YVES CLAUDE GORIN

Summary

Affiliation: University of Texas Health Science Center
Country: USA

Publications

  1. ncbi request reprint Nox4 mediates angiotensin II-induced activation of Akt/protein kinase B in mesangial cells
    Yves Gorin
    Department of Medicine, The University of Texas Health Science Center, San Antonio, TX 78229 3900, USA
    Am J Physiol Renal Physiol 285:F219-29. 2003
  2. doi request reprint Nox as a target for diabetic complications
    Yves Gorin
    Department of Medicine, University of Texas Health Science Center, San Antonio, TX 78229, USA
    Clin Sci (Lond) 125:361-82. 2013
  3. pmc Nox4 as a potential therapeutic target for treatment of uremic toxicity associated to chronic kidney disease
    Yves Gorin
    Department of Medicine, University of Texas Health Science Center, San Antonio, Texas, USA
    Kidney Int 83:541-3. 2013
  4. pmc Angiotensin II-induced ERK1/ERK2 activation and protein synthesis are redox-dependent in glomerular mesangial cells
    Yves Gorin
    Department of Medicine, The University of Texas Health Science Center, San Antonio, TX 78229 3900, USA
    Biochem J 381:231-9. 2004
  5. ncbi request reprint Nox4 NAD(P)H oxidase mediates hypertrophy and fibronectin expression in the diabetic kidney
    Yves Gorin
    Department of Medicine, University of Texas Health Science Center, San Antonio, Texas 78229 3900, USA
    J Biol Chem 280:39616-26. 2005
  6. ncbi request reprint Arachidonic acid-dependent activation of a p22(phox)-based NAD(P)H oxidase mediates angiotensin II-induced mesangial cell protein synthesis and fibronectin expression via Akt/PKB
    Karen Block
    Department of Medicine, Audie L Murphy Memorial Hospital Division, The University of Texas Health Science Center, San Antonio, 78229 3900, USA
    Antioxid Redox Signal 8:1497-508. 2006
  7. pmc Nox4 NAD(P)H oxidase mediates Src-dependent tyrosine phosphorylation of PDK-1 in response to angiotensin II: role in mesangial cell hypertrophy and fibronectin expression
    Karen Block
    Department of Medicine, University of Texas Health Science Center, 7723 Floyd Curl Drive, San Antonio, TX 78229, USA
    J Biol Chem 283:24061-76. 2008
  8. pmc Subcellular localization of Nox4 and regulation in diabetes
    Karen Block
    Department of Medicine, University of Texas Health Science Center, San Antonio, TX 78229, USA
    Proc Natl Acad Sci U S A 106:14385-90. 2009
  9. pmc PDGF receptor-{beta} modulates metanephric mesenchyme chemotaxis induced by PDGF AA
    Jill M Ricono
    Department of Molecular Medicine, Institute of Biotechnology, Univ of Texas Health Science Center at San Antonio, San Antonio, TX 78229 3900, USA
    Am J Physiol Renal Physiol 296:F406-17. 2009
  10. pmc NAD(P)H oxidase mediates TGF-beta1-induced activation of kidney myofibroblasts
    Corry D Bondi
    Department of Medicine, University of Texas Health Science Center, San Antonio, TX 78229 3900, USA
    J Am Soc Nephrol 21:93-102. 2010

