M J Goodheart

Summary

Affiliation: University of Iowa
Country: USA

Publications

  1. pmc The role of LEF1 in endometrial gland formation and carcinogenesis
    Dawne N Shelton
    Department of Obstetrics and Gynecology, Holden Comprehensive Cancer Center, The University of Iowa Hospitals and Clinics, Iowa City, Iowa, United States of America
    PLoS ONE 7:e40312. 2012
  2. doi request reprint BRCA2 alteration is important in clear cell carcinoma of the ovary
    M J Goodheart
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Iowa Hospitals and Clinics, Iowa City, Iowa 52242, USA
    Clin Genet 76:161-7. 2009
  3. ncbi request reprint Chemoradiation for invasive cervical cancer in elderly patients: outcomes and morbidity
    M Goodheart
    Department of Obstetrics and Gynecology, University of Iowa Hospitals and Clinics, Holden Comprehensive Cancer Center, Iowa City, Iowa, USA
    Int J Gynecol Cancer 18:95-103. 2008
  4. ncbi request reprint The relationship of molecular markers of p53 function and angiogenesis to prognosis of stage I epithelial ovarian cancer
    Michael J Goodheart
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Iowa Hospital and Clinics, Iowa City, Iowa, USA
    Clin Cancer Res 11:3733-42. 2005
  5. ncbi request reprint Thromboembolic events in patients treated with definitive chemotherapy and radiation therapy for invasive cervical cancer
    Geraldine M Jacobson
    Gynecological Oncology, Department of Radiation Oncology, University of Iowa Hospitals and Clinics, W 189Z General Hospital, 200 Hawkins Drive, Iowa City IA 52242, USA
    Gynecol Oncol 96:470-4. 2005
  6. ncbi request reprint The impact of p53 protein core domain structural alteration on ovarian cancer survival
    Stephen L Rose
    The Holden Comprehensive Cancer Center, Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, The University of Iowa Hospitals and Clinics, 200 Hawkins Drive, Iowa City, IA 52242, USA
    Clin Cancer Res 9:4139-44. 2003
  7. ncbi request reprint The influence of microvessel density on ovarian carcinogenesis
    Pamela J B Stone
    Holden Comprehensive Cancer Center, Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Iowa Hospitals and Clinics, 200 Hawkins Drive, 4630 John Carver Pavilion, Iowa City, IA 52242, USA
    Gynecol Oncol 90:566-71. 2003
  8. ncbi request reprint p21 expression predicts outcome in p53-null ovarian carcinoma
    Stephen L Rose
    Holden Comprehensive Cancer Center, Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, The University of Iowa Hospitals and Clinics, 200 Hawkins Drive, Iowa City, IA 52242, USA
    Clin Cancer Res 9:1028-32. 2003
  9. ncbi request reprint Ovarian cancer p53 mutation is associated with tumor microvessel density
    Michael J Goodheart
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Holden Comprehensive Cancer Center, University of Iowa Hospitals and Clinics, Iowa City, Iowa 52242, USA
    Gynecol Oncol 86:85-90. 2002
  10. ncbi request reprint Mismatch repair gene expression defects contribute to microsatellite instability in ovarian carcinoma
    John P Geisler
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Holden Comprehensive Cancer Center, University of Iowa Hospitals and Clinics, Iowa City, Iowa, USA
    Cancer 98:2199-206. 2003

