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Species | Andrea C GoreSummaryAffiliation: University of Texas Country: USA Publications
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Publications
Early life exposure to endocrine-disrupting chemicals causes lifelong molecular reprogramming of the hypothalamus and premature reproductive agingAndrea C Gore
Institute for Neuroscience, The University of Texas at Austin, Austin, Texas 78712, USA
Mol Endocrinol 25:2157-68. 2011..Thus, early life exposure to endocrine disruptors has lifelong effects on neuroendocrine gene expression and DNA methylation, together with causing the advancement of reproductive senescence...- Changes in androgen receptor, estrogen receptor alpha, and sexual behavior with aging and testosterone in male ratsDi Wu
Division of Pharmacology and Toxicology, College of Pharmacy, The University of Texas at Austin, Austin, TX 78712, USA
Horm Behav 58:306-16. 2010..Our finding that testosterone replacement in aging males has profound effects on hypothalamic receptors and behavior has potential medical implications for the treatment of age-related hypogonadism in men... - Age-related changes in hypothalamic androgen receptor and estrogen receptor alpha in male ratsDi Wu
Division of Pharmacology and Toxicology, College of Pharmacy, The University of Texas at Austin, Austin, Texas 78712, USA
J Comp Neurol 512:688-701. 2009..These results provide further information about how the neural targets of steroid hormones change with advancing age... - The recreational drug ecstasy disrupts the hypothalamic-pituitary-gonadal reproductive axis in adult male ratsSarah M Dickerson
Division of Pharmacology and Toxicology, The University of Texas at Austin, Austin, Tex 78712 0125, USA
Neuroendocrinology 88:95-102. 2008.... - Prenatal PCBs disrupt early neuroendocrine development of the rat hypothalamusSarah M Dickerson
Center for Molecular and Cellular Toxicology, Division of Pharmacology and Toxicology, University of Texas at Austin, Austin, TX 78712, USA
Toxicol Appl Pharmacol 252:36-46. 2011.... - Gonadotropin-releasing hormone neuroterminals and their microenvironment in the median eminence: effects of aging and estradiol treatmentWeiling Yin
Division of Pharmacology and Toxicology, The University of Texas at Austin, Austin, Texas 78712, USA
Endocrinology 150:5498-508. 2009.... - Sexual experience changes sex hormones but not hypothalamic steroid hormone receptor expression in young and middle-aged male ratsDi Wu
Division of Pharmacology and Toxicology, College of Pharmacy, The University of Texas at Austin, Austin, TX 78712, USA
Horm Behav 56:299-308. 2009..These results show that sexual experience can induce short-term and long-term alterations in serum hormones but these effects are not manifested upon their receptors in the hypothalamus... - Endocrine disruption of brain sexual differentiation by developmental PCB exposureSarah M Dickerson
Division of Pharmacology and Toxicology and Center for Molecular and Cellular Toxicology, The University of Texas at Austin, Texas 78712 0125, USA
Endocrinology 152:581-94. 2011..These data suggest that developmental PCBs profoundly impair the sexual differentiation of the female hypothalamus... - The hypothalamic median eminence and its role in reproductive agingWeiling Yin
Division of Pharmacology and Toxicology, College of Pharmacy, The University of Texas at Austin, Austin, Texas 78712, USA
Ann N Y Acad Sci 1204:113-22. 2010.... - Developmental profiles of neuroendocrine gene expression in the preoptic area of male ratsDeena M Walker
Institute for Neuroscience, University of Texas at Austin, Austin, Texas 78712, USA
Endocrinology 150:2308-16. 2009..Moreover, the relationships between hormones and their corresponding receptors undergo dynamic changes across development in male rats... 
Transgenerational neuroendocrine disruption of reproductionDeena M Walker
Institute for Neuroscience, The University of Texas at Austin, 1 University Station, Box A1915, Austin, TX 78712, USA
Nat Rev Endocrinol 7:197-207. 2011..New insights stress the crucial need to develop a clear understanding of how EDCs may program the epigenome of exposed individuals and their descendants...- Three-dimensional properties of GnRH neuroterminals in the median eminence of young and old ratsWeiling Yin
Division of Pharmacology and Toxicology, College of Pharmacy, University of Texas at Austin, Austin, TX 78712, USA
J Comp Neurol 517:284-95. 2009..Our data suggest reproductive aging in rats is characterized by structural organizational changes to the GnRH terminal microenvironment in the median eminence... 
