M O Goodarzi

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi Thyrotoxicosis in a male patient associated with excess human chorionic gonadotropin production by germ cell tumor
    M O Goodarzi
    Department of Medicine, University of California Los Angeles School of Medicine, UCLA Center for Health Sciences, 90095, USA
    Thyroid 10:611-9. 2000
  2. ncbi Virilization in bilateral macronodular adrenal hyperplasia controlled by luteinizing hormone
    Mark O Goodarzi
    Division of Endocrinology, Diabetes, and Hypertension, Department of Medicine and Gonda Diabetes Center, University of California Los Angeles School of Medicine, Los Angeles, California 90095, USA
    J Clin Endocrinol Metab 88:73-7. 2003
  3. ncbi Lipoprotein lipase is a gene for insulin resistance in Mexican Americans
    Mark O Goodarzi
    Division of Medical Genetics, Department of Pediatrics, Steven Spielberg Pediatric Research Center, Cedars Sinai Medical Center, Los Angeles, California 90048, USA
    Diabetes 53:214-20. 2004
  4. ncbi The importance of insulin resistance in polycystic ovary syndrome
    Mark O Goodarzi
    Department of Medicine, David Geffen School of Medicine at the University of California, Los Angeles, Los Angeles, California, USA
    Fertil Steril 80:255-8. 2003
  5. pmc Systematic evaluation of validated type 2 diabetes and glycaemic trait loci for association with insulin clearance
    M O Goodarzi
    Division of Endocrinology, Diabetes and Metabolism, Cedars Sinai Medical Center, 8700 Beverly Blvd, Room B 131, Los Angeles, CA 90048, USA
    Diabetologia 56:1282-90. 2013
  6. pmc FEM1A and FEM1B: novel candidate genes for polycystic ovary syndrome
    M O Goodarzi
    Department of Medicine, Division of Endocrinology, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Hum Reprod 23:2842-9. 2008
  7. pmc Insulin clearance: confirmation as a highly heritable trait, and genome-wide linkage analysis
    X Guo
    Medical Genetics Institute, Cedars Sinai Medical Center, Los Angeles, CA, USA
    Diabetologia 55:2183-92. 2012
  8. pmc Small glutamine-rich tetratricopeptide repeat-containing protein alpha (SGTA), a candidate gene for polycystic ovary syndrome
    M O Goodarzi
    Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Hum Reprod 23:1214-9. 2008
  9. ncbi Haplotypes in the lipoprotein lipase gene influence high-density lipoprotein cholesterol response to statin therapy and progression of atherosclerosis in coronary artery bypass grafts
    M O Goodarzi
    Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, Cedars Sinai Medical Center, Los Angeles, CA 9048, USA
    Pharmacogenomics J 7:66-73. 2007
  10. pmc Association study of four key folliculogenesis genes in polycystic ovary syndrome
    K Sproul
    Department of Obstetrics and Gynecology, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    BJOG 117:756-60. 2010

Detail Information

Publications38

  1. ncbi Thyrotoxicosis in a male patient associated with excess human chorionic gonadotropin production by germ cell tumor
    M O Goodarzi
    Department of Medicine, University of California Los Angeles School of Medicine, UCLA Center for Health Sciences, 90095, USA
    Thyroid 10:611-9. 2000
    ..In general, these patients have a poor prognosis due to the usually widespread nature of the germ cell tumor at the time of diagnosis...
  2. ncbi Virilization in bilateral macronodular adrenal hyperplasia controlled by luteinizing hormone
    Mark O Goodarzi
    Division of Endocrinology, Diabetes, and Hypertension, Department of Medicine and Gonda Diabetes Center, University of California Los Angeles School of Medicine, Los Angeles, California 90095, USA
    J Clin Endocrinol Metab 88:73-7. 2003
    ..In our patient, the control of androgen secretion by LH may explain the postmenopausal onset of virilization and the transient postoperative normalization of the serum testosterone level...
  3. ncbi Lipoprotein lipase is a gene for insulin resistance in Mexican Americans
    Mark O Goodarzi
    Division of Medical Genetics, Department of Pediatrics, Steven Spielberg Pediatric Research Center, Cedars Sinai Medical Center, Los Angeles, California 90048, USA
    Diabetes 53:214-20. 2004
    ..3 mg/min). This haplotype-based genetic analysis provides compelling evidence that variation in the LPL gene plays a role in determining insulin resistance in this ethnic group with a high prevalence of the insulin resistance syndrome...