Research Grants

Collaborators

Detail Information

Publications21

  1. ncbi request reprint Nox4 mediates angiotensin II-induced activation of Akt/protein kinase B in mesangial cells
    Yves Gorin
    Department of Medicine, The University of Texas Health Science Center, San Antonio, TX 78229 3900, USA
    Am J Physiol Renal Physiol 285:F219-29. 2003
    ..These data provide the first evidence that activation by AA of a Rac1-regulated, Nox4-based NAD(P)H oxidase and subsequent generation of ROS mediate the effect of ANG II on Akt/PKB activation and protein synthesis in MCs...
  2. doi request reprint Nox as a target for diabetic complications
    Yves Gorin
    Department of Medicine, University of Texas Health Science Center, San Antonio, TX 78229, USA
    Clin Sci (Lond) 125:361-82. 2013
    ..The bioefficacy of these agents in experimental animal models is also discussed in the present review...
  3. pmc Nox4 as a potential therapeutic target for treatment of uremic toxicity associated to chronic kidney disease
    Yves Gorin
    Department of Medicine, University of Texas Health Science Center, San Antonio, Texas, USA
    Kidney Int 83:541-3. 2013
    ....
  4. pmc Angiotensin II-induced ERK1/ERK2 activation and protein synthesis are redox-dependent in glomerular mesangial cells
    Yves Gorin
    Department of Medicine, The University of Texas Health Science Center, San Antonio, TX 78229 3900, USA
    Biochem J 381:231-9. 2004
    ..This pathway involving AA, Rac1, Nox4, reactive oxygen species and ERK1/ERK2 may play an important role in Ang II-induced mesangial cell hypertrophy...
  5. ncbi request reprint Nox4 NAD(P)H oxidase mediates hypertrophy and fibronectin expression in the diabetic kidney
    Yves Gorin
    Department of Medicine, University of Texas Health Science Center, San Antonio, Texas 78229 3900, USA
    J Biol Chem 280:39616-26. 2005
    ..These data establish a role for Nox4 as the major source of ROS in the kidneys during early stages of diabetes and establish that Nox4-derived ROS mediate renal hypertrophy and increased fibronectin expression...
  6. ncbi request reprint Arachidonic acid-dependent activation of a p22(phox)-based NAD(P)H oxidase mediates angiotensin II-induced mesangial cell protein synthesis and fibronectin expression via Akt/PKB
    Karen Block
    Department of Medicine, Audie L Murphy Memorial Hospital Division, The University of Texas Health Science Center, San Antonio, 78229 3900, USA
    Antioxid Redox Signal 8:1497-508. 2006
    ..Moreover, this pathway mediates the effect of Ang II on Akt/PKB-induced protein synthesis and fibronectin expression...
  7. pmc Nox4 NAD(P)H oxidase mediates Src-dependent tyrosine phosphorylation of PDK-1 in response to angiotensin II: role in mesangial cell hypertrophy and fibronectin expression
    Karen Block
    Department of Medicine, University of Texas Health Science Center, 7723 Floyd Curl Drive, San Antonio, TX 78229, USA
    J Biol Chem 283:24061-76. 2008
    ..These data shed light on molecular processes underlying the oxidative signaling cascade engaged by Ang II and identify potential targets for intervention to prevent renal hypertrophy and fibrosis...
  8. pmc Subcellular localization of Nox4 and regulation in diabetes
    Karen Block
    Department of Medicine, University of Texas Health Science Center, San Antonio, TX 78229, USA
    Proc Natl Acad Sci U S A 106:14385-90. 2009
    ..Our data provide evidence that a functional Nox4 is present and regulated in mitochondria, indicating the existence of a previously undescribed source of ROS in this organelle...
  9. pmc PDGF receptor-{beta} modulates metanephric mesenchyme chemotaxis induced by PDGF AA
    Jill M Ricono
    Department of Molecular Medicine, Institute of Biotechnology, Univ of Texas Health Science Center at San Antonio, San Antonio, TX 78229 3900, USA
    Am J Physiol Renal Physiol 296:F406-17. 2009
    ..During kidney development, PDGFR beta-mediated ROS generation and Ca(2+) influx suppress PDGF AA-induced chemotaxis in metanephric mesenchyme...
  10. pmc NAD(P)H oxidase mediates TGF-beta1-induced activation of kidney myofibroblasts
    Corry D Bondi
    Department of Medicine, University of Texas Health Science Center, San Antonio, TX 78229 3900, USA
    J Am Soc Nephrol 21:93-102. 2010
    ..Taken together, these results suggest that TGF-beta1-induced conversion of fibroblasts to a myofibroblast phenotype involves a signaling cascade through Smad3, NAD(P)H oxidase, and ERK1/2...
  11. pmc Mechanism of oxidative DNA damage in diabetes: tuberin inactivation and downregulation of DNA repair enzyme 8-oxo-7,8-dihydro-2'-deoxyguanosine-DNA glycosylase
    Simona Simone
    George O Brien Kidney Research Center, Department of Medicine, Division of Nephrology, University of Texas Health Science Center, San Antonio, Texas, USA
    Diabetes 57:2626-36. 2008
