MARIA LUISA GORNO TEMPINI

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Unravelling Boléro: progressive aphasia, transmodal creativity and the right posterior neocortex
    William W Seeley
    Memory and Aging Center, Department of Neurology, UCSF, USA
    Brain 131:39-49. 2008
  2. pmc Classification of primary progressive aphasia and its variants
    M L Gorno-Tempini
    Memory and Aging Center, Department of Neurology, UCSF, 350 Parnassus Avenue, Suite 905, San Francisco, CA 94143 1207, USA
    Neurology 76:1006-14. 2011
  3. pmc The logopenic/phonological variant of primary progressive aphasia
    M L Gorno-Tempini
    UCSF Memory and Aging Center, University of California, San Francisco, CA 94143, USA
    Neurology 71:1227-34. 2008
  4. ncbi request reprint Anatomical correlates of early mutism in progressive nonfluent aphasia
    M L Gorno-Tempini
    UCSF Department of Neurology, Memory and Aging Center, 350 Parnassus Ave, Suite 800, Box 1207, San Francisco, CA 94143 1207, USA
    Neurology 67:1849-51. 2006
  5. ncbi request reprint Anatomical correlates of sentence comprehension and verbal working memory in neurodegenerative disease
    Serena Amici
    Memory and Aging Center, Department of Neurology, University of California, San Francisco, San Francisco, California 94143 1207, USA
    J Neurosci 27:6282-90. 2007
  6. ncbi request reprint Performance in specific language tasks correlates with regional volume changes in progressive aphasia
    Serena Amici
    Department of Neurology, Memory and Aging Center, University of California, San Francisco, USA
    Cogn Behav Neurol 20:203-11. 2007
  7. pmc Apolipoprotein E epsilon4 is associated with disease-specific effects on brain atrophy in Alzheimer's disease and frontotemporal dementia
    Federica Agosta
    Memory and Aging Center, Department of Neurology, University of California, 350 Parnassus Avenue, Suite 905, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 106:2018-22. 2009
  8. pmc The neural basis of surface dyslexia in semantic dementia
    Stephen M Wilson
    Department of Neurology, Memory and Aging Center, University of California, San Francisco, San Francisco, CA 94143 1207, USA
    Brain 132:71-86. 2009
  9. ncbi request reprint Cognitive and behavioral profile in a case of right anterior temporal lobe neurodegeneration
    Maria Luisa Gorno-Tempini
    University of California San Francisco Department of Neurology, San Francisco, CA, USA
    Cortex 40:631-44. 2004
  10. ncbi request reprint Diagnostic criteria for the behavioral variant of frontotemporal dementia (bvFTD): current limitations and future directions
    Katya Rascovsky
    Memory and Aging Center, University of California, San Francisco, CA 94117, USA
    Alzheimer Dis Assoc Disord 21:S14-8. 2007

Research Grants

  1. Primary Progressive Aphasia: Cognition, Anatomy and Progression
    MARIA LUISA GORNO TEMPINI; Fiscal Year: 2010
  2. Progressive Aphasia Cognition Anatomy and Progression
    MARIA LUISA GORNO TEMPINI; Fiscal Year: 2007
  3. Primary Progressive Aphasia: Cognition, Anatomy and Progression
    MARIA LUISA GORNO TEMPINI; Fiscal Year: 2009

Detail Information

Publications40

  1. ncbi request reprint Unravelling Boléro: progressive aphasia, transmodal creativity and the right posterior neocortex
    William W Seeley
    Memory and Aging Center, Department of Neurology, UCSF, USA
    Brain 131:39-49. 2008
    ..The findings suggest that structural and functional enhancements in non-dominant posterior neocortex may give rise to specific forms of visual creativity that can be liberated by dominant inferior frontal cortex injury...
  2. pmc Classification of primary progressive aphasia and its variants
    M L Gorno-Tempini
    Memory and Aging Center, Department of Neurology, UCSF, 350 Parnassus Avenue, Suite 905, San Francisco, CA 94143 1207, USA
    Neurology 76:1006-14. 2011
    ..Future collaborations will collect prospective data to identify relationships between each of these syndromes and specific biomarkers for a more detailed understanding of clinicopathologic correlations...