  4. ncbi The importance of insulin resistance in polycystic ovary syndrome
    Mark O Goodarzi
    Department of Medicine, David Geffen School of Medicine at the University of California, Los Angeles, Los Angeles, California, USA
    Fertil Steril 80:255-8. 2003
  5. pmc Systematic evaluation of validated type 2 diabetes and glycaemic trait loci for association with insulin clearance
    M O Goodarzi
    Division of Endocrinology, Diabetes and Metabolism, Cedars Sinai Medical Center, 8700 Beverly Blvd, Room B 131, Los Angeles, CA 90048, USA
    Diabetologia 56:1282-90. 2013
    ..Insulin clearance is a highly heritable trait, for which few quantitative trait loci have been discovered. We sought to determine whether validated type 2 diabetes and/or glycaemic trait loci are associated with insulin clearance...
  6. pmc FEM1A and FEM1B: novel candidate genes for polycystic ovary syndrome
    M O Goodarzi
    Department of Medicine, Division of Endocrinology, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Hum Reprod 23:2842-9. 2008
    ..We previously identified a FEM1A mutation (H500Y) in a woman with PCOS; FEM1B has been implicated in insulin secretion...
  7. pmc Insulin clearance: confirmation as a highly heritable trait, and genome-wide linkage analysis
    X Guo
    Medical Genetics Institute, Cedars Sinai Medical Center, Los Angeles, CA, USA
    Diabetologia 55:2183-92. 2012
    ..We have previously documented a high heritability of insulin clearance in a Hispanic cohort. Here, our goal was to confirm the high heritability in a second cohort and search for genetic loci contributing to insulin clearance...
  8. pmc Small glutamine-rich tetratricopeptide repeat-containing protein alpha (SGTA), a candidate gene for polycystic ovary syndrome
    M O Goodarzi
    Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Hum Reprod 23:1214-9. 2008
    ..Polymorphisms in the SGTA gene have not been evaluated for a role in PCOS...
  9. ncbi Haplotypes in the lipoprotein lipase gene influence high-density lipoprotein cholesterol response to statin therapy and progression of atherosclerosis in coronary artery bypass grafts
    M O Goodarzi
    Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, Cedars Sinai Medical Center, Los Angeles, CA 9048, USA
    Pharmacogenomics J 7:66-73. 2007
    ..LPL may influence atherosclerosis risk through pleiotropic effects on each aspect of the metabolic syndrome...
  10. pmc Association study of four key folliculogenesis genes in polycystic ovary syndrome
    K Sproul
    Department of Obstetrics and Gynecology, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    BJOG 117:756-60. 2010
    ..GDF9 may thus serve as a modifier gene. These results suggest that inherited defects in folliculogenesis are not major factors in the genetic susceptibility to PCOS...
  11. ncbi Haplotypes in the lipoprotein lipase gene influence fasting insulin and discovery of a new risk haplotype
    Mark O Goodarzi
    Cedars Sinai Medical Center, Division of Endocrinology, Diabetes, and Metabolism, 8700 Beverly Boulevard, Becker B 131, Los Angeles, California 90048, USA
    J Clin Endocrinol Metab 92:293-6. 2007
    ..The most common haplotype (haplotype 1) was protective, whereas the fourth most common haplotype (haplotype 4) conferred risk for insulin resistance and atherosclerosis...
  12. ncbi Relative impact of insulin resistance and obesity on cardiovascular risk factors in polycystic ovary syndrome
    Mark O Goodarzi
    Division of Endocrinology, Diabetes, and Hypertension, Department of Medicine, University of California Los Angeles School of Medicine, Los Angeles, CA 90095, USA
    Metabolism 52:713-9. 2003
    ..Thus, early detection of insulin resistance, as well as weight reduction, should be emphasized for all patients with PCOS...
  13. pmc Genetic variants in peroxisome proliferator-activated receptor gamma influence insulin resistance and testosterone levels in normal women, but not those with polycystic ovary syndrome
    Heath J Antoine
    Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Cedars Sinai Medical Center, Los Angeles, California 90048, USA
    Fertil Steril 87:862-9. 2007
    ..To investigate the relationship of the peroxisome proliferator-activated receptor gamma (PPARG) Pro12Ala and silent exon 6 (His447His) polymorphisms with the clinical features of polycystic ovary syndrome (PCOS)...
  14. doi Metformin use in polycystic ovary syndrome: metabolic benefits and diabetes prevention
    Mark O Goodarzi
    Am J Med 121:e9; author reply e11. 2008
  15. pmc Nonreplication of the type 5 17beta-hydroxysteroid dehydrogenase gene association with polycystic ovary syndrome
    Mark O Goodarzi
    Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Cedars Sinai Medical Center, Los Angeles, California 90048, USA
    J Clin Endocrinol Metab 93:300-3. 2008
    ....
  16. pmc Association of TCF7L2 gene polymorphisms with reduced acute insulin response in Hispanic Americans
    Nicholette D Palmer
    Department of Biochemistry, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    J Clin Endocrinol Metab 93:304-9. 2008
    ..Genetic variation at the transcription factor 7-like 2 locus has been linked to type 2 diabetes in predominantly European-derived populations. The biological basis of these associations remains to be determined...
