Sven Ulrik Gorr

Summary

Affiliation: University of Minnesota
Country: USA

Publications

  1. doi request reprint Antimicrobial peptides and periodontal disease
    Sven Ulrik Gorr
    Department of Diagnostic and Biological Sciences, University of Minnesota School of Dentistry, Minneapolis, MN 55455, USA
    J Clin Periodontol 38:126-41. 2011
  2. pmc Antimicrobial peptides in periodontal innate defense
    Sven Ulrik Gorr
    Department of Diagnostic and Biological Sciences, University of Minnesota School of Dentistry, Minneapolis, MN, USA
    Front Oral Biol 15:84-98. 2012
  3. pmc Text-mining applied to autoimmune disease research: the Sjögren's syndrome knowledge base
    Sven Ulrik Gorr
    Department of Diagnostic and Biological Sciences, University of Minnesota School of Dentistry, Minneapolis, MN 55455, USA
    BMC Musculoskelet Disord 13:119. 2012
  4. pmc Dual host-defence functions of SPLUNC2/PSP and synthetic peptides derived from the protein
    Sven Ulrik Gorr
    Department of Diagnostic and Biological Sciences, University of Minnesota School of Dentistry, Minneapolis, MN 55455, USA
    Biochem Soc Trans 39:1028-32. 2011
  5. pmc Lysine substitutions convert a bacterial-agglutinating peptide into a bactericidal peptide that retains anti-lipopolysaccharide activity and low hemolytic activity
    Mahsa Abdolhosseini
    Department of Diagnostic and Biological Sciences, University of Minnesota School of Dentistry, Minneapolis, MN 55455, USA
    Peptides 35:231-8. 2012
  6. pmc Antimicrobial peptide GL13K is effective in reducing biofilms of Pseudomonas aeruginosa
    Helmut Hirt
    Department of Diagnostic and Biological Sciences, University of Minnesota School of Dentistry, Minneapolis, Minnesota, USA
    Antimicrob Agents Chemother 57:4903-10. 2013
  7. pmc Bio-inspired stable antimicrobial peptide coatings for dental applications
    Kyle V Holmberg
    Minnesota Dental Research Center for Biomaterials and Biomechanics, University of Minnesota School of Dentistry, Moos Tower, 515 Delaware St SE, Minneapolis, MN 55455, USA
    Acta Biomater 9:8224-31. 2013
  8. pmc Human parotid secretory protein is a lipopolysaccharide-binding protein: identification of an anti-inflammatory peptide domain
    Mahsa Abdolhosseini
    Department of Diagnostic and Biological Sciences, University of Minnesota School of Dentistry, Minneapolis, MN 55455, USA
    Mol Cell Biochem 359:1-8. 2012

