Vera Gorbunova

Summary

Affiliation: University of Rochester
Country: USA

Publications

  1. pmc Replicatively senescent cells are arrested in G1 and G2 phases
    Zhiyong Mao
    Department of Biology, University of Rochester, Rochester, NY 14627, USA
    Aging (Albany NY) 4:431-5. 2012
  2. pmc High-molecular-mass hyaluronan mediates the cancer resistance of the naked mole rat
    Xiao Tian
    Department of Biology, University of Rochester, Rochester, New York 14627, USA
    Nature 499:346-9. 2013
  3. pmc IGF1R levels in the brain negatively correlate with longevity in 16 rodent species
    Jorge Azpurua
    Department of Biology, University of Rochester, Rochester, NY 14627, USA
    Aging (Albany NY) 5:304-14. 2013
  4. pmc Cancer resistance in the blind mole rat is mediated by concerted necrotic cell death mechanism
    Vera Gorbunova
    Department of Biology, University of Rochester, Rochester, NY 14627, USA
    Proc Natl Acad Sci U S A 109:19392-6. 2012
  5. pmc Rodents for comparative aging studies: from mice to beavers
    Vera Gorbunova
    Department of Biology, University of Rochester, 213 Hutchison Hall, Rochester, NY, 14627, USA
    Age (Dordr) 30:111-9. 2008
  6. pmc Coevolution of telomerase activity and body mass in mammals: from mice to beavers
    Vera Gorbunova
    Department of Biology, University of Rochester, Rochester, NY 14627, USA
    Mech Ageing Dev 130:3-9. 2009
  7. pmc Distinct tumor suppressor mechanisms evolve in rodent species that differ in size and lifespan
    Andrei Seluanov
    Department of Biology, University of Rochester, Rochester, NY 14627, USA
    Aging Cell 7:813-23. 2008
  8. pmc Sirtuin 6 (SIRT6) rescues the decline of homologous recombination repair during replicative senescence
    Zhiyong Mao
    Department of Biology, University of Rochester, Rochester, NY 14627, USA
    Proc Natl Acad Sci U S A 109:11800-5. 2012
  9. pmc Hypersensitivity to contact inhibition provides a clue to cancer resistance of naked mole-rat
    Andrei Seluanov
    Department of Biology, University of Rochester, Rochester, NY 14627, USA
    Proc Natl Acad Sci U S A 106:19352-7. 2009
  10. doi request reprint SIRT6 promotes DNA repair under stress by activating PARP1
    Zhiyong Mao
    Department of Biology, University of Rochester, Rochester, NY 14627, USA
    Science 332:1443-6. 2011

Collaborators

  • Eviatar Nevo
  • Ying Jiang
  • Dmitri N Ermolenko
  • Zhengdong D Zhang
  • Andrei V Gudkov
  • DAVEN PRESGRAVES
  • K C Catania
  • Irfan Rahman
  • Andrei Seluanov
  • Zhiyong Mao
  • Michael Van Meter
  • Jorge Azpurua
  • Christopher Hine
  • Zhonghe Ke
  • Xiao Tian
  • Christopher M Hine
  • Michael Bozzella
  • Jiang Nan Yang
  • Amita Vaidya
  • Vincent Fong
  • Tais H C Sasahara
  • Antonio A C M Ribeiro
  • Xi Shi
  • Jill Ascher
  • Quanwei Zhang
  • Julia Ablaeva
  • Iris X Chen
  • Zhengshan Liu
  • Aliny A B Lobo Ladd
  • Antonio Augusto Coppi
  • Julie Kim
  • Max Myakishev-Rempel
  • Zhongle Ke
  • Cristina Capella
  • Stephen Dewhurst
  • Matthew Au
  • Marika Osterbur
  • Yo El Kim
  • Xiang Liu
  • Marina Feigenson
  • Amelia Hall
  • Jacquelynn Danek
  • Zhuoxun Chen
  • Nola Hause

