I I Gottesman
Affiliation: University of Minnesota
- Psychopathology through a life span-genetic prismI I Gottesman
University of Virginia, USA
Am Psychol 56:867-78. 2001..The challenge to the field of psychology is to join in with cross-disciplinary ventures and to adapt to rapid changes with innovations in research strategies...
- Neurological soft signs as candidate endophenotypes for schizophrenia: a shooting star or a Northern star?Raymond C K Chan
Neuropsychology and Applied Cognitive Neuroscience Laboratory, Institute of Psychology, Chinese Academy of Sciences, Beijing, China
Neurosci Biobehav Rev 32:957-71. 2008..Finally, we recommend areas in which additional research should be done to further elucidate the potential use of neurological soft signs for schizophrenia research...
- Reconciling disparate prevalence rates of PTSD in large samples of US male Vietnam veterans and their controlsWilliam W Thompson
Immunization Safety Office, US Centers for Disease Control and Prevention, Atlanta, GA, USA
BMC Psychiatry 6:19. 2006..2%. We compared alternative criteria for estimating the prevalence of PTSD using the NVVRS and VES public use data sets collected more than 10 years after the United States withdrew troops from Vietnam...
- Schizophrenia and psychotic symptoms in families of two American Indian tribesRobert W Robin
Hopi Guidance Center, Second Mesa, AZ 86043, USA
BMC Psychiatry 7:30. 2007..These tribal groups were evaluated as part of a broader program of gene-environment investigations of alcoholism and other psychiatric disorders...
- The glial growth factors deficiency and synaptic destabilization hypothesis of schizophreniaHans W Moises
Molecular Genetics Laboratory, Department of Psychiatry, Kiel University Hospital, Niemannsweg 147, 24105 Kiel, Germany
BMC Psychiatry 2:8. 2002..A systems approach to understanding the etiology of schizophrenia requires a theory which is able to integrate genetic as well as neurodevelopmental factors...
- Theories of schizophrenia: a genetic-inflammatory-vascular synthesisDaniel R Hanson
Department of Psychiatry, VA Medical Center 116A, One Veterans Drive, Minneapolis, MN 55417, USA
BMC Med Genet 6:7. 2005..A search for a more satisfying model to explain aspects of schizophrenia uncovers clues pointing to genetically mediated CNS microvascular inflammatory disease...
- Severe mental disorders in offspring with 2 psychiatrically ill parentsIrving I Gottesman
Department of Psychiatry, University of Minnesota Medical School, Minneapolis, MN 55454 1495, USA
Arch Gen Psychiatry 67:252-7. 2010..Studies of couples of psychiatric patients with children allow us to calculate the effects of double predispositions on morbid risk in the offspring, which is of interest for molecular genetic research and for genetic counseling...
- The endophenotype concept in psychiatry: etymology and strategic intentionsIrving I Gottesman
Department of Psychiatry, University of Minnesota Medical School, Minneapolis 55454, USA
Am J Psychiatry 160:636-45. 2003..The authors discuss the etymology and strategy behind the use of endophenotypes in neuropsychiatric research and, more generally, in research on other diseases with complex genetics...
- Human development: biological and genetic processesIrving I Gottesman
Department of Psychiatry and Department of Psychology, University of Minnesota, Minneapolis, MN 55454, USA
Annu Rev Psychol 56:263-86. 2005..For human behavioral disorders such as schizophrenia and autism, the inherent plasticity of the nervous system requires a systems approach to incorporate all of the myriad epigenetic factors that can influence such outcomes...
- A new MMPI-derived indicator of liability to develop schizophrenia: evidence from the New York High-Risk ProjectP K Bolinskey
Department of Psychology, University of Virginia, Charlottesville 22904 4400, USA
Assessment 8:127-43. 2001..Results suggest that the SzP scale can be an effective predictor of schizophrenia-related psychoses. A revised psychometric index is offered for further study...
- Normal and abnormal personality traits: evidence for genetic and environmental relationships in the Minnesota Study of Twins Reared ApartKristian E Markon
Department of Psychology, University of Minnesota, Minneapolis 55455, USA
J Pers 70:661-93. 2002..It is suggested that future research focus on the neurogenetic substrates of these shared systems and how dysfunction in these systems influences development of disordered personality...
- Glial fibrillary acidic protein is reduced in cerebellum of subjects with major depression, but not schizophreniaS Hossein Fatemi
Division of Neuroscience Research, Department of Psychiatry, University of Minnesota Medical School, MMC 392, Delaware Street 420, Minneapolis, MN 55455, USA
Schizophr Res 69:317-23. 2004....
- The genetic epidemiology of schizophrenia and the design of linkage studiesM McGue
Department of Psychology, University of Minnesota, Minneapolis
Eur Arch Psychiatry Clin Neurosci 240:174-81. 1991..Third, environmental influences appear to play an essential role in the etiology of at least some schizophrenia. The implications of these features for linkage strategies in schizophrenia are discussed...
- Family and twin strategies as a head start in defining prodromes and endophenotypes for hypothetical early-interventions in schizophreniaI I Gottesman
Department of Psychology, University of Virginia, PO Box 400400, Gilmer Hall, Charlottesville, VA 22904 4400, USA
Schizophr Res 51:93-102. 2001..Even more caution than usual is required, given the suggestions that the developing neocortex is vulnerable to dopaminergic exposure...
