ANDREA GORE

Summary

Affiliation: University of Texas
Country: USA

Publications

  1. ncbi request reprint Menopausal increases in pulsatile gonadotropin-releasing hormone release in a nonhuman primate (Macaca mulatta)
    Andrea C Gore
    University of Texas at Austin, Division of Pharmacology Toxicology, Austin, Texas 78712, USA
    Endocrinology 145:4653-9. 2004
  2. pmc Neuroendocrine systems as targets for environmental endocrine-disrupting chemicals
    Andrea C Gore
    The University of Texas at Austin, Division of Pharmacology and Toxicology, College of Pharmacy, Austin, Texas 78712, USA
    Fertil Steril 89:e101-2. 2008
  3. pmc Neuroendocrine targets of endocrine disruptors
    Andrea C Gore
    Center for Molecular and Cellular Toxicology, Division of Pharmacology and Toxicology, College of Pharmacy, University of Texas, Austin, USA
    Hormones (Athens) 9:16-27. 2010
  4. ncbi request reprint Glucocorticoid repression of the reproductive axis: effects on GnRH and gonadotropin subunit mRNA levels
    Andrea C Gore
    Division of Pharmacology and Toxicology, College of Pharmacy, Institute for Neuroscience, The University of Texas at Austin, Austin, TX 78712, United States
    Mol Cell Endocrinol 256:40-8. 2006
  5. ncbi request reprint Endocrine disruption for endocrinologists (and others)
    Andrea C Gore
    The University of Texas at Austin, Division of Pharmacology Toxicology, A1915, Austin, Texas 78712, USA
    Endocrinology 147:S1-3. 2006
  6. pmc Developmental programming and endocrine disruptor effects on reproductive neuroendocrine systems
    Andrea C Gore
    Division of Pharmacology and Toxicology, Institute for Neuroscience and Institute for Cellular and Molecular Biology, The University of Texas at Austin, 1 University Station A1915, Austin, TX 78712, USA
    Front Neuroendocrinol 29:358-74. 2008
  7. pmc Endocrine disruption of brain sexual differentiation by developmental PCB exposure
    Sarah M Dickerson
    Division of Pharmacology and Toxicology and Center for Molecular and Cellular Toxicology, The University of Texas at Austin, Texas 78712 0125, USA
    Endocrinology 152:581-94. 2011
  8. ncbi request reprint Estrogenic environmental endocrine-disrupting chemical effects on reproductive neuroendocrine function and dysfunction across the life cycle
    Sarah M Dickerson
    Division of Pharmacology and Toxicology, The University of Texas at Austin, P O Box A1915, Austin, TX 78712, USA
    Rev Endocr Metab Disord 8:143-59. 2007
  9. pmc The recreational drug ecstasy disrupts the hypothalamic-pituitary-gonadal reproductive axis in adult male rats
    Sarah M Dickerson
    Division of Pharmacology and Toxicology, The University of Texas at Austin, Austin, Tex 78712 0125, USA
    Neuroendocrinology 88:95-102. 2008
  10. pmc The effects of prenatal PCBs on adult female paced mating reproductive behaviors in rats
    Rebecca M Steinberg
    The Institute for Neuroscience, The University of Texas at Austin, Austin, TX, USA
    Horm Behav 51:364-72. 2007

Research Grants

  1. Neuroendocrine outcomes of prenatal PCB exposures
    ANDREA GORE; Fiscal Year: 2005
  2. Forum on Endocrine-Disrupting Chemicals
    ANDREA GORE; Fiscal Year: 2005
  3. Hypothalamic control of reproductive aging
    ANDREA GORE; Fiscal Year: 2007
  4. Hypothalamic control of reproductive aging
    ANDREA GORE; Fiscal Year: 2009
  5. Hypothalamic control of reproductive aging
    Andrea C Gore; Fiscal Year: 2010