  17. ncbi Determination and use of haplotypes: ethnic comparison and association of the lipoprotein lipase gene and coronary artery disease in Mexican-Americans
    Mark O Goodarzi
    Division of Medical Genetics, Department of Medicine, Cedars Sinai Medical Center and UCLA, Los Angeles, California, USA
    Genet Med 5:322-7. 2003
    ..To illustrate an approach of deriving haplotypes for genetic association studies, using the lipoprotein lipase (LPL) gene and coronary artery disease...
  18. ncbi Glucose lowering to control macrovascular disease in type 2 diabetes: treating the wrong surrogate end point?
    Mark O Goodarzi
    Division of Endocrinology, Diabetes and Metabolism, Medical Genetics Institute, Cedars Sinai Medical Center, and Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California, USA
    JAMA 300:2051-3. 2008
  19. ncbi beta-Cell function: a key pathological determinant in polycystic ovary syndrome
    Mark O Goodarzi
    Division of Endocrinology, Diabetes, and Hypertension, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles 90095, USA
    J Clin Endocrinol Metab 90:310-5. 2005
    ....
  20. ncbi Association of the diabetes gene calpain-10 with subclinical atherosclerosis: the Mexican-American Coronary Artery Disease Study
    Mark O Goodarzi
    Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Cedars Sinai Medical Center, Los Angeles, California 90048, USA
    Diabetes 54:1228-32. 2005
    ..The fact that the diabetes gene CAPN10 also influences the risk for atherosclerosis shows that inherited factors may underlie the frequent co-occurrence of these two conditions...
  21. ncbi The 3' untranslated region of the lipoprotein lipase gene: haplotype structure and association with post-heparin plasma lipase activity
    Mark O Goodarzi
    Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Cedars Sinai Medical Center, 8700 Beverly Boulevard, Becker B 128, Los Angeles, California 90048, USA
    J Clin Endocrinol Metab 90:4816-23. 2005
    ..Haplotypes comprising six single nucleotide polymorphisms (SNPs) (intron 7 to intron 9) of the lipoprotein lipase (LPL) gene appear to influence risk for atherosclerosis and insulin resistance in Mexican-Americans...
  22. doi Quantitative trait analysis of type 2 diabetes susceptibility loci identified from whole genome association studies in the Insulin Resistance Atherosclerosis Family Study
    Nicholette D Palmer
    Department of Biochemistry, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Diabetes 57:1093-100. 2008
    ....
  23. ncbi Blood glucose: a strong risk factor for mortality in nondiabetic patients with cardiovascular disease
    Sidney C Port
    Department of Statistics, University of California, Los Angeles, CA 90095 1555, USA
    Am Heart J 150:209-14. 2005
    ..In particular, it is unknown if for these patients there is a graded relation of mortality to glucose or if there is a lower threshold...
  24. ncbi Polycystic ovary syndrome in Mexican-Americans: prevalence and association with the severity of insulin resistance
    Mark O Goodarzi
    Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Cedars Sinai Medical Center, Los Angeles, California 90048, USA
    Fertil Steril 84:766-9. 2005
    ..Hyperinsulinemic euglycemic clamp studies showed greater insulin resistance in the women with PCOS...
  25. ncbi Metformin revisited: re-evaluation of its properties and role in the pharmacopoeia of modern antidiabetic agents
    Mark O Goodarzi
    Department of Medicine and the Gonda Goldschmied Diabetes Center, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    Diabetes Obes Metab 7:654-65. 2005
    ....
  26. ncbi The predictive role of blood glucose for mortality in subjects with cardiovascular disease
    Sidney C Port
    Department of Mathematics, University of California Los Angeles, Los Angeles, CA 90095 1555, USA
    Am J Epidemiol 163:342-51. 2006
    ..009). These findings suggest that although 5.55 mmol/liter (normal) may be a useful mortality risk division (albeit with different implications for the two sexes), 6.99 mmol/liter (diabetic) is not, especially for men...
  27. pmc Association of androgen receptor CAG repeat polymorphism and polycystic ovary syndrome
    Nissar A Shah
    Division of Endocrinology, Diabetes, and Metabolism, Cedars Sinai Medical Center, 8700 Beverly Boulevard, Los Angeles, CA 90048, USA
    J Clin Endocrinol Metab 93:1939-45. 2008
    ..Genetically determined heightened androgen sensitivity may influence the phenotype of polycystic ovary syndrome (PCOS). To date, studies of the androgen receptor exon 1 polymorphic CAG repeat have produced conflicting results in PCOS...
  28. pmc Association of CYP3A7*1C and serum dehydroepiandrosterone sulfate levels in women with polycystic ovary syndrome
    Mark O Goodarzi
    Department of Obstetrics Gynecology and Center for Androgen Related Disorders, Cedars Sinai Medical Center, 8635 West Third Street, Los Angeles, CA 90048, USA
    J Clin Endocrinol Metab 93:2909-12. 2008
    ....
