Santhi Gorantla

Summary

Affiliation: University of Nebraska Medical Center
Country: USA

Publications

  1. pmc Immunoregulation of a CB2 receptor agonist in a murine model of neuroAIDS
    Santhi Gorantla
    Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, 68198 5880, USA
    J Neuroimmune Pharmacol 5:456-68. 2010
  2. pmc Neuroprotective activities of CEP-1347 in models of neuroAIDS
    Dawn Eggert
    Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198, USA
    J Immunol 184:746-56. 2010
  3. doi request reprint Long-acting nanoformulated antiretroviral therapy elicits potent antiretroviral and neuroprotective responses in HIV-1-infected humanized mice
    Prasanta K Dash
    Center for Neurodegenerative Disorders and Department of Pharmacology and Experimental Neuroscience, College of Medicine, University of Nebraska Medical Center, Omaha, NE 68198, USA
    AIDS 26:2135-44. 2012
  4. pmc Loss of neuronal integrity during progressive HIV-1 infection of humanized mice
    Prasanta K Dash
    Department of Pharmacology and Experimental Neuroscience, Radiology, Surgery, and Internal Medicine, University of Nebraska Medical Center, Omaha, Nebraska 68198, USA
    J Neurosci 31:3148-57. 2011
  5. ncbi request reprint Quantitative magnetic resonance and SPECT imaging for macrophage tissue migration and nanoformulated drug delivery
    Santhi Gorantla
    Center for Neurovirology and Neurodegenerative Disorders, University of Nebraska Medical Center, 985880 Nebraska Medical Center, Omaha, NE 68198 5880, USA
    J Leukoc Biol 80:1165-74. 2006
  6. pmc CD8+ cell depletion accelerates HIV-1 immunopathology in humanized mice
    Santhi Gorantla
    Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198, USA
    J Immunol 184:7082-91. 2010
  7. pmc Modulation of innate immunity by copolymer-1 leads to neuroprotection in murine HIV-1 encephalitis
    Santhi Gorantla
    Center for Neurovirology and Neurodegenerative Disorders, University of Nebraska Medical Center, Omaha, Nebraska 68198 5880, USA
    Glia 56:223-32. 2008
  8. pmc HIV-1-infected and/or immune activated macrophages regulate astrocyte SDF-1 production through IL-1beta
    Hui Peng
    Laboratory of Neurotoxicology, Center for Neurovirology and Neurodegenerative Disorders, University of Nebraska Medical Center, Omaha, Nebraska 68195 5880, USA
    Glia 54:619-29. 2006
  9. ncbi request reprint Copolymer-1 induces adaptive immune anti-inflammatory glial and neuroprotective responses in a murine model of HIV-1 encephalitis
    Santhi Gorantla
    Center for Neurovirology and Neurodegenerative Disorders, University of Nebraska Medical Center, Omaha, NE 68198, USA
    J Immunol 179:4345-56. 2007
  10. pmc Development of a macrophage-based nanoparticle platform for antiretroviral drug delivery
    Huanyu Dou
    Department of Pharmacology and Experimental Neuroscience, Center for Neurovirology and Neurodegenerative Disorder, University of Nebraska Medical Center, 985880 Nebraska Medical Center, Omaha, NE 68198 5880, USA
    Blood 108:2827-35. 2006

