Gabriela Gorelik

Summary

Affiliation: University of Michigan
Country: USA

Publications

  1. pmc T cell PKCδ kinase inactivation induces lupus-like autoimmunity in mice
    Gabriela Gorelik
    Department of Medicine, University of Michigan, Ann Arbor, MI, USA Electronic address
    Clin Immunol 158:193-203. 2015
  2. pmc Protein kinase Cδ oxidation contributes to ERK inactivation in lupus T cells
    Gabriela J Gorelik
    University of Michigan, Ann Arbor, MI 48109 2200, USA
    Arthritis Rheum 64:2964-74. 2012
  3. pmc Key role of ERK pathway signaling in lupus
    Gabriela Gorelik
    Department of Medicine, University of Michigan, Ann Arbor, MI 48109 2200, USA
    Autoimmunity 43:17-22. 2010
  4. ncbi request reprint Impaired T cell protein kinase C delta activation decreases ERK pathway signaling in idiopathic and hydralazine-induced lupus
    Gabriela Gorelik
    Department of Medicine, University of Michigan, Ann Arbor, MI 48109, USA
    J Immunol 179:5553-63. 2007
  5. pmc Aberrant T cell ERK pathway signaling and chromatin structure in lupus
    Gabriela Gorelik
    Department of Medicine, University of Michigan, Ann Arbor, MI 48109 2200, USA
    Autoimmun Rev 8:196-8. 2009
  6. pmc Oxidative stress, T cell DNA methylation, and lupus
    Yepeng Li
    University of Michigan, Ann Arbor
    Arthritis Rheumatol 66:1574-82. 2014
  7. pmc Overexpression of X-linked genes in T cells from women with lupus
    Anura Hewagama
    Department of Internal Medicine, Division of Rheumatology, University of Michigan, Ann Arbor, MI 48109 2200, USA
    J Autoimmun 41:60-71. 2013

Collaborators

Detail Information

Publications7

  1. pmc T cell PKCδ kinase inactivation induces lupus-like autoimmunity in mice
    Gabriela Gorelik
    Department of Medicine, University of Michigan, Ann Arbor, MI, USA Electronic address
    Clin Immunol 158:193-203. 2015
    ..The study indicates common pathogenic mechanisms with human lupus, suggesting that environmentally-mediated T cell PKCδ inactivation plays a causative role in lupus...
  2. pmc Protein kinase Cδ oxidation contributes to ERK inactivation in lupus T cells
    Gabriela J Gorelik
    University of Michigan, Ann Arbor, MI 48109 2200, USA
    Arthritis Rheum 64:2964-74. 2012
    ..We undertook this study to test our hypothesis that nitration inactivates PKCδ, contributing to impaired ERK pathway signaling in lupus T cells...
  3. pmc Key role of ERK pathway signaling in lupus
    Gabriela Gorelik
    Department of Medicine, University of Michigan, Ann Arbor, MI 48109 2200, USA
    Autoimmunity 43:17-22. 2010
    ..Understanding the mechanism causing decreased ERK pathway signaling in lupus may shed light on mechanisms contributing to disease development in genetically predisposed people...
  4. ncbi request reprint Impaired T cell protein kinase C delta activation decreases ERK pathway signaling in idiopathic and hydralazine-induced lupus
    Gabriela Gorelik
    Department of Medicine, University of Michigan, Ann Arbor, MI 48109, USA
    J Immunol 179:5553-63. 2007
    ..These results suggest that defective T cell PKCdelta activation may contribute to the development of idiopathic and hydralazine-induced lupus through effects on T cell DNA methylation...
  5. pmc Aberrant T cell ERK pathway signaling and chromatin structure in lupus
    Gabriela Gorelik
    Department of Medicine, University of Michigan, Ann Arbor, MI 48109 2200, USA
    Autoimmun Rev 8:196-8. 2009
    ....
  6. pmc Oxidative stress, T cell DNA methylation, and lupus
    Yepeng Li
    University of Michigan, Ann Arbor
    Arthritis Rheumatol 66:1574-82. 2014
    ....
  7. pmc Overexpression of X-linked genes in T cells from women with lupus
    Anura Hewagama
    Department of Internal Medicine, Division of Rheumatology, University of Michigan, Ann Arbor, MI 48109 2200, USA
    J Autoimmun 41:60-71. 2013
    ..Together these results further support a role for X chromosome demethylation in the female predisposition to lupus...