Andrea C Gore

Summary

Affiliation: University of Texas
Country: USA

Publications

  1. pmc Early life exposure to endocrine-disrupting chemicals causes lifelong molecular reprogramming of the hypothalamus and premature reproductive aging
    Andrea C Gore
    Institute for Neuroscience, The University of Texas at Austin, Austin, Texas 78712, USA
    Mol Endocrinol 25:2157-68. 2011
  2. pmc Disruption of reproductive aging in female and male rats by gestational exposure to estrogenic endocrine disruptors
    Deena M Walker
    The University of Texas at Austin, The Institute for Neuroscience, 1 University Station, C0875, Austin, Texas 78712, USA
    Endocrinology 154:2129-43. 2013
  3. doi request reprint Molecular profiling of postnatal development of the hypothalamus in female and male rats
    Deena M Walker
    Institute for Neuroscience, The University of Texas at Austin, Austin, Texas 78712, USA
    Biol Reprod 87:129. 2012
  4. pmc Changes in androgen receptor, estrogen receptor alpha, and sexual behavior with aging and testosterone in male rats
    Di Wu
    Division of Pharmacology and Toxicology, College of Pharmacy, The University of Texas at Austin, Austin, TX 78712, USA
    Horm Behav 58:306-16. 2010
  5. pmc The recreational drug ecstasy disrupts the hypothalamic-pituitary-gonadal reproductive axis in adult male rats
    Sarah M Dickerson
    Division of Pharmacology and Toxicology, The University of Texas at Austin, Austin, Tex 78712 0125, USA
    Neuroendocrinology 88:95-102. 2008
  6. pmc Age-related changes in hypothalamic androgen receptor and estrogen receptor alpha in male rats
    Di Wu
    Division of Pharmacology and Toxicology, College of Pharmacy, The University of Texas at Austin, Austin, Texas 78712, USA
    J Comp Neurol 512:688-701. 2009
  7. pmc Prenatal PCBs disrupt early neuroendocrine development of the rat hypothalamus
    Sarah M Dickerson
    Center for Molecular and Cellular Toxicology, Division of Pharmacology and Toxicology, University of Texas at Austin, Austin, TX 78712, USA
    Toxicol Appl Pharmacol 252:36-46. 2011
  8. pmc Gonadotropin-releasing hormone neuroterminals and their microenvironment in the median eminence: effects of aging and estradiol treatment
    Weiling Yin
    Division of Pharmacology and Toxicology, The University of Texas at Austin, Austin, Texas 78712, USA
    Endocrinology 150:5498-508. 2009
  9. pmc Sexual experience changes sex hormones but not hypothalamic steroid hormone receptor expression in young and middle-aged male rats
    Di Wu
    Division of Pharmacology and Toxicology, College of Pharmacy, The University of Texas at Austin, Austin, TX 78712, USA
    Horm Behav 56:299-308. 2009
  10. pmc Endocrine disruption of brain sexual differentiation by developmental PCB exposure
    Sarah M Dickerson
    Division of Pharmacology and Toxicology and Center for Molecular and Cellular Toxicology, The University of Texas at Austin, Texas 78712 0125, USA
    Endocrinology 152:581-94. 2011

