Research Topics
Species | ANDREA GORESummaryAffiliation: University of Texas Country: USA Publications
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Publications
Menopausal increases in pulsatile gonadotropin-releasing hormone release in a nonhuman primate (Macaca mulatta)Andrea C Gore
University of Texas at Austin, Division of Pharmacology Toxicology, Austin, Texas 78712, USA
Endocrinology 145:4653-9. 2004..To our knowledge, this is the first direct demonstration of elevated pulsatile GnRH concentrations in a primate species during reproductive senescence, a result that may have implications for menopausal symptoms...
Neuroendocrine systems as targets for environmental endocrine-disrupting chemicalsAndrea C Gore
The University of Texas at Austin, Division of Pharmacology and Toxicology, College of Pharmacy, Austin, Texas 78712, USA
Fertil Steril 89:e101-2. 2008- Neuroendocrine targets of endocrine disruptorsAndrea C Gore
Center for Molecular and Cellular Toxicology, Division of Pharmacology and Toxicology, College of Pharmacy, University of Texas, Austin, USA
Hormones (Athens) 9:16-27. 2010..This article will discuss the evidence for environmental endocrine disruption of neuroendocrine systems and the effects on endocrine and reproductive functions... - Glucocorticoid repression of the reproductive axis: effects on GnRH and gonadotropin subunit mRNA levelsAndrea C Gore
Division of Pharmacology and Toxicology, College of Pharmacy, Institute for Neuroscience, The University of Texas at Austin, Austin, TX 78712, United States
Mol Cell Endocrinol 256:40-8. 2006.... - Endocrine disruption for endocrinologists (and others)Andrea C Gore
The University of Texas at Austin, Division of Pharmacology-Toxicology, A1915, Austin, Texas 78712, USA
Endocrinology 147:S1-3. 2006 - Developmental programming and endocrine disruptor effects on reproductive neuroendocrine systemsAndrea C Gore
Division of Pharmacology and Toxicology, Institute for Neuroscience and Institute for Cellular and Molecular Biology, The University of Texas at Austin, 1 University Station A1915, Austin, TX 78712, USA
Front Neuroendocrinol 29:358-74. 2008.... - Endocrine disruption of brain sexual differentiation by developmental PCB exposureSarah M Dickerson
Division of Pharmacology and Toxicology and Center for Molecular and Cellular Toxicology, The University of Texas at Austin, Texas 78712 0125, USA
Endocrinology 152:581-94. 2011..These data suggest that developmental PCBs profoundly impair the sexual differentiation of the female hypothalamus... - Estrogenic environmental endocrine-disrupting chemical effects on reproductive neuroendocrine function and dysfunction across the life cycleSarah M Dickerson
Division of Pharmacology and Toxicology, The University of Texas at Austin, P O Box A1915, Austin, TX 78712, USA
Rev Endocr Metab Disord 8:143-59. 2007..Finally, we identify the gaps of knowledge in this field and suggest future directions for study... - The recreational drug ecstasy disrupts the hypothalamic-pituitary-gonadal reproductive axis in adult male ratsSarah M Dickerson
Division of Pharmacology and Toxicology, The University of Texas at Austin, Austin, Tex 78712 0125, USA
Neuroendocrinology 88:95-102. 2008.... - The effects of prenatal PCBs on adult female paced mating reproductive behaviors in ratsRebecca M Steinberg
The Institute for Neuroscience, The University of Texas at Austin, Austin, TX, USA
Horm Behav 51:364-72. 2007..These data demonstrate that the behavioral phenotype in adulthood is disrupted by low, ecologically relevant exposures to PCBs, and the results have implications for reproductive success and health in wildlife and women... - Sexual experience changes sex hormones but not hypothalamic steroid hormone receptor expression in young and middle-aged male ratsDi Wu
Division of Pharmacology and Toxicology, College of Pharmacy, The University of Texas at Austin, Austin, TX 78712, USA