  3. pmc The logopenic/phonological variant of primary progressive aphasia
    M L Gorno-Tempini
    UCSF Memory and Aging Center, University of California, San Francisco, CA 94143, USA
    Neurology 71:1227-34. 2008
    ..A "logopenic" variant (LPA) has also been proposed, but its cognitive and anatomic profile is less defined. The aim of this study was to establish the cognitive and anatomic features of LPA...
  4. ncbi request reprint Anatomical correlates of early mutism in progressive nonfluent aphasia
    M L Gorno-Tempini
    UCSF Department of Neurology, Memory and Aging Center, 350 Parnassus Ave, Suite 800, Box 1207, San Francisco, CA 94143 1207, USA
    Neurology 67:1849-51. 2006
    ..Damage to the network of brain regions involved in both coordination and execution of speech causes mutism in PNFA...
  5. ncbi request reprint Anatomical correlates of sentence comprehension and verbal working memory in neurodegenerative disease
    Serena Amici
    Memory and Aging Center, Department of Neurology, University of California, San Francisco, San Francisco, California 94143 1207, USA
    J Neurosci 27:6282-90. 2007
    ..This study reconciles two opposing views, which hold that sentence comprehension and vWM rely on either the same or different anatomical resources...
  6. ncbi request reprint Performance in specific language tasks correlates with regional volume changes in progressive aphasia
    Serena Amici
    Department of Neurology, Memory and Aging Center, University of California, San Francisco, USA
    Cogn Behav Neurol 20:203-11. 2007
    ..Patterns of language impairment have long been used clinically to localize brain damage in stroke patients. The same approach might be useful in the differential diagnosis of progressive aphasia owing to neurodegenerative disease...
  7. pmc Apolipoprotein E epsilon4 is associated with disease-specific effects on brain atrophy in Alzheimer's disease and frontotemporal dementia
    Federica Agosta
    Memory and Aging Center, Department of Neurology, University of California, 350 Parnassus Avenue, Suite 905, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 106:2018-22. 2009
    ..The atrophy patterns in epsilon4 carriers may indicate that they are at greater risk for clinical progression...
  8. pmc The neural basis of surface dyslexia in semantic dementia
    Stephen M Wilson
    Department of Neurology, Memory and Aging Center, University of California, San Francisco, San Francisco, CA 94143 1207, USA
    Brain 132:71-86. 2009
    ....
  9. ncbi request reprint Cognitive and behavioral profile in a case of right anterior temporal lobe neurodegeneration
    Maria Luisa Gorno-Tempini
    University of California San Francisco Department of Neurology, San Francisco, CA, USA
    Cortex 40:631-44. 2004
    ..We discuss the atypical cognitive and behavioral features of this case of RTLV of FTLD and stress the importance of behavioral changes and atypical semantic deficits for early diagnosis...
  10. ncbi request reprint Diagnostic criteria for the behavioral variant of frontotemporal dementia (bvFTD): current limitations and future directions
    Katya Rascovsky
    Memory and Aging Center, University of California, San Francisco, CA 94117, USA
    Alzheimer Dis Assoc Disord 21:S14-8. 2007
    ..In this article, we discuss the limitations of current diagnostic criteria and propose the establishment of an international consortium to revise diagnostic and research criteria for the behavioral variant of frontotemporal dementia...
  11. ncbi request reprint Patterns of cerebral atrophy in primary progressive aphasia
    Howard J Rosen
    Department of Neurology, Memory and Aging Center, University of California at San Francisco, CA 94143 1207, USA
    Am J Geriatr Psychiatry 10:89-97. 2002
    ..Different clinical syndromes in PPA are associated with different patterns of atrophy. In the future, combined analysis of imaging and clinical characteristics may allow more accurate etiologic diagnosis...