Collaborators

Detail Information

Publications28

  1. pmc Early life exposure to endocrine-disrupting chemicals causes lifelong molecular reprogramming of the hypothalamus and premature reproductive aging
    Andrea C Gore
    Institute for Neuroscience, The University of Texas at Austin, Austin, Texas 78712, USA
    Mol Endocrinol 25:2157-68. 2011
    ..Thus, early life exposure to endocrine disruptors has lifelong effects on neuroendocrine gene expression and DNA methylation, together with causing the advancement of reproductive senescence...
  2. pmc Disruption of reproductive aging in female and male rats by gestational exposure to estrogenic endocrine disruptors
    Deena M Walker
    The University of Texas at Austin, The Institute for Neuroscience, 1 University Station, C0875, Austin, Texas 78712, USA
    Endocrinology 154:2129-43. 2013
    ....
  3. doi request reprint Molecular profiling of postnatal development of the hypothalamus in female and male rats
    Deena M Walker
    Institute for Neuroscience, The University of Texas at Austin, Austin, Texas 78712, USA
    Biol Reprod 87:129. 2012
    ..Moreover, the finding that few neuroendocrine genes are sexually dimorphic highlights the need to consider postnatal development from a network approach that allows assessment of interactions and patterns of expression...
  4. pmc Changes in androgen receptor, estrogen receptor alpha, and sexual behavior with aging and testosterone in male rats
    Di Wu
    Division of Pharmacology and Toxicology, College of Pharmacy, The University of Texas at Austin, Austin, TX 78712, USA
    Horm Behav 58:306-16. 2010
    ..Our finding that testosterone replacement in aging males has profound effects on hypothalamic receptors and behavior has potential medical implications for the treatment of age-related hypogonadism in men...
  5. pmc The recreational drug ecstasy disrupts the hypothalamic-pituitary-gonadal reproductive axis in adult male rats
    Sarah M Dickerson
    Division of Pharmacology and Toxicology, The University of Texas at Austin, Austin, Tex 78712 0125, USA
    Neuroendocrinology 88:95-102. 2008
    ....
  6. pmc Age-related changes in hypothalamic androgen receptor and estrogen receptor alpha in male rats
    Di Wu
    Division of Pharmacology and Toxicology, College of Pharmacy, The University of Texas at Austin, Austin, Texas 78712, USA
    J Comp Neurol 512:688-701. 2009
    ..These results provide further information about how the neural targets of steroid hormones change with advancing age...
  7. pmc Prenatal PCBs disrupt early neuroendocrine development of the rat hypothalamus
    Sarah M Dickerson
    Center for Molecular and Cellular Toxicology, Division of Pharmacology and Toxicology, University of Texas at Austin, Austin, TX 78712, USA
    Toxicol Appl Pharmacol 252:36-46. 2011
    ....
  8. pmc Gonadotropin-releasing hormone neuroterminals and their microenvironment in the median eminence: effects of aging and estradiol treatment
    Weiling Yin
    Division of Pharmacology and Toxicology, The University of Texas at Austin, Austin, Texas 78712, USA
    Endocrinology 150:5498-508. 2009
    ....
  9. pmc Sexual experience changes sex hormones but not hypothalamic steroid hormone receptor expression in young and middle-aged male rats
    Di Wu
    Division of Pharmacology and Toxicology, College of Pharmacy, The University of Texas at Austin, Austin, TX 78712, USA
    Horm Behav 56:299-308. 2009
    ..These results show that sexual experience can induce short-term and long-term alterations in serum hormones but these effects are not manifested upon their receptors in the hypothalamus...
  10. pmc Endocrine disruption of brain sexual differentiation by developmental PCB exposure
    Sarah M Dickerson
    Division of Pharmacology and Toxicology and Center for Molecular and Cellular Toxicology, The University of Texas at Austin, Texas 78712 0125, USA
    Endocrinology 152:581-94. 2011
    ..These data suggest that developmental PCBs profoundly impair the sexual differentiation of the female hypothalamus...
  11. pmc The hypothalamic median eminence and its role in reproductive aging
    Weiling Yin
    Division of Pharmacology and Toxicology, College of Pharmacy, The University of Texas at Austin, Austin, Texas 78712, USA
    Ann N Y Acad Sci 1204:113-22. 2010
    ....
  12. pmc Developmental profiles of neuroendocrine gene expression in the preoptic area of male rats
    Deena M Walker
    Institute for Neuroscience, University of Texas at Austin, Austin, Texas 78712, USA
    Endocrinology 150:2308-16. 2009
    ..Moreover, the relationships between hormones and their corresponding receptors undergo dynamic changes across development in male rats...
  13. doi request reprint Transgenerational neuroendocrine disruption of reproduction
    Deena M Walker
    Institute for Neuroscience, The University of Texas at Austin, 1 University Station, Box A1915, Austin, TX 78712, USA
    Nat Rev Endocrinol 7:197-207. 2011
    ..New insights stress the crucial need to develop a clear understanding of how EDCs may program the epigenome of exposed individuals and their descendants...
  14. pmc Three-dimensional properties of GnRH neuroterminals in the median eminence of young and old rats
    Weiling Yin
    Division of Pharmacology and Toxicology, College of Pharmacy, University of Texas at Austin, Austin, TX 78712, USA
    J Comp Neurol 517:284-95. 2009
    ..Our data suggest reproductive aging in rats is characterized by structural organizational changes to the GnRH terminal microenvironment in the median eminence...
  15. ncbi request reprint Menopausal increases in pulsatile gonadotropin-releasing hormone release in a nonhuman primate (Macaca mulatta)
    Andrea C Gore
