Research Topics
| Wayne K GoodmanSummaryAffiliation: University of Florida Country: USA Publications
Research Grants
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Detail Information
Publications
Treatment of generalized anxiety disorder with escitalopram: pooled results from double-blind, placebo-controlled trialsWayne K Goodman
Department of Psychiatry, University of Florida, PO Box 100256, Gainesville, FL 32610, USA
J Affect Disord 87:161-7. 2005..Escitalopram 10 mg/day is an effective and well-tolerated antidepressant. Three randomized controlled trials recently evaluated the safety and efficacy of escitalopram in the treatment of generalized anxiety disorder (GAD)...- Obsessive-compulsive disorder in Tourette syndromeWayne K Goodman
Department of Psychiatry, University of Florida, Gainesville, FL 32610, USA
J Child Neurol 21:704-14. 2006.... - Risk of adverse behavioral effects with pediatric use of antidepressantsWayne K Goodman
Department of Psychiatry, University of Florida College of Medicine, McKnight Brain Institute, Room L4 100, P O Box 100256, Gainesville, FL 32610 0256, USA
Psychopharmacology (Berl) 191:87-96. 2007.... - Selecting pharmacotherapy for generalized anxiety disorderWayne K Goodman
Department of Psychiatry, University of Florida College of Medicine, Gainesville, FL 32611, USA
J Clin Psychiatry 65:8-13. 2004.... 
Insight in pediatric obsessive-compulsive disorder: associations with clinical presentationEric A Storch
Department of Psychiatry, University of Florida, Gainesville, FL, USA
Psychiatry Res 160:212-20. 2008..These findings suggest that OCD with poor insight may represent a distinct clinical feature that may require more intensive and multimodal treatment approaches...- Clinical features associated with treatment-resistant pediatric obsessive-compulsive disorderEric A Storch
Department of Psychiatry, University of Florida, Gainesville, FL 32610, USA
Compr Psychiatry 49:35-42. 2008..The objective of the study was to identify clinical and sociodemographic characteristics that may differentiate youth with obsessive-compulsive disorder (OCD) who are resistant to treatment vs those who have a favorable response... - Florida Obsessive-Compulsive Inventory: development, reliability, and validityEric A Storch
Department of Psychiatry, University of Florida, Gainesville, FL 32610, USA
J Clin Psychol 63:851-9. 2007..A strength of the FOCI is that it offers a quick evaluation of both presence and severity of OCD symptoms. An important limitation is that the FOCI does not assess the severity of individual symptoms... 
Sleep-related problems in pediatric obsessive-compulsive disorderEric A Storch
Department of Psychiatry, University of Florida, Gainesville, FL 32610, USA
J Anxiety Disord 22:877-85. 2008..These results suggest that SRPs are relatively common in youth with OCD, are associated with symptom severity, and warrant attention during assessment and treatment...- Clinical features of children and adolescents with obsessive-compulsive disorder and hoarding symptomsEric A Storch
Department of Psychiatry, University of Florida, Gainesville, FL 32610, USA
Compr Psychiatry 48:313-8. 2007..This study was conducted to examine whether pediatric patients with obsessive-compulsive disorder (OCD) and hoarding symptoms differed in terms of clinical characteristics from pediatric OCD patients without hoarding symptoms... - Quality of life in youth with Tourette's syndrome and chronic tic disorderEric A Storch
Department of Psychiatry and Pediatrics, University of Florida, Gainesville, FL 32610, USA
J Clin Child Adolesc Psychol 36:217-27. 2007.... - Family accommodation in pediatric obsessive-compulsive disorderEric A Storch
Department of Psychiatry, University of Florida, Gainesville, FL 32610, USA
J Clin Child Adolesc Psychol 36:207-16. 2007..Family accommodation mediated the relation between symptom severity and parent-rated functional impairment... - Reliability and validity of the Yale Global Tic Severity ScaleEric A Storch
Department of Pediatrics, University of Florida, Gainesville, 32610, USA
Psychol Assess 17:486-91. 2005..07-.20), and child ratings of depression (r = .02-.26) and anxiety (r = -.06 -.28). Findings suggest that the YGTSS is a reliable and valid instrument for the assessment of pediatric TS... - Impact of comorbidity on cognitive-behavioral therapy response in pediatric obsessive-compulsive disorderEric A Storch
