Marco I Gonzalez

Summary

Affiliation: University of Colorado Denver
Country: USA

Publications

  1. ncbi request reprint Brain-derived neurotrophic factor promotes gephyrin protein expression and GABAA receptor clustering in immature cultured hippocampal cells
    Marco I Gonzalez
    Department of Pediatrics, Division of Neurology and Translational Epilepsy Research Program, University of Colorado School of Medicine, Aurora, CO 80045, USA Electronic address
    Neurochem Int 72:14-21. 2014
  2. pmc Down-regulation of gephyrin and GABAA receptor subunits during epileptogenesis in the CA1 region of hippocampus
    Marco I Gonzalez
    Division of Neurology and Translational Epilepsy Research Program, Department of Pediatrics, University of Colorado School of Medicine, Aurora, Colorado, USA
    Epilepsia 54:616-24. 2013
  3. pmc Altered GABA(A) receptor expression during epileptogenesis
    Marco I Gonzalez
    Department of Pediatrics, Division of Neurology, School of Medicine, University of Colorado Denver, Aurora, CO 80045, United States
    Neurosci Lett 497:218-22. 2011
  4. ncbi request reprint Evidence that Akt mediates platelet-derived growth factor-dependent increases in activity and surface expression of the neuronal glutamate transporter, EAAC1
    Elizabeth Krizman-Genda
    Department of Pediatrics, Children s Hospital of Philadelphia, University of Pennsylvania, Philadelphia, PA 19104, USA
    Neuropharmacology 49:872-82. 2005
  5. ncbi request reprint A carboxyl-terminal determinant of the neuronal glutamate transporter, EAAC1, is required for platelet-derived growth factor-dependent trafficking
    Amanda L Sheldon
    Department of Pediatrics, Children s Hospital of Philadelphia, University of Pennsylvania, Philadelphia, Pennsylvania 19104 4318, USA
    J Biol Chem 281:4876-86. 2006
  6. pmc Ubiquitination-mediated internalization and degradation of the astroglial glutamate transporter, GLT-1
    Amanda L Sheldon
    Department of Pediatrics, Children s Hospital of Philadelphia, University of Pennsylvania, Philadelphia, PA 19104, USA
    Neurochem Int 53:296-308. 2008
  7. ncbi request reprint Caveolin-1 regulates the delivery and endocytosis of the glutamate transporter, excitatory amino acid carrier 1
    Marco I Gonzalez
    Department of Pediatrics, Children s Hospital of Philadelphia, University of Pennsylvania, Philadelphia, Pennsylvania 19104 4318, USA
    J Biol Chem 282:29855-65. 2007
  8. ncbi request reprint Evidence that protein kinase Calpha interacts with and regulates the glial glutamate transporter GLT-1
    Marco I Gonzalez
    Department of Pediatrics, Children s Hospital of Philadelphia, University of Pennsylvania, Philadelphia, Pennsylvania 19104 4318, USA
    J Neurochem 94:1180-8. 2005
  9. ncbi request reprint Protein kinase C-dependent remodeling of glutamate transporter function
    Marco I Gonzalez
    Department of Pediatrics, Children s Hospital of Philadelphia, University of Pennsylvania, Philadelphia, PA 19104 4318, USA
    Mol Interv 4:48-58. 2004
  10. ncbi request reprint Rapid trafficking of the neuronal glutamate transporter, EAAC1: evidence for distinct trafficking pathways differentially regulated by protein kinase C and platelet-derived growth factor
    Keith M Fournier
    Department of Pediatrics, Children s Hospital of Philadelphia, University of Pennsylvania, 3615 Civic Center Boulevard, Philadelphia, PA 19104 4318, USA
    J Biol Chem 279:34505-13. 2004

Collaborators

  • Amy Brooks-Kayal
  • Amanda L Sheldon
  • Michael B Robinson
  • Elizabeth Krizman-Genda
  • Keith M Fournier
  • Elizabeth N Krizman-Genda
  • Bala T S Susarla
  • Olga Zelenaia