Collaborators

Detail Information

Publications8

  1. doi request reprint Antimicrobial peptides and periodontal disease
    Sven Ulrik Gorr
    Department of Diagnostic and Biological Sciences, University of Minnesota School of Dentistry, Minneapolis, MN 55455, USA
    J Clin Periodontol 38:126-41. 2011
    ..The goal of this review is to identify the antimicrobial proteins in the oral fluids, saliva and gingival crevicular fluid and identify functional families and candidates for antibacterial treatment...
  2. pmc Antimicrobial peptides in periodontal innate defense
    Sven Ulrik Gorr
    Department of Diagnostic and Biological Sciences, University of Minnesota School of Dentistry, Minneapolis, MN, USA
    Front Oral Biol 15:84-98. 2012
    ..The differential regulation of AMP expression in periodontal disease suggests that AMP panels, including up- and downregulated proteins, can be used in oral fluid diagnosis of periodontal disease and to monitor treatment outcome...
  3. pmc Text-mining applied to autoimmune disease research: the Sjögren's syndrome knowledge base
    Sven Ulrik Gorr
    Department of Diagnostic and Biological Sciences, University of Minnesota School of Dentistry, Minneapolis, MN 55455, USA
    BMC Musculoskelet Disord 13:119. 2012
    ..The goal of this study was to develop a database that collects and organizes gene and protein expression data from the existing literature for comparative analysis with future gene expression and proteomic studies of Sjögren's syndrome...
  4. pmc Dual host-defence functions of SPLUNC2/PSP and synthetic peptides derived from the protein
    Sven Ulrik Gorr
    Department of Diagnostic and Biological Sciences, University of Minnesota School of Dentistry, Minneapolis, MN 55455, USA
    Biochem Soc Trans 39:1028-32. 2011
    ..These results suggest that the GL13NH2 and the modified peptide GL13K capture the biological activity of PSP/SPLUNC2 and can serve as lead compounds for the development of novel antimicrobial and anti-inflammatory peptides...
  5. pmc Lysine substitutions convert a bacterial-agglutinating peptide into a bactericidal peptide that retains anti-lipopolysaccharide activity and low hemolytic activity
    Mahsa Abdolhosseini
    Department of Diagnostic and Biological Sciences, University of Minnesota School of Dentistry, Minneapolis, MN 55455, USA
    Peptides 35:231-8. 2012
    ..GL13K protected mice from lipopolysaccharide-induced sepsis and the peptide exhibited a low level of hemolysis, suggesting that it may be suitable for in vivo application...
  6. pmc Antimicrobial peptide GL13K is effective in reducing biofilms of Pseudomonas aeruginosa
    Helmut Hirt
    Department of Diagnostic and Biological Sciences, University of Minnesota School of Dentistry, Minneapolis, Minnesota, USA
    Antimicrob Agents Chemother 57:4903-10. 2013
    ..Bacterial metalloproteases were found to partially inactivate GL13K but not a d amino acid version of the peptide. ..
  7. pmc Bio-inspired stable antimicrobial peptide coatings for dental applications
    Kyle V Holmberg
    Minnesota Dental Research Center for Biomaterials and Biomechanics, University of Minnesota School of Dentistry, Moos Tower, 515 Delaware St SE, Minneapolis, MN 55455, USA
    Acta Biomater 9:8224-31. 2013
    ..This surface chemistry provides a basis for development of multifunctional bioactive surfaces to reduce patient morbidities and improve long-term clinical efficacy of metallic dental and orthopedic implants. ..
  8. pmc Human parotid secretory protein is a lipopolysaccharide-binding protein: identification of an anti-inflammatory peptide domain
    Mahsa Abdolhosseini
    Department of Diagnostic and Biological Sciences, University of Minnesota School of Dentistry, Minneapolis, MN 55455, USA
    Mol Cell Biochem 359:1-8. 2012
    ..PSP peptides had no or only minor effect on macrophage cell viability. These results indicate that PSP is a lipopolysaccharide-binding protein that is functionally related to LBP, as suggested by their predicted structural similarities...

Research Grants4

  1. SELECTIVE AGGREGATION AND SORTING OF SALIVARY PROTEINS
    Sven Ulrik Gorr; Fiscal Year: 2001
    ..Elucidating the mechanisms for sorting and storage of secretory proteins in salivary glands will aid in the selection or design of therapeutic peptides to be expressed in the regulated secretory pathway and saliva. ..
  2. SELECTIVE AGGREGATION AND SORTING OF SALIVARY PROTEINS
    Sven Ulrik Gorr; Fiscal Year: 1999
    ..Elucidating the mechanisms for sorting and storage of secretory proteins in salivary glands will aid in the selection or design of therapeutic peptides to be expressed in the regulated secretory pathway and saliva. ..
  3. SELECTIVE AGGREGATION AND SORTING OF SALIVARY PROTEINS
    Sven Ulrik Gorr; Fiscal Year: 2000
    ..Elucidating the mechanisms for sorting and storage of secretory proteins in salivary glands will aid in the selection or design of therapeutic peptides to be expressed in the regulated secretory pathway and saliva. ..
  4. Antibacterial and anti-inflammatory activities of Parotid Secretory Protein
    Sven Ulrik Gorr; Fiscal Year: 2010
    ..Preliminary data suggest that PSP plays a role in host-defense against oral and airway bacteria. Peptides based on the PSP sequence may have clinical utility as antibacterial or anti-inflammatory components. ..