Nestor F Gonzalez-Cadavid

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Effects of sildenafil and/or muscle derived stem cells on myocardial infarction
    Judy Sc Wang
    Department of Surgery, Los Angeles Biomedical Research Institute LABioMed at Harbor UCLA Medical Center, Torrance, CA, USA
    J Transl Med 10:159. 2012
  2. pmc Organization of the human myostatin gene and expression in healthy men and HIV-infected men with muscle wasting
    N F Gonzalez-Cadavid
    Division of Endocrinology, Charles R Drew University, Los Angeles, CA 90059, USA
    Proc Natl Acad Sci U S A 95:14938-43. 1998
  3. ncbi request reprint Therapy of erectile dysfunction: potential future treatments
    Nestor F Gonzalez-Cadavid
    Department of Urology, UCLA School of Medicine, Los Angeles, CA, and Research and Education Institute REI, Harbor UCLA Medical Center, Torrance, CA 90502, USA
    Endocrine 23:167-76. 2004
  4. ncbi request reprint Role of myostatin in metabolism
    Nestor F Gonzalez-Cadavid
    Division of Endocrinology, Department of Internal Medicine, Charles R Drew University, Los Angeles, CA, USA
    Curr Opin Clin Nutr Metab Care 7:451-7. 2004
  5. ncbi request reprint Mechanisms of Disease: new insights into the cellular and molecular pathology of Peyronie's disease
    Nestor F Gonzalez-Cadavid
    Department of Urology, David Geffen School of Medicine at UCLA, USA
    Nat Clin Pract Urol 2:291-7. 2005
  6. doi request reprint Mechanisms of penile fibrosis
    Nestor F Gonzalez-Cadavid
    Los Angeles Biomedical Research Institute LABioMed at Harbor UCLA Medical Center Urology Research Laboratory, Division of Urology, Torrance, CA 90509, USA
    J Sex Med 6:353-62. 2009
  7. ncbi request reprint Gene expression in Peyronie's disease
    N F Gonzalez-Cadavid
    Department of Urology, UCLA School of Medicine, Los Angeles, California, USA
    Int J Impot Res 14:361-74. 2002
  8. ncbi request reprint The pleiotropic effects of inducible nitric oxide synthase (iNOS) on the physiology and pathology of penile erection
    N F Gonzalez-Cadavid
    LABioMed at Harbor UCLA Medical Center, Torrance, CA, and Department of Urology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
    Curr Pharm Des 11:4041-6. 2005
  9. doi request reprint Experimental models of Peyronie's disease. Implications for new therapies
    Nestor F Gonzalez-Cadavid
    Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center Urology Research Laboratory, Torrance, CA, USA
    J Sex Med 6:303-13. 2009
  10. ncbi request reprint Presence of NMDA receptor subunits in the male lower urogenital tract
    N F Gonzalez-Cadavid
    Department of Urology, University of California at Los Angeles School of Medicine, Harbor UCLA Medical Center, Torrance 90509, USA
    J Androl 21:566-78. 2000

Research Grants

  1. CELL-SELECTIVE EXPRESSION OF FIBROTIC GENE PATHWAYS
    Nestor Gonzalez Cadavid; Fiscal Year: 2007
  2. ERECTILE DYSFUNCTION AND NITRIC OXIDE SYNTHASE IN AGING
    Nestor Gonzalez Cadavid; Fiscal Year: 2006
  3. ERECTILE DYSFUNCTION AND NITRIC OXIDE SYNTHASE IN AGING
    Nestor Gonzalez Cadavid; Fiscal Year: 2001

Collaborators

Detail Information

Publications52

  1. pmc Effects of sildenafil and/or muscle derived stem cells on myocardial infarction
    Judy Sc Wang
    Department of Surgery, Los Angeles Biomedical Research Institute LABioMed at Harbor UCLA Medical Center, Torrance, CA, USA
    J Transl Med 10:159. 2012
    ..We have now investigated whether sildenafil at lower doses and MDSC, alone or in combination are effective to attenuate LV remodeling after MI in rats...