Department of Psychiatry, University of Florida, Gainesville, FL 32610, USA
J Am Acad Child Adolesc Psychiatry 47:583-92. 2008..To examine the impact of psychiatric comorbidity on cognitive-behavioral therapy response in children and adolescents with obsessive-compulsive disorder... - Peer victimization in children with obsessive-compulsive disorder: relations with symptoms of psychopathologyEric A Storch
Department of Psychiatry and Department of Pediatrics, University of Florida, Box 100234, Gainesville, FL 32610, USA
J Clin Child Adolesc Psychol 35:446-55. 2006..Recognition of the magnitude of the problem and contribution problematic peer relations may play in comorbid psychological conditions is important for clinicians who see children with OCD... - D-cycloserine does not enhance exposure-response prevention therapy in obsessive-compulsive disorderEric A Storch
Departments of Psychiatry, University of Florida, Florida 32610, USA
Int Clin Psychopharmacol 22:230-7. 2007..As this study is the first to explore this question and a number of methodological issues must be considered when interpreting the findings, the conclusions that may be drawn from our results are limited... - Further psychometric properties of the Tourette's Disorder Scale-Parent Rated version (TODS-PR)Eric A Storch
Department of Psychiatry, University of Florida, Box 100234, Gainesville, FL 32610, USA
Child Psychiatry Hum Dev 35:107-20. 2004..The TODS-PR Total Score and factors showed good convergent validity with other measures of symptomatology and impairment. These findings suggest that the TODS-PR is a reliable and valid parent-rating scale for assessing TD symptoms... - The children's Yale-Brown obsessive-compulsive scale: psychometric properties of child- and parent-report formatsEric A Storch
Department of Pediatrics, University of Florida, Gainesville, FL 32610, USA
J Anxiety Disord 20:1055-70. 2006..Exploratory factor analyses identified a two-factor structure in both measures comprised of disturbance and severity factors. This study provides preliminary support for the use of child- and parent-report versions of the CY-BOCS... - Convergent and discriminant validity of the Children's Yale-Brown Obsessive Compulsive Scale-Symptom ChecklistJason Gallant
Department of Educational Psychology, University of Florida, Gainesville, FL 32610, United States
J Anxiety Disord 22:1369-76. 2008..These results provide initial psychometric support for the CY-BOCS-SC and support its use as a clinical and research instrument for assessing presence of a range of obsessive and compulsive symptoms in youth with OCD... - Sequential cognitive-behavioral therapy for children with obsessive-compulsive disorder with an inadequate medication response: a case series of five patientsEric A Storch
Department of Psychiatry, University of Florida, Gainesville, Florida 326110, USA
Depress Anxiety 24:375-81. 2007..Although a number of limitations of this preliminary report exist, this study provides preliminary support for the utility of an intensive intervention for youth with OCD who have had an inadequate response and/or adverse side effects... - Family-based cognitive-behavioral therapy for pediatric obsessive-compulsive disorder: comparison of intensive and weekly approachesEric A Storch
Department of Psychiatry, University of Florida, Gainesville, FL 32610, USA
J Am Acad Child Adolesc Psychiatry 46:469-78. 2007..To examine the relative efficacy of intensive versus weekly cognitive-behavioral therapy (CBT) for children and adolescents with obsessive-compulsive disorder (OCD)... - Factor analytic study of the Children's Yale-Brown Obsessive-Compulsive ScaleEric A Storch
Department of Pediatrics, University of Florida, Gainesvile, FL 32610, USA
J Clin Child Adolesc Psychol 34:312-9. 2005..These findings suggest that the CY-BOCS Total Score may represent an inaccurate assessment of symptom severity and supports the use of the revised Severity and Disturbance factors in assessing illness severity... - Clinical predictors of early fluoxetine treatment response in obsessive-compulsive disorderEric A Storch
Department of Psychiatry, University of Florida, Gainesville, Florida 32610, USA