- Lithium's antisuicidal efficacy: elucidation of neurobiological targets using endophenotype strategiesColleen E Kovacsics
Department of Psychiatry, Mood and Anxiety Disorders Program, University of Maryland School of Medicine, Baltimore, Maryland, USA
Annu Rev Pharmacol Toxicol 49:175-98. 2009....
- Deconstructing schizophrenia: an overview of the use of endophenotypes in order to understand a complex disorderDavid L Braff
Department of Psychiatry, University of California San Diego, 9500 Gilman Drive, Mail Code 0804, La Jolla, CA 92093, USA
Schizophr Bull 33:21-32. 2007..The endophenotype strategy offers powerful and exciting opportunities to understand the genetically conferred neurobiological vulnerabilities and possible new strong inference and molecularly based treatments for schizophrenia...
- HIV/AIDS risks as a consequence of schizophreniaI I Gottesman
Dept of Psychology, University of Virginia, Charlottesville 22903, USA
Schizophr Bull 23:675-84. 1997..Mental health service providers need to be aware of these findings...
- The Washington University Twin Study of alcoholismCarol A Prescott
Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, Virginia, USA
Am J Med Genet B Neuropsychiatr Genet 134:48-55. 2005..Power to test other sources of heterogeneity was limited, but the results suggest no evidence for higher heritability for male early onset alcoholism or for alcoholism with comorbid antisocial personality...
- Evaluation of familial influences on the course and severity of schizophrenia among US and Indian casesSmita N Deshpande
Dr Ram Manohar Lohia Hospital, New Delhi, India
Soc Psychiatry Psychiatr Epidemiol 39:369-74. 2004..Prior studies suggest familial (possibly genetic) influences on the course of schizophrenia...
- Toward constructing an endophenotype strategy for bipolar disordersGregor Hasler
Mood and Anxiety Disorders Program, National Institute of Mental Health, Bethesda, Maryland, USA
Biol Psychiatry 60:93-105. 2006..Studies to evaluate candidate endophenotypes with respect to specificity, heritability, temporal stability, and prevalence in unaffected relatives are encouraged...
- The Schizophrenia Proneness (SzP) scale: an MMPI-2 measure of schizophrenia liabilityP Kevin Bolinskey
Virginia Institute of Psychiatric and Behavioral Genetics, Medical College of Virginia, Richmond, 23298 0126, USA
J Clin Psychol 59:1031-44. 2003..Results suggest that an SzP T score of 65 or above is an effective indicator of personality processes associated with increased liability to developing SRI...
- MMPI vulnerability indicators for schizophrenia and attention deficit disorder: UCLA family study of biological parents of offspring with childhood-onset schizophrenia or ADHDKenneth L Subotnik
Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA 90095 6968, USA
Behav Genet 35:159-75. 2005....
- Endophenotyping schizophreniaDavid Braff
Am J Psychiatry 164:705-7. 2007
- Does glial asthenia predispose to schizophrenia?Hans W Moises
Arch Gen Psychiatry 61:1170. 2004
- Challenging the conclusion that lower preinduction cognitive ability increases risk for combat-related post-traumatic stress disorder in 2,375 combat-exposed, Vietnam War veteransWilliam W Thompson
National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
Mil Med 173:576-82. 2008..Among U.S. Vietnam War veterans, we assessed whether preinduction cognitive abilities were associated with the risk of developing combat-related post-traumatic stress disorder (PTSD)...
- Marriage and genetic variation across the lifespan: not a steady relationship?Susan L Trumbetta
Department of Psychology, Vassar College, 124 Raymond Avenue, Box 219, Poughkeepsie, NY 12604, USA
Behav Genet 37:362-75. 2007..Variance due to error and unique environmental influences increased steadily to age 50 years and then declined slightly...
- Signal transduction and genes-to-behaviors pathways in psychiatric diseasesHusseini K Manji
Laboratory of Molecular Pathophysiology, Mood and Anxiety Disorders Program, NIMH, Bethesda, MD 20892, USA
Sci STKE 2003:pe49. 2003..It is likely that genetic findings in severe psychiatric disorders will continue to implicate direct and indirect modulation of critical intracellular signaling pathways...
- Genes and antisocial behavior: perceived versus real threats to jurisprudenceGregory Carey
Department of Psychology, University of Colorado, USA
J Law Med Ethics 34:342-51. 2006
- Deconstructing, reconstructing, preserving Paul E. Meehl's legacy of construct validityBrendan A Maher
Department of Psychology, Harvard University, 33 Kirkland Street, Cambridge, MA 02138, USA
Psychol Assess 17:415-22. 2005..The significant and continuing interest generated by the landmark studies of K. MacCorquodale and P. E. Meehl (1948) and L. J. Cronbach and P. E. Meehl (1955) as well as the central importance of P. E. Meehl's thinking are described...
- Phenotypic differences in genetically identical organisms: the epigenetic perspectiveAlbert H C Wong
The Centre for Addiction and Mental Health, Department of Psychiatry, Toronto, Ontario, Canada
Hum Mol Genet 14:R11-8. 2005....
- Monozygotic twins exhibit numerous epigenetic differences: clues to twin discordance?Arturas Petronis
The Krembil Family Epigenetics Laboratory, Centre for Addiction and Mental Health, 250 College Street, Toronto, Ontario, M5T 1R8 Canada
Schizophr Bull 29:169-78. 2003..Epigenetic studies should provide insight into the molecular causes of differential susceptibility to a disease in genetically identical organisms that may generalize to singletons...