  2. pmc Organization of the human myostatin gene and expression in healthy men and HIV-infected men with muscle wasting
    N F Gonzalez-Cadavid
    Division of Endocrinology, Charles R Drew University, Los Angeles, CA 90059, USA
    Proc Natl Acad Sci U S A 95:14938-43. 1998
    ..These data support the hypothesis that myostatin is an attenuator of skeletal muscle growth in adult men and contributes to muscle wasting in HIV-infected men...
  3. ncbi request reprint Therapy of erectile dysfunction: potential future treatments
    Nestor F Gonzalez-Cadavid
    Department of Urology, UCLA School of Medicine, Los Angeles, CA, and Research and Education Institute REI, Harbor UCLA Medical Center, Torrance, CA 90502, USA
    Endocrine 23:167-76. 2004
    ..This second approach requires extensive laboratory research prior to clinical translation but may provide a means to cure ED. The current status and future directions of these strategies are discussed...
  4. ncbi request reprint Role of myostatin in metabolism
    Nestor F Gonzalez-Cadavid
    Division of Endocrinology, Department of Internal Medicine, Charles R Drew University, Los Angeles, CA, USA
    Curr Opin Clin Nutr Metab Care 7:451-7. 2004
    ..Myostatin also controls muscle mass in other animals, and appears to affect adipose tissue mass...
  5. ncbi request reprint Mechanisms of Disease: new insights into the cellular and molecular pathology of Peyronie's disease
    Nestor F Gonzalez-Cadavid
    Department of Urology, David Geffen School of Medicine at UCLA, USA
    Nat Clin Pract Urol 2:291-7. 2005
    ..Both processes seem to be related to activation of fibroblast/myofibroblast differentiation in the tunica albuginea and to osteogenic commitment of stem cells in this tissue...
  6. doi request reprint Mechanisms of penile fibrosis
    Nestor F Gonzalez-Cadavid
    Los Angeles Biomedical Research Institute LABioMed at Harbor UCLA Medical Center Urology Research Laboratory, Division of Urology, Torrance, CA 90509, USA
    J Sex Med 6:353-62. 2009
    ..These processes differ in etiology, time course, target cells, and treatment, but have many features in common...
  7. ncbi request reprint Gene expression in Peyronie's disease
    N F Gonzalez-Cadavid
    Department of Urology, UCLA School of Medicine, Los Angeles, California, USA
    Int J Impot Res 14:361-74. 2002
    ..Finally, possible therapeutic avenues for gene-based therapy in the treatment of PD are discussed that may eventually reduce the need for surgical intervention...
  8. ncbi request reprint The pleiotropic effects of inducible nitric oxide synthase (iNOS) on the physiology and pathology of penile erection
    N F Gonzalez-Cadavid
    LABioMed at Harbor UCLA Medical Center, Torrance, CA, and Department of Urology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
    Curr Pharm Des 11:4041-6. 2005
    ....
  9. doi request reprint Experimental models of Peyronie's disease. Implications for new therapies
    Nestor F Gonzalez-Cadavid
    Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center Urology Research Laboratory, Torrance, CA, USA
    J Sex Med 6:303-13. 2009
    ..The development of animal and cell culture models has advanced substantially the understanding of its molecular and cellular pathology and the proposal of new therapies...
  10. ncbi request reprint Presence of NMDA receptor subunits in the male lower urogenital tract
    N F Gonzalez-Cadavid
    Department of Urology, University of California at Los Angeles School of Medicine, Harbor UCLA Medical Center, Torrance 90509, USA
    J Androl 21:566-78. 2000
    ..Further work is necessary to determine whether the NMDAR subunits form a fully active receptor and participate in the control of organ tone that is relevant to male sexual activity...
