Research Topics
| MARIA LUISA GORNO TEMPINISummaryAffiliation: University of California Country: USA Publications
Research Grants
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Detail Information
Publications
Unravelling Boléro: progressive aphasia, transmodal creativity and the right posterior neocortexWilliam W Seeley
Memory and Aging Center, Department of Neurology, UCSF, USA
Brain 131:39-49. 2008..The findings suggest that structural and functional enhancements in non-dominant posterior neocortex may give rise to specific forms of visual creativity that can be liberated by dominant inferior frontal cortex injury...
Classification of primary progressive aphasia and its variantsM L Gorno-Tempini
Memory and Aging Center, Department of Neurology, UCSF, 350 Parnassus Avenue, Suite 905, San Francisco, CA 94143 1207, USA
Neurology 76:1006-14. 2011..Future collaborations will collect prospective data to identify relationships between each of these syndromes and specific biomarkers for a more detailed understanding of clinicopathologic correlations...- The logopenic/phonological variant of primary progressive aphasiaM L Gorno-Tempini
UCSF Memory and Aging Center, University of California, San Francisco, CA 94143, USA
Neurology 71:1227-34. 2008..A "logopenic" variant (LPA) has also been proposed, but its cognitive and anatomic profile is less defined. The aim of this study was to establish the cognitive and anatomic features of LPA... - Anatomical correlates of early mutism in progressive nonfluent aphasiaM L Gorno-Tempini
UCSF Department of Neurology, Memory and Aging Center, 350 Parnassus Ave, Suite 800, Box 1207, San Francisco, CA 94143 1207, USA
Neurology 67:1849-51. 2006..Damage to the network of brain regions involved in both coordination and execution of speech causes mutism in PNFA... - Anatomical correlates of sentence comprehension and verbal working memory in neurodegenerative diseaseSerena Amici
Memory and Aging Center, Department of Neurology, University of California, San Francisco, San Francisco, California 94143 1207, USA
J Neurosci 27:6282-90. 2007..This study reconciles two opposing views, which hold that sentence comprehension and vWM rely on either the same or different anatomical resources... - Performance in specific language tasks correlates with regional volume changes in progressive aphasiaSerena Amici
Department of Neurology, Memory and Aging Center, University of California, San Francisco, USA
Cogn Behav Neurol 20:203-11. 2007..Patterns of language impairment have long been used clinically to localize brain damage in stroke patients. The same approach might be useful in the differential diagnosis of progressive aphasia owing to neurodegenerative disease... - Apolipoprotein E epsilon4 is associated with disease-specific effects on brain atrophy in Alzheimer's disease and frontotemporal dementiaFederica Agosta
Memory and Aging Center, Department of Neurology, University of California, 350 Parnassus Avenue, Suite 905, San Francisco, CA 94143, USA
Proc Natl Acad Sci U S A 106:2018-22. 2009..The atrophy patterns in epsilon4 carriers may indicate that they are at greater risk for clinical progression... - The neural basis of surface dyslexia in semantic dementiaStephen M Wilson
Department of Neurology, Memory and Aging Center, University of California, San Francisco, San Francisco, CA 94143 1207, USA
Brain 132:71-86. 2009.... - Cognitive and behavioral profile in a case of right anterior temporal lobe neurodegenerationMaria Luisa Gorno-Tempini
University of California San Francisco Department of Neurology, San Francisco, CA, USA
Cortex 40:631-44. 2004..We discuss the atypical cognitive and behavioral features of this case of RTLV of FTLD and stress the importance of behavioral changes and atypical semantic deficits for early diagnosis... - Diagnostic criteria for the behavioral variant of frontotemporal dementia (bvFTD): current limitations and future directionsKatya Rascovsky
Memory and Aging Center, University of California, San Francisco, CA 94117, USA
Alzheimer Dis Assoc Disord 21:S14-8. 2007..In this article, we discuss the limitations of current diagnostic criteria and propose the establishment of an international consortium to revise diagnostic and research criteria for the behavioral variant of frontotemporal dementia... - Patterns of cerebral atrophy in primary progressive aphasiaHoward J Rosen
Department of Neurology, Memory and Aging Center, University of California at San Francisco, CA 94143 1207, USA
Am J Geriatr Psychiatry 10:89-97. 2002..Different clinical syndromes in PPA are associated with different patterns of atrophy. In the future, combined analysis of imaging and clinical characteristics may allow more accurate etiologic diagnosis... - Cinguloparietal atrophy distinguishes Alzheimer disease from semantic dementiaAdam L Boxer
Memory and Aging Center and the Department of Neurology, University of California at San Francisco, 94143, USA
Arch Neurol 60:949-56. 2003..Progressive brain atrophy is associated with Alzheimer disease (AD) and other dementias. Regional differences in brain atrophy may reflect clinical features of disease... - An overview on Primary Progressive Aphasia and its variantsSerena Amici
Memory and Aging Center, Department of Neurology, University of California, San Francisco, USA
