Research Topics
Genomes and Genes | Santhi GorantlaSummaryAffiliation: University of Nebraska Medical Center Country: USA Publications
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Publications
Immunoregulation of a CB2 receptor agonist in a murine model of neuroAIDSSanthi Gorantla
Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, 68198 5880, USA
J Neuroimmune Pharmacol 5:456-68. 2010..Gp1a down modulated CCR5 expression on human cells in the spleen with an increase in Fas ligand expression. Our results support the notion that CB2 receptor agonists may be a viable therapeutic candidate for HAND...- Neuroprotective activities of CEP-1347 in models of neuroAIDSDawn Eggert
Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198, USA
J Immunol 184:746-56. 2010..These results demonstrate that CEP-1347 elicits anti-inflammatory and neuroprotective responses in an HIVE model of human disease and as such warrants further study as an adjunctive therapy for human disease... - Loss of neuronal integrity during progressive HIV-1 infection of humanized micePrasanta K Dash
Department of Pharmacology and Experimental Neuroscience, Radiology, Surgery, and Internal Medicine, University of Nebraska Medical Center, Omaha, Nebraska 68198, USA
J Neurosci 31:3148-57. 2011..As such, the model permits studies of the relationships between ongoing viral replication and virus-associated neurodegeneration... - CD8+ cell depletion accelerates HIV-1 immunopathology in humanized miceSanthi Gorantla
Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198, USA
J Immunol 184:7082-91. 2010..These data support a role of CD8+ cells in viral surveillance and the relevance of this humanized mouse model for the studies of HIV-1 pathobiology and virus-specific immunity... - Modulation of innate immunity by copolymer-1 leads to neuroprotection in murine HIV-1 encephalitisSanthi Gorantla
Center for Neurovirology and Neurodegenerative Disorders, University of Nebraska Medical Center, Omaha, Nebraska 68198 5880, USA
Glia 56:223-32. 2008..The data, taken together, demonstrate that Cop-1 can modulate innate immunity and, as such, improve disease outcomes in an animal model of HIVE... - HIV-1-infected and/or immune activated macrophages regulate astrocyte SDF-1 production through IL-1betaHui Peng
Laboratory of Neurotoxicology, Center for Neurovirology and Neurodegenerative Disorders, University of Nebraska Medical Center, Omaha, Nebraska 68195 5880, USA
Glia 54:619-29. 2006.... 
Quantitative magnetic resonance and SPECT imaging for macrophage tissue migration and nanoformulated drug deliverySanthi Gorantla
Center for Neurovirology and Neurodegenerative Disorders, University of Nebraska Medical Center, 985880 Nebraska Medical Center, Omaha, NE 68198-5880, USA
J Leukoc Biol 80:1165-74. 2006..These data show real-time kinetics and destinations of macrophage trafficking and demonstrate the feasibility of monitoring macrophage-based, nanoformulated ART...- Development of a macrophage-based nanoparticle platform for antiretroviral drug deliveryHuanyu Dou
Department of Pharmacology and Experimental Neuroscience, Center for Neurovirology and Neurodegenerative Disorder, University of Nebraska Medical Center, 985880 Nebraska Medical Center, Omaha, NE 68198-5880, USA
Blood 108:2827-35. 2006..We conclude that a single dose of NP-IDV, using BMMs as a carrier, is effective and warrants consideration for human testing... - Copolymer-1 induces adaptive immune anti-inflammatory glial and neuroprotective responses in a murine model of HIV-1 encephalitisSanthi Gorantla
Center for Neurovirology and Neurodegenerative Disorders, University of Nebraska Medical Center, Omaha, NE 68198, USA
J Immunol 179:4345-56. 2007..Ingress of Foxp3- and IL-4-expressing lymphocytes into brains of COP-1-immunized animals was observed. We conclude that COP-1 may warrant therapeutic consideration for HIV-1-associated cognitive impairments... - Neuroregulatory events follow adaptive immune-mediated elimination of HIV-1-infected macrophages: studies in a murine model of viral encephalitisLarisa Poluektova
Laboratory of Neuroregeneration, Center for Neurovirology and Neurodegenerative Disorders, and Department of Pathology and Microbiology, University of Nebraska Medical Center, 958215 Nebraska Medical Center, Omaha, NE 68198 5215, USA
J Immunol 172:7610-7. 2004..This murine model of HIV-1 encephalitis can be useful in elucidating the role played by innate and adaptive immunity in disease progression and resolution... - Mononuclear phagocyte intercellular crosstalk facilitates transmission of cell-targeted nanoformulated antiretroviral drugs to human brain endothelial cellsGeorgette D Kanmogne
Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198 5215, USA
Int J Nanomedicine 7:2373-88. 2012..We postulate that monocyte-macrophage transfer of nanoART to brain endothelial cells could facilitate drug entry into the brain... 