  11. ncbi request reprint Expression of penile neuronal nitric oxide synthase variants in the rat and mouse penile nerves
    N F Gonzalez-Cadavid
    Department of Urology, UCLA School of Medicine, Harbor UCLA Medical Center, Torrance, California 90509, USA
    Biol Reprod 63:704-14. 2000
    ....
  12. ncbi request reprint Gene therapy of erectile dysfunction in the rat with penile neuronal nitric oxide synthase
    Thomas R Magee
    Department of Urology, UCLA School of Medicine, Los Angeles, California 90509, USA
    Biol Reprod 67:1033-41. 2002
    ..In conclusion, intracavernosal gene therapy with PnNOS cDNA corrected the aging-related erectile dysfunction for at least 18 days when given by electroporation in a helper-dependent AdV at low viral loads...
  13. ncbi request reprint Myostatin short interfering hairpin RNA gene transfer increases skeletal muscle mass
    Thomas R Magee
    Department of Urology, David Geffen School of Medicine, UCLA, Los Angeles, CA 90024, USA
    J Gene Med 8:1171-81. 2006
    ..We investigated whether a plasmid expressing a short hairpin interfering RNA (shRNA) against myostatin and transduced using electroporation would increase local skeletal muscle mass...
  14. ncbi request reprint Antisense and short hairpin RNA (shRNA) constructs targeting PIN (Protein Inhibitor of NOS) ameliorate aging-related erectile dysfunction in the rat
    Thomas R Magee
    Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, CA, USA
    J Sex Med 4:633-43. 2007
    ..Over-expression of penile neuronal nitric oxide synthase (PnNOS) from a plasmid ameliorates aging-related erectile dysfunction (ED), whereas over-expression of the protein inhibitor of NOS (PIN), that binds to nNOS, increases ED...
  15. ncbi request reprint L-arginine and phosphodiesterase (PDE) inhibitors counteract fibrosis in the Peyronie's fibrotic plaque and related fibroblast cultures
    Eliane G A Valente
    Division of Urology, Research and Education Institute, Harbor UCLA Medical Center, Torrance, CA, USA
    Nitric Oxide 9:229-44. 2003
    ....
  16. doi request reprint Myostatin promotes a fibrotic phenotypic switch in multipotent C3H 10T1/2 cells without affecting their differentiation into myofibroblasts
    Jorge N Artaza
    Division of Endocrinology Metabolism and Molecular Medicine and RCMI Molecular Core, The Charles R Drew University of Medicine and Science, 1731 East 120th Street, Los Angeles, California, 90059 USA
    J Endocrinol 196:235-49. 2008
    ....
  17. ncbi request reprint Androgens stimulate myogenic differentiation and inhibit adipogenesis in C3H 10T1/2 pluripotent cells through an androgen receptor-mediated pathway
    Rajan Singh
    Division of Endocrinology, Metabolism, and Molecular Medicine, Charles R Drew University of Medicine and Science, Los Angeles, California 90059, USA
    Endocrinology 144:5081-8. 2003
    ..The observation that differentiation of pluripotent cells is androgen dependent provides a unifying explanation for the reciprocal effects of androgens on muscle and fat mass in men...
  18. doi request reprint Early onset of fibrosis within the arterial media in a rat model of type 2 diabetes mellitus with erectile dysfunction
    Istvan Kovanecz
    Division of Urology at Harbor UCLA Medical Center, Urology Research Laboratory, Los Angeles Biomedical Research Institute, Torrance, CA 90502, USA
    BJU Int 103:1396-404. 2009
    ....
  19. doi request reprint Effect of muscle-derived stem cells on the restoration of corpora cavernosa smooth muscle and erectile function in the aged rat
    Gaby Nolazco
    Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Urology Research Laboratory, Torrance, CA 90509, USA
    BJU Int 101:1156-64. 2008
    ....