    ..To investigate potential mechanisms of oxidative DNA damage in a rat model of type 1 diabetes and in murine proximal tubular epithelial cells and primary culture of rat proximal tubular epithelial cells...
  12. ncbi request reprint Involvement of calcineurin in transforming growth factor-beta-mediated regulation of extracellular matrix accumulation
    Jennifer L Gooch
    Department of Medicine, Division of Nephrology, University of Texas Health Science Center, San Antonio, Texas 78229 3900, USA
    J Biol Chem 279:15561-70. 2004
    ..In conclusion, this study describes a new pathway for TGF-beta-mediated regulation of ECM via generation of ROS, calcium influx, and activation of calcineurin...
  13. pmc The NADPH oxidase subunit p22phox inhibits the function of the tumor suppressor protein tuberin
    Karen Block
    Department of Medicine, University of Texas Health Science Center, San Antonio, Texas 78229 3900, USA
    Am J Pathol 176:2447-55. 2010
    ..Our data provide the first evidence that p22(phox)-based Nox oxidases maintain HIF-2alpha protein expression through inactivation of tuberin and downstream activation of ribosomal protein S6 kinase 1/4E-BP1 pathway...
  14. pmc Mechanisms of podocyte injury in diabetes: role of cytochrome P450 and NADPH oxidases
    Assaad A Eid
    University of Texas Health Science Center, Department of Medicine, San Antonio, Texas, USA
    Diabetes 58:1201-11. 2009
    ....
  15. ncbi request reprint Angiotensin II stimulation of VEGF mRNA translation requires production of reactive oxygen species
    Denis Feliers
    Department of Medicine Nephrology, The University of Texas Health Science Center, South Texas Veterans Health Care System, San Antonio 78229 3900, USA
    Am J Physiol Renal Physiol 290:F927-36. 2006
    ..These data show that ROS, generated probably through activation of an NAD(P)H oxidase, mediate ANG II stimulation of VEGF mRNA translation...
  16. ncbi request reprint NAD(P)H oxidases regulate HIF-2alpha protein expression
    Karen Block
    Division of Nephrology, Department of Medicine, George O Brien Kidney Research Center, University of Texas Health Science Center, San Antonio, Texas 78229 3900, USA
    J Biol Chem 282:8019-26. 2007
    ..Collectively, the data demonstrate that VHL protein exerts its tumor suppressor action, at least partially, via inhibition of p22phox-based Nox4/Nox1 NADPH oxidase-dependent reactive oxygen species generation...
  17. ncbi request reprint ZO-1 expression and phosphorylation in diabetic nephropathy
    Hernan Rincon-Choles
    South Texas Veterans Health Care System, San Antonio, TX, USA
    Diabetes 55:894-900. 2006
    ..These findings suggest that alterations in the content and localization of ZO-1 may be relevant to the pathogenesis of proteinuria in diabetes...
  18. ncbi request reprint Mitogenic signaling via platelet-derived growth factor beta in metanephric mesenchymal cells
    Brent Wagner
    Division of Nephrology, Department of Medicine, University of Texas Health Science Center, San Antonio, Texas 78229 3900, USA
    J Am Soc Nephrol 18:2903-11. 2007
    ..In conclusion, the present study demonstrates Nox4 involvement in PDGF-induced DNA synthesis in metanephric mesenchymal cells and provides the first evidence that PDGF-induced PI3-K activity enhances production of ROS by Nox4...
  19. ncbi request reprint Redox dependence of glomerular epithelial cell hypertrophy in response to glucose
    Nam Ho Kim
    University of Texas Health Science Center, Department of Medicine, Division of Nephrology, MC 7882, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
    Am J Physiol Renal Physiol 290:F741-51. 2006
    ..Enhanced ROS generation accounts for the additive effects of high glucose and ANG II, suggesting that this signaling cascade contributes to GEC injury in diabetes...
  20. pmc AMP-activated protein kinase (AMPK) negatively regulates Nox4-dependent activation of p53 and epithelial cell apoptosis in diabetes
    Assaad A Eid
    Department of Medicine, University of Texas Health Science Center, San Antonio, Texas 78229 3900, USA
    J Biol Chem 285:37503-12. 2010
    ..The data indicate the potential therapeutic utility of AMPK activators to block Nox4 and reactive oxygen species generation and to reduce urinary albumin excretion in type 1 diabetes...
  21. ncbi request reprint PI 3 kinase-dependent Akt kinase and PKCepsilon independently regulate interferon-gamma-induced STAT1alpha serine phosphorylation to induce monocyte chemotactic protein-1 expression
    Balachandar A Venkatesan
    Department of Medicine, University of Texas Health Science Center, San Antonio, TX 78220 3900, USA
    Cell Signal 18:508-18. 2006
    ..These data provide the first evidence that PI 3 kinase-dependent Akt and PKCepsilon activation independently regulate MAPK activity and serine phosphorylation of STAT1alpha to increase expression of MCP-1...

Research Grants1

  1. Mechanism of eNOS Uncoupling in the Renal Microvasculature
    YVES CLAUDE GORIN; Fiscal Year: 2010
    ....