Research Topics
Species | CHRISTOPHER HOOPER GOSSSummaryAffiliation: University of Washington Country: USA Publications
Research Grants
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Detail Information
Publications
Factors associated with mortality in patients with tuberculosisDavid J Horne
Department of Medicine, University of Washington School of Medicine, Seattle, WA, USA
BMC Infect Dis 10:258. 2010..Known risk factors for death following a diagnosis of tuberculosis may not be applicable to current U.S. cases. We evaluated the factors associated with all-cause mortality in patients with tuberculosis in Washington State...
Detecting Stenotrophomonas maltophilia does not reduce survival of patients with cystic fibrosisChristopher H Goss
Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Washington Medical Center, Campus Box 356522, 1959 N E Pacific, Seattle, WA 98195, USA
Am J Respir Crit Care Med 166:356-61. 2002..89 (95% confidence interval, 0.75-1.05). Although patients with CF who acquire S. maltophilia have more advanced disease than those who do not acquire this organism, detection does not independently affect short-term survival (3 years)...- Laboratory parameter profiles among patients with cystic fibrosisChristopher H Goss
Department of Medicine, University of Washington Medical Center, Seattle, WA 98195, USA
J Cyst Fibros 6:117-23. 2007..Laboratory-specific normal reference ranges may not accurately reflect what is abnormal but clinically insignificant among CF patients... - Patient-reported outcomes in cystic fibrosisChristopher H Goss
Department of Medicine, University of Washington Medical Center, Seattle, Washington 98195, USA
Proc Am Thorac Soc 4:378-86. 2007.... - Experience using centralized spirometry in the phase 2 randomized, placebo-controlled, double-blind trial of denufosol in patients with mild to moderate cystic fibrosisC H Goss
Department of Medicine, University of Washington, Seattle WA 98195, United States
J Cyst Fibros 7:147-53. 2008..Centralized spirometry may significantly improve quality of spirometry and reduce variability of this outcome measure in clinical trials in cystic fibrosis (CF)... - Clinical trial participants compared with nonparticipants in cystic fibrosisChristopher H Goss
University of Washington Medical Center, Campus Box 356522, 1959 N E Pacific, Seattle, WA 98195, USA
Am J Respir Crit Care Med 173:98-104. 2006..The randomized clinical trial has been an important tool for expanding our knowledge of disease. This study is the first to compare trial participants to the entire eligible population... - Association between Stenotrophomonas maltophilia and lung function in cystic fibrosisC H Goss
Department of Medicine, University of Washington Medical Center, Seattle, WA 98195, USA
Thorax 59:955-9. 2004..Stenotrophomonas maltophilia (SM) is a Gram-negative non-fermenting bacteria cultured from the sputum of patients with cystic fibrosis (CF). To date, no information is available regarding the effect of this organism on lung function in CF... - Update on cystic fibrosis epidemiologyChristopher H Goss
Department of Medicine, University of Washington Medical Center, Seattle, Washington 98195, USA
Curr Opin Pulm Med 10:510-4. 2004..This review is not meant to be comprehensive, but highlights selected studies, many of which have particular relevance to the growing number of older CF patients... 
Review: Staphylococcus aureus and MRSA in cystic fibrosisChristopher H Goss
Department of Medicine, University of Washington, Seattle WA, USA
J Cyst Fibros 10:298-306. 2011..aureus) is one of the earliest bacteria detected in infants and children with cystic fibrosis (CF). The rise of methicillin resistant S. aureus (MRSA) in the last 10 years has caused a lot of attention to this organism...- Effect of ambient air pollution on pulmonary exacerbations and lung function in cystic fibrosisChristopher H Goss
Department of Medicine, University of Washington, Seattle, WA 98195, USA
Am J Respir Crit Care Med 169:816-21. 2004..91-1.93; 95% CI). Annual average exposures to particulate air pollution was associated with an increased risk of pulmonary exacerbations and a decline in lung function, suggesting a role of environmental exposures on prognosis in CF... - Cost and incidence of social comorbidities in low-risk patients with community-acquired pneumonia admitted to a public hospitalChristopher H Goss
Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Washington School of Medicine, Medical Center Campus, Box 356522, 1959 N E Pacific, Seattle, WA 98195, USA
Chest 124:2148-55. 2003..A newly validated CAP outcomes prediction rule developed by Fine and colleagues has been advocated as a guide to hospitalization decisions... - The cystic fibrosis therapeutics development network (CF TDN): a paradigm of a clinical trials network for genetic and orphan diseasesC H Goss