  20. ncbi request reprint Ageing-related corpora veno-occlusive dysfunction in the rat is ameliorated by pioglitazone
    Istvan Kovanecz
    Urology Research Laboratory, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, CA, USA
    BJU Int 100:867-74. 2007
    ....
  21. ncbi request reprint Vardenafil prevents fibrosis and loss of corporal smooth muscle that occurs after bilateral cavernosal nerve resection in the rat
    Monica G Ferrini
    Department of Urology, University of California, Los Angeles, David Geffen School of Medicine, Los Angeles, California, USA
    Urology 68:429-35. 2006
    ..We aimed to determine whether bilateral cavernosal nerve resection (BCNX) in the rat leads to CVOD and whether long-term phosphodiesterase-5 inhibition ameliorates these histologic and functional impairments...
  22. ncbi request reprint Increased vaginal oxidative stress, apoptosis, and inducible nitric oxide synthase in a diabetic rat model: implications for vaginal fibrosis
    Monica G Ferrini
    Department of Urology, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, California, USA
    Fertil Steril 86:1152-63. 2006
    ..To determine whether vaginal fibrosis occurs in diabetic animals and is associated with oxidative stress and cell death and with the expression of inducible nitric oxide synthase (iNOS), as a putative antifibrotic mechanism...
  23. ncbi request reprint Effect of nitric oxide on the differentiation of fibroblasts into myofibroblasts in the Peyronie's fibrotic plaque and in its rat model
    Dolores Vernet
    Division of Urology, Research and Education Institute, Harbor UCLA Medical Center, Torrance, CA 90509, USA
    Nitric Oxide 7:262-76. 2002
    ....
  24. ncbi request reprint Evidence that osteogenic progenitor cells in the human tunica albuginea may originate from stem cells: implications for peyronie disease
    Dolores Vernet
    Department of Urology, UCLA School of Medicine, Los Angeles, California 90095, USA
    Biol Reprod 73:1199-210. 2005
    ..This may explain progression of fibrosis in the PD plaque and its eventual calcification...
  25. pmc Separate or combined treatments with daily sildenafil, molsidomine, or muscle-derived stem cells prevent erectile dysfunction in a rat model of cavernosal nerve damage
    Istvan Kovanecz
    Department of Surgery, Division of Urology, Los Angeles Biomedical Research Institute LABioMed at Harbor UCLA Medical Center, Torrance, CA, USA
    J Sex Med 9:2814-26. 2012
    ..In the aging rat model, corporal implantation of skeletal muscle-derived stem cells (MDSC) reverses CVOD. Nitric oxide (NO) and cyclic guanosine monophosphate can modulate stem cell lineage...
  26. ncbi request reprint Myostatin inhibits myogenesis and promotes adipogenesis in C3H 10T(1/2) mesenchymal multipotent cells
    Jorge N Artaza
    Division of Endocrinology, Metabolism, and Molecular Medicine, Charles R Drew University of Medicine and Science, 1731 East 120th Street, Los Angeles, California 90059, USA
    Endocrinology 146:3547-57. 2005
    ..In conclusion, myostatin promotes the differentiation of multipotent mesenchymal cells into the adipogenic lineage and inhibits myogenesis...
  27. doi request reprint Profibrotic role of myostatin in Peyronie's disease
    Liliana P Cantini
    Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Urology Research Laboratory, Los Angeles, CA, USA
    J Sex Med 5:1607-22. 2008
    ..The primary histologic finding in many urologic disorders, including Peyronie's disease (PD), is fibrosis, mainly mediated by the transforming growth factor beta1 (TGFbeta1)...
  28. ncbi request reprint Gene therapy of erectile dysfunction in the rat with penile neuronal nitric oxide synthase
    Thomas R Magee
    Department of Urology, UCLA School of Medicine, Los Angeles, CA 90509, USA
    Biol Reprod 67:20-8. 2002
    ..In conclusion, intracavernosal gene therapy with PnNOS cDNA corrected the aging-related erectile dysfunction for at least 18 days when given by electroporation in a helper-dependent AdV at low viral loads...
