Research Topics
Genomes and Genes | Nestor F Gonzalez-CadavidSummaryAffiliation: University of California Country: USA Publications
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Publications
Organization of the human myostatin gene and expression in healthy men and HIV-infected men with muscle wastingN F Gonzalez-Cadavid
Division of Endocrinology, Charles R Drew University, Los Angeles, CA 90059, USA
Proc Natl Acad Sci U S A 95:14938-43. 1998..These data support the hypothesis that myostatin is an attenuator of skeletal muscle growth in adult men and contributes to muscle wasting in HIV-infected men...
Therapy of erectile dysfunction: potential future treatmentsNestor F Gonzalez-Cadavid
Department of Urology, UCLA School of Medicine, Los Angeles, CA, and Research and Education Institute REI, Harbor UCLA Medical Center, Torrance, CA 90502, USA
Endocrine 23:167-76. 2004..This second approach requires extensive laboratory research prior to clinical translation but may provide a means to cure ED. The current status and future directions of these strategies are discussed...- Role of myostatin in metabolismNestor F Gonzalez-Cadavid
Division of Endocrinology, Department of Internal Medicine, Charles R Drew University, Los Angeles, CA, USA
Curr Opin Clin Nutr Metab Care 7:451-7. 2004..Myostatin also controls muscle mass in other animals, and appears to affect adipose tissue mass... 
Mechanisms of penile fibrosisNestor F Gonzalez-Cadavid
Los Angeles Biomedical Research Institute LABioMed at Harbor UCLA Medical Center Urology Research Laboratory, Division of Urology, Torrance, CA 90509, USA
J Sex Med 6:353-62. 2009..These processes differ in etiology, time course, target cells, and treatment, but have many features in common...- Gene expression in Peyronie's diseaseN F Gonzalez-Cadavid
Department of Urology, UCLA School of Medicine, Los Angeles, California, USA
Int J Impot Res 14:361-74. 2002..Finally, possible therapeutic avenues for gene-based therapy in the treatment of PD are discussed that may eventually reduce the need for surgical intervention... - Mechanisms of Disease: new insights into the cellular and molecular pathology of Peyronie's diseaseNestor F Gonzalez-Cadavid
Department of Urology, David Geffen School of Medicine at UCLA, USA
Nat Clin Pract Urol 2:291-7. 2005..Both processes seem to be related to activation of fibroblast/myofibroblast differentiation in the tunica albuginea and to osteogenic commitment of stem cells in this tissue... - Experimental models of Peyronie's disease. Implications for new therapiesNestor F Gonzalez-Cadavid
Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center Urology Research Laboratory, Torrance, CA, USA
J Sex Med 6:303-13. 2009..The development of animal and cell culture models has advanced substantially the understanding of its molecular and cellular pathology and the proposal of new therapies... - Presence of NMDA receptor subunits in the male lower urogenital tractN F Gonzalez-Cadavid
Department of Urology, University of California at Los Angeles School of Medicine, Harbor UCLA Medical Center, Torrance 90509, USA
J Androl 21:566-78. 2000..Further work is necessary to determine whether the NMDAR subunits form a fully active receptor and participate in the control of organ tone that is relevant to male sexual activity... - The pleiotropic effects of inducible nitric oxide synthase (iNOS) on the physiology and pathology of penile erectionN F Gonzalez-Cadavid
LABioMed at Harbor UCLA Medical Center, Torrance, CA, and Department of Urology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
Curr Pharm Des 11:4041-6. 2005.... - Expression of penile neuronal nitric oxide synthase variants in the rat and mouse penile nervesN F Gonzalez-Cadavid
Department of Urology, UCLA School of Medicine, Harbor UCLA Medical Center, Torrance, California 90509, USA
Biol Reprod 63:704-14. 2000.... - Gene therapy of erectile dysfunction in the rat with penile neuronal nitric oxide synthaseThomas R Magee
Department of Urology, UCLA School of Medicine, Los Angeles, California 90509, USA
Biol Reprod 67:1033-41. 2002..In conclusion, intracavernosal gene therapy with PnNOS cDNA corrected the aging-related erectile dysfunction for at least 18 days when given by electroporation in a helper-dependent AdV at low viral loads... - Myostatin short interfering hairpin RNA gene transfer increases skeletal muscle massThomas R Magee