Collaborators

Detail Information

Publications10

  1. pmc The role of LEF1 in endometrial gland formation and carcinogenesis
    Dawne N Shelton
    Department of Obstetrics and Gynecology, Holden Comprehensive Cancer Center, The University of Iowa Hospitals and Clinics, Iowa City, Iowa, United States of America
    PLoS ONE 7:e40312. 2012
    ..Finally, Lef1 is overexpressed in human and mouse endometrial tumors, consistent with it playing a role in gland proliferation...
  2. doi request reprint BRCA2 alteration is important in clear cell carcinoma of the ovary
    M J Goodheart
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Iowa Hospitals and Clinics, Iowa City, Iowa 52242, USA
    Clin Genet 76:161-7. 2009
    ..5%, compared to only 40% for those patients without a BRCA2 alteration (p = 0.39). Alterations in BRCA2 gene sequence, copy number, or expression are extremely common in CCC and may contribute to a paradoxical better clinical outcome...
  3. ncbi request reprint Chemoradiation for invasive cervical cancer in elderly patients: outcomes and morbidity
    M Goodheart
    Department of Obstetrics and Gynecology, University of Iowa Hospitals and Clinics, Holden Comprehensive Cancer Center, Iowa City, Iowa, USA
    Int J Gynecol Cancer 18:95-103. 2008
    ..Treatment with chemoradiation was associated with similar survival increases in both age cohorts. Complication rates between the two were similar. Chemoradiation should be considered in elderly patients with invasive cervical cancer...
  4. ncbi request reprint The relationship of molecular markers of p53 function and angiogenesis to prognosis of stage I epithelial ovarian cancer
    Michael J Goodheart
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Iowa Hospital and Clinics, Iowa City, Iowa, USA
    Clin Cancer Res 11:3733-42. 2005
    ..Multiple angiogenic factors may influence tumor progression and metastasis. Several are modified by the p53 gene. We sought to identify molecular markers for high-risk stage I epithelial ovarian cancers...
  5. ncbi request reprint Thromboembolic events in patients treated with definitive chemotherapy and radiation therapy for invasive cervical cancer
    Geraldine M Jacobson
    Gynecological Oncology, Department of Radiation Oncology, University of Iowa Hospitals and Clinics, W 189Z General Hospital, 200 Hawkins Drive, Iowa City IA 52242, USA
    Gynecol Oncol 96:470-4. 2005
    ..Determine the incidence of and risk factors for thromboembolic events (TE) in patients treated with definitive chemoradiation for cervical cancer at our institution...
  6. ncbi request reprint The impact of p53 protein core domain structural alteration on ovarian cancer survival
    Stephen L Rose
    The Holden Comprehensive Cancer Center, Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, The University of Iowa Hospitals and Clinics, 200 Hawkins Drive, Iowa City, IA 52242, USA
    Clin Cancer Res 9:4139-44. 2003
    ..By evaluating ovarian cancer survival based upon a structure function analysis of the p53 protein, we tested the hypothesis that not all missense mutations are equivalent...
  7. ncbi request reprint The influence of microvessel density on ovarian carcinogenesis
    Pamela J B Stone
    Holden Comprehensive Cancer Center, Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Iowa Hospitals and Clinics, 200 Hawkins Drive, 4630 John Carver Pavilion, Iowa City, IA 52242, USA
    Gynecol Oncol 90:566-71. 2003
    ....
  8. ncbi request reprint p21 expression predicts outcome in p53-null ovarian carcinoma
    Stephen L Rose
    Holden Comprehensive Cancer Center, Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, The University of Iowa Hospitals and Clinics, 200 Hawkins Drive, Iowa City, IA 52242, USA
    Clin Cancer Res 9:1028-32. 2003
    ..We hypothesize that such an analysis may be useful in prognosticating outcome for individuals diagnosed with epithelial ovarian cancer...
  9. ncbi request reprint Ovarian cancer p53 mutation is associated with tumor microvessel density
    Michael J Goodheart
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Holden Comprehensive Cancer Center, University of Iowa Hospitals and Clinics, Iowa City, Iowa 52242, USA
    Gynecol Oncol 86:85-90. 2002
    ..The objective of this study was to investigate the relationship between microvessel density, as measured by CD31 staining, and histopathologic factors as well as p53 tumor suppressor gene mutation in ovarian cancer...
  10. ncbi request reprint Mismatch repair gene expression defects contribute to microsatellite instability in ovarian carcinoma
    John P Geisler
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Holden Comprehensive Cancer Center, University of Iowa Hospitals and Clinics, Iowa City, Iowa, USA
    Cancer 98:2199-206. 2003
    ..The purpose of the current study was to determine the relation between MSI of ovarian carcinoma and MMR gene expression, hMLH1 and hMSH2 hypermethylation, and hMLH1 and hMSH2 null mutations...