Depress Anxiety 23:429-33. 2006..Furthermore, findings suggest early predictors of patients with certain characteristics who may ultimately need adjunctive care to facilitate response... - Obsessive-compulsive disorder in youth with and without a chronic tic disorderEric A Storch
Department of Psychiatry, University of Florida, Gainesville, Florida 32610, USA
Depress Anxiety 25:761-7. 2008..Implications of these findings on clinical presentation and treatment efficacy are highlighted... - Effect of comorbid tics on a clinically meaningful response to 8-week open-label trial of fluoxetine in obsessive compulsive disorderDavid S Husted
Department of Psychiatry, University of Florida College of Medicine, P O Box 100256, Gainesville, FL 32610 0256, USA
J Psychiatr Res 41:332-7. 2007..Limitations include the relatively low number of tic subjects and the open-label nature of the study. Additional data are needed on how comorbid tics may affect SRI treatment response in OCD... - Cognitive behavioral therapy plus motivational interviewing improves outcome for pediatric obsessive-compulsive disorder: a preliminary studyLisa J Merlo
Department of Psychiatry, University of Florida, Gainesville, Florida, USA
Cogn Behav Ther 39:24-7. 2010.... - Deep brain stimulation for intractable obsessive compulsive disorder: pilot study using a blinded, staggered-onset designWayne K Goodman
Department of Psychiatry, Mount Sinai School of Medicine, New York, New York, USA
Biol Psychiatry 67:535-42. 2010..Prior promising results have been reported with deep brain stimulation (DBS) of the anterior limb of the internal capsule in cases with severe obsessive compulsive disorder (OCD) who had exhausted conventional therapies... - Associations between miscellaneous symptoms and symptom dimensions in adults with obsessive-compulsive disorderEric A Storch
Department of Psychiatry, University of Florida, Gainesville, FL 32610 USA
Anxiety Stress Coping 21:199-212. 2008..g., hierarchy development)... - Associations between miscellaneous symptoms and symptom dimensions: an examination of pediatric obsessive-compulsive disorderEric A Storch
Department of Psychiatry, University of Florida, Gainesville, FL 32610, USA
Behav Res Ther 45:2593-603. 2007..g., understanding which miscellaneous symptoms relate to certain dimensions) and treatment implications (e.g., hierarchy development)... - Deep brain stimulation in the internal capsule and nucleus accumbens region: responses observed during active and sham programmingMichael S Okun
Department of Neurology, Movement Disorders Center, University of Florida, PO Box 100236, Gainesville, FL 32610, USA
J Neurol Neurosurg Psychiatry 78:310-4. 2007..The stimulation-induced benefits and side effects can be reversibly and blindly applied to a variety of locations in this region... - A measure of functional impairment in youth with Tourette's syndromeEric A Storch
Department of Psychiatry, University of Florida, Box 100234, Gainesville, FL 32610, USA
J Pediatr Psychol 32:950-9. 2007..The current study was undertaken to examine both tic-related impairment and impairment from other psychological problems in 59 youth (mean age 11.4 years, 69% male) with TS... - Reliability and validity of the Child Behavior Checklist Obsessive-Compulsive ScaleEric A Storch
Department of Pediatrics, University of Florida, Gainesville, 32610, USA
J Anxiety Disord 20:473-85. 2006..Suggestions for cutoff scores are provided using results from ROC analyses. Overall, these findings suggest that the OCS-R is a reliable and valid instrument for the assessment of pediatric OCD... - A pilot study of vagus nerve stimulation (VNS) for treatment-resistant anxiety disordersMark S George
Department of Psychiatry, Medical University of South Carolina, Charleston, South Carolina 29425, USA
Brain Stimul 1:112-21. 2008.... - Cognitive-behavioral therapy for PANDAS-related obsessive-compulsive disorder: findings from a preliminary waitlist controlled open trialEric A Storch
Department of Psychiatry, University of Florida, Gainesville, FL 32610, USA
J Am Acad Child Adolesc Psychiatry 45:1171-8. 2006.... - Cognitive-behavioral therapy for obsessive-compulsive disorder: a non-randomized comparison of intensive and weekly approachesEric A Storch
Department of Psychiatry, University of Florida, Gainesville, FL 32610, USA