Detail Information

Publications29

  1. pmc Replicatively senescent cells are arrested in G1 and G2 phases
    Zhiyong Mao
    Department of Biology, University of Rochester, Rochester, NY 14627, USA
    Aging (Albany NY) 4:431-5. 2012
    ..The notion that a large fraction of senescent cell population is arrested in G2 is important for understanding the biology of replicative senescence...
  2. pmc High-molecular-mass hyaluronan mediates the cancer resistance of the naked mole rat
    Xiao Tian
    Department of Biology, University of Rochester, Rochester, New York 14627, USA
    Nature 499:346-9. 2013
    ..This trait may have then been co-opted to provide cancer resistance and longevity to this species. ..
  3. pmc IGF1R levels in the brain negatively correlate with longevity in 16 rodent species
    Jorge Azpurua
    Department of Biology, University of Rochester, Rochester, NY 14627, USA
    Aging (Albany NY) 5:304-14. 2013
    ..These results suggest that modulation of IGF1R signaling in nervous tissue, but not in the peripheral tissues, is an important factor in the evolution of longevity in mammals...
  4. pmc Cancer resistance in the blind mole rat is mediated by concerted necrotic cell death mechanism
    Vera Gorbunova
    Department of Biology, University of Rochester, Rochester, NY 14627, USA
    Proc Natl Acad Sci U S A 109:19392-6. 2012
    ..Thus, we have identified a unique mechanism that contributes to cancer resistance of this subterranean mammal extremely adapted to life underground...
  5. pmc Rodents for comparative aging studies: from mice to beavers
    Vera Gorbunova
    Department of Biology, University of Rochester, 213 Hutchison Hall, Rochester, NY, 14627, USA
    Age (Dordr) 30:111-9. 2008
    ..Here we discuss the evolution of lifespan in rodents, review the biology of slow-aging rodents, and show an example of how the use of a comparative approach revealed that telomerase activity coevolved with body mass in rodents...
  6. pmc Coevolution of telomerase activity and body mass in mammals: from mice to beavers
    Vera Gorbunova
    Department of Biology, University of Rochester, Rochester, NY 14627, USA
    Mech Ageing Dev 130:3-9. 2009
    ..We discuss a model that large body mass presents an increased cancer risk, which drives the evolution of telomerase suppression and replicative senescence...
  7. pmc Distinct tumor suppressor mechanisms evolve in rodent species that differ in size and lifespan
    Andrei Seluanov
    Department of Biology, University of Rochester, Rochester, NY 14627, USA
    Aging Cell 7:813-23. 2008
    ..Thus, large-bodied species and small but long-lived species have evolved distinct tumor suppressor mechanisms...
  8. pmc Sirtuin 6 (SIRT6) rescues the decline of homologous recombination repair during replicative senescence
    Zhiyong Mao
    Department of Biology, University of Rochester, Rochester, NY 14627, USA
    Proc Natl Acad Sci U S A 109:11800-5. 2012
    ..These changes in the processing of DSBs may contribute to age-related genomic instability and a higher incidence of cancer with age. SIRT6 activation provides a potential therapeutic strategy to prevent the decline in genome maintenance...
  9. pmc Hypersensitivity to contact inhibition provides a clue to cancer resistance of naked mole-rat
    Andrei Seluanov
    Department of Biology, University of Rochester, Rochester, NY 14627, USA
    Proc Natl Acad Sci U S A 106:19352-7. 2009
    ..We propose that the additional layer of protection conferred by two-tiered contact inhibition contributes to the remarkable tumor resistance of the naked mole-rat...
  10. doi request reprint SIRT6 promotes DNA repair under stress by activating PARP1
    Zhiyong Mao
    Department of Biology, University of Rochester, Rochester, NY 14627, USA
    Science 332:1443-6. 2011
    ....
  11. pmc SIRT6 overexpression induces massive apoptosis in cancer cells but not in normal cells
    Michael Van Meter
    University of Rochester, Rochester, NY, USA
    Cell Cycle 10:3153-8. 2011
    ..These results suggest that SIRT6 is an attractive target for pharmacological activation in cancer treatment...
  12. pmc Repairing split ends: SIRT6, mono-ADP ribosylation and DNA repair
    Michael Van Meter
    Department of Biology, University of Rochester, Rochester, NY 14627, USA
    Aging (Albany NY) 3:829-35. 2011
    ..In this research perspective we review the role of SIRT6 in DNA repair and discuss the emerging implications for sirtuin directed mono-ADP ribosylation in aging and age-related diseases...
  13. pmc Novel husbandry techniques support survival of naked mole rat (Heterocephalus glaber) pups
    Zhonghe Ke
    Department of Biology, University of Rochester, University of Rochester Medical Center, Rochester, New York, USA
    J Am Assoc Lab Anim Sci 53:89-91. 2014
    ....
  14. pmc Mitochondrial inverted repeats strongly correlate with lifespan: mtDNA inversions and aging
    Jiang Nan Yang
    Department of Biology, University of Rochester, Rochester, New York, United States of America
    PLoS ONE 8:e73318. 2013
    ..Our study identifies IR-induced mitochondrial genome instability during mtDNA replication as a potential cause for mitochondrial defects. ..
  15. pmc Naked mole-rat has increased translational fidelity compared with the mouse, as well as a unique 28S ribosomal RNA cleavage
    Jorge Azpurua
    Department of Biology, University of Rochester, Rochester, NY 14627
