Bret Goodpaster

Summary

Affiliation: University of Pittsburgh
Country: USA

Publications

  1. pmc Insulin resistance is associated with higher intramyocellular triglycerides in type I but not type II myocytes concomitant with higher ceramide content
    Paul M Coen
    Division of Endocrinology and Metabolism, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Diabetes 59:80-8. 2010
  2. pmc Skeletal muscle triglycerides, diacylglycerols, and ceramides in insulin resistance: another paradox in endurance-trained athletes?
    Francesca Amati
    Department of Medicine, Division of Endocrinology and Metabolism, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Diabetes 60:2588-97. 2011
  3. pmc Mitochondrial deficiency is associated with insulin resistance
    Bret H Goodpaster
    Division of Endocrinology and Metabolism, Department of Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Diabetes 62:1032-5. 2013
  4. pmc PET imaging reveals distinctive roles for different regional adipose tissue depots in systemic glucose metabolism in nonobese humans
    Jason M Ng
    Division of Endocrinology and Metabolism, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Am J Physiol Endocrinol Metab 303:E1134-41. 2012
  5. pmc Effects of physical activity on strength and skeletal muscle fat infiltration in older adults: a randomized controlled trial
    Bret H Goodpaster
    Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    J Appl Physiol (1985) 105:1498-503. 2008
  6. ncbi request reprint Skeletal muscle lipid concentration quantified by magnetic resonance imaging
    Bret H Goodpaster
    Department of Medicine, 809 North MUH, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Am J Clin Nutr 79:748-54. 2004
  7. ncbi request reprint The loss of skeletal muscle strength, mass, and quality in older adults: the health, aging and body composition study
    Bret H Goodpaster
    Department of Medicine, MUH N809, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    J Gerontol A Biol Sci Med Sci 61:1059-64. 2006
  8. ncbi request reprint Skeletal muscle lipid and its association with insulin resistance: what is the role for exercise?
    Bret H Goodpaster
    Division of Endocrinology and Metabolism, University of Pittsburgh Department of Medicine, Montefiore Hospital, Pittsburgh, PA 15213, USA
    Exerc Sport Sci Rev 33:150-4. 2005
  9. ncbi request reprint Obesity, regional body fat distribution, and the metabolic syndrome in older men and women
    Bret H Goodpaster
    Department of Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Arch Intern Med 165:777-83. 2005
  10. ncbi request reprint Association between regional adipose tissue distribution and both type 2 diabetes and impaired glucose tolerance in elderly men and women
    Bret H Goodpaster
    Department of Medicine, University of Pittsburgh Medical Center, Pennsylvania 15213, USA
    Diabetes Care 26:372-9. 2003

Research Grants

Collaborators

Detail Information

Publications73

  1. pmc Insulin resistance is associated with higher intramyocellular triglycerides in type I but not type II myocytes concomitant with higher ceramide content
    Paul M Coen
    Division of Endocrinology and Metabolism, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Diabetes 59:80-8. 2010
    ....
  2. pmc Skeletal muscle triglycerides, diacylglycerols, and ceramides in insulin resistance: another paradox in endurance-trained athletes?
    Francesca Amati
    Department of Medicine, Division of Endocrinology and Metabolism, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Diabetes 60:2588-97. 2011
    ..We also hypothesized that the expression of key skeletal muscle proteins involved in lipid droplet hydrolysis, DAG formation, and fatty-acid partitioning and oxidation would be associated with the lipotoxic phenotype...
  3. pmc Mitochondrial deficiency is associated with insulin resistance
    Bret H Goodpaster
    Division of Endocrinology and Metabolism, Department of Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Diabetes 62:1032-5. 2013
    ..In summary, mitochondrial "deficiency" is not merely a reduced energy generation or low fatty acid oxidation; this concept should be expanded to numerous additional important functions, many of which can cause IR if perturbed...
  4. pmc PET imaging reveals distinctive roles for different regional adipose tissue depots in systemic glucose metabolism in nonobese humans
    Jason M Ng
    Division of Endocrinology and Metabolism, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Am J Physiol Endocrinol Metab 303:E1134-41. 2012
    ..These dynamic PET imaging studies indicate that both quantity and quality of specific AT depots have distinct roles in systemic insulin resistance and may help explain the metabolically obese but normal-weight phenotype...