Behav Neurol 17:77-87. 2006..The neuroimaging analysis showed left perisylvian region involvement. A comprehensive cognitive, neuroimaging and pathological approach is necessary to identify the clinical and pathogenetic features of different PPA variants... - Patterns of brain atrophy that differentiate corticobasal degeneration syndrome from progressive supranuclear palsyAdam L Boxer
Memory and Aging Center, Department of Neurology, University of California, San Francisco, CA 94143 1207, USA
Arch Neurol 63:81-6. 2006..Progressive brain atrophy is associated with the corticobasal degeneration syndrome (CBDS) and progressive supranuclear palsy (PSP). Regional differences in brain atrophy may reflect the clinical features of disease... - Clinical and neuropsychological features of corticobasal degenerationNataliya Belfor
University of California San Francisco, Memory and Aging Center, 350 Parnassus Avenue, Suite 705, 94143, USA
Mech Ageing Dev 127:203-7. 2006..Increasing awareness of this disorder has led to the realization that specific cognitive and imaging changes are common with CBD degeneration and that these changes help with clinical diagnosis... - Neuroanatomical correlates of impaired recognition of emotion in dementiaHoward J Rosen
University of California at San Francisco Department of Neurology, Memory and Aging Center, 350 Parnassus Avenue, Suite 706, Box 1207, San Francisco, CA 94143 1207, USA
Neuropsychologia 44:365-73. 2006.... - Abeta amyloid and glucose metabolism in three variants of primary progressive aphasiaGil D Rabinovici
Memory and Aging Center, University of California San Francisco, San Francisco, CA 94143, USA
Ann Neurol 64:388-401. 2008.... - White matter damage in frontotemporal dementia and Alzheimer's disease measured by diffusion MRIYu Zhang
Center for Imaging of Neurodegenerative Diseases, Department of Veterans Affairs Medical Center, San Francisco, CA 94121, USA
Brain 132:2579-92. 2009..Taken together, the results suggest that white matter degradation measured with DTI may improve the diagnostic differentiation between FTD and Alzheimer's disease... - Detecting sarcasm from paralinguistic cues: anatomic and cognitive correlates in neurodegenerative diseaseKatherine P Rankin
Memory and Aging Center, University of California San Francisco, Department of Neurology, San Francisco, CA 94143 1207, USA
Neuroimage 47:2005-15. 2009.... - Frontal paralimbic network atrophy in very mild behavioral variant frontotemporal dementiaWilliam W Seeley
UCSF Memory and Aging Center, University of California San Francisco, 350 Parnassus Avenue, San Francisco, CA 94143 1207, USA
Arch Neurol 65:249-55. 2008..Behavioral variant frontotemporal dementia (bvFTD) strikes hardest at the frontal lobes, but the sites of earliest injury remain unclear... - Neonatal watershed brain injury on magnetic resonance imaging correlates with verbal IQ at 4 yearsKyle J Steinman
MAS, University of California, Division of Child Neurology, 350 Parnassus Ave, Suite 609, San Francisco, CA 94117, USA
Pediatrics 123:1025-30. 2009.... - Automated MRI-based classification of primary progressive aphasia variantsStephen M Wilson
Memory and Aging Center, Department of Neurology, University of California, San Francisco, CA, USA
Neuroimage 47:1558-67. 2009..These results suggest that automated methods could assist in the differential diagnosis of PPA variants, enabling therapies to be targeted to likely underlying etiologies... - Different regional patterns of cortical thinning in Alzheimer's disease and frontotemporal dementiaAn Tao Du
Center for Imaging of Neurodegenerative Diseases, Department of Veterans Affairs Medical Center, San Francisco, CA 94121, USA
Brain 130:1159-66. 2007..In conclusion, the characteristic patterns of cortical thinning in Alzheimer's disease and FTD suggest that cortical thickness may be a useful surrogate marker for these types of dementia... - The logopenic variant of primary progressive aphasiaMaya L Henry
Department of Neurology, Memory and Aging Center, University of California, San Francisco, California, USA
Curr Opin Neurol 23:633-7. 2010..This is particularly relevant as researchers attempt to identify clinico-pathological relationships in subtypes of primary progressive aphasia in hopes of utilizing language phenotype as a marker of underlying disease... - Cognition and anatomy in three variants of primary progressive aphasiaMaria Luisa Gorno-Tempini
Department of Neurology, UCSF Memory and Aging Center, University of California San Francisco, 350 Parnassus Avenue, San Francisco, CA 94143, USA
Ann Neurol 55:335-46. 2004..Cognitive, genetic, and anatomical features indicate that different PPA clinical variants may correspond to different underlying pathological processes... - Connected speech production in three variants of primary progressive aphasiaStephen M Wilson
Memory and Aging Center, Department of Neurology, University of California, San Francisco, 350 Parnassus Avenue, Suite 905, San Francisco, CA 94143, USA
Brain 133:2069-88. 2010.... - Structural anatomy of empathy in neurodegenerative diseaseKatherine P Rankin
Memory and Aging Center, UCSF Department of Neurology, University of California San Francisco CA 94143 1207, USA
Brain 129:2945-56. 2006..The results suggest that the right anterior temporal and medial frontal regions are essential for real-life empathic behaviour... - Clinical, cognitive and anatomical evolution from nonfluent progressive aphasia to corticobasal syndrome: a case reportMaria Luisa Gorno-Tempini