Department of Urology, David Geffen School of Medicine, UCLA, Los Angeles, CA 90024, USA
J Gene Med 8:1171-81. 2006..We investigated whether a plasmid expressing a short hairpin interfering RNA (shRNA) against myostatin and transduced using electroporation would increase local skeletal muscle mass... - Antisense and short hairpin RNA (shRNA) constructs targeting PIN (Protein Inhibitor of NOS) ameliorate aging-related erectile dysfunction in the ratThomas R Magee
Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, CA, USA
J Sex Med 4:633-43. 2007..Over-expression of penile neuronal nitric oxide synthase (PnNOS) from a plasmid ameliorates aging-related erectile dysfunction (ED), whereas over-expression of the protein inhibitor of NOS (PIN), that binds to nNOS, increases ED... - Myostatin promotes a fibrotic phenotypic switch in multipotent C3H 10T1/2 cells without affecting their differentiation into myofibroblastsJorge N Artaza
Division of Endocrinology Metabolism and Molecular Medicine and RCMI Molecular Core, The Charles R Drew University of Medicine and Science, 1731 East 120th Street, Los Angeles, California, 90059 USA
J Endocrinol 196:235-49. 2008.... - Androgens stimulate myogenic differentiation and inhibit adipogenesis in C3H 10T1/2 pluripotent cells through an androgen receptor-mediated pathwayRajan Singh
Division of Endocrinology, Metabolism, and Molecular Medicine, Charles R Drew University of Medicine and Science, Los Angeles, California 90059, USA
Endocrinology 144:5081-8. 2003..The observation that differentiation of pluripotent cells is androgen dependent provides a unifying explanation for the reciprocal effects of androgens on muscle and fat mass in men... - Effect of muscle-derived stem cells on the restoration of corpora cavernosa smooth muscle and erectile function in the aged ratGaby Nolazco
Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Urology Research Laboratory, Torrance, CA 90509, USA
BJU Int 101:1156-64. 2008.... - Early onset of fibrosis within the arterial media in a rat model of type 2 diabetes mellitus with erectile dysfunctionIstvan Kovanecz
Division of Urology at Harbor UCLA Medical Center, Urology Research Laboratory, Los Angeles Biomedical Research Institute, Torrance, CA 90502, USA
BJU Int 103:1396-404. 2009.... - L-arginine and phosphodiesterase (PDE) inhibitors counteract fibrosis in the Peyronie's fibrotic plaque and related fibroblast culturesEliane G A Valente
Division of Urology, Research and Education Institute, Harbor-UCLA Medical Center, Torrance, CA, USA
Nitric Oxide 9:229-44. 2003.... - Ageing-related corpora veno-occlusive dysfunction in the rat is ameliorated by pioglitazoneIstvan Kovanecz
Urology Research Laboratory, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, CA, USA
BJU Int 100:867-74. 2007.... - Vardenafil prevents fibrosis and loss of corporal smooth muscle that occurs after bilateral cavernosal nerve resection in the ratMonica G Ferrini
Department of Urology, University of California, Los Angeles, David Geffen School of Medicine, Los Angeles, California, USA
Urology 68:429-35. 2006..We aimed to determine whether bilateral cavernosal nerve resection (BCNX) in the rat leads to CVOD and whether long-term phosphodiesterase-5 inhibition ameliorates these histologic and functional impairments... - Increased vaginal oxidative stress, apoptosis, and inducible nitric oxide synthase in a diabetic rat model: implications for vaginal fibrosisMonica G Ferrini
Department of Urology, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, California, USA
Fertil Steril 86:1152-63. 2006..To determine whether vaginal fibrosis occurs in diabetic animals and is associated with oxidative stress and cell death and with the expression of inducible nitric oxide synthase (iNOS), as a putative antifibrotic mechanism... - Effect of nitric oxide on the differentiation of fibroblasts into myofibroblasts in the Peyronie's fibrotic plaque and in its rat modelDolores Vernet
Division of Urology, Research and Education Institute, Harbor-UCLA Medical Center, Torrance, CA 90509, USA
Nitric Oxide 7:262-76. 2002.... - Separate or combined treatments with daily sildenafil, molsidomine, or muscle-derived stem cells prevent erectile dysfunction in a rat model of cavernosal nerve damageIstvan Kovanecz