  12. ncbi request reprint Cinguloparietal atrophy distinguishes Alzheimer disease from semantic dementia
    Adam L Boxer
    Memory and Aging Center and the Department of Neurology, University of California at San Francisco, 94143, USA
    Arch Neurol 60:949-56. 2003
    ..Progressive brain atrophy is associated with Alzheimer disease (AD) and other dementias. Regional differences in brain atrophy may reflect clinical features of disease...
  13. ncbi request reprint An overview on Primary Progressive Aphasia and its variants
    Serena Amici
    Memory and Aging Center, Department of Neurology, University of California, San Francisco, USA
    Behav Neurol 17:77-87. 2006
    ..The neuroimaging analysis showed left perisylvian region involvement. A comprehensive cognitive, neuroimaging and pathological approach is necessary to identify the clinical and pathogenetic features of different PPA variants...
  14. ncbi request reprint Patterns of brain atrophy that differentiate corticobasal degeneration syndrome from progressive supranuclear palsy
    Adam L Boxer
    Memory and Aging Center, Department of Neurology, University of California, San Francisco, CA 94143 1207, USA
    Arch Neurol 63:81-6. 2006
    ..Progressive brain atrophy is associated with the corticobasal degeneration syndrome (CBDS) and progressive supranuclear palsy (PSP). Regional differences in brain atrophy may reflect the clinical features of disease...
  15. ncbi request reprint Clinical and neuropsychological features of corticobasal degeneration
    Nataliya Belfor
    University of California San Francisco, Memory and Aging Center, 350 Parnassus Avenue, Suite 705, 94143, USA
    Mech Ageing Dev 127:203-7. 2006
    ..Increasing awareness of this disorder has led to the realization that specific cognitive and imaging changes are common with CBD degeneration and that these changes help with clinical diagnosis...
  16. ncbi request reprint Neuroanatomical correlates of impaired recognition of emotion in dementia
    Howard J Rosen
    University of California at San Francisco Department of Neurology, Memory and Aging Center, 350 Parnassus Avenue, Suite 706, Box 1207, San Francisco, CA 94143 1207, USA
    Neuropsychologia 44:365-73. 2006
    ....
  17. pmc Abeta amyloid and glucose metabolism in three variants of primary progressive aphasia
    Gil D Rabinovici
    Memory and Aging Center, University of California San Francisco, San Francisco, CA 94143, USA
    Ann Neurol 64:388-401. 2008
    ....
  18. pmc White matter damage in frontotemporal dementia and Alzheimer's disease measured by diffusion MRI
    Yu Zhang
    Center for Imaging of Neurodegenerative Diseases, Department of Veterans Affairs Medical Center, San Francisco, CA 94121, USA
    Brain 132:2579-92. 2009
    ..Taken together, the results suggest that white matter degradation measured with DTI may improve the diagnostic differentiation between FTD and Alzheimer's disease...
  19. pmc Detecting sarcasm from paralinguistic cues: anatomic and cognitive correlates in neurodegenerative disease
    Katherine P Rankin
    Memory and Aging Center, University of California San Francisco, Department of Neurology, San Francisco, CA 94143 1207, USA
    Neuroimage 47:2005-15. 2009
    ....
  20. pmc Frontal paralimbic network atrophy in very mild behavioral variant frontotemporal dementia
    William W Seeley
    UCSF Memory and Aging Center, University of California San Francisco, 350 Parnassus Avenue, San Francisco, CA 94143 1207, USA
    Arch Neurol 65:249-55. 2008
    ..Behavioral variant frontotemporal dementia (bvFTD) strikes hardest at the frontal lobes, but the sites of earliest injury remain unclear...
  21. pmc Neonatal watershed brain injury on magnetic resonance imaging correlates with verbal IQ at 4 years
    Kyle J Steinman
    MAS, University of California, Division of Child Neurology, 350 Parnassus Ave, Suite 609, San Francisco, CA 94117, USA
    Pediatrics 123:1025-30. 2009
    ....
