F Gonzalez-Lima

Summary

Affiliation: University of Texas
Country: USA

Publications

  1. ncbi request reprint Quantitative cytochemistry of cytochrome oxidase and cellular morphometry of the human inferior colliculus in control and Alzheimer's patients
    F Gonzalez-Lima
    Department of Psychology, University of Texas at Austin, 78712, USA
    Brain Res 752:117-26. 1997
  2. doi request reprint Methylene blue provides behavioral and metabolic neuroprotection against optic neuropathy
    Julio C Rojas
    Institute for Neuroscience, University of Texas at Austin, 1 University Station A8000, Austin, TX 78712, USA
    Neurotox Res 15:260-73. 2009
  3. ncbi request reprint Methylene blue facilitates the extinction of fear in an animal model of susceptibility to learned helplessness
    Kathryn M Wrubel
    Department of Psychology and Institute for Neuroscience, University of Texas at Austin, Austin, TX 78712, USA
    Neurobiol Learn Mem 87:209-17. 2007
  4. pmc Mother-infant separation leads to hypoactive behavior in adolescent Holtzman rats
    Jaclyn Spivey
    Department of Psychology and Institute for Neuroscience, University of Texas at Austin, Austin, TX 78712 0187, USA
    Behav Processes 79:59-65. 2008
  5. pmc Animal model of posterior cingulate cortex hypometabolism implicated in amnestic MCI and AD
    P D Riha
    Department of Psychology, University of Texas, 1 University Station A8000, Austin, TX 78712, USA
    Neurobiol Learn Mem 90:112-24. 2008
  6. pmc Adolescent female rats are more resistant than males to the effects of early stress on prefrontal cortex and impulsive behavior
    Jaclyn M Spivey
    Department of Psychology, Pharmacology and Toxicology, University of Texas at Austin, 1 University Station A8000, Austin, Texas 78712, USA
    Dev Psychobiol 51:277-88. 2009
  7. ncbi request reprint Mapping Pavlovian conditioning effects on the brain: blocking, contiguity, and excitatory effects
    D Jones
    Department of Psychology and Institute for Neuroscience, University of Texas at Austin, 78712, USA
    J Neurophysiol 86:809-23. 2001
  8. pmc Strain, sex, and open-field behavior: factors underlying the genetic susceptibility to helplessness
    Eimeira Padilla
    Institute for Neuroscience and Department of Psychology, University of Texas at Austin, 1 University Station A8000, Austin, TX 78712 0187, USA
    Behav Brain Res 201:257-64. 2009
  9. ncbi request reprint Metabolic mapping of brain regions associated with behavioral extinction in preweanling rats
    H P Nair
    Behavioral Neuroscience, Mezes Hall 330, Institute for Neuroscience and Department of Psychology, University of Texas at Austin, Austin, TX 78712, USA
    Brain Res 903:141-53. 2001
  10. ncbi request reprint Energy hypometabolism in posterior cingulate cortex of Alzheimer's patients: superficial laminar cytochrome oxidase associated with disease duration
    J Valla
    Institute for Neuroscience and Department of Psychology, University of Texas at Austin, Austin, Texas 78712, USA
    J Neurosci 21:4923-30. 2001

Collaborators

Detail Information

Publications62

  1. ncbi request reprint Quantitative cytochemistry of cytochrome oxidase and cellular morphometry of the human inferior colliculus in control and Alzheimer's patients
    F Gonzalez-Lima
    Department of Psychology, University of Texas at Austin, 78712, USA
    Brain Res 752:117-26. 1997
    ..O. activity in humans. They also suggest that cellular alterations in C.O. metabolism in AD affect predominantly specific groups of larger projection neurons while neighboring neurons are spared...
  2. doi request reprint Methylene blue provides behavioral and metabolic neuroprotection against optic neuropathy
    Julio C Rojas
    Institute for Neuroscience, University of Texas at Austin, 1 University Station A8000, Austin, TX 78712, USA
    Neurotox Res 15:260-73. 2009
    ....
  3. ncbi request reprint Methylene blue facilitates the extinction of fear in an animal model of susceptibility to learned helplessness
    Kathryn M Wrubel
    Department of Psychology and Institute for Neuroscience, University of Texas at Austin, Austin, TX 78712, USA
    Neurobiol Learn Mem 87:209-17. 2007
    ....