Department of Surgery, Division of Urology, Los Angeles Biomedical Research Institute LABioMed at Harbor UCLA Medical Center, Torrance, CA, USA
J Sex Med 9:2814-26. 2012..In the aging rat model, corporal implantation of skeletal muscle-derived stem cells (MDSC) reverses CVOD. Nitric oxide (NO) and cyclic guanosine monophosphate can modulate stem cell lineage... - Myostatin inhibits myogenesis and promotes adipogenesis in C3H 10T(1/2) mesenchymal multipotent cellsJorge N Artaza
Division of Endocrinology, Metabolism, and Molecular Medicine, Charles R Drew University of Medicine and Science, 1731 East 120th Street, Los Angeles, California 90059, USA
Endocrinology 146:3547-57. 2005..In conclusion, myostatin promotes the differentiation of multipotent mesenchymal cells into the adipogenic lineage and inhibits myogenesis... - Profibrotic role of myostatin in Peyronie's diseaseLiliana P Cantini
Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Urology Research Laboratory, Los Angeles, CA, USA
J Sex Med 5:1607-22. 2008..The primary histologic finding in many urologic disorders, including Peyronie's disease (PD), is fibrosis, mainly mediated by the transforming growth factor beta1 (TGFbeta1)... - Gene therapy of erectile dysfunction in the rat with penile neuronal nitric oxide synthaseThomas R Magee
Department of Urology, UCLA School of Medicine, Los Angeles, CA 90509, USA
Biol Reprod 67:20-8. 2002..In conclusion, intracavernosal gene therapy with PnNOS cDNA corrected the aging-related erectile dysfunction for at least 18 days when given by electroporation in a helper-dependent AdV at low viral loads... - Gene transfer of inducible nitric oxide synthase complementary DNA regresses the fibrotic plaque in an animal model of Peyronie's diseaseHugo H Davila
Department of Urology, UCLA School of Medicine, Los Angeles, California 90095, USA
Biol Reprod 71:1568-77. 2004..The piNOS gene transfer regressed the PD plaque and expression of profibrotic factors, supporting the view that endogenous iNOS induction in PD is defense mechanism by the tissue against fibrosis... - Penile neuronal nitric oxide synthase and its regulatory proteins are present in hypothalamic and spinal cord regions involved in the control of penile erectionMonica G Ferrini
Research and Education Institute, Harbor UCLA Medical Center, Torrance, California 90502, USA
J Comp Neurol 458:46-61. 2003..These results indicate that both nNOS variants, and their respective regulatory proteins are present and colocalize in the hypothalamic and spinal cord regions involved in penile erection... - The genetic inactivation of inducible nitric oxide synthase (iNOS) intensifies fibrosis and oxidative stress in the penile corpora cavernosa in type 1 diabetesMonica G Ferrini
Charles Drew University CDU, Department of Internal Medicine, Los Angeles, CA, USA
J Sex Med 7:3033-44. 2010..Endogenously elicited inducible nitric oxide synthase (iNOS) induction counteracts fibrosis and oxidative stress in penile tissues in rat models of Peyronie's disease and erectile dysfunction... - Evidence that osteogenic progenitor cells in the human tunica albuginea may originate from stem cells: implications for peyronie diseaseDolores Vernet
Department of Urology, UCLA School of Medicine, Los Angeles, California 90095, USA
Biol Reprod 73:1199-210. 2005..This may explain progression of fibrosis in the PD plaque and its eventual calcification... - Alterations in myostatin expression are associated with changes in cardiac left ventricular mass but not ejection fraction in the mouseJorge N Artaza
Division of Endocrinology Metabolism and Molecular Medicine, Charles R Drew University of Medicine and Science, Los Angeles, CA 90059, USA
J Endocrinol 194:63-76. 2007..In conclusion, Mst does not affect cardiac systolic function in mice overexpressing or lacking the active protein, but it reduces cardiac mass and cardiomyocyte proliferation... - Testosterone inhibits adipogenic differentiation in 3T3-L1 cells: nuclear translocation of androgen receptor complex with beta-catenin and T-cell factor 4 may bypass canonical Wnt signaling to down-regulate adipogenic transcription factorsRajan Singh
Division of Endocrinology, Metabolism, and Molecular Medicine, Charles R Drew School of Medicine, Los Angeles, California 90059, USA
