200 cells/microL... - HIV type 1 superinfection with a dual-tropic virus and rapid progression to AIDS: a case reportGeoffrey S Gottlieb
Division of Allergy and Infectious Diseases, School of Medicine, University of Washington, Seattle, WA 98195, USA
Clin Infect Dis 45:501-9. 2007..The occurrence of human immunodeficiency virus type 1 (HIV-1) superinfection has implications for vaccine development and our understanding of HIV pathogenesis and transmission... - Lower levels of HIV RNA in semen in HIV-2 compared with HIV-1 infection: implications for differences in transmissionGeoffrey S Gottlieb
Department of Medicine, School of Medicine, University of Washington, Seattle, Washington 98195, USA
AIDS 20:895-900. 2006..To gain further insight into why HIV-1 is more readily transmitted as compared with HIV-2, we analyzed semen and plasma HIV RNA levels in HIV-1 and HIV-2-positive men from Senegal... - Molecular epidemiology of dual HIV-1/HIV-2 seropositive adults from Senegal, West AfricaGeoffrey S Gottlieb
Division of Allergy and Infectious Diseases, Department of Medicine, University of Washington, Seattle, Washington 98195, USA
AIDS Res Hum Retroviruses 19:575-84. 2003..The common HIV-1 subtypes prevalent in West Africa (CRF-02 and subtype A) have a similar distribution to those found in our cohort of dually infected and dually seropositive subjects... - Dual HIV-1 infection associated with rapid disease progressionGeoffrey S Gottlieb
Department of Microbiology, School of Medicine, University of Washington, Seattle, WA 98195 8070, USA
Lancet 363:619-22. 2004..4 and <3.1 years, respectively). Our findings should prompt larger studies to assess the effect of dual infection at the population level... - Disseminated sporotrichosis associated with treatment with immunosuppressants and tumor necrosis factor-alpha antagonistsGeoffrey S Gottlieb
Division of Allergy and Infectious Diseases, Department of Medicine, University of Washington, Seattle, WA 98195, USA
Clin Infect Dis 37:838-40. 2003..This case illustrates the potential for infectious complications related to the use of cytotoxic immunosuppressants and anticytokine agents, such as TNF-alpha antagonists... - Unusual appendicitisGeoffrey S Gottlieb
Division of Allergy and Infectious Diseases, Department of Medicine, Harborview Medical Center, University of Washington, Seattle 98195, USA
Clin Infect Dis 37:1334, 1378-9. 2003 - Transmission cluster of multiclass highly drug-resistant HIV-1 among 9 men who have sex with men in Seattle/King County, WA, 2005-2007Susan E Buskin
HIV AIDS Epidemiology Unit, HIV AIDS Program, Public Health Seattle and King County, 400 Yesler Way, Seattle, WA 98104, USA
J Acquir Immune Defic Syndr 49:205-11. 2008..Through surveillance activities and genetic analysis, the local Health Department and the University of Washington identified phylogenetically linked cases among ARV treatment-naive and -experienced individuals... - Equal plasma viral loads predict a similar rate of CD4+ T cell decline in human immunodeficiency virus (HIV) type 1- and HIV-2-infected individuals from Senegal, West AfricaGeoffrey S Gottlieb
Division of Allergy and Infectious Diseases, Department of Medicine, School of Medicine, University of Washington, Seattle, Washington 98103, USA
J Infect Dis 185:905-14. 2002.... - Lack of evidence for changing virulence of HIV-1 in North AmericaJoshua T Herbeck
University of Washington School of Medicine, Seattle, Washington, USA
PLoS ONE 3:e1525. 2008.... - Role of human immunodeficiency virus (HIV)-specific T-cell immunity in control of dual HIV-1 and HIV-2 infectionNatalie N Zheng
Department of Pathology, University of Washington, Seattle, WA 98195, USA
J Virol 81:9061-71. 2007..In conclusion, the T-cell memory responses associated with containment of single HIV-1 and HIV-2 infection play a similar significant role in the immune control of dual HIV-1 and HIV-2 infection... - No evidence for recombination between HIV type 1 and HIV type 2 within the envelope region in dually seropositive individuals from SenegalMarcel E Curlin
Department of Medicine, University of Washington School of Medicine, Seattle, Washington 98104, USA
AIDS Res Hum Retroviruses 20:958-63. 2004..Although genetic recombination between HIV-1 and HIV-2 may occur, we conclude that any such events within env are exceedingly rare, and do not result in the outgrowth of recombinant strains... - Human immunodeficiency virus types 1 and 2 exhibit comparable sensitivities to Zidovudine and other nucleoside analog inhibitors in vitroRobert A Smith
University of Washington, Department of Pathology, K 046 HSB, Box 357705, 1959 NE Pacific St, Seattle, WA 98195, USA