  4. pmc Mother-infant separation leads to hypoactive behavior in adolescent Holtzman rats
    Jaclyn Spivey
    Department of Psychology and Institute for Neuroscience, University of Texas at Austin, Austin, TX 78712 0187, USA
    Behav Processes 79:59-65. 2008
    ..Sex differences in these behaviors were limited. This study suggests a genetic predisposition in HO rats for predominantly hypoactive/anxiety-like behaviors when exposed to an early life stressor...
  5. pmc Animal model of posterior cingulate cortex hypometabolism implicated in amnestic MCI and AD
    P D Riha
    Department of Psychology, University of Texas, 1 University Station A8000, Austin, TX 78712, USA
    Neurobiol Learn Mem 90:112-24. 2008
    ..This model may be useful as an in vivo testing platform to investigate neuroprotective strategies to prevent or reduce the amnestic effects produced by posterior cingulate energy hypometabolism...
  6. pmc Adolescent female rats are more resistant than males to the effects of early stress on prefrontal cortex and impulsive behavior
    Jaclyn M Spivey
    Department of Psychology, Pharmacology and Toxicology, University of Texas at Austin, 1 University Station A8000, Austin, Texas 78712, USA
    Dev Psychobiol 51:277-88. 2009
    ..Neuroanatomical and behavioral documentation that adolescent females are more resistant than males to ADHD-like effects of maternal separation have not been previously reported...
  7. ncbi request reprint Mapping Pavlovian conditioning effects on the brain: blocking, contiguity, and excitatory effects
    D Jones
    Department of Psychology and Institute for Neuroscience, University of Texas at Austin, 78712, USA
    J Neurophysiol 86:809-23. 2001
    ..In particular, the results suggest that suppression of prefrontal activity and activation of unconditioned stimulus pathways are important neural substrates of the Kamin blocking effect...
  8. pmc Strain, sex, and open-field behavior: factors underlying the genetic susceptibility to helplessness
    Eimeira Padilla
    Institute for Neuroscience and Department of Psychology, University of Texas at Austin, 1 University Station A8000, Austin, TX 78712 0187, USA
    Behav Brain Res 201:257-64. 2009
    ..The Holtzman strain therefore appears to be a commercially available model for studying susceptibility to helplessness in males, and novelty-seeking may be a marker of this susceptibility...
  9. ncbi request reprint Metabolic mapping of brain regions associated with behavioral extinction in preweanling rats
    H P Nair
    Behavioral Neuroscience, Mezes Hall 330, Institute for Neuroscience and Department of Psychology, University of Texas at Austin, Austin, TX 78712, USA
    Brain Res 903:141-53. 2001
    ..Recruitment of limbic structures may allow the older pups to modify extinction behavior based on prior learning...
  10. ncbi request reprint Energy hypometabolism in posterior cingulate cortex of Alzheimer's patients: superficial laminar cytochrome oxidase associated with disease duration
    J Valla
    Institute for Neuroscience and Department of Psychology, University of Texas at Austin, Austin, Texas 78712, USA
    J Neurosci 21:4923-30. 2001
    ..Such decrement could contribute to some of the behavioral symptoms displayed by AD patients. This decrement appeared greater in women...
  11. ncbi request reprint Maturation of extinction behavior in infant rats: large-scale regional interactions with medial prefrontal cortex, orbitofrontal cortex, and anterior cingulate cortex
    H P Nair
    Institute for Neuroscience and Department of Psychology, University of Texas at Austin, Austin, Texas 78712, USA
    J Neurosci 21:4400-7. 2001
    ..The data suggest that functional maturation of the frontal cortical regions and their interactions with other brain systems are related to the maturational shift in behavior...
  12. pmc Neuroprotective effects of memantine in a mouse model of retinal degeneration induced by rotenone
    Julio C Rojas
    Institute for Neuroscience, University of Texas at Austin, Austin, TX 78712, USA
    Brain Res 1215:208-17. 2008
    ....