Horm Behav 56:299-308. 2009..These results show that sexual experience can induce short-term and long-term alterations in serum hormones but these effects are not manifested upon their receptors in the hypothalamus... - Three-dimensional properties of GnRH neuroterminals in the median eminence of young and old ratsWeiling Yin
Division of Pharmacology and Toxicology, College of Pharmacy, University of Texas at Austin, Austin, TX 78712, USA
J Comp Neurol 517:284-95. 2009..Our data suggest reproductive aging in rats is characterized by structural organizational changes to the GnRH terminal microenvironment in the median eminence... - Neuroendocrine control of reproductive aging: roles of GnRH neuronsWeiling Yin
Division of Pharmacology and Toxicology, College of Pharmacy and Institute for Neuroscience and Institute for Cellular and Molecular Biology, University of Texas at Austin, Austin, TX 78712, USA
Reproduction 131:403-14. 2006..Therefore, the aging hypothalamus is characterized by changes intrinsic to the GnRH cell, as well as its regulatory inputs, which summate to contribute to a loss of reproductive competence in aging females... - The hypothalamic median eminence and its role in reproductive agingWeiling Yin
Division of Pharmacology and Toxicology, College of Pharmacy, The University of Texas at Austin, Austin, Texas 78712, USA
Ann N Y Acad Sci 1204:113-22. 2010.... - NMDA receptor subunit NR2b: effects on LH release and GnRH gene expression in young and middle-aged female rats, with modulation by estradiolJacqueline A Maffucci
Institute for Neuroscience, University of Texas, Austin, Tex, USA
Neuroendocrinology 87:129-41. 2008..Here, we examined the functional implications of the NR2b subunit on the onset of reproductive aging, using an NR2b-specific antagonist ifenprodil... - Effects of perinatal polychlorinated biphenyls on adult female rat reproduction: development, reproductive physiology, and second generational effectsRebecca M Steinberg
The Institute for Neuroscience, The University of Texas at Austin, Austin, Texas 78712, USA
Biol Reprod 78:1091-101. 2008..These findings have implications for reproductive health and fertility of wildlife and humans... - Changes in androgen receptor, estrogen receptor alpha, and sexual behavior with aging and testosterone in male ratsDi Wu
Division of Pharmacology and Toxicology, College of Pharmacy, The University of Texas at Austin, Austin, TX 78712, USA
Horm Behav 58:306-16. 2010..Our finding that testosterone replacement in aging males has profound effects on hypothalamic receptors and behavior has potential medical implications for the treatment of age-related hypogonadism in men... - Gonadotropin-releasing hormone neuroterminals and their microenvironment in the median eminence: effects of aging and estradiol treatmentWeiling Yin
Division of Pharmacology and Toxicology, The University of Texas at Austin, Austin, Texas 78712, USA
Endocrinology 150:5498-508. 2009.... - Age-related changes in hypothalamic androgen receptor and estrogen receptor alpha in male ratsDi Wu
Division of Pharmacology and Toxicology, College of Pharmacy, The University of Texas at Austin, Austin, Texas 78712, USA
J Comp Neurol 512:688-701. 2009..These results provide further information about how the neural targets of steroid hormones change with advancing age... - Chapter 2: hypothalamic neural systems controlling the female reproductive life cycle gonadotropin-releasing hormone, glutamate, and GABAJacqueline A Maffucci
Institute for Neuroscience, University of Texas, Austin, Texas 78712, USA
Int Rev Cell Mol Biol 274:69-127. 2009..Here, we present evidence for the modulation of GnRH neurosecretory cells by the balance of glutamate and GABA in the hypothalamus, and the functional consequences of these interactions on reproductive physiology across the life cycle... - Cell death mechanisms in GT1-7 GnRH cells exposed to polychlorinated biphenyls PCB74, PCB118, and PCB153Sarah M Dickerson