  29. ncbi request reprint Gene transfer of inducible nitric oxide synthase complementary DNA regresses the fibrotic plaque in an animal model of Peyronie's disease
    Hugo H Davila
    Department of Urology, UCLA School of Medicine, Los Angeles, California 90095, USA
    Biol Reprod 71:1568-77. 2004
    ..The piNOS gene transfer regressed the PD plaque and expression of profibrotic factors, supporting the view that endogenous iNOS induction in PD is defense mechanism by the tissue against fibrosis...
  30. doi request reprint The genetic inactivation of inducible nitric oxide synthase (iNOS) intensifies fibrosis and oxidative stress in the penile corpora cavernosa in type 1 diabetes
    Monica G Ferrini
    Charles Drew University CDU, Department of Internal Medicine, Los Angeles, CA, USA
    J Sex Med 7:3033-44. 2010
    ..Endogenously elicited inducible nitric oxide synthase (iNOS) induction counteracts fibrosis and oxidative stress in penile tissues in rat models of Peyronie's disease and erectile dysfunction...
  31. ncbi request reprint Penile neuronal nitric oxide synthase and its regulatory proteins are present in hypothalamic and spinal cord regions involved in the control of penile erection
    Monica G Ferrini
    Research and Education Institute, Harbor UCLA Medical Center, Torrance, California 90502, USA
    J Comp Neurol 458:46-61. 2003
    ..These results indicate that both nNOS variants, and their respective regulatory proteins are present and colocalize in the hypothalamic and spinal cord regions involved in penile erection...
  32. ncbi request reprint Effects of long-term vardenafil treatment on the development of fibrotic plaques in a rat model of Peyronie's disease
    Monica G Ferrini
    Division of Urology, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, CA, USA
    BJU Int 97:625-33. 2006
    ....
  33. ncbi request reprint Testosterone inhibits adipogenic differentiation in 3T3-L1 cells: nuclear translocation of androgen receptor complex with beta-catenin and T-cell factor 4 may bypass canonical Wnt signaling to down-regulate adipogenic transcription factors
    Rajan Singh
    Division of Endocrinology, Metabolism, and Molecular Medicine, Charles R Drew School of Medicine, Los Angeles, California 90059, USA
    Endocrinology 147:141-54. 2006
    ..These data provide evidence for a regulatory role for androgens in inhibiting adipogenic differentiation and a mechanistic explanation consistent with the observed reduction in fat mass in men treated with androgens...
  34. ncbi request reprint Alterations in myostatin expression are associated with changes in cardiac left ventricular mass but not ejection fraction in the mouse
    Jorge N Artaza
    Division of Endocrinology Metabolism and Molecular Medicine, Charles R Drew University of Medicine and Science, Los Angeles, CA 90059, USA
    J Endocrinol 194:63-76. 2007
    ..In conclusion, Mst does not affect cardiac systolic function in mice overexpressing or lacking the active protein, but it reduces cardiac mass and cardiomyocyte proliferation...
  35. ncbi request reprint Lower skeletal muscle mass in male transgenic mice with muscle-specific overexpression of myostatin
    Suzanne Reisz-Porszasz
    Division of Endocrinology, Metabolism and Molecular Medicine, Charles R Drew University of Medicine and Science, 1731 East 120th Street, Los Angeles, CA 90059, USA
    Am J Physiol Endocrinol Metab 285:E876-88. 2003
    ..The mechanism of gender specificity remains to be clarified...
  36. ncbi request reprint Involvement of nitric oxide-mediated intrinsic pathway signaling in age-related increase in germ cell apoptosis in male Brown-Norway rats
    Amiya P Sinha Hikim
    Division of Endocrinology, Box 446, Harbor UCLA Medical Center, 1000 West Carson Street, Torrance, CA 90509, USA
    J Gerontol A Biol Sci Med Sci 60:702-8. 2005
    ....