  13. ncbi request reprint Repeated interactions with females elevate metabolic capacity in the limbic system of male rats
    Jon T Sakata
    Institute for Neuroscience, Patterson Hall, University of Texas at Austin, Austin, TX 78712, USA
    Brain Res 936:27-37. 2002
    ..We speculate that these changes in brain metabolic capacity could be related to immediate early gene expression during copulation and could underlie the long-term behavioral changes accompanying heterosexual social experience...
  14. pmc Juvenile male rats display lower cortical metabolic capacity than females
    Jaclyn M Spivey
    Departments of Psychology, Pharmacology and Toxicology, University of Texas at Austin, 1 University Station A8000, Austin, TX 78712, USA
    Neurosci Lett 440:255-9. 2008
    ..This is the first study to show sex differences in brain metabolic capacity in regions such as the prefrontal cortex that may be hypometabolic in juvenile males relative to females...
  15. ncbi request reprint Methylene blue prevents neurodegeneration caused by rotenone in the retina
    Xian Zhang
    Institute for Neuroscience, University of Texas at Austin, 1 University Station A8000, 78712, USA
    Neurotox Res 9:47-57. 2006
    ..The findings suggest that methylene blue may be a promising neuroprotective agent in optic neuropathy and perhaps other neurodegenerative diseases caused by mitochondrial dysfunction...
  16. ncbi request reprint Behavioral characteristics of rats predisposed to learned helplessness: reduced reward sensitivity, increased novelty seeking, and persistent fear memories
    Jason Shumake
    University of Texas at Austin, Department of Psychology, 1 University Station A8000, Austin, TX 78712 0187, USA
    Behav Brain Res 164:222-30. 2005
    ..This behavioral phenotype is discussed as resembling the personality of humans vulnerable to post-traumatic stress disorder...
  17. ncbi request reprint Neuregulin-1 immunoglobulin-like domain mutant mice: clozapine sensitivity and impaired latent inhibition
    Mendell Rimer
    Section of Neurobiology, University of Texas at Austin, Austin, TX 78712 0248, USA
    Neuroreport 16:271-5. 2005
    ..These results suggest that Ig-Nrg-1's contribute to some - but not all - aspects of the schizophrenia-like phenotype of nrg-1 mutants, and further support nrg-1 as a candidate gene for schizophrenia...
  18. pmc Extinction memory improvement by the metabolic enhancer methylene blue
    F Gonzalez-Lima
    Institute for Neuroscience and Department of Psychology, University of Texas at Austin, Austin, Texas 78712, USA
    Learn Mem 11:633-40. 2004
    ..It was concluded that MB administered postextinction could enhance retention of extinction memory through an increase in brain cytochrome oxidase activity...
  19. pmc Striatal neuroprotection with methylene blue
    J C Rojas
    Institute for Neuroscience, University of Texas at Austin, Austin, TX, USA
    Neuroscience 163:877-89. 2009
    ....
  20. ncbi request reprint Hypermetabolism of paraventricular hypothalamus in the congenitally helpless rat
    J Shumake
    Department of Psychology and Institute for Neuroscience, University of Texas at Austin, Austin, TX 78712, USA
    Neurosci Lett 311:45-8. 2001
    ..Thus, paraventricular nucleus activity may be associated with genetic susceptibility to helpless behavior...
  21. pmc Beneficial network effects of methylene blue in an amnestic model
    Penny D Riha
    Departments of Psychology, Pharmacology and Toxicology, University of Texas at Austin, Austin, TX 78712, USA
    Neuroimage 54:2623-34. 2011
    ..These results implicate MB as a candidate intervention to improve memory. Because of its neuroprotective properties, MB may have disease-modifying effects in amnestic conditions associated with hypometabolism...
  22. pmc Neurometabolic mechanisms for memory enhancement and neuroprotection of methylene blue
    Julio C Rojas
    Departments of Psychology, Pharmacology and Toxicology, University of Texas at Austin, 1 University Station A8000, Austin, TX 78712, USA
    Prog Neurobiol 96:32-45. 2012
    ....
  23. pmc Metabolic mapping of the effects of the antidepressant fluoxetine on the brains of congenitally helpless rats
    Jason Shumake
    Department of Psychology and Pharmacology, University of Texas at Austin, TX 78712, USA
    Brain Res 1343:218-25. 2010
    ....