  22. pmc Automated MRI-based classification of primary progressive aphasia variants
    Stephen M Wilson
    Memory and Aging Center, Department of Neurology, University of California, San Francisco, CA, USA
    Neuroimage 47:1558-67. 2009
    ..These results suggest that automated methods could assist in the differential diagnosis of PPA variants, enabling therapies to be targeted to likely underlying etiologies...
  23. pmc Different regional patterns of cortical thinning in Alzheimer's disease and frontotemporal dementia
    An Tao Du
    Center for Imaging of Neurodegenerative Diseases, Department of Veterans Affairs Medical Center, San Francisco, CA 94121, USA
    Brain 130:1159-66. 2007
    ..In conclusion, the characteristic patterns of cortical thinning in Alzheimer's disease and FTD suggest that cortical thickness may be a useful surrogate marker for these types of dementia...
  24. pmc The logopenic variant of primary progressive aphasia
    Maya L Henry
    Department of Neurology, Memory and Aging Center, University of California, San Francisco, California, USA
    Curr Opin Neurol 23:633-7. 2010
    ..This is particularly relevant as researchers attempt to identify clinico-pathological relationships in subtypes of primary progressive aphasia in hopes of utilizing language phenotype as a marker of underlying disease...
  25. pmc Cognition and anatomy in three variants of primary progressive aphasia
    Maria Luisa Gorno-Tempini
    Department of Neurology, UCSF Memory and Aging Center, University of California San Francisco, 350 Parnassus Avenue, San Francisco, CA 94143, USA
    Ann Neurol 55:335-46. 2004
    ..Cognitive, genetic, and anatomical features indicate that different PPA clinical variants may correspond to different underlying pathological processes...
  26. pmc Connected speech production in three variants of primary progressive aphasia
    Stephen M Wilson
    Memory and Aging Center, Department of Neurology, University of California, San Francisco, 350 Parnassus Avenue, Suite 905, San Francisco, CA 94143, USA
    Brain 133:2069-88. 2010
    ....
  27. pmc Structural anatomy of empathy in neurodegenerative disease
    Katherine P Rankin
    Memory and Aging Center, UCSF Department of Neurology, University of California San Francisco CA 94143 1207, USA
    Brain 129:2945-56. 2006
    ..The results suggest that the right anterior temporal and medial frontal regions are essential for real-life empathic behaviour...
  28. pmc Clinical, cognitive and anatomical evolution from nonfluent progressive aphasia to corticobasal syndrome: a case report
    Maria Luisa Gorno-Tempini
    Department of Neurology, University of California San Francisco, San Francisco, CA 94143 1207, USA
    Neurocase 10:426-36. 2004
    ..This case demonstrates the clinical overlap between FTLD and CBS and shows that the two can appear in the same patient at different stages of the disease in relation to the progression of anatomical damage...
  29. pmc Neuroanatomical correlates of behavioural disorders in dementia
    Howard J Rosen
    Department of Neurology, Memory and Aging Center, University of California, San Francisco, CA 94143 1207, USA
    Brain 128:2612-25. 2005
    ..Furthermore, the findings underscore the utility of studying patients with dementia for understanding the neuroanatomical basis of social and emotional functions...
  30. pmc Language networks in semantic dementia
    Federica Agosta
    Memory and Aging Center, Department of Neurology, University of California, San Francisco, 350 Parnassus Avenue, Suite 905, San Francisco, CA 94143 1207, USA
    Brain 133:286-99. 2010
    ....
  31. pmc A tensor based morphometry study of longitudinal gray matter contraction in FTD
    Simona M Brambati
    Memory and Aging Center, UCSF Department of Neurology, 350 Parnassus Ave, Suite 706, San Francisco, CA 94143, USA
    Neuroimage 35:998-1003. 2007
    ..These results suggest that TBM might be useful in tracking progression of regional atrophy in FTD...
  32. pmc Multimodal cuing of autobiographical memory in semantic dementia
    Daniel L Greenberg
    Department of Psychology, University of California, CA, USA
    Neuropsychology 25:98-104. 2011
    ..In the present study, we sought to disentangle the effects of retrieval support and cue modality...