Collaborators

Detail Information

Publications38

  1. ncbi request reprint Menopausal increases in pulsatile gonadotropin-releasing hormone release in a nonhuman primate (Macaca mulatta)
    Andrea C Gore
    University of Texas at Austin, Division of Pharmacology Toxicology, Austin, Texas 78712, USA
    Endocrinology 145:4653-9. 2004
    ..To our knowledge, this is the first direct demonstration of elevated pulsatile GnRH concentrations in a primate species during reproductive senescence, a result that may have implications for menopausal symptoms...
  2. pmc Neuroendocrine systems as targets for environmental endocrine-disrupting chemicals
    Andrea C Gore
    The University of Texas at Austin, Division of Pharmacology and Toxicology, College of Pharmacy, Austin, Texas 78712, USA
    Fertil Steril 89:e101-2. 2008
  3. pmc Neuroendocrine targets of endocrine disruptors
    Andrea C Gore
    Center for Molecular and Cellular Toxicology, Division of Pharmacology and Toxicology, College of Pharmacy, University of Texas, Austin, USA
    Hormones (Athens) 9:16-27. 2010
    ..This article will discuss the evidence for environmental endocrine disruption of neuroendocrine systems and the effects on endocrine and reproductive functions...
  4. ncbi request reprint Glucocorticoid repression of the reproductive axis: effects on GnRH and gonadotropin subunit mRNA levels
    Andrea C Gore
    Division of Pharmacology and Toxicology, College of Pharmacy, Institute for Neuroscience, The University of Texas at Austin, Austin, TX 78712, United States
    Mol Cell Endocrinol 256:40-8. 2006
    ....
  5. ncbi request reprint Endocrine disruption for endocrinologists (and others)
    Andrea C Gore
    The University of Texas at Austin, Division of Pharmacology Toxicology, A1915, Austin, Texas 78712, USA
    Endocrinology 147:S1-3. 2006
  6. pmc Developmental programming and endocrine disruptor effects on reproductive neuroendocrine systems
    Andrea C Gore
    Division of Pharmacology and Toxicology, Institute for Neuroscience and Institute for Cellular and Molecular Biology, The University of Texas at Austin, 1 University Station A1915, Austin, TX 78712, USA
    Front Neuroendocrinol 29:358-74. 2008
    ....
  7. pmc Endocrine disruption of brain sexual differentiation by developmental PCB exposure
    Sarah M Dickerson
    Division of Pharmacology and Toxicology and Center for Molecular and Cellular Toxicology, The University of Texas at Austin, Texas 78712 0125, USA
    Endocrinology 152:581-94. 2011
    ..These data suggest that developmental PCBs profoundly impair the sexual differentiation of the female hypothalamus...
  8. ncbi request reprint Estrogenic environmental endocrine-disrupting chemical effects on reproductive neuroendocrine function and dysfunction across the life cycle
    Sarah M Dickerson
    Division of Pharmacology and Toxicology, The University of Texas at Austin, P O Box A1915, Austin, TX 78712, USA
    Rev Endocr Metab Disord 8:143-59. 2007
    ..Finally, we identify the gaps of knowledge in this field and suggest future directions for study...
  9. pmc The recreational drug ecstasy disrupts the hypothalamic-pituitary-gonadal reproductive axis in adult male rats
    Sarah M Dickerson
    Division of Pharmacology and Toxicology, The University of Texas at Austin, Austin, Tex 78712 0125, USA
    Neuroendocrinology 88:95-102. 2008
    ....
  10. pmc The effects of prenatal PCBs on adult female paced mating reproductive behaviors in rats
    Rebecca M Steinberg
    The Institute for Neuroscience, The University of Texas at Austin, Austin, TX, USA
    Horm Behav 51:364-72. 2007
    ..These data demonstrate that the behavioral phenotype in adulthood is disrupted by low, ecologically relevant exposures to PCBs, and the results have implications for reproductive success and health in wildlife and women...
  11. pmc Sexual experience changes sex hormones but not hypothalamic steroid hormone receptor expression in young and middle-aged male rats
    Di Wu
    Division of Pharmacology and Toxicology, College of Pharmacy, The University of Texas at Austin, Austin, TX 78712, USA
    Horm Behav 56:299-308. 2009