    University of Texas at Austin, Division of Pharmacology Toxicology, Austin, Texas 78712, USA
    Endocrinology 145:4653-9. 2004
    ..To our knowledge, this is the first direct demonstration of elevated pulsatile GnRH concentrations in a primate species during reproductive senescence, a result that may have implications for menopausal symptoms...
  16. ncbi request reprint Estrogenic environmental endocrine-disrupting chemical effects on reproductive neuroendocrine function and dysfunction across the life cycle
    Sarah M Dickerson
    Division of Pharmacology and Toxicology, The University of Texas at Austin, P O Box A1915, Austin, TX 78712, USA
    Rev Endocr Metab Disord 8:143-59. 2007
    ..Finally, we identify the gaps of knowledge in this field and suggest future directions for study...
  17. pmc Neuroendocrine systems as targets for environmental endocrine-disrupting chemicals
    Andrea C Gore
    The University of Texas at Austin, Division of Pharmacology and Toxicology, College of Pharmacy, Austin, Texas 78712, USA
    Fertil Steril 89:e101-2. 2008
  18. ncbi request reprint Endocrine disruption for endocrinologists (and others)
    Andrea C Gore
    The University of Texas at Austin, Division of Pharmacology Toxicology, A1915, Austin, Texas 78712, USA
    Endocrinology 147:S1-3. 2006
  19. ncbi request reprint Glucocorticoid repression of the reproductive axis: effects on GnRH and gonadotropin subunit mRNA levels
    Andrea C Gore
    Division of Pharmacology and Toxicology, College of Pharmacy, Institute for Neuroscience, The University of Texas at Austin, Austin, TX 78712, United States
    Mol Cell Endocrinol 256:40-8. 2006
    ....
  20. pmc Neuroendocrine control of the transition to reproductive senescence: lessons learned from the female rodent model
    Bailey A Kermath
    Institute for Neuroscience, University of Texas at Austin, Austin, TX 78712, USA
    Neuroendocrinology 96:1-12. 2012
    ..Work discussed herein shows that in order to understand neuroendocrine mechanisms of reproductive senescence, further research needs to be conducted in ovarian-intact models...
  21. pmc Effects of perinatal polychlorinated biphenyls on adult female rat reproduction: development, reproductive physiology, and second generational effects
    Rebecca M Steinberg
    The Institute for Neuroscience, The University of Texas at Austin, Austin, Texas 78712, USA
    Biol Reprod 78:1091-101. 2008
    ..These findings have implications for reproductive health and fertility of wildlife and humans...
  22. pmc Neuroendocrine targets of endocrine disruptors
    Andrea C Gore
    Center for Molecular and Cellular Toxicology, Division of Pharmacology and Toxicology, College of Pharmacy, University of Texas, Austin, USA
    Hormones (Athens) 9:16-27. 2010
    ..This article will discuss the evidence for environmental endocrine disruption of neuroendocrine systems and the effects on endocrine and reproductive functions...
  23. pmc NMDA receptor subunit NR2b: effects on LH release and GnRH gene expression in young and middle-aged female rats, with modulation by estradiol
    Jacqueline A Maffucci
    Institute for Neuroscience, University of Texas, Austin, Tex, USA
    Neuroendocrinology 87:129-41. 2008
    ..Here, we examined the functional implications of the NR2b subunit on the onset of reproductive aging, using an NR2b-specific antagonist ifenprodil...
  24. pmc Chapter 2: hypothalamic neural systems controlling the female reproductive life cycle gonadotropin-releasing hormone, glutamate, and GABA
    Jacqueline A Maffucci
    Institute for Neuroscience, University of Texas, Austin, Texas 78712, USA
    Int Rev Cell Mol Biol 274:69-127. 2009
    ..Here, we present evidence for the modulation of GnRH neurosecretory cells by the balance of glutamate and GABA in the hypothalamus, and the functional consequences of these interactions on reproductive physiology across the life cycle...
  25. pmc The effects of prenatal PCBs on adult female paced mating reproductive behaviors in rats
    Rebecca M Steinberg
    The Institute for Neuroscience, The University of Texas at Austin, Austin, TX, USA
    Horm Behav 51:364-72. 2007
    ..These data demonstrate that the behavioral phenotype in adulthood is disrupted by low, ecologically relevant exposures to PCBs, and the results have implications for reproductive success and health in wildlife and women...
  26. ncbi request reprint Neuroendocrine control of reproductive aging: roles of GnRH neurons
    Weiling Yin
    Division of Pharmacology and Toxicology, College of Pharmacy and Institute for Neuroscience and Institute for Cellular and Molecular Biology, University of Texas at Austin, Austin, TX 78712, USA
    Reproduction 131:403-14. 2006
    ..Therefore, the aging hypothalamus is characterized by changes intrinsic to the GnRH cell, as well as its regulatory inputs, which summate to contribute to a loss of reproductive competence in aging females...
  27. pmc Developmental programming and endocrine disruptor effects on reproductive neuroendocrine systems
    Andrea C Gore
    Division of Pharmacology and Toxicology, Institute for Neuroscience and Institute for Cellular and Molecular Biology, The University of Texas at Austin, 1 University Station A1915, Austin, TX 78712, USA
    Front Neuroendocrinol 29:358-74. 2008
    ....
  28. pmc Cell death mechanisms in GT1-7 GnRH cells exposed to polychlorinated biphenyls PCB74, PCB118, and PCB153
    Sarah M Dickerson
    Division of Pharmacology and Toxicology, University of Texas at Austin, Austin, TX 78712, USA
    Toxicol Appl Pharmacol 237:237-45. 2009
    ..These results provide evidence that PCB congeners have endocrine disrupting and/or neurotoxic effects on the hypothalamic GnRH cell line, a finding that has implications for environmental endocrine disruption in animals...