  5. pmc Effects of physical activity on strength and skeletal muscle fat infiltration in older adults: a randomized controlled trial
    Bret H Goodpaster
    Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    J Appl Physiol (1985) 105:1498-503. 2008
    ..3 +/- 5.7%). In conclusion, regular physical activity prevents both the age-associated loss of muscle strength and increase in muscle fat infiltration in older adults with moderate functional limitations...
  6. ncbi request reprint Skeletal muscle lipid concentration quantified by magnetic resonance imaging
    Bret H Goodpaster
    Department of Medicine, 809 North MUH, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Am J Clin Nutr 79:748-54. 2004
    ..Skeletal muscle lipid is associated with obesity and type 2 diabetes and may be altered by diet, physical activity, and weight loss...
  7. ncbi request reprint The loss of skeletal muscle strength, mass, and quality in older adults: the health, aging and body composition study
    Bret H Goodpaster
    Department of Medicine, MUH N809, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    J Gerontol A Biol Sci Med Sci 61:1059-64. 2006
    ..The loss of muscle mass is considered to be a major determinant of strength loss in aging. However, large-scale longitudinal studies examining the association between the loss of mass and strength in older adults are lacking...
  8. ncbi request reprint Skeletal muscle lipid and its association with insulin resistance: what is the role for exercise?
    Bret H Goodpaster
    Division of Endocrinology and Metabolism, University of Pittsburgh Department of Medicine, Montefiore Hospital, Pittsburgh, PA 15213, USA
    Exerc Sport Sci Rev 33:150-4. 2005
    ..The balance between storage and use of muscle triglycerides is likely a key to the interaction between dysregulated fat and glucose metabolism by healthy and insulin resistant muscle...
  9. ncbi request reprint Obesity, regional body fat distribution, and the metabolic syndrome in older men and women
    Bret H Goodpaster
    Department of Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Arch Intern Med 165:777-83. 2005
    ..We determined whether patterns of regional fat deposition are associated with metabolic syndrome in older adults...
  10. ncbi request reprint Association between regional adipose tissue distribution and both type 2 diabetes and impaired glucose tolerance in elderly men and women
    Bret H Goodpaster
    Department of Medicine, University of Pittsburgh Medical Center, Pennsylvania 15213, USA
    Diabetes Care 26:372-9. 2003
    ....
  11. ncbi request reprint Measuring body fat distribution and content in humans
    Bret H Goodpaster
    Division of Endocrinology and Metabolism, University of Pittsburgh Department of Medicine, Montefiore Hospital, Pittsburgh, Pennsylvania 15213, USA
    Curr Opin Clin Nutr Metab Care 5:481-7. 2002
    ..The review particularly emphasizes methods to characterize regional fat distribution and ectopic fat (fat contained within other tissues) including specific applications and implications of region-specific or tissue-specific fat content...
  12. pmc Effects of diet and physical activity interventions on weight loss and cardiometabolic risk factors in severely obese adults: a randomized trial
    Bret H Goodpaster
    Division of Endocrinology and Metabolism, Department of Medicine, School of Medicine, University of Pittsburgh, MUH N810, 3459 Fifth Ave, Pittsburgh, PA 15213, USA
    JAMA 304:1795-802. 2010
    ....
  13. ncbi request reprint Sarcopenia: alternative definitions and associations with lower extremity function
    Anne B Newman
    Division of Geriatric Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    J Am Geriatr Soc 51:1602-9. 2003
    ....
  14. ncbi request reprint Adipocytokines and incident diabetes mellitus in older adults: the independent effect of plasminogen activator inhibitor 1
    Alka M Kanaya
    Division of General Internal Medicine, Department of Medicine, University of California, San Francisco, Suite 500, San Francisco, CA 94143 1732, USA
    Arch Intern Med 166:350-6. 2006
    ..Adipose tissue produces "adipocytokines" of uncertain clinical significance...
  15. ncbi request reprint Strength and muscle quality in a well-functioning cohort of older adults: the Health, Aging and Body Composition Study
    Anne B Newman
    Department of Medicine, Division of Geriatric Medicine, University of Pittsburgh School of Medicine, 3520 5th Avenue, Suite 300, Pittsburgh, PA 15213, USA
    J Am Geriatr Soc 51:323-30. 2003
    ..To determine whether lower lean mass and higher fat mass have independent effects on the loss of strength and muscle quality in older adults and might explain part of the effect of age...