Antimicrob Agents Chemother 52:329-32. 2008..These data support the use of nucleoside analogs for antiviral therapy of HIV-2 infection... - Antiretroviral drug resistance in HIV-2: three amino acid changes are sufficient for classwide nucleoside analogue resistanceRobert A Smith
Department of Pathology, Division of Allergy and Infectious Diseases, University of Washington, Seattle, WA 98133, USA
J Infect Dis 199:1323-6. 2009..These data suggest that current NRTI-based regimens are suboptimal for treating HIV-2 infection... - HIV-1 superinfection in the antiretroviral therapy era: are seroconcordant sexual partners at risk?Mary S Campbell
Department of Medicine, School of Medicine, University of Washington, Seattle, Washington, United States of America
PLoS ONE 4:e5690. 2009..In some cases, HIV-1 superinfection may become apparent when recombinant viral strains are detected... - Human immunodeficiency virus type 1 env evolves toward ancestral states upon transmission to a new hostJoshua T Herbeck
Department of Microbiology, SC 42, University of Washington, Seattle, WA 98195, USA
J Virol 80:1637-44. 2006..These results have important implications for the study of HIV population genetics and rational vaccine design, including favoring the inclusion of viral gene sequences taken early in infection... - Fidelity of SNP array genotyping using Epstein Barr virus-transformed B-lymphocyte cell lines: implications for genome-wide association studiesJoshua T Herbeck
University of Washington School of Medicine, Seattle, Washington, United States of America
PLoS ONE 4:e6915. 2009..LCL are created in a transformation process that entails in vitro infection of human B-lymphocytes with the Epstein-Barr Virus (EBV)... - Multistage genomewide association study identifies a locus at 1q41 associated with rate of HIV-1 disease progression to clinical AIDSJoshua T Herbeck
Department of Microbiology, University of Washington School of Medicine, Seattle, WA 98195 8070, USA
J Infect Dis 201:618-26. 2010..To investigate host genetic determinants of the rate of progression to clinical AIDS, we performed a multistage genomewide association study... - Lower levels of HIV-2 than HIV-1 in the female genital tract: correlates and longitudinal assessment of viral sheddingStephen E Hawes
Department of Epidemiology, School of Public Health and Community Medicine, University of Washington, Seattle, Washington 98103, USA
AIDS 22:2517-25. 2008..Thus, understanding patterns of, and risk factors for HIV genital tract shedding is critical to effective control of HIV transmission... - HIV-1 envelope subregion length variation during disease progressionMarcel E Curlin
Department of Medicine, University of Washington School of Medicine, Seattle, Washington, United States of America
PLoS Pathog 6:e1001228. 2010..V1V2 shortening during early and late-stage infection may reflect ineffective host immunity. Transmission from donors with chronic illness may have caused the modest increase in V1V2 length observed during the course of the pandemic... - Differences in proviral DNA load between HIV-1-infected and HIV-2-infected patientsGeoffrey S Gottlieb
AIDS 22:1379-80. 2008 - Presenting plasma HIV RNA level and rate of CD4 T-cell declineGeoffrey S Gottlieb
JAMA 297:805; author reply 806-7. 2007 - Multidrug-resistant, dual-tropic HIV-1 and rapid progressionGeoffrey S Gottlieb
Lancet 365:1923-4; author reply 1924. 2005 - Characteristics and presenting complaints of outpatients with undiagnosed HIV infection: potential utility in selecting subjects for HIV testingPapa Salif Sow
Department of Infectious Diseases, University of Dakar, Senegal
J Acquir Immune Defic Syndr 37:1520-8. 2004..This study suggests that this method might provide a cost-effective approach that permits limited screening resources to be spent in a way that maximizes individual and societal benefit... - Consensus and ancestral state HIV vaccinesDavid C Nickle
Science 299:1515-8; author reply 1515-8. 2003 - HIV-1 over time: fitness loss or robustness gain?Morgane Rolland
Nat Rev Microbiol 5:C1. 2007
Research Grants
- Epidemiology of HIV-1/HIV-2 Dual InfectionGeoffrey Gottlieb; Fiscal Year: 2005....
- Antiretroviral Therapy for HIV-2 Infection in SenegalGeoffrey Gottlieb; Fiscal Year: 2007..abstract_text> ..
- Antiretroviral Therapy for HIV-2 Infection in SenegalGeoffrey Gottlieb; Fiscal Year: 2009..abstract_text> ..
- Antiretroviral Therapy for HIV-2 Infection in SenegalGEOFFREY SCOTT GOTTLIEB; Fiscal Year: 2010..Understanding how to better treat HIV-2 and dual HIV-1/HIV-2 infection is an import public health priority in West Africa. ..