Menopausal increases in pulsatile gonadotropin-releasing hormone release in a nonhuman primate (Macaca mulatta)Andrea C Gore
University of Texas at Austin, Division of Pharmacology Toxicology, Austin, Texas 78712, USA
Endocrinology 145:4653-9. 2004..To our knowledge, this is the first direct demonstration of elevated pulsatile GnRH concentrations in a primate species during reproductive senescence, a result that may have implications for menopausal symptoms...- Neuroendocrine systems as targets for environmental endocrine-disrupting chemicalsAndrea C Gore
The University of Texas at Austin, Division of Pharmacology and Toxicology, College of Pharmacy, Austin, Texas 78712, USA
Fertil Steril 89:e101-2. 2008 - Estrogenic environmental endocrine-disrupting chemical effects on reproductive neuroendocrine function and dysfunction across the life cycleSarah M Dickerson
Division of Pharmacology and Toxicology, The University of Texas at Austin, P O Box A1915, Austin, TX 78712, USA
Rev Endocr Metab Disord 8:143-59. 2007..Finally, we identify the gaps of knowledge in this field and suggest future directions for study... - Glucocorticoid repression of the reproductive axis: effects on GnRH and gonadotropin subunit mRNA levelsAndrea C Gore
Division of Pharmacology and Toxicology, College of Pharmacy, Institute for Neuroscience, The University of Texas at Austin, Austin, TX 78712, United States
Mol Cell Endocrinol 256:40-8. 2006.... - Endocrine disruption for endocrinologists (and others)Andrea C Gore
The University of Texas at Austin, Division of Pharmacology-Toxicology, A1915, Austin, Texas 78712, USA
Endocrinology 147:S1-3. 2006 - Neuroendocrine control of the transition to reproductive senescence: lessons learned from the female rodent modelBailey A Kermath
Institute for Neuroscience, University of Texas at Austin, Austin, TX 78712, USA
Neuroendocrinology 96:1-12. 2012..Work discussed herein shows that in order to understand neuroendocrine mechanisms of reproductive senescence, further research needs to be conducted in ovarian-intact models... - Effects of perinatal polychlorinated biphenyls on adult female rat reproduction: development, reproductive physiology, and second generational effectsRebecca M Steinberg
The Institute for Neuroscience, The University of Texas at Austin, Austin, Texas 78712, USA
Biol Reprod 78:1091-101. 2008..These findings have implications for reproductive health and fertility of wildlife and humans... - Neuroendocrine targets of endocrine disruptorsAndrea C Gore
Center for Molecular and Cellular Toxicology, Division of Pharmacology and Toxicology, College of Pharmacy, University of Texas, Austin, USA
Hormones (Athens) 9:16-27. 2010..This article will discuss the evidence for environmental endocrine disruption of neuroendocrine systems and the effects on endocrine and reproductive functions... - Chapter 2: hypothalamic neural systems controlling the female reproductive life cycle gonadotropin-releasing hormone, glutamate, and GABAJacqueline A Maffucci
Institute for Neuroscience, University of Texas, Austin, Texas 78712, USA
Int Rev Cell Mol Biol 274:69-127. 2009..Here, we present evidence for the modulation of GnRH neurosecretory cells by the balance of glutamate and GABA in the hypothalamus, and the functional consequences of these interactions on reproductive physiology across the life cycle... - NMDA receptor subunit NR2b: effects on LH release and GnRH gene expression in young and middle-aged female rats, with modulation by estradiolJacqueline A Maffucci
Institute for Neuroscience, University of Texas, Austin, Tex, USA
Neuroendocrinology 87:129-41. 2008..Here, we examined the functional implications of the NR2b subunit on the onset of reproductive aging, using an NR2b-specific antagonist ifenprodil... - The effects of prenatal PCBs on adult female paced mating reproductive behaviors in ratsRebecca M Steinberg
The Institute for Neuroscience, The University of Texas at Austin, Austin, TX, USA
Horm Behav 51:364-72. 2007..These data demonstrate that the behavioral phenotype in adulthood is disrupted by low, ecologically relevant exposures to PCBs, and the results have implications for reproductive success and health in wildlife and women... - Neuroendocrine control of reproductive aging: roles of GnRH neuronsWeiling Yin
Division of Pharmacology and Toxicology, College of Pharmacy and Institute for Neuroscience and Institute for Cellular and Molecular Biology, University of Texas at Austin, Austin, TX 78712, USA
Reproduction 131:403-14. 2006..Therefore, the aging hypothalamus is characterized by changes intrinsic to the GnRH cell, as well as its regulatory inputs, which summate to contribute to a loss of reproductive competence in aging females... - Molecular profiling of postnatal development of the hypothalamus in female and male ratsDeena M Walker
Institute for Neuroscience, The University of Texas at Austin, Austin, Texas 78712, USA
Biol Reprod 87:129. 2012..Moreover, the finding that few neuroendocrine genes are sexually dimorphic highlights the need to consider postnatal development from a network approach that allows assessment of interactions and patterns of expression... - Developmental programming and endocrine disruptor effects on reproductive neuroendocrine systemsAndrea C Gore
Division of Pharmacology and Toxicology, Institute for Neuroscience and Institute for Cellular and Molecular Biology, The University of Texas at Austin, 1 University Station A1915, Austin, TX 78712, USA
Front Neuroendocrinol 29:358-74. 2008.... - Cell death mechanisms in GT1-7 GnRH cells exposed to polychlorinated biphenyls PCB74, PCB118, and PCB153Sarah M Dickerson
Division of Pharmacology and Toxicology, University of Texas at Austin, Austin, TX 78712, USA
Toxicol Appl Pharmacol 237:237-45. 2009..These results provide evidence that PCB congeners have endocrine disrupting and/or neurotoxic effects on the hypothalamic GnRH cell line, a finding that has implications for environmental endocrine disruption in animals...