Detail Information

Publications11

  1. ncbi request reprint Brain-derived neurotrophic factor promotes gephyrin protein expression and GABAA receptor clustering in immature cultured hippocampal cells
    Marco I Gonzalez
    Department of Pediatrics, Division of Neurology and Translational Epilepsy Research Program, University of Colorado School of Medicine, Aurora, CO 80045, USA Electronic address
    Neurochem Int 72:14-21. 2014
    ..Together, these observations indicate that BDNF might regulate the assembly of GABAergic synapses by promoting the association of GABAAR with gephyrin. ..
  2. pmc Down-regulation of gephyrin and GABAA receptor subunits during epileptogenesis in the CA1 region of hippocampus
    Marco I Gonzalez
    Division of Neurology and Translational Epilepsy Research Program, Department of Pediatrics, University of Colorado School of Medicine, Aurora, Colorado, USA
    Epilepsia 54:616-24. 2013
    ..Here, we analyzed the effects of status epilepticus on the expression of GABAA receptors (GABAA Rs) and scaffolding proteins involved in the regulation of GABAA R trafficking and anchoring...
  3. pmc Altered GABA(A) receptor expression during epileptogenesis
    Marco I Gonzalez
    Department of Pediatrics, Division of Neurology, School of Medicine, University of Colorado Denver, Aurora, CO 80045, United States
    Neurosci Lett 497:218-22. 2011
    ....
  4. ncbi request reprint Evidence that Akt mediates platelet-derived growth factor-dependent increases in activity and surface expression of the neuronal glutamate transporter, EAAC1
    Elizabeth Krizman-Genda
    Department of Pediatrics, Children s Hospital of Philadelphia, University of Pennsylvania, Philadelphia, PA 19104, USA
    Neuropharmacology 49:872-82. 2005
    ..Together, these studies suggest that Akt is required for PDGF-induced regulation of EAAC1...
  5. ncbi request reprint A carboxyl-terminal determinant of the neuronal glutamate transporter, EAAC1, is required for platelet-derived growth factor-dependent trafficking
    Amanda L Sheldon
    Department of Pediatrics, Children s Hospital of Philadelphia, University of Pennsylvania, Philadelphia, Pennsylvania 19104 4318, USA
    J Biol Chem 281:4876-86. 2006
    ..These studies identify a novel motif within the carboxyl terminus of EAAC1 which is required for regulated trafficking. The possibility that this motif targets EAAC1 to an intracellular, "regulated pool" is discussed...
  6. pmc Ubiquitination-mediated internalization and degradation of the astroglial glutamate transporter, GLT-1
    Amanda L Sheldon
    Department of Pediatrics, Children s Hospital of Philadelphia, University of Pennsylvania, Philadelphia, PA 19104, USA
    Neurochem Int 53:296-308. 2008
    ..Together these data define a novel mechanism by which the predominant forebrain glutamate transporter can be rapidly targeted for degradation...
  7. ncbi request reprint Caveolin-1 regulates the delivery and endocytosis of the glutamate transporter, excitatory amino acid carrier 1
    Marco I Gonzalez
    Department of Pediatrics, Children s Hospital of Philadelphia, University of Pennsylvania, Philadelphia, Pennsylvania 19104 4318, USA
    J Biol Chem 282:29855-65. 2007
    ..Together, these data provide strong evidence that caveolin-1 contributes to the trafficking of EAAC1 on and off the plasma membrane and that these effects are associated with formation of EAAC1-caveolin complexes...
  8. ncbi request reprint Evidence that protein kinase Calpha interacts with and regulates the glial glutamate transporter GLT-1
    Marco I Gonzalez
    Department of Pediatrics, Children s Hospital of Philadelphia, University of Pennsylvania, Philadelphia, Pennsylvania 19104 4318, USA
    J Neurochem 94:1180-8. 2005
    ..These studies suggest that PKCalpha may be required for the regulated redistribution of GLT-1...
  9. ncbi request reprint Protein kinase C-dependent remodeling of glutamate transporter function
    Marco I Gonzalez
    Department of Pediatrics, Children s Hospital of Philadelphia, University of Pennsylvania, Philadelphia, PA 19104 4318, USA
    Mol Interv 4:48-58. 2004
    ....
  10. ncbi request reprint Rapid trafficking of the neuronal glutamate transporter, EAAC1: evidence for distinct trafficking pathways differentially regulated by protein kinase C and platelet-derived growth factor
    Keith M Fournier
    Department of Pediatrics, Children s Hospital of Philadelphia, University of Pennsylvania, 3615 Civic Center Boulevard, Philadelphia, PA 19104 4318, USA
    J Biol Chem 279:34505-13. 2004
    ..The data also suggest that basal and regulated pools of EAAC1 exist in distinct compartments...