  29. doi Looking for polycystic ovary syndrome genes: rational and best strategy
    Mark O Goodarzi
    Department of Medicine, David Geffen School of Medicine at UCLA, CA, USA
    Semin Reprod Med 26:5-13. 2008
    ....
  30. ncbi Genetic markers: progress and potential for cardiovascular disease
    Gary H Gibbons
    Cardiovascular Research Institute, Morehouse School of Medicine, Atlanta, GA, USA
    Circulation 109:IV47-58. 2004
  31. ncbi Variation in the gene for muscle-specific AMP deaminase is associated with insulin clearance, a highly heritable trait
    Mark O Goodarzi
    Medical Genetics Institute, Department of Pediatrics, Steven Spielberg Pediatric Research Center, Cedars Sinai Medical Center, Los Angeles, California 90048, USA
    Diabetes 54:1222-7. 2005
    ..We postulated that the processes of insulin action and insulin clearance in skeletal muscle are highly regulated and that AMPD1 function may play an important role in these phenomena...
  32. ncbi Diagnosis, epidemiology, and genetics of the polycystic ovary syndrome
    Mark O Goodarzi
    Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Medical Genetics Institute, Los Angeles, CA, USA
    Best Pract Res Clin Endocrinol Metab 20:193-205. 2006
    ..Genetically, PCOS is a common, complex disorder. Despite repeated attempts to identify the putative gene or genes responsible for this disorder, the PCOS gene(s) remain elusive...
  33. ncbi Variants in the 5alpha-reductase type 1 and type 2 genes are associated with polycystic ovary syndrome and the severity of hirsutism in affected women
    Mark O Goodarzi
    Department of Ob Gyn and Center for Androgen Related Disorders, Cedars Sinai Medical Center, 8635 West Third Street, Suite 160W, Los Angeles, CA 90048, USA
    J Clin Endocrinol Metab 91:4085-91. 2006
    ..Despite the importance of dihydrotestosterone in androgen action, polymorphisms in the genes for the two isoforms of 5alpha-reductase (SRD5A1 and SRD5A2) have not been evaluated as risk factors for polycystic ovary syndrome (PCOS)...
  34. pmc Preliminary evidence of glycogen synthase kinase 3 beta as a genetic determinant of polycystic ovary syndrome
    Mark O Goodarzi
    Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, Cedars Sinai Medical Center, Los Angeles, California 90048, USA
    Fertil Steril 87:1473-6. 2007
    ..In each racial group, we observed that a specific, although different, GSK3B haplotype was associated with increased frequency of PCOS, suggesting that GSK3beta contributes to the pathophysiology and inherited basis of PCOS...
  35. ncbi Correlation of adrenocorticotropin steroid levels between women with polycystic ovary syndrome and their sisters
    Mark O Goodarzi
    Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Am J Obstet Gynecol 196:398.e1-5; discussion 398.e5-6. 2007
    ..The purpose of this study was to assess the sibling correlation of adrenocorticotropic hormone-stimulated steroid hormone levels between probands with polycystic ovary syndrome and their sisters...
  36. ncbi Genes for enzymes regulating dehydroepiandrosterone sulfonation are associated with levels of dehydroepiandrosterone sulfate in polycystic ovary syndrome
    Mark O Goodarzi
    Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Sinai Medical Center, Los Angeles, California 90048, USA
    J Clin Endocrinol Metab 92:2659-64. 2007
    ..Dehydroepiandrosterone (DHEA) sulfonation is controlled by the enzymes DHEA sulfotransferase (SULT2A1) and steroid sulfatase (STS). Polymorphisms in these genes have not been evaluated as modulators of DHEAS level in PCOS...
  37. ncbi SORCS1: a novel human type 2 diabetes susceptibility gene suggested by the mouse
    Mark O Goodarzi
    Cedars Sinai Medical Center, Division of Endocrinology, Diabetes, and Metabolism, 8700 Beverly Blvd, Becker B 131, Los Angeles, CA 90048, USA
    Diabetes 56:1922-9. 2007
    ..Thus, we sought to determine whether variation in the human SORCS1 gene was associated with diabetes-related traits...
  38. ncbi Heritability of dehydroepiandrosterone sulfate in women with polycystic ovary syndrome and their sisters
    Bulent O Yildiz
    Hacettepe University Faculty of Medicine, Department of Internal Medicine, Endocrinology and Metabolism Unit, Ankara, Turkey
    Fertil Steril 86:1688-93. 2006
    ..To test the hypothesis that adrenal androgen (AA) secretion is an inherited trait in PCOS and that serum DHEAS concentrations, as a marker of AA secretion, will be correlated between women with PCOS and their sisters...