Jonathan A R Gordon

Summary

Affiliation: University of Massachusetts Medical School
Country: USA

Publications

  1. ncbi request reprint Bone sialoprotein expression enhances osteoblast differentiation and matrix mineralization in vitro
    Jonathan A R Gordon
    Department of Biochemistry and Division of Oral Biology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada
    Bone 41:462-73. 2007
  2. doi request reprint Activation of the mitogen-activated protein kinase pathway by bone sialoprotein regulates osteoblast differentiation
    Jonathan A R Gordon
    Department of Biochemistry and Schulich Dentistry, CIHR Group in Skeletal Development and Remodeling, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ont, Canada
    Cells Tissues Organs 189:138-43. 2009
  3. ncbi request reprint Bone sialoprotein stimulates focal adhesion-related signaling pathways: role in migration and survival of breast and prostate cancer cells
    Jonathan A R Gordon
    CIHR Group in Skeletal Development and Remodeling, Department of Biochemistry and Division of Oral Biology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada
    J Cell Biochem 107:1118-28. 2009
  4. ncbi request reprint Delineation of the hydroxyapatite-nucleating domains of bone sialoprotein
    Coralee E Tye
    Canadian Institutes of Health Research Group in Skeletal Development and Remodeling, Division of Oral Biology and Department of Biochemistry, School of Dentistry, University of Western Ontario, London, Canada
    J Biol Chem 278:7949-55. 2003

Collaborators

  • Graeme K Hunter
  • Coralee E Tye
  • Kevin J Warner
  • Harvey A Goldberg
  • Jaro Sodek
  • Kevin R Rattray

Detail Information

Publications4

  1. ncbi request reprint Bone sialoprotein expression enhances osteoblast differentiation and matrix mineralization in vitro
    Jonathan A R Gordon
    Department of Biochemistry and Division of Oral Biology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada
    Bone 41:462-73. 2007
    ..These results demonstrate that BSP may serve as a matrix-associated signal directly promoting osteoblast differentiation resulting in the increased production of a mineralized matrix...
  2. doi request reprint Activation of the mitogen-activated protein kinase pathway by bone sialoprotein regulates osteoblast differentiation
    Jonathan A R Gordon
    Department of Biochemistry and Schulich Dentistry, CIHR Group in Skeletal Development and Remodeling, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ont, Canada
    Cells Tissues Organs 189:138-43. 2009
    ..Thus, the mechanism regulating osteoblast differentiation by BSP was determined to be dependent on integrin-mediated intracellular signaling pathways...
  3. ncbi request reprint Bone sialoprotein stimulates focal adhesion-related signaling pathways: role in migration and survival of breast and prostate cancer cells
    Jonathan A R Gordon
    CIHR Group in Skeletal Development and Remodeling, Department of Biochemistry and Division of Oral Biology, Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada
    J Cell Biochem 107:1118-28. 2009
    ..This study thus defines the cooperative mechanisms by which BSP can enhance specific factors associated with a metastatic phenotype in tumor cell lines, an effect that is increased by circulating TGF-beta1 and EGF...
  4. ncbi request reprint Delineation of the hydroxyapatite-nucleating domains of bone sialoprotein
    Coralee E Tye
    Canadian Institutes of Health Research Group in Skeletal Development and Remodeling, Division of Oral Biology and Department of Biochemistry, School of Dentistry, University of Western Ontario, London, Canada
    J Biol Chem 278:7949-55. 2003
    ..These results demonstrate that a sequence of at least eight contiguous glutamic acid residues is required for the nucleation of HA by BSP and that this nucleating "site" is not alpha-helical in conformation...