    ..These results show that sexual experience can induce short-term and long-term alterations in serum hormones but these effects are not manifested upon their receptors in the hypothalamus...
  12. pmc Three-dimensional properties of GnRH neuroterminals in the median eminence of young and old rats
    Weiling Yin
    Division of Pharmacology and Toxicology, College of Pharmacy, University of Texas at Austin, Austin, TX 78712, USA
    J Comp Neurol 517:284-95. 2009
    ..Our data suggest reproductive aging in rats is characterized by structural organizational changes to the GnRH terminal microenvironment in the median eminence...
  13. ncbi request reprint Neuroendocrine control of reproductive aging: roles of GnRH neurons
    Weiling Yin
    Division of Pharmacology and Toxicology, College of Pharmacy and Institute for Neuroscience and Institute for Cellular and Molecular Biology, University of Texas at Austin, Austin, TX 78712, USA
    Reproduction 131:403-14. 2006
    ..Therefore, the aging hypothalamus is characterized by changes intrinsic to the GnRH cell, as well as its regulatory inputs, which summate to contribute to a loss of reproductive competence in aging females...
  14. pmc The hypothalamic median eminence and its role in reproductive aging
    Weiling Yin
    Division of Pharmacology and Toxicology, College of Pharmacy, The University of Texas at Austin, Austin, Texas 78712, USA
    Ann N Y Acad Sci 1204:113-22. 2010
    ....
  15. pmc NMDA receptor subunit NR2b: effects on LH release and GnRH gene expression in young and middle-aged female rats, with modulation by estradiol
    Jacqueline A Maffucci
    Institute for Neuroscience, University of Texas, Austin, Tex, USA
    Neuroendocrinology 87:129-41. 2008
    ..Here, we examined the functional implications of the NR2b subunit on the onset of reproductive aging, using an NR2b-specific antagonist ifenprodil...
  16. pmc Effects of perinatal polychlorinated biphenyls on adult female rat reproduction: development, reproductive physiology, and second generational effects
    Rebecca M Steinberg
    The Institute for Neuroscience, The University of Texas at Austin, Austin, Texas 78712, USA
    Biol Reprod 78:1091-101. 2008
    ..These findings have implications for reproductive health and fertility of wildlife and humans...
  17. pmc Changes in androgen receptor, estrogen receptor alpha, and sexual behavior with aging and testosterone in male rats
    Di Wu
    Division of Pharmacology and Toxicology, College of Pharmacy, The University of Texas at Austin, Austin, TX 78712, USA
    Horm Behav 58:306-16. 2010
    ..Our finding that testosterone replacement in aging males has profound effects on hypothalamic receptors and behavior has potential medical implications for the treatment of age-related hypogonadism in men...
  18. pmc Gonadotropin-releasing hormone neuroterminals and their microenvironment in the median eminence: effects of aging and estradiol treatment
    Weiling Yin
    Division of Pharmacology and Toxicology, The University of Texas at Austin, Austin, Texas 78712, USA
    Endocrinology 150:5498-508. 2009
    ....
  19. pmc Age-related changes in hypothalamic androgen receptor and estrogen receptor alpha in male rats
    Di Wu
    Division of Pharmacology and Toxicology, College of Pharmacy, The University of Texas at Austin, Austin, Texas 78712, USA
    J Comp Neurol 512:688-701. 2009
    ..These results provide further information about how the neural targets of steroid hormones change with advancing age...
  20. pmc Chapter 2: hypothalamic neural systems controlling the female reproductive life cycle gonadotropin-releasing hormone, glutamate, and GABA
    Jacqueline A Maffucci
    Institute for Neuroscience, University of Texas, Austin, Texas 78712, USA
    Int Rev Cell Mol Biol 274:69-127. 2009
    ..Here, we present evidence for the modulation of GnRH neurosecretory cells by the balance of glutamate and GABA in the hypothalamus, and the functional consequences of these interactions on reproductive physiology across the life cycle...
  21. pmc Cell death mechanisms in GT1-7 GnRH cells exposed to polychlorinated biphenyls PCB74, PCB118, and PCB153
    Sarah M Dickerson
    Division of Pharmacology and Toxicology, University of Texas at Austin, Austin, TX 78712, USA