J Anxiety Disord 22:1146-58. 2008..Since many people with OCD do not have access to trained CBT providers, intensive treatment may be a viable option in such cases... - A double-blind, placebo-controlled trial of olanzapine addition in fluoxetine-refractory obsessive-compulsive disorderNathan A Shapira
Department of Psychiatry, College of Medicine, University of Florida, Gainesville, Florida 32610-0256, USA
Biol Psychiatry 55:553-5. 2004..CONCLUSIONS: These findings indicate no additional advantage of adding olanzapine for 6 weeks in OCD patients who have not had a satisfactory response to fluoxetine for 8 weeks, compared with extending the monotherapy trial... - Right and left dorsolateral pre-frontal rTMS treatment of refractory depression: a randomized, sham-controlled trialWilliam J Triggs
Neurology Service and the Brain Rehabilitation Research Center of Excellence, Department of Veterans Affairs Medical Center, Gainesville, FL 32608 1197, USA
Psychiatry Res 178:467-74. 2010..2007), albeit not statistically significant. These results suggest that somatosensory stimuli that repeatedly engage the left hemisphere may be important to the achievement of therapeutic effect... - Hope and coping in family members of patients with obsessive-compulsive disorderGary R Geffken
Department of Psychiatry, University of Florida, Gainesville, FL 32610, USA
J Anxiety Disord 20:614-29. 2006..Coping mediated the relationship between hope and depressive symptoms. Given the importance of family members in treatment, clinical implications of these findings are discussed... - Psychometric evaluation of the Children's Yale-Brown Obsessive-Compulsive ScaleEric A Storch
Department of Psychiatry, University of Florida, Gainesville, FL 32610, USA
Psychiatry Res 129:91-8. 2004..Findings suggest that the CY-BOCS is a reliable and valid instrument for the assessment of childhood obsessions and compulsions... - SSRI adverse events: how to monitor and manageTanya K Murphy
Department of Psychiatry, University of Florida, Gainesville, FL 32610, USA
Int Rev Psychiatry 20:203-8. 2008..With diligence to appropriate prescribing and monitoring, the benefits of therapy outweigh the potential of treatment related risk... - Assessment of pediatric obsessive-compulsive disorder: a critical review of current methodologyLisa J Merlo
Department of Psychiatry, University of Florida, Gainesville, FL 32610, USA
Child Psychiatry Hum Dev 36:195-214. 2005..Finally, a critical review is offered of major trends in the assessment of pediatric OCD (e.g., diagnostic interviews, self-report and parent-report measures, and clinician-administered inventories)... - Concurrent validity of the Yale-Brown Obsessive-Compulsive Scale-Symptom ChecklistMichael L Sulkowski
University of Florida, FL, USA
J Clin Psychol 64:1338-51. 2008..54) with the STAI-T. These findings reveal some of the strengths and weaknesses of these two OCD instruments, and the results provide guidance for selecting scales that are suitable for measuring OCD symptoms... - Factor-analytic study of the Yale Global Tic Severity ScaleEric A Storch
Department of Psychiatry, University of Florida, Gainesville, FL 32610, USA
Psychiatry Res 149:231-7. 2007..These findings support the use of the original scoring structure in assessing pediatric tic severity... - Further psychometric examination of the Tourette's Disorder ScalesEric A Storch
Department of Psychiatry, University of Florida, Gainesville, FL 32610, USA
Child Psychiatry Hum Dev 38:89-98. 2007..Excellent inter-rater agreement and convergent and divergent validity was found. These results provide further psychometric support for the TODS-PR and TODS-CR... - Relationship of movements and behaviors to Group A Streptococcus infections in elementary school childrenTanya K Murphy
Department of Psychiatry, College of Medicine, Gainesville, Florida 32610, USA
Biol Psychiatry 61:279-84. 2007..Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcus (PANDAS) research is based on the hypothesis that infections trigger changes in behavior and movement in children... - Yale-Brown Obsessive Compulsive Scale: the dimensional structure revisitedEric A Storch
Department of Pediatrics, University of Florida, Gainesville, Florida 32610, USA
Depress Anxiety 22:28-35. 2005..Reliability and convergent validity of these factors were generally satisfactory, although divergent validity was not entirely supported. Implications of these findings on scoring the Y-BOCS are discussed... - Long-term habituation of the smile response with deep brain stimulationUtaka S Springer