Collaborators

Detail Information

Publications33

  1. pmc Immunoregulation of a CB2 receptor agonist in a murine model of neuroAIDS
    Santhi Gorantla
    Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, 68198 5880, USA
    J Neuroimmune Pharmacol 5:456-68. 2010
    ..Gp1a down modulated CCR5 expression on human cells in the spleen with an increase in Fas ligand expression. Our results support the notion that CB2 receptor agonists may be a viable therapeutic candidate for HAND...
  2. pmc Neuroprotective activities of CEP-1347 in models of neuroAIDS
    Dawn Eggert
    Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198, USA
    J Immunol 184:746-56. 2010
    ..These results demonstrate that CEP-1347 elicits anti-inflammatory and neuroprotective responses in an HIVE model of human disease and as such warrants further study as an adjunctive therapy for human disease...
  3. doi request reprint Long-acting nanoformulated antiretroviral therapy elicits potent antiretroviral and neuroprotective responses in HIV-1-infected humanized mice
    Prasanta K Dash
    Center for Neurodegenerative Disorders and Department of Pharmacology and Experimental Neuroscience, College of Medicine, University of Nebraska Medical Center, Omaha, NE 68198, USA
    AIDS 26:2135-44. 2012
    ..Long-acting nanoformulated antiretroviral therapy (nanoART) with improved pharmacokinetics, biodistribution and limited systemic toxicities will likely improve drug adherence and access to viral reservoirs...
  4. pmc Loss of neuronal integrity during progressive HIV-1 infection of humanized mice
    Prasanta K Dash
    Department of Pharmacology and Experimental Neuroscience, Radiology, Surgery, and Internal Medicine, University of Nebraska Medical Center, Omaha, Nebraska 68198, USA
    J Neurosci 31:3148-57. 2011
    ..As such, the model permits studies of the relationships between ongoing viral replication and virus-associated neurodegeneration...
  5. ncbi request reprint Quantitative magnetic resonance and SPECT imaging for macrophage tissue migration and nanoformulated drug delivery
    Santhi Gorantla
    Center for Neurovirology and Neurodegenerative Disorders, University of Nebraska Medical Center, 985880 Nebraska Medical Center, Omaha, NE 68198 5880, USA
    J Leukoc Biol 80:1165-74. 2006
    ..These data show real-time kinetics and destinations of macrophage trafficking and demonstrate the feasibility of monitoring macrophage-based, nanoformulated ART...
  6. pmc CD8+ cell depletion accelerates HIV-1 immunopathology in humanized mice
    Santhi Gorantla
    Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198, USA
    J Immunol 184:7082-91. 2010
    ..These data support a role of CD8+ cells in viral surveillance and the relevance of this humanized mouse model for the studies of HIV-1 pathobiology and virus-specific immunity...
  7. pmc Modulation of innate immunity by copolymer-1 leads to neuroprotection in murine HIV-1 encephalitis
    Santhi Gorantla
    Center for Neurovirology and Neurodegenerative Disorders, University of Nebraska Medical Center, Omaha, Nebraska 68198 5880, USA
    Glia 56:223-32. 2008
    ..The data, taken together, demonstrate that Cop-1 can modulate innate immunity and, as such, improve disease outcomes in an animal model of HIVE...
  8. pmc HIV-1-infected and/or immune activated macrophages regulate astrocyte SDF-1 production through IL-1beta
    Hui Peng
    Laboratory of Neurotoxicology, Center for Neurovirology and Neurodegenerative Disorders, University of Nebraska Medical Center, Omaha, Nebraska 68195 5880, USA
    Glia 54:619-29. 2006
    ....
  9. ncbi request reprint Copolymer-1 induces adaptive immune anti-inflammatory glial and neuroprotective responses in a murine model of HIV-1 encephalitis
    Santhi Gorantla
    Center for Neurovirology and Neurodegenerative Disorders, University of Nebraska Medical Center, Omaha, NE 68198, USA
    J Immunol 179:4345-56. 2007
    ..Ingress of Foxp3- and IL-4-expressing lymphocytes into brains of COP-1-immunized animals was observed. We conclude that COP-1 may warrant therapeutic consideration for HIV-1-associated cognitive impairments...
  10. pmc Development of a macrophage-based nanoparticle platform for antiretroviral drug delivery
    Huanyu Dou
    Department of Pharmacology and Experimental Neuroscience, Center for Neurovirology and Neurodegenerative Disorder, University of Nebraska Medical Center, 985880 Nebraska Medical Center, Omaha, NE 68198 5880, USA
    Blood 108:2827-35. 2006
    ..We conclude that a single dose of NP-IDV, using BMMs as a carrier, is effective and warrants consideration for human testing...
  11. ncbi request reprint Neuroregulatory events follow adaptive immune-mediated elimination of HIV-1-infected macrophages: studies in a murine model of viral encephalitis
    Larisa Poluektova
    Laboratory of Neuroregeneration, Center for Neurovirology and Neurodegenerative Disorders, and Department of Pathology and Microbiology, University of Nebraska Medical Center, 958215 Nebraska Medical Center, Omaha, NE 68198 5215, USA
    J Immunol 172:7610-7. 2004
    ..This murine model of HIV-1 encephalitis can be useful in elucidating the role played by innate and adaptive immunity in disease progression and resolution...