    Toxicol Appl Pharmacol 237:237-45. 2009
    ..These results provide evidence that PCB congeners have endocrine disrupting and/or neurotoxic effects on the hypothalamic GnRH cell line, a finding that has implications for environmental endocrine disruption in animals...
  22. pmc Transgenerational epigenetic imprints on mate preference
    David Crews
    Section of Integrative Biology, University of Texas, Austin, TX 78712, USA
    Proc Natl Acad Sci U S A 104:5942-6. 2007
    ..Our observations provide direct experimental evidence for a role of epigenetics as a determinant factor in evolution...
  23. ncbi request reprint Is reproductive ageing controlled by the brain?
    Andrea C Gore
    Division of Pharmacology and Toxicology The University of Texas at Austin, TX, USA
    J Neuroendocrinol 19:667-8. 2007
    ..Surprisingly, recent evidence indicates a more important role for the brain in the initiation and transition to reproductive senescence...
  24. ncbi request reprint Developmental changes in hypothalamic insulin-like growth factor-1: relationship to gonadotropin-releasing hormone neurons
    Shabrine S Daftary
    Kastor Neurobiology of Aging Laboratories, Fishberg Research Center for Neurobiology, Brookdale Department of Geriatrics, Mount Sinai School of Medicine, New York, New York 10029, USA
    Endocrinology 144:2034-45. 2003
    ..Taken together, the results suggest that IGF-1 can modulate GnRH neurons, that the sensitivity of GnRH neurons to IGF-1 changes developmentally, and that GnRH cells coexpress IGF-1...
  25. ncbi request reprint N-Methyl-D-aspartate receptor subunit expression in GnRH neurons changes during reproductive senescence in the female rat
    Brooke H Miller
    Kastor Neurobiology of Aging Laboratories, Fishberg Research Center for Neurobiology, and Brookdale Department of Geriatrics, Mount Sinai School of Medicine, New York, New York 10029, USA
    Endocrinology 143:3568-74. 2002
    ....
  26. ncbi request reprint Colocalization and hormone regulation of estrogen receptor alpha and N-methyl-D-aspartate receptor in the hypothalamus of female rats
    Tandra R Chakraborty
    Kastor Neurobiology of Aging Labs, Fishberg Research Center for Neurobiology, New York, New York 10029, USA
    Endocrinology 144:299-305. 2003
    ....
  27. ncbi request reprint Aging-related changes in in vivo release of growth hormone-releasing hormone and somatostatin from the stalk-median eminence in female rhesus monkeys (Macaca mulatta)
    Shinichiro Nakamura
    Wisconsin National Primate Research Center, University of Wisconsin Madison, Madison, Wisconsin 53715, USA
    J Clin Endocrinol Metab 88:827-33. 2003
    ..There were no significant changes in the pulse frequency of SS release. Therefore, the aging-related decrease in GH release is due to a substantial decrease in GHRH release and an increase in SS release from the hypothalamus...
  28. pmc Effects of polychlorinated biphenyls on estrogen receptor-beta expression in the anteroventral periventricular nucleus
    Jacklyn Salama
    Kastor Neurobiology of Aging Laboratories, Fishberg Research Center for Neurobiology, Mount Sinai School of Medicine, New York, New York, USA
    Environ Health Perspect 111:1278-82. 2003
    ....
  29. ncbi request reprint Age-related changes in estrogen receptor beta in rat hypothalamus: a quantitative analysis
    Tandra R Chakraborty
    Kastor Neurobiology of Aging Laboratories, Fishberg Research Center for Neurobiology, and Brookdale Department of Geriatrics and Adult Development, Mount Sinai School of Medicine, New York, New York 10029, USA
    Endocrinology 144:4164-71. 2003
    ....
  30. ncbi request reprint Stereologic analysis of estrogen receptor alpha (ER alpha) expression in rat hypothalamus and its regulation by aging and estrogen
    Tandra R Chakraborty
    Kastor Neurobiology of Aging Laboratories, Fishberg Research Center for Neurobiology, and Brookdale Department of Geriatrics and Adult Development, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Comp Neurol 466:409-21. 2003