  33. ncbi request reprint Progressive nonfluent aphasia and its characteristic motor speech deficits
    Jennifer M Ogar
    Department of Neurology, University of California San Francisco, San Francisco, CA 94143, USA
    Alzheimer Dis Assoc Disord 21:S23-30. 2007
    ..PNFA is a distinct frontotemporal lobar degeneration clinical syndrome associated with characteristic clinical, neuroimaging, and pathologic features. The clinical features are driven by the severity of left frontal and caudate damage...
  34. ncbi request reprint Apraxia of speech: an overview
    Jennifer Ogar
    UCSF Memory and Aging Center, San Francisco, CA 94143 1207, USA
    Neurocase 11:427-32. 2005
    ..Current models of motor programming will also be addressed as they relate to AOS and finally, typical treatment strategies used in rehabilitating the articulation and prosody deficits associated with AOS will be summarized...
  35. pmc White matter damage in primary progressive aphasias: a diffusion tensor tractography study
    Sebastiano Galantucci
    Memory and Ageing Centre, Department of Neurology, University of California, San Francisco, San Francisco, CA 94143 1207, USA
    Brain 134:3011-29. 2011
    ..These results highlight the potential value of diffusion tensor imaging as a new tool in the multimodal diagnostic evaluation of primary progressive aphasia...
  36. ncbi request reprint Anterior temporal cortex and semantic memory: reconciling findings from neuropsychology and functional imaging
    Timothy T Rogers
    MRC Cognition and Brain Sciences Unit, Cambridge, England, USA
    Cogn Affect Behav Neurosci 6:201-13. 2006
    ..Critically, in patients with atrophy in precisely these areas, the most pronounced deficit was in the retrieval of specific semantic information...
  37. ncbi request reprint Neuroimaging studies of word and pseudoword reading: consistencies, inconsistencies, and limitations
    Andrea Mechelli
    Institute of Neurology, London, UK
    J Cogn Neurosci 15:260-71. 2003
    ..Furthermore, (iii) they suggest that inconsistencies observed in the previous literature may result from effects arising from a small number of subjects only...
  38. ncbi request reprint Human brain language processing areas identified by functional magnetic resonance imaging using a lexical decision task
    Giovanna Calandra-Buonaura
    Department of Neurosciences, University of Modena and Reggio Emilia, Italy
    Funct Neurol 17:183-91. 2002
    ..Single subject analysis demonstrated that the activation paradigm we propose is suitable for detecting language processing areas in humans for clinical studies...
  39. ncbi request reprint Normal and pathological reading: converging data from lesion and imaging studies
    Cathy J Price
    Wellcome Department of Imaging Neuroscience, University College, London, WC1N 3BG, UK
    Neuroimage 20:S30-41. 2003
    ..Future studies are required to examine the connectivity between these areas during normal and abnormal reading...
  40. ncbi request reprint Echo time dependence of BOLD contrast and susceptibility artifacts
    Maria Luisa Gorno-Tempini
    Wellcome Department of Cognitive Neurology, Institute of Neurology, 12 Queen Square, London WC1N 3BG, United Kingdom
    Neuroimage 15:136-42. 2002
    ..However, although the amount of signal loss is reduced at the lower TE, this does not appear to be sufficient to recover the BOLD signal in regions affected by susceptibility artifacts (i.e., anterior temporal lobes)...

Research Grants7

  1. Primary Progressive Aphasia: Cognition, Anatomy and Progression
    MARIA LUISA GORNO TEMPINI; Fiscal Year: 2010
    ..Results form this study will also further our knowledge regarding the neural basis of language. ..
  2. Progressive Aphasia Cognition Anatomy and Progression
    MARIA LUISA GORNO TEMPINI; Fiscal Year: 2007
    ....
  3. Primary Progressive Aphasia: Cognition, Anatomy and Progression
    MARIA LUISA GORNO TEMPINI; Fiscal Year: 2009
    ..Results form this study will also further our knowledge regarding the neural basis of language. ..