J L Goodier

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. ncbi A novel active L1 retrotransposon subfamily in the mouse
    J L Goodier
    Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Genome Res 11:1677-85. 2001
  2. ncbi A potential role for the nucleolus in L1 retrotransposition
    John L Goodier
    Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    Hum Mol Genet 13:1041-8. 2004
  3. ncbi LINE-1 ORF1 protein localizes in stress granules with other RNA-binding proteins, including components of RNA interference RNA-induced silencing complex
    John L Goodier
    Dept of Genetics, University of Pennsylvania School of Medicine, Rm 515 CRB, 415 Curie Blvd, Philadelphia, PA 19104, USA
    Mol Cell Biol 27:6469-83. 2007
  4. ncbi Retrotransposons revisited: the restraint and rehabilitation of parasites
    John L Goodier
    Department of Genetics, University of Pennsylvania School of Medicine, 415 Curie Boulevard, Philadelphia, PA 19104, USA
    Cell 135:23-35. 2008
  5. ncbi Discrete subcellular partitioning of human retrotransposon RNAs despite a common mechanism of genome insertion
    John L Goodier
    Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Hum Mol Genet 19:1712-25. 2010
  6. ncbi LINE drive. retrotransposition and genome instability
    Haig H Kazazian
    Department of Genetics, School of Medicine, 475 Clinical Research Building, 415 Curie Boulevard, University of Pennsylvania, Philadelphia 19105, USA
    Cell 110:277-80. 2002
  7. ncbi Rapid amplification of a retrotransposon subfamily is evolving the mouse genome
    R J DeBerardinis
    Department of Genetics, University of Pennsylvania, Philadelphia 19104, USA
    Nat Genet 20:288-90. 1998
  8. ncbi A mouse model of human L1 retrotransposition
    Eric M Ostertag
    Department of Genetics and University of Pennsylvania School of Medicine, 475 Clinical Research Bldg, 415 Curie Blvd, Philadelphia, Pennsylvania 19104, USA
    Nat Genet 32:655-60. 2002
  9. ncbi SVA elements are nonautonomous retrotransposons that cause disease in humans
    Eric M Ostertag
    Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104-6145, USA
    Am J Hum Genet 73:1444-51. 2003

Research Grants

  1. Retrotransposons as site-specific gene delivery vectors
    JOHN GOODIER; Fiscal Year: 2003

Detail Information

Publications9

  1. ncbi A novel active L1 retrotransposon subfamily in the mouse
    J L Goodier
    Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Genome Res 11:1677-85. 2001
    ..This number is in great excess to the number of L1 elements thought to be active in the human genome...
  2. ncbi A potential role for the nucleolus in L1 retrotransposition
    John L Goodier
    Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    Hum Mol Genet 13:1041-8. 2004
    ..These findings help explain the presence of chimeras between L1s and small RNA gene sequences recently discovered in the human genome...
  3. ncbi LINE-1 ORF1 protein localizes in stress granules with other RNA-binding proteins, including components of RNA interference RNA-induced silencing complex
    John L Goodier
    Dept of Genetics, University of Pennsylvania School of Medicine, Rm 515 CRB, 415 Curie Blvd, Philadelphia, PA 19104, USA
    Mol Cell Biol 27:6469-83. 2007
    ..We suggest that targeting ORF1p, and possibly the L1 RNP, to stress granules is a mechanism for controlling retrotransposition and its associated genetic and cellular damage...
  4. ncbi Retrotransposons revisited: the restraint and rehabilitation of parasites
    John L Goodier
    Department of Genetics, University of Pennsylvania School of Medicine, 415 Curie Boulevard, Philadelphia, PA 19104, USA
    Cell 135:23-35. 2008
    ..Recent insights and new technologies promise answers to fundamental questions about the biology of transposable elements...
  5. ncbi Discrete subcellular partitioning of human retrotransposon RNAs despite a common mechanism of genome insertion
    John L Goodier
    Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Hum Mol Genet 19:1712-25. 2010
    ..Such variability predicts significant differences in the life cycles of these elements...
  6. ncbi LINE drive. retrotransposition and genome instability
    Haig H Kazazian
    Department of Genetics, School of Medicine, 475 Clinical Research Building, 415 Curie Boulevard, University of Pennsylvania, Philadelphia 19105, USA
    Cell 110:277-80. 2002
    ..If these events occur at a similar frequency in vivo, they have had a substantial effect on human genome evolution...
  7. ncbi Rapid amplification of a retrotransposon subfamily is evolving the mouse genome
    R J DeBerardinis
    Department of Genetics, University of Pennsylvania, Philadelphia 19104, USA
    Nat Genet 20:288-90. 1998
    ..Our data show that mice and humans differ considerably in the number of active L1s, and probably differ in the contribution of retrotransposition to ongoing sequence evolution...
  8. ncbi A mouse model of human L1 retrotransposition
    Eric M Ostertag
    Department of Genetics and University of Pennsylvania School of Medicine, 475 Clinical Research Bldg, 415 Curie Blvd, Philadelphia, Pennsylvania 19104, USA
    Nat Genet 32:655-60. 2002
    ..In addition to providing a valuable in vivo model of retrotransposition in mammals, these mice are an important step in the development of a new random mutagenesis system...
  9. ncbi SVA elements are nonautonomous retrotransposons that cause disease in humans
    Eric M Ostertag
    Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, PA 19104-6145, USA
    Am J Hum Genet 73:1444-51. 2003
    ..SVA elements, like Alus and L1s, occasionally insert into genes and cause disease. Furthermore, SVA elements are probably mobilized in trans by active L1 elements...

Research Grants1

  1. Retrotransposons as site-specific gene delivery vectors
    JOHN GOODIER; Fiscal Year: 2003
    ..In addition, I will assay in cell culture the efficiency of the L1 at integrating increasing lengths of exogenous DNA. ..