Department of Medicine, University of Washington, School of Medicine, Seattle, WA, USA
Adv Drug Deliv Rev 54:1505-28. 2002..The Cystic Fibrosis Therapeutics Development Network represents a network that has met this challenge and will continue to provide a venue for the safe and efficient conduct of clinical trials in Cystic Fibrosis... - Patient-reported respiratory symptoms in cystic fibrosisC H Goss
Department of Medicine, University of Washington, Seattle, WA, USA
J Cyst Fibros 8:245-52. 2009..Cystic fibrosis (CF) specific patient-derived and reported symptom tools are critical steps toward evaluating the outcomes of new therapies for CF... - A story of success: continuous quality improvement in cystic fibrosis care in the USABradley S Quon
Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Washington Medical Center, Seattle, Washington 98195, USA
Thorax 66:1106-8. 2011..CQI represents one model to achieve quality improvement (QI) and has long been recognized as a key to success in the manufacturing industry with companies like Toyota leading the way... - The effect of pregnancy on survival in women with cystic fibrosisChristopher H Goss
Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Washington Medical Center, Seattle, WA 98195, USA
Chest 124:1460-8. 2003..Patients with cystic fibrosis (CF) are currently living to their fourth decade and are making reproductive decisions. Information concerning the reproductive health of women with CF has been limited to small or single-center studies... - Exacerbations in cystic fibrosis. 1: Epidemiology and pathogenesisChristopher H Goss
Department of Medicine, University of Washington Medical Center, Campus Box 356522, 1959 NE Pacific, Seattle, Washington 98195, USA
Thorax 62:360-7. 2007..This review provides a summary of the pathophysiology, clinical epidemiology and microbial epidemiology of a CF pulmonary exacerbation... - Developing cystic fibrosis lung transplant referral criteria using predictors of 2-year mortalityNicole Mayer-Hamblett
Department of Pediatrics, University of Washington, Seattle, Washington 98105 0371, USA
Am J Respir Crit Care Med 166:1550-5. 2002..Better clinical predictors of short-term mortality among patients with CF are needed... - Long-term survival after hospitalization for community-acquired and healthcare-associated pneumoniaLaura M Cecere
Division of Pulmonary and Critical Care Medicine, University of Washington School of Medicine, Seattle, WA 98101, USA
Respiration 79:128-36. 2010..Elderly patients surviving community-acquired pneumonia (CAP) have subsequent increased mortality. However, little is known regarding long-term survival in younger adults or those with healthcare-associated pneumonia (HCAP)... - A patient with vanishing lung syndrome and remarkable tolerance to high altitudeAndrew Mark Luks
Division of Pulmonary and Critical Care Medicine, University of Washington, Seattle, WA 98195 6522, USA
Med Sci Sports Exerc 39:1891-5. 2007..Such travel may, in fact, be safe as long as the patient has undergone appropriate pretravel evaluation, and we provide recommendations regarding such evaluation in patients with chronic obstructive pulmonary disease... - Lung allocation score for lung transplantation: impact on disease severity and survivalCynthia J Gries
Division of Pulmonary and Critical Care Medicine, University of Washington, Seattle, WA 98195, USA
Chest 132:1954-61. 2007..The impact of LAS implementation on patient characteristics and survival is unknown... - Influenza-associated cystic fibrosis pulmonary exacerbationsJustin R Ortiz
Division of Pulmonary and Critical Care Medicine, University of Washington Medical Center, Box 356522, 1959 NE Pacific St, Seattle, WA 98195 6522, USA
Chest 137:852-60. 2010..Although cystic fibrosis (CF) is the most common inherited respiratory disease, the burden of influenza among individuals with CF is not well characterized... - CFTR genotype as a predictor of prognosis in cystic fibrosisEdward F McKone
Division of Pulmonary and Critical Care Medicine and Adult Cystic Fibrosis Center, University of Washington Medical Center, Seattle, WA 98195 6522, USA
Chest 130:1441-7. 2006..STUDY RATIONALE: Certain CFTR genotypes are associated with reduced mortality. The accuracy of using CFTR genotype as a predictor of survival and the mechanisms through which CFTR genotype influences survival are unknown... - Out-of-hospital fluid in severe sepsis: effect on early resuscitation in the emergency departmentChristopher W Seymour
Division of Pulmonary and Critical Care Medicine, University of Washington, Seattle, Washington, USA
Prehosp Emerg Care 14:145-52. 2010..Early identification and treatment of patients with severe sepsis improves outcome, yet the role of out-of-hospital intravenous (IV) fluid is unknown... - Development of a predictive model for long-term survival after lung transplantation and implications for the lung allocation scoreCynthia J Gries