  16. pmc Adipose tissue in muscle: a novel depot similar in size to visceral adipose tissue
    Dympna Gallagher
    Department of Medicine, Obesity Research Center, St Luke s Roosevelt Hospital, New York, NY, USA
    Am J Clin Nutr 81:903-10. 2005
    ..The manner in which fat depot volumes and distributions, particularly the adipose tissue (AT) between the muscles, vary by race is unknown...
  17. ncbi request reprint Deficiency of subsarcolemmal mitochondria in obesity and type 2 diabetes
    Vladimir B Ritov
    Division of Endocrinology and Metabolism, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Diabetes 54:8-14. 2005
    ..Because of the potential importance of subsarcolemmal mitochondria for signal transduction and substrate transport, this deficit may contribute to the pathogenesis of muscle insulin resistance in type 2 diabetes...
  18. ncbi request reprint Enhanced fat oxidation through physical activity is associated with improvements in insulin sensitivity in obesity
    Bret H Goodpaster
    Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Diabetes 52:2191-7. 2003
    ..In conclusion, exercise combined with weight loss enhances postabsorptive fat oxidation, which appears to be a key aspect of the improvement in insulin sensitivity in obesity...
  19. ncbi request reprint Effects of weight loss and physical activity on muscle lipid content and droplet size
    Jing He
    Division of Endocrinology and Metabolism, Department of Medicine, University of Pittsburgh School of Medicine, Pennsyvania, USA
    Obes Res 12:761-9. 2004
    ..To address the potential effects of weight loss and physical activity (WL + Ex) on intramyocellular lipid (IMCL) and lipid droplet size in overweight and obese previously sedentary individuals...
  20. ncbi request reprint Effects of weight loss and physical activity on skeletal muscle mitochondrial function in obesity
    Elizabeth V Menshikova
    Division of Endocrinology and Metabolism, Department of Medicine, University of Pittsburgh, School of Medicine, Pennsylvania, USA
    Am J Physiol Endocrinol Metab 288:E818-25. 2005
    ..We conclude that improved skeletal muscle ETC activity following moderate WL and improved aerobic capacity contributes to associated alleviation of insulin resistance...
  21. doi request reprint Muscle mass predicts outcomes following liver transplantation
    Andrea DiMartini
    Departments of Transplantation Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA Psychiatry, University of Pittsburgh Medical Center, Pittsburgh, PA Starzl Transplant Institute, University of Pittsburgh Medical Center, Pittsburgh, PA
    Liver Transpl 19:1172-80. 2013
    ....
  22. ncbi request reprint Skeletal muscle lipid accumulation in obesity, insulin resistance, and type 2 diabetes
    Bret H Goodpaster
    Division of Endocrinology and Metabolism, Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    Pediatr Diabetes 5:219-26. 2004
    ..Further defining the links between muscle lipid accumulation and insulin action should help develop more effective strategies to prevent or treat type 2 diabetes and other obesity-associated disorders...
  23. ncbi request reprint Assessment of intramuscular triglycerides: contribution to metabolic abnormalities
    John Dube
    Division of Endocrinology and Metabolism, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Curr Opin Clin Nutr Metab Care 9:553-9. 2006
    ..In addition to both invasive (muscle biopsy) and noninvasive methods, techniques to assess other lipids within muscle will be reviewed...
  24. ncbi request reprint Exercise training increases intramyocellular lipid and oxidative capacity in older adults
    Ryan Pruchnic
    Dept of Medicine, University of Pittsburgh Medical Center, 3459 Fifth Ave, Pittsburgh, PA 15213, USA
    Am J Physiol Endocrinol Metab 287:E857-62. 2004
    ..6 AU. The percentage of type I fibers significantly increased (P < 0.05) from 35.4 +/- 2.1 to 40.1 +/- 2.3%. In conclusion, exercise training increases IMCL in older persons in parallel with an enhanced capacity for fat oxidation...
  25. pmc Physical inactivity and obesity underlie the insulin resistance of aging
    Francesca Amati
    Department of Health and Physical Activity, School of Education, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Diabetes Care 32:1547-9. 2009
    ..CONCLUSIONS Insulin resistance may not be characteristic of aging but rather associated with obesity and physical inactivity...