  12. pmc Mononuclear phagocyte intercellular crosstalk facilitates transmission of cell-targeted nanoformulated antiretroviral drugs to human brain endothelial cells
    Georgette D Kanmogne
    Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198 5215, USA
    Int J Nanomedicine 7:2373-88. 2012
    ..We postulate that monocyte-macrophage transfer of nanoART to brain endothelial cells could facilitate drug entry into the brain...
  13. pmc Human dendritic cells transduced with herpes simplex virus amplicons encoding human immunodeficiency virus type 1 (HIV-1) gp120 elicit adaptive immune responses from human cells engrafted into NOD/SCID mice and confer partial protection against HIV-1 chal
    Santhi Gorantla
    Center for Neurovirology and Neurodegenerative Disorders, 985880 Nebraska Medical Center, Omaha, NE 68198 5880, USA
    J Virol 79:2124-32. 2005
    ..This mouse model may be a useful tool to evaluate human immune responses and protection against viral infection following vaccination...
  14. pmc Human immunodeficiency virus type 1 pathobiology studied in humanized BALB/c-Rag2-/-gammac-/- mice
    Santhi Gorantla
    Centere for Neurovirology and Neurodegenerative Disorders, Department of Pharmacology, University of Nebraska Medical Center, 985880 Nebraska Medical Center, Omaha, NE 68198 5880, USA
    J Virol 81:2700-12. 2007
    ..We conclude that humanized BALB/c-Rag2(-/-)gamma(c)(-/-) mice represent a unique and valuable resource for HIV-1 pathobiology studies...
  15. pmc Links between progressive HIV-1 infection of humanized mice and viral neuropathogenesis
    Santhi Gorantla
    Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198 5880, USA
    Am J Pathol 177:2938-49. 2010
    ..This model of neuroAIDS reflects the virological, immunological, and early disease-associated neuropathological components of human disease...
  16. pmc Mechanism of alcohol-induced oxidative stress and neuronal injury
    James Haorah
    Center for Neurovirology and Neurodegenerative Disorders, Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198 5215, USA
    Free Radic Biol Med 45:1542-50. 2008
    ..Novel quantitative methods of ROS and NO detection help dissect the mechanisms of alcohol-induced neurodegeneration. Uncovering the basic mechanisms of oxidative neuronal injury will serve as the basis for development of new therapies...
  17. pmc Pharmacodynamic and antiretroviral activities of combination nanoformulated antiretrovirals in HIV-1-infected human peripheral blood lymphocyte-reconstituted mice
    Upal Roy
    Department of Pharmacology and Experimental Neuroscience, College of Medicine, University of Nebraska Medical Center, Omaha, NE 68198 5880, USA
    J Infect Dis 206:1577-88. 2012
    ..NanoART treatment attenuated viral replication and preserved CD4(+) Tcell numbers beyond that seen with orally administered native drugs. These investigations bring us one step closer toward using long-acting antiretrovirals in humans...
  18. pmc Brain ingress of regulatory T cells in a murine model of HIV-1 encephalitis
    Nan Gong
    Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198, USA
    J Neuroimmunol 230:33-41. 2011
    ..In non-inflamed peripheral tissues (liver and spleen) Treg were depleted. These observations demonstrate that Treg migrate to sites of inflammation where they modulate immune responses...
  19. pmc Development of a platelet-activating factor antagonist for HIV-1 associated neurocognitive disorders
    Dawn Eggert
    Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198 5880, USA
    J Neuroimmunol 213:47-59. 2009
    ..These observations support the further development of PMS-601 as an adjunctive therapy for HIV-1 associated neurocognitive disorders...
  20. ncbi request reprint Neuroprotective activities of sodium valproate in a murine model of human immunodeficiency virus-1 encephalitis
    Huanyu Dou
    Center for Neurovirology and Neurodegenerative Disorders, University of Nebraska Medical Center, Omaha, Nebraska 68198 5215, USA
    J Neurosci 23:9162-70. 2003
    ..We conclude that VPA protects neurons against HIV-1 infected MDM neurotoxicity, possibly through its effects on the phosphorylation of tau and beta-catenin. The use of VPA as an adjuvant in treatment of human HAD is being pursued...
  21. doi request reprint Combinatorial assessments of brain tissue metabolomics and histopathology in rodent models of human immunodeficiency virus infection
    Adrian A Epstein
    Department of Pharmacology and Experimental Neuroscience, College of Medicine, University of Nebraska Medical Center, Omaha, NE, 68198, USA
    J Neuroimmune Pharmacol 8:1224-38. 2013
    ..Metabolite responses were contingent on the animal model. Taken together, these studies integrate brain metabolomics with histopathology towards uncovering putative biomarkers for neuroAIDS. ..
  22. pmc Rodent models for HIV-associated neurocognitive disorders
    Santhi Gorantla
    Center for Neurodegenerative Disorders and Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, USA
    Trends Neurosci 35:197-208. 2012
    ..We review these and other rodent models of HAND and discuss their unmet potential in reflecting human pathobiology and in facilitating disease monitoring and therapeutic discoveries...