    Proc Natl Acad Sci U S A 110:17350-5. 2013
    ..In summary, our results show that naked mole-rat cells produce fewer aberrant proteins, supporting the hypothesis that the more stable proteome of the naked mole-rat contributes to its longevity. ..
  16. pmc Telomerase activity coevolves with body mass not lifespan
    Andrei Seluanov
    Department of Biology, University of Rochester, Rochester, NY 14627, USA
    Aging Cell 6:45-52. 2007
    ..These results suggest that large body mass presents a greater risk of cancer than long lifespan, and large animals evolve repression of telomerase activity to mitigate that risk...
  17. pmc Rad51 promoter-targeted gene therapy is effective for in vivo visualization and treatment of cancer
    Christopher M Hine
    Department of Biology, University of Rochester, Rochester, New York 14627, USA
    Mol Ther 20:347-55. 2012
    ..This study demonstrates the clinical potential of pRad51-based constructs delivered by nanoparticles for the diagnostics and treatment of a wide range of cancers...
  18. pmc DNA repair by nonhomologous end joining and homologous recombination during cell cycle in human cells
    Zhiyong Mao
    Department of Biology, University of Rochester, Rochester, New York 14627, USA
    Cell Cycle 7:2902-6. 2008
    ..We conclude that human somatic cells utilize error-prone NHEJ as the major DSB repair pathway at all cell cycle stages, while HR is used, primarily, in the S phase...
  19. pmc Comparison of nonhomologous end joining and homologous recombination in human cells
    Zhiyong Mao
    Department of Biology, University of Rochester, Rochester, NY 14627 0211, USA
    DNA Repair (Amst) 7:1765-71. 2008
    ..In actively cycling cells NHEJ-C is twice as efficient as NHEJ-I, and NHEJ-I is three times more efficient than HR. Our results suggest that NHEJ is a faster and more efficient DSB repair pathway than HR...
  20. pmc Cell divisions are required for L1 retrotransposition
    Xi Shi
    University of Rochester, 213 Hutchison Hall, River Campus, Rochester, NY 14627 0211, USA
    Mol Cell Biol 27:1264-70. 2007
    ..We hypothesize that inhibition of retrotransposition in nondividing cells protects somatic tissues from accumulation of deleterious mutations caused by L1 elements...
  21. pmc TRF2 is required for repair of nontelomeric DNA double-strand breaks by homologous recombination
    Zhiyong Mao
    Department of Biology, University of Rochester, Rochester, NY 14627 0211, USA
    Proc Natl Acad Sci U S A 104:13068-73. 2007
    ..We propose, based on our results and on the ability of TRF2 to mediate strand invasion, that TRF2 plays an essential role in HR by facilitating the formation of early recombination intermediates...
  22. pmc DNA repair by homologous recombination, but not by nonhomologous end joining, is elevated in breast cancer cells
    Zhiyong Mao
    Department of Biology, University of Rochester, Rochester, NY 14627, USA
    Neoplasia 11:683-91. 2009
    ..Our finding of elevated HR in sporadic breast cancer cell lines suggests that therapies directed against the components of HR will be highly tumor-specific...
  23. pmc Changes in DNA repair during aging
    Vera Gorbunova
    Department of Biology, University of Rochester, Rochester, NY 14627, USA
    Nucleic Acids Res 35:7466-74. 2007
    ..Mutations in DNA repair genes and premature aging phenotypes they cause have been reviewed extensively elsewhere, therefore the focus of this review is on the comparison of DNA repair mechanisms in young versus old...
  24. pmc Changes in the level and distribution of Ku proteins during cellular senescence
    Andrei Seluanov
    Department of Biology, University of Rochester, Rochester, NY 14627 0211, United States
    DNA Repair (Amst) 6:1740-8. 2007
    ....
  25. pmc Use of the Rad51 promoter for targeted anti-cancer therapy
    Christopher M Hine
    Department of Biology, University of Rochester, Rochester, NY 14627, USA
    Proc Natl Acad Sci U S A 105:20810-5. 2008
    ..Our results suggest that therapies based on the Rad51 promoter will be highly tumor specific and open new avenues for targeting a broad range of cancers...
  26. pmc SIRT1 as a therapeutic target in inflammaging of the pulmonary disease
    Irfan Rahman
    Department of Environmental Medicine, Lung Biology and Disease Program, University of Rochester Medical Center, Rochester, NY 14642, USA
    Prev Med 54:S20-8. 2012
    ..The role of dietary polyphenols in regulation of SIRT1 in inflammaging is also discussed...
  27. pmc Adenoviral vector driven by a minimal Rad51 promoter is selective for p53-deficient tumor cells
    Vincent Fong
    Department of Microbiology and Immunology, University of Rochester, Rochester, New York, United States of America
    PLoS ONE 6:e28714. 2011
    ..The full length Rad51 promoter is highly active in cancer cells but not in normal cells. We therefore set out to assess whether we could confer this tumor-selectivity to an adenovirus vector...
  28. ncbi request reprint SIRT6: A Promising Target for Cancer Prevention and Therapy
    Michael Van Meter
    Department of Biology, University of Rochester, 432 Hutchison Hall, River Campus, Rochester, NY, 14627 0211, USA
    Adv Exp Med Biol 818:181-96. 2014
    ....
  29. ncbi request reprint Making ends meet in old age: DSB repair and aging
    Vera Gorbunova
    Department of Biology, University of Rochester, NY 14627, USA
    Mech Ageing Dev 126:621-8. 2005
    ....