    ..No significant effects of estrogen on ERalpha cell number were detected in any of the four regions studied. Therefore, ERalpha cell number in the rat hypothalamus and preoptic area changes with aging in a region-specific manner...
  31. ncbi request reprint Chronic daily ethanol and withdrawal: 4. Long-term changes in plasma testosterone regulation, but no effect on GnRH gene expression or plasma LH concentrations
    Dennis D Rasmussen
    VA Puget Sound Health Care System, S 116 Mental Illness Research, Education and Clinical Center, 1660 S Columbian Way, Seattle, WA, USA
    Endocrine 22:143-50. 2003
    ....
  32. ncbi request reprint Increased expression of forebrain GnRH mRNA and changes in testosterone negative feedback following pubertal maturation
    Heather N Richardson
    Department of Psychology and Neuroscience Program, Michigan State University, East Lansing, MI 48824, USA
    Mol Cell Endocrinol 214:63-70. 2004
    ..Furthermore, the pubertal increase in GnRH mRNA appears to occur via steroid feedback-independent mechanisms in the male Syrian hamster...
  33. ncbi request reprint Aging-related changes in ovarian hormones, their receptors, and neuroendocrine function
    Tandra R Chakraborty
    Fishberg Research Center for Neurobiology, Mount Sinai School of Medicine, New York, New York 10029, USA
    Exp Biol Med (Maywood) 229:977-87. 2004
    ..We have also discussed several important experimental design considerations, focusing on rodent models in current use for understanding the mechanisms of menopause in women...
  34. ncbi request reprint IGF-1 in the brain as a regulator of reproductive neuroendocrine function
    Shabrine S Daftary
    Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, New York, NY 10029, USA
    Exp Biol Med (Maywood) 230:292-306. 2005
    ..Here, we examine the role of IGF-1 acting in the hypothalamus as a critical link between reproductive and other neuroendocrine functions...
  35. ncbi request reprint Estrogen, menopause, and the aging brain: how basic neuroscience can inform hormone therapy in women
    John H Morrison
    Fishberg Department of Neuroscience, Kastor Neurobiology of Aging Laboratories, New York, New York 10029, USA
    J Neurosci 26:10332-48. 2006
  36. ncbi request reprint How the brain controls puberty, and implications for sex and ethnic differences
    Sonya M Hughes
    Fam Community Health 30:S112-4. 2007
  37. pmc Postpubertal decrease in hippocampal dendritic spines of female rats
    Murat Yildirim
    Department of Pharmacology, Hacettepe University, Faculty of Medicine, Ankara, 06100, Turkey
    Exp Neurol 210:339-48. 2008
    ..These changes in spine density coincident with puberty may be related to altered hippocampal plasticity and synaptic consolidation at this phase of maturity...
  38. ncbi request reprint Organochlorine pesticides directly regulate gonadotropin-releasing hormone gene expression and biosynthesis in the GT1-7 hypothalamic cell line
    Andrea C Gore
    Kastor Neurobiology of Aging Laboratories, Fishberg Research Center for Neurobiology, and Brookdale Department of Geriatrics and Adult Development, Mount Sinai School of Medicine, Box 1639, New York, NY 10029, USA
    Mol Cell Endocrinol 192:157-70. 2002
    ..These results indicate that chlorpyrifos and methoxychlor alter GnRH biosynthesis in this hypothalamic cell line in vitro, suggesting that they may have endocrine disrupting effects on GnRH neurons in vivo...

Research Grants6

  1. Neuroendocrine outcomes of prenatal PCB exposures
    ANDREA GORE; Fiscal Year: 2005
    ..The results should have important implications for understanding consequences of, and developing therapies for, exposures of wildlife and humans to EDCs such as PCBs. ..
  2. Forum on Endocrine-Disrupting Chemicals
    ANDREA GORE; Fiscal Year: 2005
    ..In order to limit future contaminations and to mitigate existing exposures, it is critical that we educate the endocrine community and make this subject a permanent part of the Endocrine Society's agenda. ..
  3. Hypothalamic control of reproductive aging
    ANDREA GORE; Fiscal Year: 2007
    ....
  4. Hypothalamic control of reproductive aging
    ANDREA GORE; Fiscal Year: 2009
    ....
  5. Hypothalamic control of reproductive aging
    Andrea C Gore; Fiscal Year: 2010
    ....