  26. pmc Exercise-induced alterations in intramyocellular lipids and insulin resistance: the athlete's paradox revisited
    John J Dube
    Division of Endocrinology and Metabolism, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Am J Physiol Endocrinol Metab 294:E882-8. 2008
    ..Therefore, several key deleterious effects of aging and/or obesity on the metabolic profile of skeletal muscle can be reversed with only moderate increases in physical activity...
  27. ncbi request reprint Effects of obesity on substrate utilization during exercise
    Bret H Goodpaster
    Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA
    Obes Res 10:575-84. 2002
    ..The capacity for lipid and carbohydrate (CHO) oxidation during exercise is important for energy partitioning and storage. This study examined the effects of obesity on lipid and CHO oxidation during exercise...
  28. ncbi request reprint Diabetes, inflammation, and functional decline in older adults: findings from the Health, Aging and Body Composition (ABC) study
    M Kathleen Figaro
    Department of Medicine, Vanderbilt University Medical Center GRECC, 1310 24th Ave South, Room 4B111, Nashville, TN 37212, USA
    Diabetes Care 29:2039-45. 2006
    ..We examined the effect of C-reactive protein (CRP) and interleukin-6 (IL-6) on the incident mobility limitation in older adults with and without diabetes...
  29. pmc Effects of exercise on mitochondrial content and function in aging human skeletal muscle
    Elizabeth V Menshikova
    Division of Endocrinology and Metabolism, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    J Gerontol A Biol Sci Med Sci 61:534-40. 2006
    ..01). In conclusion, exercise enhances mitochondria ETC activity in older human skeletal muscle, particularly in subsarcolemmal mitochondria, which is likely related to the concomitant increases in mitochondrial biogenesis...
  30. doi request reprint Improvements in insulin sensitivity are blunted by subclinical hypothyroidism
    Francesca Amati
    Department of Health and Physical Activity, School of Education, University of Pittsburgh, PA 15213, USA
    Med Sci Sports Exerc 41:265-9. 2009
    ..The purpose of this study was to examine whether thyroid hormone status is related to the improvement in insulin sensitivity and physical fitness after weight loss and exercise training...
  31. ncbi request reprint Characteristics of skeletal muscle mitochondrial biogenesis induced by moderate-intensity exercise and weight loss in obesity
    Elizabeth V Menshikova
    Division of Endocrinology and Metabolism, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    J Appl Physiol 103:21-7. 2007
    ....
  32. ncbi request reprint Skeletal muscle fatigue, strength, and quality in the elderly: the Health ABC Study
    Andreas Katsiaras
    Division of Endocrinology and Metabolism, Department of Medicine, University of Pittsburgh, Pennsylvania, USA
    J Appl Physiol (1985) 99:210-6. 2005
    ..In conclusion, older men were more fatigue resistant than women, although in both men and women greater fatigue was not related to muscle weakness...
  33. doi request reprint Chronic exercise preserves lean muscle mass in masters athletes
    Andrew P Wroblewski
    Department of Orthopaedic Surgery, University of Pittsburgh, Pittsburgh, PA, USA
    Phys Sportsmed 39:172-8. 2011
    ..This maintenance of muscle mass and strength may decrease or eliminate the falls, functional decline, and loss of independence that are commonly seen in aging adults...
  34. pmc Separate and combined effects of exercise training and weight loss on exercise efficiency and substrate oxidation
    Francesca Amati
    Univ of Pittsburgh, Pittsburgh, PA 15213, USA
    J Appl Physiol (1985) 105:825-31. 2008
    ..Weight loss alone, however, significantly improves neither efficiency nor utilization of fat during exercise...
  35. pmc Adipose tissue infiltration in skeletal muscle: age patterns and association with diabetes among men of African ancestry
    Iva Miljkovic-Gacic
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Am J Clin Nutr 87:1590-5. 2008
    ..Although obesity is strongly associated with diabetes, the greater prevalence of diabetes in persons of African ancestry than in those of other ancestries cannot be explained simply by differences in total or central adiposity...
  36. pmc The relationship of reduced peripheral nerve function and diabetes with physical performance in older white and black adults: the Health, Aging, and Body Composition (Health ABC) study
    Elsa S Strotmeyer
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Diabetes Care 31:1767-72. 2008
    ..Poor peripheral nerve function is prevalent in diabetes and older populations, and it has great potential to contribute to poor physical performance...