  24. pmc Novelty-evoked activity in open field predicts susceptibility to helpless behavior
    Eimeira Padilla
    Institute for Neuroscience, University of Texas at Austin, 1 University Station A8000, Austin, TX 78712, USA
    Physiol Behav 101:746-54. 2010
    ..Our most important finding was that by using an innocuous screening tool such as the novel and familiar open-field tests, it was possible to identify subjects that were susceptible to learned helplessness...
  25. ncbi request reprint Associative effects of Pavlovian differential inhibition of behaviour
    D Jones
    Department of Psychology and Institute for Neuroscience, University of Texas at Austin, Austin, TX 78712, USA
    Eur J Neurosci 14:1915-27. 2001
    ..The findings provide the first detailed map of neural regions involved in the learned associations controlling differential inhibition of conditioned behaviour...
  26. ncbi request reprint Network operations revealed by brain metabolic mapping in a genetic model of hyperactivity and attention deficit: the naples high- and low-excitability rats
    F Gonzalez-Lima
    lnstitute of Neuroscience, Department of Psychology, University of Texas at Austin, 78712, USA
    Neurosci Biobehav Rev 24:157-60. 2000
    ..The results support the involvement of limbic circuits in attentive processes and impulsiveness, and support the use of the NLE and NHE strains as animal models of Attention Deficit Hyperactivity Disorder (ADHD) in children...
  27. pmc Mesolimbic effects of the antidepressant fluoxetine in Holtzman rats, a genetic strain with increased vulnerability to stress
    Eimeira Padilla
    Department of Psychology, University of Texas at Austin, 1 University Station A8000, Austin, TX 78712, USA
    Brain Res 1387:71-84. 2011
    ....
  28. ncbi request reprint Brain activity associated with fear renewal
    A K Bruchey
    Institute for Neuroscience and Department of Psychology, University of Texas at Austin, Austin, TX 78712, USA
    Eur J Neurosci 24:3567-77. 2006
    ..These findings support Pavlov's stimulus-substitution theory as a neural mechanism contributing to the renewal effect...
  29. pmc The brain metabolic enhancer methylene blue improves discrimination learning in rats
    Kathryn M Wrubel
    Department of Psychology, University of Texas at Austin, Austin, TX 78712, USA
    Pharmacol Biochem Behav 86:712-7. 2007
    ....
  30. ncbi request reprint In vivo low-level light therapy increases cytochrome oxidase in skeletal muscle
    Christopher R Hayworth
    Departments of Psychology, Pharmacology and Toxicology, Institute for Neuroscience, University of Texas at Austin, Austin, TX, USA
    Photochem Photobiol 86:673-80. 2010
    ..The findings suggest that LLLT may enhance the oxidative energy metabolic capacity of different types of muscle fibers, and that LLLT may be used to enhance the aerobic potential of skeletal muscle...
  31. pmc Effects of maternal separation, early handling, and gonadal sex on regional metabolic capacity of the preweanling rat brain
    Jaclyn M Spivey
    Department of Psychology and Institute for Neuroscience, University of Texas at Austin, 1 University Station A8000, Austin, TX 78712, USA
    Brain Res 1367:198-206. 2011
    ..These findings suggest that early life mother-infant separation results in dysfunction of prefrontal and mesolimbic regions in the preweanling rat brain that may contribute to behavioral changes later in life...
  32. ncbi request reprint Brain differences in newborn rats predisposed to helpless and depressive behavior
    J Shumake
    Department of Psychology and Institute for Neuroscience, 1 University Station A8000, University of Texas at Austin, Austin, TX 78712, USA
    Brain Res 1030:267-76. 2004
    ..This implies that vulnerable animals have innate deficits in brain systems that would normally allow them to cope with stress, predisposing them in this manner to more readily develop helpless and depressive behaviors...
  33. ncbi request reprint Mitochondrial respiration as a target for neuroprotection and cognitive enhancement
    F Gonzalez-Lima
    Department of Psychology, University of Texas at Austin, Austin, TX 78712, USA Department of Pharmacology and Toxicology, University of Texas at Austin, Austin, TX 78712, USA Institute for Neuroscience, University of Texas at Austin, Austin, TX 78712, USA Electronic address
    Biochem Pharmacol 88:584-93. 2014
    ..This strategy represents a promising new bioenergetics direction for treatment of AD and other neuropsychological disorders featuring cognitive impairment and neurodegeneration. ..