Clinical and Health Psychology, McKnight Brain Institute, University of Florida, Gainsville, Florida 32610 0165, USA
Neurocase 12:191-6. 2006..The smiles could not be elicited even with long washout periods. These findings imply potential long-term habituation and changes in the neural chemistry (possibly neuroplasticity) induced by chronic DBS... - Cognitive-behavioral therapy for obsessive-compulsive disorder: review of treatment techniquesGary R Geffken
Department of Psychiatry, University of Florida Health Science Center, Gainesville, FL 32610, USA
J Psychosoc Nurs Ment Health Serv 42:44-51. 2004..This article provides a review of CBT for OCD. Issues related to treatment delivery and assessment are presented and highlighted by an individual example... - Immunology of obsessive-compulsive disorderTanya K Murphy
Department of Psychiatry, University of Florida School of Medicine, Gainesville, FL 32610, USA
Psychiatr Clin North Am 29:445-69. 2006..The assimilation of these study results should allow for elucidation of the immune system's role in the onset and maintenance of OCD... - Lessons learned in deep brain stimulation for movement and neuropsychiatric disordersFrank M Skidmore
Department of Neurology, McKnight Brain Institute, University of Florida College of Medicine in Gainesville, 32610, USA
CNS Spectr 11:521-36. 2006..Also discussed are the emerging targets, what is known about the cognitive sequelae of DBS, and what has been learned about the complications and therapeutic failures... - The neurocircuitry of obsessive-compulsive disorder and disgustDavid S Husted
Department of Psychiatry, University of Florida College of Medicine, P O Box 100256 Gainesville, FL 32610 0256, USA
Prog Neuropsychopharmacol Biol Psychiatry 30:389-99. 2006..This review focuses on describing what is known to date concerning the neurocircuitry of disgust, and its relevance to the apparent neurocircuitry of OCD... - Cognitive-behavioral treatment for obsessive-compulsive disorder in an elderly male with concurrent medical constraintsAdam Hirsh
Department of Psychiatry, University of Florida, Gainesville, FL 32610, USA
Am J Geriatr Psychiatry 14:380-1. 2006 - Recognition and treatment of obsessive-compulsive disorderWayne K Goodman
Department of Psychiatry, University of Florida College of Medicine, Gainesville, USA
J Clin Psychiatry 68:e30. 2007..Neurosurgery, such as deep brain stimulation, has also been shown to be effective in select patients with debilitating and refractory OCD... - Cerebral blood flow changes in depressed patients after treatment with repetitive transcranial magnetic stimulation: evidence of individual variabilityStephen E Nadeau
Geriatric Research, Education and Clinical Center, Malcolm Randall Department of Veteran Affairs Medical Center, Gainseville, Florida 32608 1197, USA
Neuropsychiatry Neuropsychol Behav Neurol 15:159-75. 2002..To elucidate the neural mechanisms of depression... - Topiramate attenuates self-injurious behaviour in Prader-Willi SyndromeNathan A Shapira
Department of Psychiatry, Evelyn F and William L McKnight Brain Institute of the University of Florida, Gainsville 32610 0256, USA
Int J Neuropsychopharmacol 5:141-5. 2002.... - Deep brain stimulation for intractable psychiatric disordersWayne K Goodman
Department of Psychiatry, Friedman Brain Institute of the Mount Sinai School of Medicine, New York, New York 10029, USA
Annu Rev Med 63:511-24. 2012..g., hypomania). Further research is needed to test the efficacy and safety of DBS in psychiatric disorders, compare targets, and identify predictors of response... - Effects of topiramate in adults with Prader-Willi syndromeNathan A Shapira
College of Medicine, University of Florida, Gainesville 32610, USA
Am J Ment Retard 109:301-9. 2004..e., skin-picking) that is characteristic of this syndrome. Potential benefits of topiramate for self-injury should be evaluated further in controlled trials... - Deep brain stimulation for refractory obsessive-compulsive disorderAdam Burdick
University of Florida, Department of Neurosurgery, PO Box 100265, Gainesville, FL, 32610, USA