  37. pmc Greater adipose tissue infiltration in skeletal muscle among older men of African ancestry
    Iva Miljkovic
    Department of Epidemiology, Center for Aging and Population Health, University of Pittsburgh, 130 North Bellefield Avenue, Room 542, Pittsburgh, PA 15213, USA
    J Clin Endocrinol Metab 94:2735-42. 2009
    ..Skeletal muscle fat has been identified as an important depot that increases with aging and may contribute to the development of diabetes...
  38. pmc Association of the CPT1B gene with skeletal muscle fat infiltration in Afro-Caribbean men
    Iva Miljkovic
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Obesity (Silver Spring) 17:1396-401. 2009
    ..03 and 0.007, respectively). Our results suggest a novel association between common nonsynonymous coding variants in CPT1B and ectopic skeletal muscle fat among middle-aged and older African ancestry men...
  39. pmc Sensory and motor peripheral nerve function and lower-extremity quadriceps strength: the health, aging and body composition study
    Elsa S Strotmeyer
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    J Am Geriatr Soc 57:2004-10. 2009
    ..To determine whether sensory and motor nerve function is associated cross-sectionally with quadriceps or ankle dorsiflexion strength in an older community-based population...
  40. pmc Deficiency of electron transport chain in human skeletal muscle mitochondria in type 2 diabetes mellitus and obesity
    Vladimir B Ritov
    Univ of Pittsburgh, School of Medicine, Div of Endocrinology and Metabolism, 810N MUH, 3459 5th Ave, Pittsburgh, PA 15213, USA
    Am J Physiol Endocrinol Metab 298:E49-58. 2010
    ..The specific activity of NADH oxidase (per mg cardiolipin) and NADH oxidase/citrate synthase and NADH oxidase/beta-HAD ratios are reduced two- to threefold in both T2DM and obesity...
  41. ncbi request reprint Muscle triglyceride and insulin resistance
    David E Kelley
    Division of Endocrinology and Metabolism, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Annu Rev Nutr 22:325-46. 2002
    ..This inflexibility in fuel selection by skeletal muscle appears to be related to the accumulation of imTG and is an important aspect of IR of skeletal muscle in obesity and type 2 DM...
  42. ncbi request reprint Skeletal muscle triglyceride: marker or mediator of obesity-induced insulin resistance in type 2 diabetes mellitus?
    Bret H Goodpaster
    Division of Endocrinology and Metabolism, 3459 Fifth Avenue, 810N MUH, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Curr Diab Rep 2:216-22. 2002
    ..Defining mechanisms by which dysregulation of fatty acid metabolism and persistent lipid oversupply alter insulin action may help to target more effective strategies to prevent or treat type 2 diabetes...
  43. ncbi request reprint Neuromuscular electrical stimulation and volitional exercise for individuals with rheumatoid arthritis: a multiple-patient case report
    Sara R Piva
    Department of Physical Therapy, School of Health and Rehabilitation Sciences, University of Pittsburgh, 6035 Forbes Tower, Pittsburgh, PA 15260, USA
    Phys Ther 87:1064-77. 2007
    ....
  44. ncbi request reprint Strength, but not muscle mass, is associated with mortality in the health, aging and body composition study cohort
    Anne B Newman
    University of Pittsburgh, Department of Epidemiology, 130 N Bellefield Avenue, Room 532, Pittsburgh, PA 15213, USA
    J Gerontol A Biol Sci Med Sci 61:72-7. 2006
    ..Although muscle strength and mass are highly correlated, the relationship between direct measures of low muscle mass (sarcopenia) and strength in association with mortality has not been examined...
  45. ncbi request reprint Weight change and the conservation of lean mass in old age: the Health, Aging and Body Composition Study
    Anne B Newman
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Am J Clin Nutr 82:872-8; quiz 915-6. 2005
    ..Weight loss may contribute to the loss of lean mass with age...
  46. pmc Moderate exercise attenuates the loss of skeletal muscle mass that occurs with intentional caloric restriction-induced weight loss in older, overweight to obese adults
    Peter Chomentowski
    Division of Endocrinology and Metabolism, Department of Medicine, University of Pittsburgh School of Medicine, Pennsylvania 15213, USA
    J Gerontol A Biol Sci Med Sci 64:575-80. 2009
    ..Aging is associated with a loss of muscle mass and increased body fat. The effects of diet-induced weight loss on muscle mass in older adults are not clear...