Endocrinology 147:141-54. 2006..These data provide evidence for a regulatory role for androgens in inhibiting adipogenic differentiation and a mechanistic explanation consistent with the observed reduction in fat mass in men treated with androgens... - Lower skeletal muscle mass in male transgenic mice with muscle-specific overexpression of myostatinSuzanne Reisz-Porszasz
Division of Endocrinology, Metabolism and Molecular Medicine, Charles R Drew University of Medicine and Science, 1731 East 120th Street, Los Angeles, CA 90059, USA
Am J Physiol Endocrinol Metab 285:E876-88. 2003..The mechanism of gender specificity remains to be clarified... - Fibrosis and loss of smooth muscle in the corpora cavernosa precede corporal veno-occlusive dysfunction (CVOD) induced by experimental cavernosal nerve damage in the ratMonica G Ferrini
Charles Drew University, Department of Medicine, Los Angeles, CA 90059, USA
J Sex Med 6:415-28. 2009..The corporal tissue expresses inducible nitric oxide synthase (iNOS), presumably as an antifibrotic and SMC-protective response... - Endogenous expression and localization of myostatin and its relation to myosin heavy chain distribution in C2C12 skeletal muscle cellsJorge N Artaza
Division of Endocrinology, Metabolism and Molecular Medicine, Charles R Drew University of Medicine and Science, Los Angeles, California 90059, USA
J Cell Physiol 190:170-9. 2002..In conclusion, myostatin was expressed mostly in C2C12 myotubes nuclei expressing MHC-II. Its predominant nuclear localization suggests that it may play a role in transcriptional regulation... - Involvement of nitric oxide-mediated intrinsic pathway signaling in age-related increase in germ cell apoptosis in male Brown-Norway ratsAmiya P Sinha Hikim
Division of Endocrinology, Box 446, Harbor UCLA Medical Center, 1000 West Carson Street, Torrance, CA 90509, USA
J Gerontol A Biol Sci Med Sci 60:702-8. 2005.... - Aging-related induction of inducible nitric oxide synthase is vasculo-protective to the arterial mediaMonica G Ferrini
Research and Education Institute, Harbor-UCLA Medical Center, Urology, Bldg F-6, 1124 West Carson Street, Torrance, CA 90502, USA
Cardiovasc Res 61:796-805. 2004..CONCLUSIONS: These observations suggest that ED and arteriosclerosis in the aging male may share a common etiology, and that the expression of iNOS by the SMC is an attempt to counteract this fibrosis... - Pioglitazone prevents corporal veno-occlusive dysfunction in a rat model of type 2 diabetes mellitusIstvan Kovanecz
Department of Surgery, Urology Research Laboratory, Division of Urology, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA 90502, USA
BJU Int 98:116-24. 2006.... - Androgen receptor in human skeletal muscle and cultured muscle satellite cells: up-regulation by androgen treatmentIndrani Sinha-Hikim
Division of Endocrinology, Metabolism, and Molecular Medicine, Charles R Drew University of Medicine and Science, Los Angeles, California 90059, USA
J Clin Endocrinol Metab 89:5245-55. 2004..These observations support the hypothesis that androgens increase muscle mass in part by acting on several cell types to regulate the differentiation of mesenchymal precursor cells in the skeletal muscle... - Effects of long-term vardenafil treatment on the development of fibrotic plaques in a rat model of Peyronie's diseaseMonica G Ferrini
Division of Urology, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA
BJU Int 97:625-33. 2006..CONCLUSIONS: Long-term oral treatment with vardenafil slows and reverses the early stages of an experimental PD-like plaque in the rat, and might ameliorate a more advanced plaque... - Amelioration of diabetes-induced cavernosal fibrosis by antioxidant and anti-transforming growth factor-β1 therapies in inducible nitric oxide synthase-deficient miceMonica G Ferrini
Department of Internal Medicine, Charles R Drew University Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
BJU Int 109:586-93. 2012.... - The mechanisms of androgen effects on body composition: mesenchymal pluripotent cell as the target of androgen actionShalender Bhasin
Division of Endocrinology, Metabolism, and Molecular Medicine, Charles R Drew University of Medicine and Science, Los Angeles, California 90059, USA
J Gerontol A Biol Sci Med Sci 58:M1103-10. 2003..The hypothesis that the primary site of androgen action is the pluripotent stem cell provides a unifying explanation for the observed reciprocal effects of testosterone on muscle and fat mass... - Effects of sildenafil and/or muscle derived stem cells on myocardial infarctionJudy Sc Wang