Long-acting nanoformulated antiretroviral therapy elicits potent antiretroviral and neuroprotective responses in HIV-1-infected humanized micePrasanta K Dash
Center for Neurodegenerative Disorders and Department of Pharmacology and Experimental Neuroscience, College of Medicine, University of Nebraska Medical Center, Omaha, NE 68198, USA
AIDS 26:2135-44. 2012..Long-acting nanoformulated antiretroviral therapy (nanoART) with improved pharmacokinetics, biodistribution and limited systemic toxicities will likely improve drug adherence and access to viral reservoirs...- Human dendritic cells transduced with herpes simplex virus amplicons encoding human immunodeficiency virus type 1 (HIV-1) gp120 elicit adaptive immune responses from human cells engrafted into NOD/SCID mice and confer partial protection against HIV-1 chalSanthi Gorantla
Center for Neurovirology and Neurodegenerative Disorders, 985880 Nebraska Medical Center, Omaha, NE 68198-5880, USA
J Virol 79:2124-32. 2005..This mouse model may be a useful tool to evaluate human immune responses and protection against viral infection following vaccination... - Human immunodeficiency virus type 1 pathobiology studied in humanized BALB/c-Rag2-/-gammac-/- miceSanthi Gorantla
Centere for Neurovirology and Neurodegenerative Disorders, Department of Pharmacology, University of Nebraska Medical Center, 985880 Nebraska Medical Center, Omaha, NE 68198 5880, USA
J Virol 81:2700-12. 2007..We conclude that humanized BALB/c-Rag2(-/-)gamma(c)(-/-) mice represent a unique and valuable resource for HIV-1 pathobiology studies... - Mechanism of alcohol-induced oxidative stress and neuronal injuryJames Haorah
Center for Neurovirology and Neurodegenerative Disorders, Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198 5215, USA
Free Radic Biol Med 45:1542-50. 2008..Novel quantitative methods of ROS and NO detection help dissect the mechanisms of alcohol-induced neurodegeneration. Uncovering the basic mechanisms of oxidative neuronal injury will serve as the basis for development of new therapies... - Links between progressive HIV-1 infection of humanized mice and viral neuropathogenesisSanthi Gorantla
Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198 5880, USA
Am J Pathol 177:2938-49. 2010..This model of neuroAIDS reflects the virological, immunological, and early disease-associated neuropathological components of human disease... - Neuroprotective activities of sodium valproate in a murine model of human immunodeficiency virus-1 encephalitisHuanyu Dou
Center for Neurovirology and Neurodegenerative Disorders, University of Nebraska Medical Center, Omaha, Nebraska 68198-5215, USA
J Neurosci 23:9162-70. 2003..We conclude that VPA protects neurons against HIV-1 infected MDM neurotoxicity, possibly through its effects on the phosphorylation of tau and beta-catenin. The use of VPA as an adjuvant in treatment of human HAD is being pursued... - Development of a platelet-activating factor antagonist for HIV-1 associated neurocognitive disordersDawn Eggert
Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198 5880, USA
J Neuroimmunol 213:47-59. 2009..These observations support the further development of PMS-601 as an adjunctive therapy for HIV-1 associated neurocognitive disorders... - Brain ingress of regulatory T cells in a murine model of HIV-1 encephalitisNan Gong
Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198, USA
J Neuroimmunol 230:33-41. 2011..In non-inflamed peripheral tissues (liver and spleen) Treg were depleted. These observations demonstrate that Treg migrate to sites of inflammation where they modulate immune responses... - Rodent models for HIV-associated neurocognitive disordersSanthi Gorantla