  47. ncbi request reprint Decreased muscle strength and quality in older adults with type 2 diabetes: the health, aging, and body composition study
    Seok Won Park
    Department of Internal Medicine, Pochon CHA University, Pochon, Korea
    Diabetes 55:1813-8. 2006
    ..In conclusion, diabetes is associated with lower skeletal muscle strength and quality. These characteristics may contribute to the development of physical disability in older adults with diabetes...
  48. pmc Hospitalization and change in body composition and strength in a population-based cohort of older persons
    Dawn E Alley
    Department of Epidemiology and Public Health, School of Medicine, University of Maryland, Baltimore, Maryland 21201, USA
    J Am Geriatr Soc 58:2085-91. 2010
    ..To examine the association between hospitalization and annual changes in body composition and strength in older adults...
  49. pmc Longitudinal study of muscle strength, quality, and adipose tissue infiltration
    Matthew J Delmonico
    Department of Epidemiology and Medicine, University of Pittsburgh, Pittsburgh, PA, USA
    Am J Clin Nutr 90:1579-85. 2009
    ..Sarcopenia is thought to be accompanied by increased muscle fat infiltration. However, no longitudinal studies have examined concomitant changes in muscle mass, strength, or fat infiltration in older adults...
  50. doi request reprint Preoperative weight loss in high-risk superobese bariatric patients: a computed tomography-based analysis
    Joy Collins
    Division of General and Thoracic Surgery, Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
    Surg Obes Relat Dis 7:480-5. 2011
    ..Our study examined the utility of preoperative weight loss with a liquid low-calorie diet (LCD) as a method of risk reduction...
  51. doi request reprint Objective radiologic assessment of body composition in patients with end-stage liver disease: going beyond the BMI
    Ruy J Cruz
    Department of Transplantation Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, USA
    Transplantation 95:617-22. 2013
    ..This technology is widely used in other medically ill populations but not yet in liver transplantation...
  52. doi request reprint Mechanisms of insulin resistance assessed by dynamic in-vivo positron emission tomography imaging
    Jason M Ng
    Department of Medicine, University of Pittsburgh, Montefiore Hospital, Pittsburgh, PA 15213, USA
    Curr Opin Clin Nutr Metab Care 12:508-12. 2009
    ..In this review, we examine recent studies utilizing dynamic in-vivo PET imaging in assessing insulin resistance in humans...
  53. pmc Regional adiposity and risk for coronary artery disease in type 1 diabetes: does having greater amounts of gluteal-femoral adiposity lower the risk?
    Christina M Shay
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA
    Diabetes Res Clin Pract 89:288-95. 2010
    ..Evidence suggests that the degree of gluteal-femoral adiposity may be inversely associated with coronary artery disease (CAD) risk; however, this association has not been evaluated in type 1 diabetes (T1D)...
  54. ncbi request reprint Physical activity in prefrail older adults: confidence and satisfaction related to physical function
    W Jack Rejeski
    Department of Health and Exercise Science, Box 7868, Wake Forest University, Winston Salem, NC 27109, USA
    J Gerontol B Psychol Sci Soc Sci 63:P19-26. 2008
    ..This is an important finding in light of the importance of these process variables in behavior change and quality of life...
  55. ncbi request reprint Increased intramuscular lipid storage in the insulin-resistant and endurance-trained state
    Luc J C van Loon
    Department of Movement Sciences, Nutrition Research Institute Maastricht, Maastricht University, 616, 6200, Maastricht, MD, The Netherlands
    Pflugers Arch 451:606-16. 2006
    ..Interventions to augment mitochondrial density and/or function are likely to improve the balance between FA uptake and oxidation and should be applied to prevent and/or treat insulin resistance...
  56. ncbi request reprint Lower serum albumin concentration and change in muscle mass: the Health, Aging and Body Composition Study
    Marjolein Visser
    Institute of Health Sciences, Faculty of Earth and Life Sciences, Vrije Universiteit, Amsterdam, The Netherlands
    Am J Clin Nutr 82:531-7. 2005
    ..Low albumin concentrations in older persons increase the risk of poor health outcomes, including functional decline...
