I I Gottesman

Summary

Affiliation: University of Minnesota
Country: USA

Publications

  1. ncbi request reprint Psychopathology through a life span-genetic prism
    I I Gottesman
    University of Virginia, USA
    Am Psychol 56:867-78. 2001
  2. doi request reprint Neurological soft signs as candidate endophenotypes for schizophrenia: a shooting star or a Northern star?
    Raymond C K Chan
    Neuropsychology and Applied Cognitive Neuroscience Laboratory, Institute of Psychology, Chinese Academy of Sciences, Beijing, China
    Neurosci Biobehav Rev 32:957-71. 2008
  3. pmc Reconciling disparate prevalence rates of PTSD in large samples of US male Vietnam veterans and their controls
    William W Thompson
    Immunization Safety Office, US Centers for Disease Control and Prevention, Atlanta, GA, USA
    BMC Psychiatry 6:19. 2006
  4. pmc Schizophrenia and psychotic symptoms in families of two American Indian tribes
    Robert W Robin
    Hopi Guidance Center, Second Mesa, AZ 86043, USA
    BMC Psychiatry 7:30. 2007
  5. pmc The glial growth factors deficiency and synaptic destabilization hypothesis of schizophrenia
    Hans W Moises
    Molecular Genetics Laboratory, Department of Psychiatry, Kiel University Hospital, Niemannsweg 147, 24105 Kiel, Germany
    BMC Psychiatry 2:8. 2002
  6. pmc Theories of schizophrenia: a genetic-inflammatory-vascular synthesis
    Daniel R Hanson
    Department of Psychiatry, VA Medical Center 116A, One Veterans Drive, Minneapolis, MN 55417, USA
    BMC Med Genet 6:7. 2005
  7. doi request reprint Severe mental disorders in offspring with 2 psychiatrically ill parents
    Irving I Gottesman
    Department of Psychiatry, University of Minnesota Medical School, Minneapolis, MN 55454 1495, USA
    Arch Gen Psychiatry 67:252-7. 2010
  8. ncbi request reprint The endophenotype concept in psychiatry: etymology and strategic intentions
    Irving I Gottesman
    Department of Psychiatry, University of Minnesota Medical School, Minneapolis 55454, USA
    Am J Psychiatry 160:636-45. 2003
  9. ncbi request reprint Human development: biological and genetic processes
    Irving I Gottesman
    Department of Psychiatry and Department of Psychology, University of Minnesota, Minneapolis, MN 55454, USA
    Annu Rev Psychol 56:263-86. 2005
  10. ncbi request reprint A new MMPI-derived indicator of liability to develop schizophrenia: evidence from the New York High-Risk Project
    P K Bolinskey
    Department of Psychology, University of Virginia, Charlottesville 22904 4400, USA
    Assessment 8:127-43. 2001