  23. ncbi request reprint Alcohol-induced blood-brain barrier dysfunction is mediated via inositol 1,4,5-triphosphate receptor (IP3R)-gated intracellular calcium release
    James Haorah
    Center for Neurovirology and Neurodegenerative Disorders, Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, Nebraska 68198 5215, USA
    J Neurochem 100:324-36. 2007
    ..These putative events can lead to BBB dysfunction in the setting of alcoholism, and to neuro-inflammatory disorders promoting leukocyte migration across the BBB...
  24. ncbi request reprint Isolation, propagation, and HIV-1 infection of monocyte-derived macrophages and recovery of virus from brain and cerebrospinal fluid
    Santhi Gorantla
    Center for Neurovirology and Neurodegenerative Disorders, Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, USA
    Methods Mol Biol 304:35-48. 2005
    ..Mario Stevenson, William Tyor, David Volsky, Loyda Melendez, and Mary-Jane Potash, among others. The importance of these cells as targets for virus and reservoirs of persistent infection are discussed...
  25. ncbi request reprint Neuropathologic and neuroinflammatory activities of HIV-1-infected human astrocytes in murine brain
    Huanyu Dou
    Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, Nebraska 68198 5880, USA
    Glia 54:81-93. 2006
    ..We conclude that HIV-1 infection of astrocytes leads to limited neurodegeneration, underscoring the early and active role of macrophage-driven neurotoxicity in disease...
  26. doi request reprint Induction of oxidative and nitrosative damage leads to cerebrovascular inflammation in an animal model of mild traumatic brain injury induced by primary blast
    P M Abdul-Muneer
    Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198, USA
    Free Radic Biol Med 60:282-91. 2013
    ..Thus, induction of oxidative stress and activation of matrix metalloproteinases by shock wave underlie the mechanisms of cerebral vascular BBB leakage and neuroinflammation...
  27. pmc Improved visualization of neuronal injury following glial activation by manganese enhanced MRI
    Aditya N Bade
    Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, USA
    J Neuroimmune Pharmacol 8:1027-36. 2013
    ..We conclude that the MEMRI signal enhancement is induced by inflammation stimulating neuronal Mn²⁺ uptake...
  28. pmc Therapeutic immunization protects dopaminergic neurons in a mouse model of Parkinson's disease
    Eric J Benner
    Center for Neurovirology and Neurodegenerative Disorders and Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, 68198, USA
    Proc Natl Acad Sci U S A 101:9435-40. 2004
    ..Such vaccine treatment strategies may provide benefit for Parkinson's disease...
  29. ncbi request reprint Peripheral nerve induces macrophage neurotrophic activities: regulation of neuronal process outgrowth, intracellular signaling and synaptic function
    Annemarie Shibata
    Center for Neurovirology and Neurodegenerative Disorders and the Department of Pathology and Microbiology, University of Nebraska Medical Center, 985215 Nebraska Medical Center, Omaha, NE 68198 5215, USA
    J Neuroimmunol 142:112-29. 2003
    ..MDM activation cues may serve to balance toxic activities produced during neurodegenerative diseases and thus, under certain circumstances, mitigate neuronal degeneration...
  30. pmc Can humanized mice reflect the complex pathobiology of HIV-associated neurocognitive disorders?
    Santhi Gorantla
    Department of Pharmacology and Experimental Neuroscience and Center for Neurodegenerative Disorders, University of Nebraska Medical Center, Omaha, NE, USA
    J Neuroimmune Pharmacol 7:352-62. 2012
    ..To this end, we now review the evidence for how and under what circumstances humanized mice may be utilized for studies of HIV-1 neuropathogenesis...
  31. pmc Nano-NRTIs demonstrate low neurotoxicity and high antiviral activity against HIV infection in the brain
    Trevor Gerson
    Department of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, NE, USA
    Nanomedicine 10:177-85. 2014
    ..Our data provide proof of the advanced efficacy of nano-NRTIs as safer alternative of current antiviral drugs...
  32. ncbi request reprint Inhibition of long-term potentiation by interleukin-8: implications for human immunodeficiency virus-1-associated dementia
    Huangui Xiong
    The Laboratory of Neurophysiology, Center for Neurovirology and Neurodegenerative Disorders, University of Nebraska Medical Center, Omaha, Nebraska 68198 5215, USA
    J Neurosci Res 71:600-7. 2003
    ..The induction of IL-8 in HAD, its inhibition of LTP, and the expression of its receptor, CXCR2, in the hippocampus all suggest that it plays a role in the cognitive dysfunction associated with HAD...
  33. pmc Human Hepatocytes and Hematolymphoid Dual Reconstitution in Treosulfan-Conditioned uPA-NOG Mice
    Tanuja L Gutti
    Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, Nebraska
    Am J Pathol 184:101-9. 2014
    ..Even major histocompatibility complex mismatched transplantation was sustained without any evidence of hepatocyte rejection by the human immune system. ..