  57. ncbi request reprint Predicting the development of diabetes in older adults: the derivation and validation of a prediction rule
    Alka M Kanaya
    Department of Medicine and Epidemiology and Biostatics, University of California, San Francisco, California 94115, USA
    Diabetes Care 28:404-8. 2005
    ..We created a prediction rule in one sample and prospectively validated it for incident diabetes in a separate cohort...
  58. ncbi request reprint Estrogen replacement, muscle composition, and physical function: The Health ABC Study
    Dennis R Taaffe
    School of Human Movement Studies, Faculty of Health Sciences, The University of Queensland, Brisbane, Australia
    Med Sci Sports Exerc 37:1741-7. 2005
    ..Therefore, the purpose of this study was to determine whether estrogen use is associated with enhanced muscle composition and, if so, whether this translates into improved strength and physical function...
  59. ncbi request reprint Adipocytokines attenuate the association between visceral adiposity and diabetes in older adults
    Alka M Kanaya
    University of California San Francisco, 1635 Divisadero Street, Suite 600, San Francisco, CA 94115, USA
    Diabetes Care 27:1375-80. 2004
    ..To examine whether adiponectin is independently associated with diabetes and whether adiponectin and other adipocytokines account for the relationship between fat and diabetes...
  60. ncbi request reprint Muscle mass, muscle strength, and muscle fat infiltration as predictors of incident mobility limitations in well-functioning older persons
    Marjolein Visser
    Institute for Research in Extramural Medicine, VU University Medical Center, Van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands
    J Gerontol A Biol Sci Med Sci 60:324-33. 2005
    ..This study aims to investigate whether low muscle mass, low muscle strength, and greater fat infiltration into the muscle predict incident mobility limitation...
  61. ncbi request reprint Relationship of interleukin-6 and tumor necrosis factor-alpha with muscle mass and muscle strength in elderly men and women: the Health ABC Study
    Marjolein Visser
    Institute for Research in Extramural Medicine, VU University Medical Center, Amsterdam, The Netherlands
    J Gerontol A Biol Sci Med Sci 57:M326-32. 2002
    ....
  62. ncbi request reprint Accelerated loss of skeletal muscle strength in older adults with type 2 diabetes: the health, aging, and body composition study
    Seok Won Park
    Department of Internal Medicine, Pochon CHA University, Pochon, Korea
    Diabetes Care 30:1507-12. 2007
    ..The aim of the study was to investigate longitudinal changes of muscle mass and strength in community-dwelling older adults with and without type 2 diabetes...
  63. ncbi request reprint Daily activity energy expenditure and mortality among older adults
    Todd M Manini
    National Institute on Aging, Laboratory of Epidemiology, Demography and Biometry, Bethesda, MD 20892, USA
    JAMA 296:171-9. 2006
    ..Exercise is associated with mortality benefits but simply expending energy through any activity in an individual's free-living environment may confer survival advantages...
  64. ncbi request reprint Leg muscle mass and composition in relation to lower extremity performance in men and women aged 70 to 79: the health, aging and body composition study
    Marjolein Visser
    Institute for Research in Extramural Medicine, Faculty of Medicine, Vrije Universiteit, Amsterdam, The Netherlands
    J Am Geriatr Soc 50:897-904. 2002
    ..Our aim was to determine whether low leg muscle mass and greater fat infiltration in the muscle were associated with poor lower extremity performance (LEP)...
  65. ncbi request reprint Serum leptin concentrations and body adipose measures in older black and white adults
    Constance E Ruhl
    Social and Scientific Systems, Inc, 8758 Georgia Avenue, Silver Spring, MD 20910, USA
    Am J Clin Nutr 80:576-83. 2004
    ..Among US adults, serum leptin concentrations are higher in women than in men and are higher in blacks than in whites independent of anthropometric measures of body fatness...
  66. ncbi request reprint Body mass index and serum leptin concentration independently estimate percentage body fat in older adults
    Constance E Ruhl
    Social and Scientific Systems Inc, Silver Spring, MD, USA
    Am J Clin Nutr 85:1121-6. 2007
    ....
  67. ncbi request reprint Angiotensin-converting enzyme insertion/deletion genotype, exercise, and physical decline
    Stephen B Kritchevsky
    The Sticht Center on Aging and Center for Human Genomics, Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, NC, USA
    JAMA 294:691-8. 2005
    ....