  34. doi request reprint Neurological and psychological applications of transcranial lasers and LEDs
    Julio C Rojas
    Departments of Psychology, Pharmacology and Toxicology, University of Texas at Austin, Austin, TX 78712, USA
    Biochem Pharmacol 86:447-57. 2013
    ..This evidence supports enhancement of mitochondrial respiratory function as a generalizable therapeutic principle relevant to highly adaptable systems that are exquisitely sensitive to energy availability such as the nervous system. ..
  35. doi request reprint Transcranial infrared laser stimulation produces beneficial cognitive and emotional effects in humans
    D W Barrett
    Department of Psychology and Institute for Neuroscience, University of Texas at Austin, Austin, TX 78712, USA
    Neuroscience 230:13-23. 2013
    ..This innovative approach could lead to the development of non-invasive, performance-enhancing interventions in healthy humans and in those in need of neuropsychological rehabilitation...
  36. ncbi request reprint Effects of chronic sodium azide on brain and muscle cytochrome oxidase activity: a potential model to investigate environmental contributions to neurodegenerative diseases
    J D Berndt
    Institute for Neuroscience and Center for Molecular and Cellular Toxicology, University of Texas at Austin, 78712, USA
    J Toxicol Environ Health A 63:67-77. 2001
    ....
  37. pmc Pre-symptomatic detection of chronic motor deficits and genotype prediction in congenic B6.SOD1(G93A) ALS mouse model
    C R Hayworth
    Department of Psychology, Institute for Neuroscience, University of Texas at Austin, 2701 Speedway, Austin, TX 78712, USA
    Neuroscience 164:975-85. 2009
    ..To our knowledge, these findings are the first to report early chronic motor performance and physical deficits that are coincident with the earliest known motor dysfunction in any ALS mouse model...
  38. ncbi request reprint Heterosexual housing increases the retention of courtship behavior following castration and elevates metabolic capacity in limbic brain nuclei in male whiptail lizards, Cnemidophorus inornatus
    Jon T Sakata
    Institute for Neuroscience, University of Texas at Austin, Texas 78712, USA
    Horm Behav 42:263-73. 2002
    ..Altogether, this demonstrates that elevations in metabolic capacity correlate with experience-dependent increases in robustness to castration...
  39. pmc Neuroprotective effects of near-infrared light in an in vivo model of mitochondrial optic neuropathy
    Julio C Rojas
    Institute for Neuroscience, University of Texas at Austin, Austin, Texas 78712, USA
    J Neurosci 28:13511-21. 2008
    ..The results show that NIL treatment can effectively prevent the neurotoxic effects of rotenone and that it might be used in the treatment of neurodegenerative disorders associated with mitochondrial dysfunction...
  40. doi request reprint Transgenic mice expressing cyan fluorescent protein as a reporter strain to detect the effects of rotenone toxicity on retinal ganglion cells
    C R Hayworth
    Institute for Neuroscience and Division of Pharmacology and Toxicology, University of Texas at Austin, Austin, TX 78712 0187, USA
    J Toxicol Environ Health A 71:1582-92. 2008
    ....
  41. ncbi request reprint Neurodegeneration produced by rotenone in the mouse retina: a potential model to investigate environmental pesticide contributions to neurodegenerative diseases
    Xian Zhang
    Institute for Neuroscience and Center for Molecular and Cellular Toxicology, University of Texas at Austin, Austin, Texas 78712, USA
    J Toxicol Environ Health A 69:1681-97. 2006
    ....
  42. pmc Functional networks underlying latent inhibition learning in the mouse brain
    Frank Puga
    Department of Psychology and Institute for Neuroscience, University of Texas at Austin, 1 University Station A8000, Austin, TX 78712 0187, USA
    Neuroimage 38:171-83. 2007
    ....
  43. ncbi request reprint Effects of maternal separation, early handling, and standard facility rearing on orienting and impulsive behavior of adolescent rats
    Rene A Colorado
    Department of Psychology, Institute for Neuroscience, University of Texas at Austin, 1 University Station A8000, Austin, TX 78712, USA
    Behav Processes 71:51-8. 2006
    ..The impulsive/hyperactive phenotype produced by this MS protocol may provide a useful animal model to investigate the neurological basis for the similar behavioral phenotype found in attention deficit/hyperactivity disorder...