Center for Neurodegenerative Disorders and Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, USA
Trends Neurosci 35:197-208. 2012..We review these and other rodent models of HAND and discuss their unmet potential in reflecting human pathobiology and in facilitating disease monitoring and therapeutic discoveries... - Isolation, propagation, and HIV-1 infection of monocyte-derived macrophages and recovery of virus from brain and cerebrospinal fluidSanthi Gorantla
Center for Neurovirology and Neurodegenerative Disorders, Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, USA
Methods Mol Biol 304:35-48. 2005..Mario Stevenson, William Tyor, David Volsky, Loyda Melendez, and Mary-Jane Potash, among others. The importance of these cells as targets for virus and reservoirs of persistent infection are discussed... - Neuropathologic and neuroinflammatory activities of HIV-1-infected human astrocytes in murine brainHuanyu Dou
Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, Nebraska 68198-5880, USA
Glia 54:81-93. 2006..We conclude that HIV-1 infection of astrocytes leads to limited neurodegeneration, underscoring the early and active role of macrophage-driven neurotoxicity in disease... - Alcohol-induced blood-brain barrier dysfunction is mediated via inositol 1,4,5-triphosphate receptor (IP3R)-gated intracellular calcium releaseJames Haorah
Center for Neurovirology and Neurodegenerative Disorders, Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, Nebraska 68198 5215, USA
J Neurochem 100:324-36. 2007..These putative events can lead to BBB dysfunction in the setting of alcoholism, and to neuro-inflammatory disorders promoting leukocyte migration across the BBB... - Peripheral nerve induces macrophage neurotrophic activities: regulation of neuronal process outgrowth, intracellular signaling and synaptic functionAnnemarie Shibata
Center for Neurovirology and Neurodegenerative Disorders and the Department of Pathology and Microbiology, University of Nebraska Medical Center, 985215 Nebraska Medical Center, Omaha, NE 68198-5215, USA
J Neuroimmunol 142:112-29. 2003..MDM activation cues may serve to balance toxic activities produced during neurodegenerative diseases and thus, under certain circumstances, mitigate neuronal degeneration... - Therapeutic immunization protects dopaminergic neurons in a mouse model of Parkinson's diseaseEric J Benner
Center for Neurovirology and Neurodegenerative Disorders and Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, 68198, USA
Proc Natl Acad Sci U S A 101:9435-40. 2004..Such vaccine treatment strategies may provide benefit for Parkinson's disease... - Can humanized mice reflect the complex pathobiology of HIV-associated neurocognitive disorders?Santhi Gorantla
Department of Pharmacology and Experimental Neuroscience and Center for Neurodegenerative Disorders, University of Nebraska Medical Center, Omaha, NE, USA
J Neuroimmune Pharmacol 7:352-62. 2012..To this end, we now review the evidence for how and under what circumstances humanized mice may be utilized for studies of HIV-1 neuropathogenesis... - Inhibition of long-term potentiation by interleukin-8: implications for human immunodeficiency virus-1-associated dementiaHuangui Xiong
The Laboratory of Neurophysiology, Center for Neurovirology and Neurodegenerative Disorders, University of Nebraska Medical Center, Omaha, Nebraska 68198 5215, USA
J Neurosci Res 71:600-7. 2003..The induction of IL-8 in HAD, its inhibition of LTP, and the expression of its receptor, CXCR2, in the hippocampus all suggest that it plays a role in the cognitive dysfunction associated with HAD...