Division of Pharmacology and Toxicology, University of Texas at Austin, Austin, TX 78712, USA
Toxicol Appl Pharmacol 237:237-45. 2009..These results provide evidence that PCB congeners have endocrine disrupting and/or neurotoxic effects on the hypothalamic GnRH cell line, a finding that has implications for environmental endocrine disruption in animals... - Transgenerational epigenetic imprints on mate preferenceDavid Crews
Section of Integrative Biology, University of Texas, Austin, TX 78712, USA
Proc Natl Acad Sci U S A 104:5942-6. 2007..Our observations provide direct experimental evidence for a role of epigenetics as a determinant factor in evolution... - Is reproductive ageing controlled by the brain?Andrea C Gore
Division of Pharmacology and Toxicology The University of Texas at Austin, TX, USA
J Neuroendocrinol 19:667-8. 2007..Surprisingly, recent evidence indicates a more important role for the brain in the initiation and transition to reproductive senescence... - Developmental changes in hypothalamic insulin-like growth factor-1: relationship to gonadotropin-releasing hormone neuronsShabrine S Daftary
Kastor Neurobiology of Aging Laboratories, Fishberg Research Center for Neurobiology, Brookdale Department of Geriatrics, Mount Sinai School of Medicine, New York, New York 10029, USA
Endocrinology 144:2034-45. 2003..Taken together, the results suggest that IGF-1 can modulate GnRH neurons, that the sensitivity of GnRH neurons to IGF-1 changes developmentally, and that GnRH cells coexpress IGF-1... - N-Methyl-D-aspartate receptor subunit expression in GnRH neurons changes during reproductive senescence in the female ratBrooke H Miller
Kastor Neurobiology of Aging Laboratories, Fishberg Research Center for Neurobiology, and Brookdale Department of Geriatrics, Mount Sinai School of Medicine, New York, New York 10029, USA
Endocrinology 143:3568-74. 2002.... - Colocalization and hormone regulation of estrogen receptor alpha and N-methyl-D-aspartate receptor in the hypothalamus of female ratsTandra R Chakraborty
Kastor Neurobiology of Aging Labs, Fishberg Research Center for Neurobiology, New York, New York 10029, USA
Endocrinology 144:299-305. 2003.... - Aging-related changes in in vivo release of growth hormone-releasing hormone and somatostatin from the stalk-median eminence in female rhesus monkeys (Macaca mulatta)Shinichiro Nakamura
Wisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, Wisconsin 53715, USA
J Clin Endocrinol Metab 88:827-33. 2003..There were no significant changes in the pulse frequency of SS release. Therefore, the aging-related decrease in GH release is due to a substantial decrease in GHRH release and an increase in SS release from the hypothalamus... - Effects of polychlorinated biphenyls on estrogen receptor-beta expression in the anteroventral periventricular nucleusJacklyn Salama
Kastor Neurobiology of Aging Laboratories, Fishberg Research Center for Neurobiology, Mount Sinai School of Medicine, New York, New York, USA
Environ Health Perspect 111:1278-82. 2003.... - Age-related changes in estrogen receptor beta in rat hypothalamus: a quantitative analysisTandra R Chakraborty
Kastor Neurobiology of Aging Laboratories, Fishberg Research Center for Neurobiology, and Brookdale Department of Geriatrics and Adult Development, Mount Sinai School of Medicine, New York, New York 10029, USA
Endocrinology 144:4164-71. 2003.... - Stereologic analysis of estrogen receptor alpha (ER alpha) expression in rat hypothalamus and its regulation by aging and estrogenTandra R Chakraborty
Kastor Neurobiology of Aging Laboratories, Fishberg Research Center for Neurobiology, and Brookdale Department of Geriatrics and Adult Development, Mount Sinai School of Medicine, New York, New York 10029, USA