Department of Neurology, University of California San Francisco, San Francisco, CA 94143 1207, USA
Neurocase 10:426-36. 2004..This case demonstrates the clinical overlap between FTLD and CBS and shows that the two can appear in the same patient at different stages of the disease in relation to the progression of anatomical damage... - Neuroanatomical correlates of behavioural disorders in dementiaHoward J Rosen
Department of Neurology, Memory and Aging Center, University of California, San Francisco, CA 94143 1207, USA
Brain 128:2612-25. 2005..Furthermore, the findings underscore the utility of studying patients with dementia for understanding the neuroanatomical basis of social and emotional functions... - Language networks in semantic dementiaFederica Agosta
Memory and Aging Center, Department of Neurology, University of California, San Francisco, 350 Parnassus Avenue, Suite 905, San Francisco, CA 94143 1207, USA
Brain 133:286-99. 2010.... - A tensor based morphometry study of longitudinal gray matter contraction in FTDSimona M Brambati
Memory and Aging Center, UCSF Department of Neurology, 350 Parnassus Ave, Suite 706, San Francisco, CA 94143, USA
Neuroimage 35:998-1003. 2007..These results suggest that TBM might be useful in tracking progression of regional atrophy in FTD... - Multimodal cuing of autobiographical memory in semantic dementiaDaniel L Greenberg
Department of Psychology, University of California, CA, USA
Neuropsychology 25:98-104. 2011..In the present study, we sought to disentangle the effects of retrieval support and cue modality... - Progressive nonfluent aphasia and its characteristic motor speech deficitsJennifer M Ogar
Department of Neurology, University of California San Francisco, San Francisco, CA 94143, USA
Alzheimer Dis Assoc Disord 21:S23-30. 2007..PNFA is a distinct frontotemporal lobar degeneration clinical syndrome associated with characteristic clinical, neuroimaging, and pathologic features. The clinical features are driven by the severity of left frontal and caudate damage... - Apraxia of speech: an overviewJennifer Ogar
UCSF Memory and Aging Center, San Francisco, CA 94143 1207, USA
Neurocase 11:427-32. 2005..Current models of motor programming will also be addressed as they relate to AOS and finally, typical treatment strategies used in rehabilitating the articulation and prosody deficits associated with AOS will be summarized... - White matter damage in primary progressive aphasias: a diffusion tensor tractography studySebastiano Galantucci
Memory and Ageing Centre, Department of Neurology, University of California, San Francisco, San Francisco, CA 94143 1207, USA
Brain 134:3011-29. 2011..These results highlight the potential value of diffusion tensor imaging as a new tool in the multimodal diagnostic evaluation of primary progressive aphasia... - Anterior temporal cortex and semantic memory: reconciling findings from neuropsychology and functional imagingTimothy T Rogers
MRC Cognition and Brain Sciences Unit, Cambridge, England, USA
Cogn Affect Behav Neurosci 6:201-13. 2006..Critically, in patients with atrophy in precisely these areas, the most pronounced deficit was in the retrieval of specific semantic information... - Neuroimaging studies of word and pseudoword reading: consistencies, inconsistencies, and limitationsAndrea Mechelli
Institute of Neurology, London, UK
J Cogn Neurosci 15:260-71. 2003..Furthermore, (iii) they suggest that inconsistencies observed in the previous literature may result from effects arising from a small number of subjects only... - Human brain language processing areas identified by functional magnetic resonance imaging using a lexical decision taskGiovanna Calandra-Buonaura
Department of Neurosciences, University of Modena and Reggio Emilia, Italy
Funct Neurol 17:183-91. 2002..Single subject analysis demonstrated that the activation paradigm we propose is suitable for detecting language processing areas in humans for clinical studies... - Normal and pathological reading: converging data from lesion and imaging studiesCathy J Price
Wellcome Department of Imaging Neuroscience, University College, London, WC1N 3BG, UK
Neuroimage 20:S30-41. 2003..Future studies are required to examine the connectivity between these areas during normal and abnormal reading... - Echo time dependence of BOLD contrast and susceptibility artifactsMaria Luisa Gorno-Tempini
Wellcome Department of Cognitive Neurology, Institute of Neurology, 12 Queen Square, London WC1N 3BG, United Kingdom
Neuroimage 15:136-42. 2002..However, although the amount of signal loss is reduced at the lower TE, this does not appear to be sufficient to recover the BOLD signal in regions affected by susceptibility artifacts (i.e., anterior temporal lobes)...
Research Grants
- Primary Progressive Aphasia: Cognition, Anatomy and ProgressionMARIA LUISA GORNO TEMPINI; Fiscal Year: 2010..Results form this study will also further our knowledge regarding the neural basis of language. ..
- Progressive Aphasia Cognition Anatomy and ProgressionMARIA LUISA GORNO TEMPINI; Fiscal Year: 2007....
- Primary Progressive Aphasia: Cognition, Anatomy and ProgressionMARIA LUISA GORNO TEMPINI; Fiscal Year: 2009..Results form this study will also further our knowledge regarding the neural basis of language. ..