  68. ncbi request reprint Reduced physical activity increases intermuscular adipose tissue in healthy young adults
    Todd M Manini
    Department of Aging and Geriatrics, Institute on Aging, University of Florida, Gainesville, FL 32611 0107, USA
    Am J Clin Nutr 85:377-84. 2007
    ..Although several studies have described adaptations in muscle after reduced physical activity, the change in IMAT in healthy young adults is unknown...
  69. pmc Discontinuing hormone replacement therapy: attenuating the effect on CVD risk with lifestyle changes
    Kelley K Pettee
    Department of Exercise and Wellness, Arizona State University, 7350 E Unity Drive, Mesa, AZ 85212, USA
    Am J Prev Med 32:483-9. 2007
    ..Concern about the potential risks associated with hormone replacement therapy (HRT) has left post-menopausal women and healthcare providers searching for safe and effective means for cardiovascular disease (CVD) risk factor reduction...
  70. ncbi request reprint The metabolic syndrome is associated with circulating adipokines in older adults across a wide range of adiposity
    Tongjian You
    Department of Exercise and Nutrition Sciences, University at Buffalo, Buffalo, NY 14214, USA
    J Gerontol A Biol Sci Med Sci 63:414-9. 2008
    ..The purpose of this study was to examine the relationship of metabolic syndrome to several adipokines and the role of total and visceral adiposity in influencing this relationship in older adults...
  71. ncbi request reprint Insulin-like growth factor-1
    Lisa H Colbert
    J Am Geriatr Soc 52:1962-3. 2004
  72. ncbi request reprint Associations among walking performance, physical activity, and subclinical cardiovascular disease
    Kelley K Pettee
    Department of Exercise and Wellness, Arizona State Univerisity, Mesa, AZ 85212, USA
    Prev Cardiol 10:134-40. 2007
    ..001, respectively). Findings from the current report support the utility of the LDCW to identify women at higher risk for CVD who may be candidates for further cardiovascular testing or intensive lifestyle intervention...

Research Grants10

  1. Skeletal Muscle Lipid and Insulin Resistance in Aging
    Bret Goodpaster; Fiscal Year: 2004
    ..Ultimately this should help identify mechanisms and therapeutic targets implicated in skeletal muscle metabolic dysregulation. ..
  2. Physical Activity Following Surgery-Induced Weight Loss
    Bret H Goodpaster; Fiscal Year: 2010
    ..Information emanating from this study would thus help to determine the most effective treatments to prevent weight regain and to improve outcomes of these patients following surgery. ..
  3. Multi-Tracer PET Quantitation of Insulin Action
    Bret Goodpaster; Fiscal Year: 2009
    ..Resistance to the action of insulin to stimulate glucose uptake into muscle is a major risk factor to develop diabetes. This proposed research will identify causes for type 2 diabetes and point to new targets for effective treatment. ..
  4. Physical Activity Following Surgery-Induced Weight Loss
    Bret Goodpaster; Fiscal Year: 2009
    ..Information emanating from this study would thus help to determine the most effective treatments to prevent weight regain and to improve outcomes of these patients following surgery. ..
  5. Multi-Tracer PET Quantitation of Insulin Action
    Bret Goodpaster; Fiscal Year: 2007
    ..Resistance to the action of insulin to stimulate glucose uptake into muscle is a major risk factor to develop diabetes. This proposed research will identify causes for type 2 diabetes and point to new targets for effective treatment. ..
  6. Skeletal Muscle Lipid and Insulin Resistance in Aging
    Bret Goodpaster; Fiscal Year: 2007
    ..Ultimately this should help identify mechanisms and therapeutic targets implicated in skeletal muscle metabolic dysregulation. ..
  7. Skeletal Muscle Lipid and Insulin Resistance in Aging
    Bret Goodpaster; Fiscal Year: 2006
    ..Ultimately this should help identify mechanisms and therapeutic targets implicated in skeletal muscle metabolic dysregulation. ..
  8. Skeletal Muscle Lipid and Insulin Resistance in Aging
    Bret Goodpaster; Fiscal Year: 2005
    ..Ultimately this should help identify mechanisms and therapeutic targets implicated in skeletal muscle metabolic dysregulation. ..
  9. Physical Activity Following Surgery-Induced Weight Loss
    Bret Goodpaster; Fiscal Year: 2009
    ..Information emanating from this study would thus help to determine the most effective treatments to prevent weight regain and to improve outcomes of these patients following surgery. ..