Department of Medicine, University of Washington, Seattle, WA, USA
J Heart Lung Transplant 29:731-8. 2010..Validated survival modeling is important for guiding clinical decision-making, case-mix adjustment in comparative effectiveness research and refinement of the lung allocation system (LAS)... - Improved survival among young patients with cystic fibrosisMichal Kulich
Department of Biostatistics, University of Washington, Seattle 98195 7232, USA
J Pediatr 142:631-6. 2003..To investigate age-specific trends in survival among US patients with cystic fibrosis between 1985 and 1999 and to assess whether survival in female patients with cystic fibrosis has improved relative to survival in male patients... - Genetic variation in the FAS gene and associations with acute lung injuryBradford J Glavan
Section of Pulmonary Critical Care Medicine, Harborview Medical Center, Seattle, Washington, USA
Am J Respir Crit Care Med 183:356-63. 2011..Fas (CD95) modulates apoptosis and inflammation and is believed to play an important role in lung injury... - Predictors of influenza vaccination in the Cystic Fibrosis Foundation patient registry, 2006 through 2007Justin R Ortiz
Division of Pulmonary and Critical Care Medicine, University of Washington Medical Center, Seattle, WA 98195 6522, USA
Chest 138:1448-55. 2010..Influenza vaccination is recommended for all persons with cystic fibrosis (CF). Despite this recommendation, no study has been performed to determine factors associated with receipt of influenza vaccination among persons with CF... - Out-of-hospital characteristics and care of patients with severe sepsis: a cohort studyChristopher W Seymour
Division of Pulmonary and Critical Care Medicine, University of Washington, Seattle, WA 98104, USA
J Crit Care 25:553-62. 2010.... - Respiratory adverse event profiles in cystic fibrosis placebo subjects in short- and long-term inhaled therapy trialsHeidi Sucharew
CF Therapeutics Development Network Coordinating Center, Seattle, WA, United States
Contemp Clin Trials 27:561-70. 2006..The tables published from this study can be used to assist those charged with safety monitoring in CF clinical trials... - Analysis of sequential aliquots of hypertonic saline solution-induced sputum from clinically stable patients with cystic fibrosisMoira L Aitken
Department of Medicine, Division of Pulmonary and Critical Care, University of Washington, Seattle 98195, USA
Chest 123:792-9. 2003..When induced-sputum samples are fractionated for research monitoring of inflammatory or microbiologic indexes, power calculations accounting for these variations over time are required... - Changes in arterial oxygenation and self-reported oxygen use after lung volume reduction surgeryMargaret L Snyder
Division of Pulmonary and Critical Care Medicine, University of Washington, Seattle, Washington 98195 6522, USA
Am J Respir Crit Care Med 178:339-45. 2008..Lung volume reduction surgery (LVRS) is inconsistently reported to improve arterial oxygenation in patients with chronic obstructive pulmonary disease... - Pulmonary function in the morbidly obeseJoshua A Saliman
Department of Medicine, University of Washington Medical Center, Seattle, Washington 98195, USA
Surg Obes Relat Dis 4:632-9; discussion 639. 2008..To assess the relationship between lung function tests and clinical characteristics in a cohort of morbidly obese patients undergoing evaluation for bariatric procedures in a university hospital in the United States... - Contraceptive practices in women with cystic fibrosisBarry J Plant
Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Washington Medical Center, Seattle WA 98195 6522, United States
J Cyst Fibros 7:412-4. 2008..Despite theoretical concerns regarding efficacy and toxicity, the choices of contraception are similar to those of the general U.S. population... - Early tumor necrosis factor-alpha release from the pulmonary macrophage in lung ischemia-reperfusion injuryBabu V Naidu
Division of Cardiothoracic Surgery, Department of Surgery, University of Washington Medical Center, Seattle 98195, USA
J Thorac Cardiovasc Surg 127:1502-8. 2004..Gadolinium pretreatment markedly reduces tumor necrosis factor-alpha elaboration, resulting in significant protection against lung ischemia-reperfusion injury... - Cystic fibrosis pulmonary guidelines: chronic medications for maintenance of lung healthPatrick A Flume
Department of Medicine, Medical University of South Carolina, Charleston, South Carolina 29425, USA
Am J Respir Crit Care Med 176:957-69. 2007..Hence, it is important that treatments should be recommended on the basis of available evidence of efficacy and safety... - Effect of mycophenolate mofetil on pulmonary function in scleroderma-associated interstitial lung diseaseAnthony J Gerbino