  37. ncbi request reprint Endogenous expression and localization of myostatin and its relation to myosin heavy chain distribution in C2C12 skeletal muscle cells
    Jorge N Artaza
    Division of Endocrinology, Metabolism and Molecular Medicine, Charles R Drew University of Medicine and Science, Los Angeles, California 90059, USA
    J Cell Physiol 190:170-9. 2002
    ..In conclusion, myostatin was expressed mostly in C2C12 myotubes nuclei expressing MHC-II. Its predominant nuclear localization suggests that it may play a role in transcriptional regulation...
  38. ncbi request reprint Pioglitazone prevents corporal veno-occlusive dysfunction in a rat model of type 2 diabetes mellitus
    Istvan Kovanecz
    Department of Surgery, Urology Research Laboratory, Division of Urology, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, CA 90502, USA
    BJU Int 98:116-24. 2006
    ....
  39. ncbi request reprint Aging-related induction of inducible nitric oxide synthase is vasculo-protective to the arterial media
    Monica G Ferrini
    Research and Education Institute, Harbor UCLA Medical Center, Urology, Bldg F 6, 1124 West Carson Street, Torrance, CA 90502, USA
    Cardiovasc Res 61:796-805. 2004
    ..We investigated whether with aging similar processes occur within the arterial media SMC that share some common physiological functions with the cavernosal SMC...
  40. ncbi request reprint Androgen receptor in human skeletal muscle and cultured muscle satellite cells: up-regulation by androgen treatment
    Indrani Sinha-Hikim
    Division of Endocrinology, Metabolism, and Molecular Medicine, Charles R Drew University of Medicine and Science, Los Angeles, California 90059, USA
    J Clin Endocrinol Metab 89:5245-55. 2004
    ..These observations support the hypothesis that androgens increase muscle mass in part by acting on several cell types to regulate the differentiation of mesenchymal precursor cells in the skeletal muscle...
  41. pmc Fibrosis and loss of smooth muscle in the corpora cavernosa precede corporal veno-occlusive dysfunction (CVOD) induced by experimental cavernosal nerve damage in the rat
    Monica G Ferrini
    Charles Drew University, Department of Medicine, Los Angeles, CA 90059, USA
    J Sex Med 6:415-28. 2009
    ..The corporal tissue expresses inducible nitric oxide synthase (iNOS), presumably as an antifibrotic and SMC-protective response...
  42. pmc Amelioration of diabetes-induced cavernosal fibrosis by antioxidant and anti-transforming growth factor-β1 therapies in inducible nitric oxide synthase-deficient mice
    Monica G Ferrini
    Department of Internal Medicine, Charles R Drew University Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
    BJU Int 109:586-93. 2012
    ....
  43. ncbi request reprint The mechanisms of androgen effects on body composition: mesenchymal pluripotent cell as the target of androgen action
    Shalender Bhasin
    Division of Endocrinology, Metabolism, and Molecular Medicine, Charles R Drew University of Medicine and Science, Los Angeles, California 90059, USA
    J Gerontol A Biol Sci Med Sci 58:M1103-10. 2003
    ..The hypothesis that the primary site of androgen action is the pluripotent stem cell provides a unifying explanation for the observed reciprocal effects of testosterone on muscle and fat mass...
  44. ncbi request reprint Peyronie's disease: a review
    Shahram S Gholami
    Knupps Molecular Urology Laboratory, Department of Urology, School of Medicine, University of California, San Francisco, 94143, USA
    J Urol 169:1234-41. 2003
    ..We provide a current review of Peyronie's disease...
  45. ncbi request reprint Alteration of gene expression profiles in skeletal muscle of rats exposed to microgravity during a spaceflight
    Wayne E Taylor
    Division of Endocrinology, Metabolism, and Molecular Medicine, Charles R Drew University of Medicine and Science, Los Angeles, CA, USA
    J Gravit Physiol 9:61-70. 2002
    ..These data indicate that following exposure to microgravity, there is downregulation of genes involved in regulation of muscle satellite cell replication...