  44. ncbi request reprint Behavioral effects of metyrapone on Pavlovian extinction
    Douglas Barrett
    Institute for Neuroscience and Department of Psychology, University of Texas at Austin, Austin, TX 78712 0187, USA
    Neurosci Lett 371:91-6. 2004
    ..This interpretation is consistent with previous studies showing that metyrapone may interfere with memory consolidation for a variety of learned responses...
  45. ncbi request reprint Behavioral correlates of differences in neural metabolic capacity
    Jon T Sakata
    Institute for Neuroscience, University of Texas at Austin, Austin, TX 78712, USA
    Brain Res Brain Res Rev 48:1-15. 2005
    ..We propose that knowledge of neurometabolic differences can yield valuable predictions about behavioral phenotype in other systems...
  46. ncbi request reprint Effects of age and sociosexual experience on the morphology and metabolic capacity of brain nuclei in the leopard gecko (Eublepharis macularius), a lizard with temperature-dependent sex determination
    D Crews
    Institute of Reproductive Biology and Department of Zoology, University of Texas at Austin, 78712, USA
    Brain Res 758:169-79. 1997
    ..These data suggest that the volume and metabolic capacity of specific brain regions change as animals age and gain sociosexual experience, but the nature and degree of change depend upon prenatal events...
  47. doi request reprint Rapid, effective, and long-lasting behavioral recovery produced by microsutures, methylene blue, and polyethylene glycol after completely cutting rat sciatic nerves
    G D Bittner
    Institute for Cellular and Molecular Biology, University of Texas at Austin, Austin, Texas Section of Neurobiology, University of Texas at Austin, Austin, Texas, USA
    J Neurosci Res 90:967-80. 2012
    ..These and other data suggest that PEG-sealing is neuroprotective, and our PEG-fusion protocols that repair cut- and crush-severed rat nerves might rapidly translate to clinical procedures...
  48. ncbi request reprint Reduced corpus callosum, fornix and hippocampus in PDAPP transgenic mouse model of Alzheimer's disease
    F Gonzalez-Lima
    Behavioral Neuroscience, Institute for Neuroscience, University of Texas at Austin, Austin, TX 78712, USA
    Neuroreport 12:2375-9. 2001
    ..These findings, which might account for the early, nonprogressive behavioral abnormalities observed in these animals, have implications for the study of AD...
  49. ncbi request reprint Memory facilitation by methylene blue: dose-dependent effect on behavior and brain oxygen consumption
    Penny D Riha
    Department of Psychology, University of Texas at Austin, TX 78712, USA
    Eur J Pharmacol 511:151-8. 2005
    ..Therefore, methylene blue doses that increase brain oxygen consumption also facilitate memory retention...
  50. ncbi request reprint Brain systems underlying susceptibility to helplessness and depression
    J Shumake
    Department of Psycology, University of Texas at Austin, USA
    Behav Cogn Neurosci Rev 2:198-221. 2003
    ..Functional interconnections and causal relationships among these systems are considered and further experiments are suggested, with theoretical attention to how an abnormality in any one system could affect the others...
  51. ncbi request reprint Metabolic mapping of mouse brain activity after extinction of a conditioned emotional response
    Douglas Barrett
    Institute for Neuroscience and Department of Psychology, University of Texas at Austin, Austin, Texas 78712 0187, USA
    J Neurosci 23:5740-9. 2003
    ....
  52. ncbi request reprint Opposite metabolic changes in the habenula and ventral tegmental area of a genetic model of helpless behavior
    J Shumake
    Department of Psychology and Institute for Neuroscience, University of Texas at Austin, Austin, TX 78712, USA
    Brain Res 963:274-81. 2003
    ....
  53. ncbi request reprint Impaired metabolic capacity in the perirhinal and posterior parietal cortex lead to dissociation between attentional, motivational and spatial components of exploration in the Naples High-Excitability rat
    A Gallo
    Laboratory of Neurophysiology, Behaviour and Neural Networks, Department of Experimental Medicine, Section of Human Physiology F Bottazzi, II University of Naples, Costantinopoli 16, Naples 80138, Italy
    Behav Brain Res 130:133-40. 2002
    ..Therefore, they appear as an useful tool to the understanding of Attention-Deficit Hyperactivity Disorder (ADHD) in children...