Sections of Pulmonary Critical Care Medicine, Virginia Mason Medical Center, 1100 Ninth Ave, Seattle, WA 98111, USA
Chest 133:455-60. 2008..We sought to determine the effectiveness of mycophenolate mofetil (MMF) in scleroderma- associated interstitial lung disease (SSc-ILD)... - Clinician statements and family satisfaction with family conferences in the intensive care unitRenee D Stapleton
Division of Pulmonary and Critical Care Medicine, Department of Medicine, School of Medicine, University of Washington, Seattle, WA, USA
Crit Care Med 34:1679-85. 2006.... - Hospital volume and the outcomes of mechanical ventilationJeremy M Kahn
Division of Pulmonary and Critical Care Medicine, University of Washington, Seattle 98104, USA
N Engl J Med 355:41-50. 2006..Further research is needed to determine the mechanism of the relationship between volume and outcome among patients with a critical illness. Copyright 2006 Massachusetts Medical Society... - Alveolar macrophage secretory products augment the response of rat pulmonary artery endothelial cells to hypoxia and reoxygenationAnton S McCourtie
Department of Surgery, Division of Cardiothoracic Surgery, University of Washington Medical Center, Seattle, Washington 98195, USA
Ann Thorac Surg 85:1056-60. 2008..The aim of this study was to determine whether alveolar macrophage secretory products amplify the response of the endothelial cell using an in vitro model of lung reperfusion injury... - Incidence of acute lung injury in the United StatesChristopher H Goss
Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Washington Medical Center, Seattle, WA, USA
Crit Care Med 31:1607-11. 2003.... - Safety and preliminary clinical activity of a novel pancreatic enzyme preparation in pancreatic insufficient cystic fibrosis patientsDrucy Borowitz
CF Therapeutics Development Network, Seattle, Wash, USA
Pancreas 32:258-63. 2006..We conducted a phase 1 study of a novel pancreatic enzyme product, TheraCLEC-Total (TCT), a proprietary formulation of microbial-derived lipase, protease, and amylase, to determine its safety and preliminary efficacy in cystic fibrosis... - Incidence and risk factors for multiple antibiotic-resistant Pseudomonas aeruginosa in cystic fibrosisChristian A Merlo
The Johns Hopkins University School of Medicine, 1830 E Monument St Fifth Floor, Baltimore, MD 21205, USA
Chest 132:562-8. 2007..The main objective of the study was to estimate the incidence and identify risk factors for the acquisition of MARPA among individuals with CF... - Disease-specific reference equations for lung function in patients with cystic fibrosisMichal Kulich
Department of Probability and Mathematical Statistics, Charles University, Prague, Czech Republic
Am J Respir Crit Care Med 172:885-91. 2005..There are limitations to comparing the lung function of a patient with CF to that of healthy control subjects, and potential advantages to comparing it to that of other patients with CF... - Should we stop using intravenous gentamicin in patients with cystic fibrosis?Christopher H Goss
Thorax 63:479-80. 2008 - Study of a novel pancreatic enzyme replacement therapy in pancreatic insufficient subjects with cystic fibrosisDrucy Borowitz
Women and Children s Hospital of Buffalo, Division of Pediatric Pulmonology, State University of New York at Buffalo, Buffalo, NY 14222, USA
J Pediatr 149:658-662. 2006.... - Factors associated with severe disease in a population of asthmatic children of Bogota, ColombiaCarlos Rodriguez Martinez
Department of Pediatric Respiratory Medicine, Clinica Colsanitas, Clinica Infantil Colsubsidio, Bogota, Colombia
J Asthma 45:141-7. 2008..The aim of this study was to investigate the role of suspected, potential risk factors for asthma severity in a population of children living in urban Bogota... - Airway clearance in cystic fibrosisChristopher H Goss
Respir Care 48:20-1. 2003
Research Grants
- Quality of Life in patients with severe Cystic FibrosisChristopher Goss; Fiscal Year: 2007....
- Environmental Effects on Lung Function in Cystic Fibrosis PatientsChristopher Goss; Fiscal Year: 2007..Our proposal will also enhance our understanding of lung growth in CF and represents the initial phase of a program to understand environmental effects on CF lung disease. ..
- A pharmacokinetic and safety study of IV gallium nitrate (Ganite) in cystic fibroCHRISTOPHER HOOPER GOSS; Fiscal Year: 2010..A pharmacokinetic and safety study of intravenous (IV) Ga in subjects with cystic fibrosis (CF) is being proposed as chronic P. aeruginosa airway infections are the major cause of death in these patients and few treatments exist. ..
- Early Intervention in Pulmonary Exacerbation in CFNoah Lechtzin; Fiscal Year: 2010..This approach will utilize state of the art, telehealth equipment to improve the assessment and delivery of care to adolescents and adults with CF. ..