  46. ncbi request reprint Gene expression profiles in the Peyronie's disease plaque
    Thomas R Magee
    Department of Urology, University of California, Los Angeles, School of Medicine, Los Angeles, California 90509, USA
    Urology 59:451-7. 2002
    ..To provide molecular insight into the pathophysiology of Peyronie's disease (PD), a preliminary profile of differential gene expression between the PD plaque and control tunica albuginea was obtained with DNA microarrays...
  47. doi request reprint Involvement of oxidative stress and caspase 2-mediated intrinsic pathway signaling in age-related increase in muscle cell apoptosis in mice
    Melissa Braga
    Division of Endocrinology, Metabolism, and Molecular Medicine, Charles R Drew University, Los Angeles, CA 90059, USA
    Apoptosis 13:822-32. 2008
    ..Taken together, our data indicate that caspase 2 and JNK-mediated intrinsic pathway signaling is one of the mechanisms involved in age-related increase in muscle cell apoptosis...
  48. doi request reprint Treatment of Peyronie's disease with PDE5 inhibitors: an antifibrotic strategy
    Nestor F Gonzalez-Cadavid
    Department of Urology, David Geffen School of Medicine at UCLA, and Los Angeles Biomedical Research Institute LABioMed at Harbor UCLA Medical Center, Building F 6, 1124 West Carson Street, Torrance, CA 90502, USA
    Nat Rev Urol 7:215-21. 2010
    ....
  49. ncbi request reprint Peyronie's disease associated with increase in plasminogen activator inhibitor in fibrotic plaque
    Hugo H Davila
    Department of Urology, University of California, Los Angeles, School of Medicine, Los Angeles, California, USA
    Urology 65:645-8. 2005
    ..Recently, it was reported that PAI-1 expression was also increased in the fibrotic plaque of an animal model of PD induced by the injection of fibrin into the tunica albuginea (TA) of the penis...
  50. pmc Stimulating vaginal repair in rats through skeletal muscle-derived stem cells seeded on small intestinal submucosal scaffolds
    Matthew H Ho
    Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, California 90502, USA
    Obstet Gynecol 114:300-9. 2009
    ....
  51. ncbi request reprint Correlation of androgen receptors, aromatase, and 5-alpha reductase in the human vagina with menopausal status
    Jennifer R Berman
    Department of Urology, Harbor UCLA Medical Center, Torrance, California, USA
    Fertil Steril 79:925-31. 2003
    ..To determine whether aromatase and 5alpha-reductase mRNAs are expressed in human vagina and to evaluate the presence of androgen receptors in human vaginal tissue based on age and menopausal status...
  52. ncbi request reprint Male reproductive ageing: using the brown Norway rat as a model for man
    Christina Wang
    Department of Medicine, Harbor UCLA Medical Center and Research and Education Institute, Carson, CA 90509, USA
    Novartis Found Symp 242:82-95; discussion 95-7. 2002
    ....

Research Grants12

  1. CELL-SELECTIVE EXPRESSION OF FIBROTIC GENE PATHWAYS
    Nestor Gonzalez Cadavid; Fiscal Year: 2007
    ..We expect that our studies would lead to the detection of novel targets of antifibrotic therapy for penile and vascular diseases of considerable public health impact. ..
  2. ERECTILE DYSFUNCTION AND NITRIC OXIDE SYNTHASE IN AGING
    Nestor Gonzalez Cadavid; Fiscal Year: 2006
    ....
  3. ERECTILE DYSFUNCTION AND NITRIC OXIDE SYNTHASE IN AGING
    Nestor Gonzalez Cadavid; Fiscal Year: 2001
    ..The long-term goal is to validate pre-clinically the use of these agents for medical treatment of erectile dysfunction associated with aging. ..