J Comp Neurol 466:409-21. 2003..No significant effects of estrogen on ERalpha cell number were detected in any of the four regions studied. Therefore, ERalpha cell number in the rat hypothalamus and preoptic area changes with aging in a region-specific manner... - Chronic daily ethanol and withdrawal: 4. Long-term changes in plasma testosterone regulation, but no effect on GnRH gene expression or plasma LH concentrationsDennis D Rasmussen
VA Puget Sound Health Care System, S 116 Mental Illness Research, Education and Clinical Center, 1660 S Columbian Way, Seattle, WA, USA
Endocrine 22:143-50. 2003.... - Increased expression of forebrain GnRH mRNA and changes in testosterone negative feedback following pubertal maturationHeather N Richardson
Department of Psychology and Neuroscience Program, Michigan State University, East Lansing, MI 48824, USA
Mol Cell Endocrinol 214:63-70. 2004..Furthermore, the pubertal increase in GnRH mRNA appears to occur via steroid feedback-independent mechanisms in the male Syrian hamster... - Aging-related changes in ovarian hormones, their receptors, and neuroendocrine functionTandra R Chakraborty
Fishberg Research Center for Neurobiology, Mount Sinai School of Medicine, New York, New York 10029, USA
Exp Biol Med (Maywood) 229:977-87. 2004..We have also discussed several important experimental design considerations, focusing on rodent models in current use for understanding the mechanisms of menopause in women... - IGF-1 in the brain as a regulator of reproductive neuroendocrine functionShabrine S Daftary
Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, New York, NY 10029, USA
Exp Biol Med (Maywood) 230:292-306. 2005..Here, we examine the role of IGF-1 acting in the hypothalamus as a critical link between reproductive and other neuroendocrine functions... - Estrogen, menopause, and the aging brain: how basic neuroscience can inform hormone therapy in womenJohn H Morrison
Fishberg Department of Neuroscience, Kastor Neurobiology of Aging Laboratories, New York, New York 10029, USA
J Neurosci 26:10332-48. 2006 - How the brain controls puberty, and implications for sex and ethnic differencesSonya M Hughes
Fam Community Health 30:S112-4. 2007 - Postpubertal decrease in hippocampal dendritic spines of female ratsMurat Yildirim
Department of Pharmacology, Hacettepe University, Faculty of Medicine, Ankara, 06100, Turkey
Exp Neurol 210:339-48. 2008..These changes in spine density coincident with puberty may be related to altered hippocampal plasticity and synaptic consolidation at this phase of maturity... - Organochlorine pesticides directly regulate gonadotropin-releasing hormone gene expression and biosynthesis in the GT1-7 hypothalamic cell lineAndrea C Gore
Kastor Neurobiology of Aging Laboratories, Fishberg Research Center for Neurobiology, and Brookdale Department of Geriatrics and Adult Development, Mount Sinai School of Medicine, Box 1639, New York, NY 10029, USA
Mol Cell Endocrinol 192:157-70. 2002..These results indicate that chlorpyrifos and methoxychlor alter GnRH biosynthesis in this hypothalamic cell line in vitro, suggesting that they may have endocrine disrupting effects on GnRH neurons in vivo...
Research Grants
- Neuroendocrine outcomes of prenatal PCB exposuresANDREA GORE; Fiscal Year: 2005..The results should have important implications for understanding consequences of, and developing therapies for, exposures of wildlife and humans to EDCs such as PCBs. ..
- Forum on Endocrine-Disrupting ChemicalsANDREA GORE; Fiscal Year: 2005..In order to limit future contaminations and to mitigate existing exposures, it is critical that we educate the endocrine community and make this subject a permanent part of the Endocrine Society's agenda. ..
- Hypothalamic control of reproductive agingANDREA GORE; Fiscal Year: 2007....
- Hypothalamic control of reproductive agingANDREA GORE; Fiscal Year: 2009....
- Hypothalamic control of reproductive agingAndrea C Gore; Fiscal Year: 2010....