Department of Surgery, Los Angeles Biomedical Research Institute LABioMed at Harbor UCLA Medical Center, Torrance, CA, USA
J Transl Med 10:159. 2012..We have now investigated whether sildenafil at lower doses and MDSC, alone or in combination are effective to attenuate LV remodeling after MI in rats... - Alteration of gene expression profiles in skeletal muscle of rats exposed to microgravity during a spaceflightWayne E Taylor
Division of Endocrinology, Metabolism, and Molecular Medicine, Charles R Drew University of Medicine and Science, Los Angeles, CA, USA
J Gravit Physiol 9:61-70. 2002..These data indicate that following exposure to microgravity, there is downregulation of genes involved in regulation of muscle satellite cell replication... - Peyronie's disease: a reviewShahram S Gholami
Knupps Molecular Urology Laboratory, Department of Urology, School of Medicine, University of California, San Francisco, 94143, USA
J Urol 169:1234-41. 2003..CONCLUSIONS: Currently patients with Peyronie's disease have had improvements in prognosis and experienced an expansion of the available therapeutic options... - Gene expression profiles in the Peyronie's disease plaqueThomas R Magee
Department of Urology, University of California, Los Angeles, School of Medicine, Los Angeles, California 90509, USA
Urology 59:451-7. 2002.... - Treatment of Peyronie's disease with PDE5 inhibitors: an antifibrotic strategyNestor F Gonzalez-Cadavid
Department of Urology, David Geffen School of Medicine at UCLA, and Los Angeles Biomedical Research Institute LABioMed at Harbor UCLA Medical Center, Building F 6, 1124 West Carson Street, Torrance, CA 90502, USA
Nat Rev Urol 7:215-21. 2010.... - Peyronie's disease associated with increase in plasminogen activator inhibitor in fibrotic plaqueHugo H Davila
Department of Urology, University of California, Los Angeles, School of Medicine, Los Angeles, California, USA
Urology 65:645-8. 2005..CONCLUSIONS: The observed increase in PAI-1 in the human PD plaque agrees with what has been observed in the rat and suggests that PAI-1 may be a key pro-fibrotic factor in the development of human PD... - Involvement of oxidative stress and caspase 2-mediated intrinsic pathway signaling in age-related increase in muscle cell apoptosis in miceMelissa Braga
Division of Endocrinology, Metabolism, and Molecular Medicine, Charles R Drew University, Los Angeles, CA 90059, USA
Apoptosis 13:822-32. 2008..Taken together, our data indicate that caspase 2 and JNK-mediated intrinsic pathway signaling is one of the mechanisms involved in age-related increase in muscle cell apoptosis... - Stimulating vaginal repair in rats through skeletal muscle-derived stem cells seeded on small intestinal submucosal scaffoldsMatthew H Ho
Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, California 90502, USA
Obstet Gynecol 114:300-9. 2009.... - Correlation of androgen receptors, aromatase, and 5-alpha reductase in the human vagina with menopausal statusJennifer R Berman
Department of Urology, Harbor UCLA Medical Center, Torrance, California, USA
Fertil Steril 79:925-31. 2003..To determine whether aromatase and 5alpha-reductase mRNAs are expressed in human vagina and to evaluate the presence of androgen receptors in human vaginal tissue based on age and menopausal status... - Male reproductive ageing: using the brown Norway rat as a model for manChristina Wang
Department of Medicine, Harbor-UCLA Medical Center and Research and Education Institute, Carson, CA 90509, USA
Novartis Found Symp 242:82-95; discussion 95-7. 2002....
Research Grants
- CELL-SELECTIVE EXPRESSION OF FIBROTIC GENE PATHWAYSNestor Gonzalez Cadavid; Fiscal Year: 2007..We expect that our studies would lead to the detection of novel targets of antifibrotic therapy for penile and vascular diseases of considerable public health impact. ..
- ERECTILE DYSFUNCTION AND NITRIC OXIDE SYNTHASE IN AGINGNestor Gonzalez Cadavid; Fiscal Year: 2006....
- ERECTILE DYSFUNCTION AND NITRIC OXIDE SYNTHASE IN AGINGNestor Gonzalez Cadavid; Fiscal Year: 2001..The long-term goal is to validate pre-clinically the use of these agents for medical treatment of erectile dysfunction associated with aging. ..