Front Biosci 14:1880-90. 2009..The promising early results of DBS for OCD are summarized, including a discussion of current targets and programming issues. Finally, the ethical implications of the procedure are briefly discussed... - What's in a "smile?" Intra-operative observations of contralateral smiles induced by deep brain stimulationMichael S Okun
Movement Disorders Center, University of Florida, Department of Neurology, McKnight Brain Institute, Gaineville, FL 32610, USA
Neurocase 10:271-9. 2004..To describe smiling and euphoria induced by deep brain stimulation (DBS)... - A double-blind, placebo-controlled study of the efficacy and safety of controlled-release fluvoxamine in patients with obsessive-compulsive disorderEric Hollander
Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA
J Clin Psychiatry 64:640-7. 2003.... - Brain activation by disgust-inducing pictures in obsessive-compulsive disorderNathan A Shapira
Department of Psychiatry, College of Medicine, University of Florida, Gainesville, Florida, USA
Biol Psychiatry 54:751-6. 2003.... - Detecting pediatric autoimmune neuropsychiatric disorders associated with streptococcus in children with obsessive-compulsive disorder and ticsTanya K Murphy
Department of Psychiatry, University of Florida, Gainesville, Florida 32610-0256, USA
Biol Psychiatry 55:61-8. 2004..03). CONCLUSIONS: Patients with marked obsessive-compulsive/tic symptom changes may be characterized by streptococcal titer elevations and exhibit evidence of seasonal tic exacerbations... - Where does obsessive-compulsive disorder belong in DSM-V?Eric A Storch
Department of Psychiatry, University of Florida, Gainesville, Florida, USA
Depress Anxiety 25:336-47. 2008..We conclude that a reclassification of OCD into a separate OCSD spectrum is premature and not supported by the currently available data... - A qualitative analysis of nonresponse: management of treatment-refractory obsessive-compulsive disorderStefano Pallanti
Department of Psychiatry, University of Florence, Italy
J Clin Psychiatry 65:6-10. 2004..More results are needed before the effectiveness of the nonpharmacologic treatments for OCD can be determined... - Suicidality as a possible side effect of antidepressant treatmentLarry Culpepper
Department of Family Medicine, Boston Medical Center, MA, USA
J Clin Psychiatry 65:742-9. 2004 - Symptom stability in adult obsessive-compulsive disorder: data from a naturalistic two-year follow-up studyDavid Mataix-Cols
Department of Psychiatry, Imperial College School of Medicine, London, UK
Am J Psychiatry 159:263-8. 2002..This study systematically investigated the temporal stability of individual symptoms and symptom dimensions of OCD in adult patients who were followed prospectively for 2 years... - Escitalopram for the treatment of GAD: efficacy across different subgroups and outcomesDan J Stein
University of Stellenbosch, Department of Psychiatry, P.O. Box 19063, Tygerberg, 7505, South Africa
Ann Clin Psychiatry 17:71-5. 2005..It is equally effective in GAD patients, with an above-median level of depressive symptoms. Further research is needed to determine whether these results can be extrapolated to GAD patients with comorbid major depression... - Three-year outcomes in deep brain stimulation for highly resistant obsessive-compulsive disorderBenjamin D Greenberg
Department of Psychiatry and Human Behavior, Brown Medical School, Butler Hospital and Rhode Island Hospital, Providence, RI 02906, USA
Neuropsychopharmacology 31:2384-93. 2006..This open study found promising long-term effects of DBS in highly treatment-resistant OCD... - Avoiding deep brain stimulation failures in Tourette syndromeMichael S Okun
J Neurol Neurosurg Psychiatry 79:111-2. 2008 - Tourette syndrome: diagnosis, strategies, therapies, pathogenesis, and future research directionsLori L Olson
College of Medicine, University of Missouri-Columbia, Columbia, MO, USA
J Child Neurol 21:630-41. 2006
Research Grants
- Pilot Study of DBS for Treatment-Refractory OCDHerbert Ward; Fiscal Year: 2006..If shown effective, DBS might replace ablative neurosurgery, but should still be considered the intervention of last resort in the most profoundly ill and intractable cases of OCD. ..
- SSRI-Induced Activation Syndrome In Pediatric OCDTanya Murphy; Fiscal Year: 2007..Development of an activation syndrome measurement tool will be useful in future large-scale clinical trials that test the relationship between activation syndrome and suicidality. ..