  54. ncbi request reprint Dissociation of septo-hippocampal metabolism in the congenitally helpless rat
    J Shumake
    Department of Psychology and Institute for Neuroscience, Behavioral Neuroscience, University of Texas, Austin, TX 78712, USA
    Neuroscience 114:373-7. 2002
    ..This dissociation between hippocampal and septal activity may be a predisposing factor for the development of helpless behavior...
  55. ncbi request reprint Methylene blue restores spatial memory retention impaired by an inhibitor of cytochrome oxidase in rats
    Narriman Lee Callaway
    Department of Psychology and Institute for Neuroscience, University of Texas at Austin, Austin, TX 78712, USA
    Neurosci Lett 332:83-6. 2002
    ..Memory retention deficits found in some neurodegenerative diseases may be improved by drugs targeting impaired mitochondrial respiration...
  56. pmc Enhanced metabolic capacity of the frontal cerebral cortex after Pavlovian conditioning
    A K Bruchey
    Department of Psychology and Institute for Neuroscience, University of Texas, Austin, TX 78712 0187, USA
    Neuroscience 152:299-307. 2008
    ..Enhanced metabolic capacity of these anterior cortical areas after Pavlovian conditioning suggests that the frontal cortex may play a role in the retention and regulation of learned associations...
  57. pmc Network model of fear extinction and renewal functional pathways
    A K Bruchey
    Department of Psychology and Institute for Neuroscience, 1 University Station A8000, University of Texas, Austin, TX 78712 0187, USA
    Neuroscience 145:423-37. 2007
    ..Interestingly, the results also suggest that two independent pathways influence conditioned freezing: one from the central amygdaloid nucleus and the other from the infralimbic cortex directly to the ventrolateral periaqueductal gray...
  58. ncbi request reprint Methylene blue improves brain oxidative metabolism and memory retention in rats
    Narriman Lee Callaway
    Departments of Psychology, Neuroscience, and Pharmacology, University of Texas at Austin, 1 University Station A8000, Austin, TX 78712, USA
    Pharmacol Biochem Behav 77:175-81. 2004
    ..31%). Together the findings suggest that low-dose MB enhances spatial memory retention in normal rats by increasing brain cytochrome c oxidase activity...
  59. ncbi request reprint Chronic administration of 13-cis-retinoic acid increases depression-related behavior in mice
    Kally C O'Reilly
    Institute of Cellular and Molecular Biology, The University of Texas at Austin, Austin, TX, USA
    Neuropsychopharmacology 31:1919-27. 2006
    ..Taken together, these results suggest that administration of 13-cis-RA increases depression-related behaviors in mice...
  60. ncbi request reprint Effects of image resolution on autoradiographic measurements of posterior cingulate activity in PDAPP mice: implications for functional brain imaging studies of transgenic mouse models of Alzheimer's Disease
    J Valla
    Alzheimer s Disease Research Laboratory, Harrington Arthritis Research Center, USA
    Neuroimage 16:1-6. 2002
    ..It remains possible that these imaging techniques will prove useful in transgenic mouse lines that do not exhibit the same morphological abnormalities in neighboring white matter regions...
  61. ncbi request reprint Mouse model of optic neuropathy caused by mitochondrial complex I dysfunction
    Xian Zhang
    Institute for Neuroscience and Center for Molecular and Cellular Toxicology, University of Texas at Austin, Austin, TX 78712, USA
    Neurosci Lett 326:97-100. 2002
    ..This is the first animal model of optic neuropathy caused by mitochondrial dysfunction, and it could be used as a quick and convenient way to test new treatments for mitochondrial neurodegenerative diseases...
  62. ncbi request reprint Water maze training in aged rats: effects on brain metabolic capacity and behavior
    J S Villarreal
    Cajal Neuroscience Research Center, Department of Biology, University of Texas at San Antonio, 6900 North Loop 1604 West, San Antonio, TX 78249, USA
    Brain Res 939:43-51. 2002
    ..The results suggest that, at the time point investigated, water maze training in aged Fischer 344 rats produces altered oxidative energy metabolism in task-relevant limbic and vestibular regions...