Detail Information

Publications31

  1. ncbi request reprint Psychopathology through a life span-genetic prism
    I I Gottesman
    University of Virginia, USA
    Am Psychol 56:867-78. 2001
    ..The challenge to the field of psychology is to join in with cross-disciplinary ventures and to adapt to rapid changes with innovations in research strategies...
  2. doi request reprint Neurological soft signs as candidate endophenotypes for schizophrenia: a shooting star or a Northern star?
    Raymond C K Chan
    Neuropsychology and Applied Cognitive Neuroscience Laboratory, Institute of Psychology, Chinese Academy of Sciences, Beijing, China
    Neurosci Biobehav Rev 32:957-71. 2008
    ..Finally, we recommend areas in which additional research should be done to further elucidate the potential use of neurological soft signs for schizophrenia research...
  3. pmc Reconciling disparate prevalence rates of PTSD in large samples of US male Vietnam veterans and their controls
    William W Thompson
    Immunization Safety Office, US Centers for Disease Control and Prevention, Atlanta, GA, USA
    BMC Psychiatry 6:19. 2006
    ..2%. We compared alternative criteria for estimating the prevalence of PTSD using the NVVRS and VES public use data sets collected more than 10 years after the United States withdrew troops from Vietnam...
  4. pmc Schizophrenia and psychotic symptoms in families of two American Indian tribes
    Robert W Robin
    Hopi Guidance Center, Second Mesa, AZ 86043, USA
    BMC Psychiatry 7:30. 2007
    ..These tribal groups were evaluated as part of a broader program of gene-environment investigations of alcoholism and other psychiatric disorders...
  5. pmc The glial growth factors deficiency and synaptic destabilization hypothesis of schizophrenia
    Hans W Moises
    Molecular Genetics Laboratory, Department of Psychiatry, Kiel University Hospital, Niemannsweg 147, 24105 Kiel, Germany
    BMC Psychiatry 2:8. 2002
    ..A systems approach to understanding the etiology of schizophrenia requires a theory which is able to integrate genetic as well as neurodevelopmental factors...
  6. pmc Theories of schizophrenia: a genetic-inflammatory-vascular synthesis
    Daniel R Hanson
    Department of Psychiatry, VA Medical Center 116A, One Veterans Drive, Minneapolis, MN 55417, USA
    BMC Med Genet 6:7. 2005
    ..A search for a more satisfying model to explain aspects of schizophrenia uncovers clues pointing to genetically mediated CNS microvascular inflammatory disease...
  7. doi request reprint Severe mental disorders in offspring with 2 psychiatrically ill parents
    Irving I Gottesman
    Department of Psychiatry, University of Minnesota Medical School, Minneapolis, MN 55454 1495, USA
    Arch Gen Psychiatry 67:252-7. 2010
    ..Studies of couples of psychiatric patients with children allow us to calculate the effects of double predispositions on morbid risk in the offspring, which is of interest for molecular genetic research and for genetic counseling...
  8. ncbi request reprint The endophenotype concept in psychiatry: etymology and strategic intentions
    Irving I Gottesman
    Department of Psychiatry, University of Minnesota Medical School, Minneapolis 55454, USA
    Am J Psychiatry 160:636-45. 2003
    ..The authors discuss the etymology and strategy behind the use of endophenotypes in neuropsychiatric research and, more generally, in research on other diseases with complex genetics...
  9. ncbi request reprint Human development: biological and genetic processes
    Irving I Gottesman
    Department of Psychiatry and Department of Psychology, University of Minnesota, Minneapolis, MN 55454, USA
    Annu Rev Psychol 56:263-86. 2005
    ..For human behavioral disorders such as schizophrenia and autism, the inherent plasticity of the nervous system requires a systems approach to incorporate all of the myriad epigenetic factors that can influence such outcomes...
  10. ncbi request reprint A new MMPI-derived indicator of liability to develop schizophrenia: evidence from the New York High-Risk Project
    P K Bolinskey
    Department of Psychology, University of Virginia, Charlottesville 22904 4400, USA
    Assessment 8:127-43. 2001
    ..Results suggest that the SzP scale can be an effective predictor of schizophrenia-related psychoses. A revised psychometric index is offered for further study...
  11. ncbi request reprint Normal and abnormal personality traits: evidence for genetic and environmental relationships in the Minnesota Study of Twins Reared Apart
    Kristian E Markon
    Department of Psychology, University of Minnesota, Minneapolis 55455, USA
    J Pers 70:661-93. 2002
    ..It is suggested that future research focus on the neurogenetic substrates of these shared systems and how dysfunction in these systems influences development of disordered personality...
  12. ncbi request reprint Glial fibrillary acidic protein is reduced in cerebellum of subjects with major depression, but not schizophrenia
    S Hossein Fatemi
    Division of Neuroscience Research, Department of Psychiatry, University of Minnesota Medical School, MMC 392, Delaware Street 420, Minneapolis, MN 55455, USA
    Schizophr Res 69:317-23. 2004
    ....
  13. ncbi request reprint The genetic epidemiology of schizophrenia and the design of linkage studies
    M McGue
    Department of Psychology, University of Minnesota, Minneapolis
    Eur Arch Psychiatry Clin Neurosci 240:174-81. 1991
    ..Third, environmental influences appear to play an essential role in the etiology of at least some schizophrenia. The implications of these features for linkage strategies in schizophrenia are discussed...
  14. ncbi request reprint Family and twin strategies as a head start in defining prodromes and endophenotypes for hypothetical early-interventions in schizophrenia
    I I Gottesman
    Department of Psychology, University of Virginia, PO Box 400400, Gilmer Hall, Charlottesville, VA 22904 4400, USA
    Schizophr Res 51:93-102. 2001
    ..Even more caution than usual is required, given the suggestions that the developing neocortex is vulnerable to dopaminergic exposure...
  15. doi request reprint Lithium's antisuicidal efficacy: elucidation of neurobiological targets using endophenotype strategies
    Colleen E Kovacsics
    Department of Psychiatry, Mood and Anxiety Disorders Program, University of Maryland School of Medicine, Baltimore, Maryland, USA
    Annu Rev Pharmacol Toxicol 49:175-98. 2009
    ....
  16. pmc Deconstructing schizophrenia: an overview of the use of endophenotypes in order to understand a complex disorder
    David L Braff
    Department of Psychiatry, University of California San Diego, 9500 Gilman Drive, Mail Code 0804, La Jolla, CA 92093, USA
    Schizophr Bull 33:21-32. 2007
    ..The endophenotype strategy offers powerful and exciting opportunities to understand the genetically conferred neurobiological vulnerabilities and possible new strong inference and molecularly based treatments for schizophrenia...
  17. ncbi request reprint HIV/AIDS risks as a consequence of schizophrenia
    I I Gottesman
    Dept of Psychology, University of Virginia, Charlottesville 22903, USA
    Schizophr Bull 23:675-84. 1997
    ..Mental health service providers need to be aware of these findings...
  18. ncbi request reprint The Washington University Twin Study of alcoholism
    Carol A Prescott
    Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, Virginia, USA
    Am J Med Genet B Neuropsychiatr Genet 134:48-55. 2005
    ..Power to test other sources of heterogeneity was limited, but the results suggest no evidence for higher heritability for male early onset alcoholism or for alcoholism with comorbid antisocial personality...
  19. ncbi request reprint Evaluation of familial influences on the course and severity of schizophrenia among US and Indian cases
    Smita N Deshpande
    Dr Ram Manohar Lohia Hospital, New Delhi, India
    Soc Psychiatry Psychiatr Epidemiol 39:369-74. 2004
    ..Prior studies suggest familial (possibly genetic) influences on the course of schizophrenia...
  20. ncbi request reprint Toward constructing an endophenotype strategy for bipolar disorders
    Gregor Hasler
    Mood and Anxiety Disorders Program, National Institute of Mental Health, Bethesda, Maryland, USA
    Biol Psychiatry 60:93-105. 2006
    ..Studies to evaluate candidate endophenotypes with respect to specificity, heritability, temporal stability, and prevalence in unaffected relatives are encouraged...
  21. ncbi request reprint The Schizophrenia Proneness (SzP) scale: an MMPI-2 measure of schizophrenia liability
    P Kevin Bolinskey
    Virginia Institute of Psychiatric and Behavioral Genetics, Medical College of Virginia, Richmond, 23298 0126, USA
    J Clin Psychol 59:1031-44. 2003
    ..Results suggest that an SzP T score of 65 or above is an effective indicator of personality processes associated with increased liability to developing SRI...
  22. ncbi request reprint MMPI vulnerability indicators for schizophrenia and attention deficit disorder: UCLA family study of biological parents of offspring with childhood-onset schizophrenia or ADHD
    Kenneth L Subotnik
    Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA 90095 6968, USA
    Behav Genet 35:159-75. 2005
    ....
  23. ncbi request reprint Endophenotyping schizophrenia
    David Braff
    Am J Psychiatry 164:705-7. 2007
  24. ncbi request reprint Does glial asthenia predispose to schizophrenia?
    Hans W Moises
    Arch Gen Psychiatry 61:1170. 2004
  25. ncbi request reprint Challenging the conclusion that lower preinduction cognitive ability increases risk for combat-related post-traumatic stress disorder in 2,375 combat-exposed, Vietnam War veterans
    William W Thompson
    National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Mil Med 173:576-82. 2008
    ..Among U.S. Vietnam War veterans, we assessed whether preinduction cognitive abilities were associated with the risk of developing combat-related post-traumatic stress disorder (PTSD)...
  26. ncbi request reprint Marriage and genetic variation across the lifespan: not a steady relationship?
    Susan L Trumbetta
    Department of Psychology, Vassar College, 124 Raymond Avenue, Box 219, Poughkeepsie, NY 12604, USA
    Behav Genet 37:362-75. 2007
    ..Variance due to error and unique environmental influences increased steadily to age 50 years and then declined slightly...
  27. ncbi request reprint Signal transduction and genes-to-behaviors pathways in psychiatric diseases
    Husseini K Manji
    Laboratory of Molecular Pathophysiology, Mood and Anxiety Disorders Program, NIMH, Bethesda, MD 20892, USA
    Sci STKE 2003:pe49. 2003
    ..It is likely that genetic findings in severe psychiatric disorders will continue to implicate direct and indirect modulation of critical intracellular signaling pathways...
  28. ncbi request reprint Genes and antisocial behavior: perceived versus real threats to jurisprudence
    Gregory Carey
    Department of Psychology, University of Colorado, USA
    J Law Med Ethics 34:342-51. 2006
  29. ncbi request reprint Deconstructing, reconstructing, preserving Paul E. Meehl's legacy of construct validity
    Brendan A Maher
    Department of Psychology, Harvard University, 33 Kirkland Street, Cambridge, MA 02138, USA
    Psychol Assess 17:415-22. 2005
    ..The significant and continuing interest generated by the landmark studies of K. MacCorquodale and P. E. Meehl (1948) and L. J. Cronbach and P. E. Meehl (1955) as well as the central importance of P. E. Meehl's thinking are described...
  30. ncbi request reprint Phenotypic differences in genetically identical organisms: the epigenetic perspective
    Albert H C Wong
    The Centre for Addiction and Mental Health, Department of Psychiatry, Toronto, Ontario, Canada
    Hum Mol Genet 14:R11-8. 2005
    ....
  31. ncbi request reprint Monozygotic twins exhibit numerous epigenetic differences: clues to twin discordance?
    Arturas Petronis
    The Krembil Family Epigenetics Laboratory, Centre for Addiction and Mental Health, 250 College Street, Toronto, Ontario, M5T 1R8 Canada
    Schizophr Bull 29:169-78. 2003
    ..Epigenetic studies should provide insight into the molecular causes of differential susceptibility to a disease in genetically identical organisms that may generalize to singletons...