P Gonzalez-Alegre

Summary

Affiliation: University of Iowa
Country: USA

Publications

  1. ncbi Aberrant cellular behavior of mutant torsinA implicates nuclear envelope dysfunction in DYT1 dystonia
    Pedro Gonzalez-Alegre
    Department of Neurology, Carver College of Medicine at The University of Iowa, Iowa City, Iowa 52242, USA
    J Neurosci 24:2593-601. 2004
  2. pmc Severe interscapular pain and increased creatine kinase activity: the answer was in the ankles
    P Gonzalez-Alegre
    Department of Neurology, University of Iowa Hospitals and Clinics, 200 Hawkins Drive, Iowa City, IA 52242, USA
    Emerg Med J 22:152-3. 2005
  3. pmc Transcriptional and proteomic profiling in a cellular model of DYT1 dystonia
    J N Martin
    Graduate Program in Genetics, The University of Iowa, Iowa City, IA, USA
    Neuroscience 164:563-72. 2009
  4. pmc The ubiquitin ligase F-box/G-domain protein 1 promotes the degradation of the disease-linked protein torsinA through the ubiquitin-proteasome pathway and macroautophagy
    K L Gordon
    Graduate Program of Neuroscience, University of Iowa, Iowa City, IA 52242, USA
    Neuroscience 224:160-71. 2012
  5. ncbi Silencing primary dystonia: lentiviral-mediated RNA interference therapy for DYT1 dystonia
    Pedro Gonzalez-Alegre
    Department of Neurology, Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA
    J Neurosci 25:10502-9. 2005
  6. ncbi Therapeutic RNA interference for neurodegenerative diseases: From promise to progress
    Pedro Gonzalez-Alegre
    Department of Neurology, 2 RCP, Carver College of Medicine at The University of Iowa, Iowa City, IA 52242, United States
    Pharmacol Ther 114:34-55. 2007
  7. doi Descriptions of cervical dystonia by Sir Charles Bell
    Pedro Gonzalez-Alegre
    Department of Neurology, University of Iowa Hospitals and Clinics, Iowa City, Iowa 52242 1101, USA
    Mov Disord 25:257-9. 2010
  8. ncbi Monomelic parkinsonian tremor caused by contralateral substantia nigra stroke
    Pedro Gonzalez-Alegre
    Department of Neurology, University of Iowa College of Medicine, Iowa, USA
    Parkinsonism Relat Disord 13:182-4. 2007
  9. ncbi Silencing neurodegenerative disease: bringing RNA interference to the clinic
    Edgardo Rodriguez-Lebron
    Department of Neurology, Carver College of Medicine, University of Iowa, Iowa City, IA 52242 1101, USA
    Expert Rev Neurother 6:223-33. 2006
  10. pmc Lethal toxicity caused by expression of shRNA in the mouse striatum: implications for therapeutic design
    J N Martin
    Graduate Program in Genetics, University of Iowa, Iowa City, IA, USA
    Gene Ther 18:666-73. 2011

Detail Information

Publications20

  1. ncbi Aberrant cellular behavior of mutant torsinA implicates nuclear envelope dysfunction in DYT1 dystonia
    Pedro Gonzalez-Alegre
    Department of Neurology, Carver College of Medicine at The University of Iowa, Iowa City, Iowa 52242, USA
    J Neurosci 24:2593-601. 2004
    ..DYT1 dystonia can be added to the growing list of inherited neurological disorders involving the NE...
  2. pmc Severe interscapular pain and increased creatine kinase activity: the answer was in the ankles
    P Gonzalez-Alegre
    Department of Neurology, University of Iowa Hospitals and Clinics, 200 Hawkins Drive, Iowa City, IA 52242, USA
    Emerg Med J 22:152-3. 2005
    ..This case expands the differential diagnosis of severe thoracic back pain and increased creatine kinase activity, and illustrates the importance of physical examination in reaching a final diagnosis...
  3. pmc Transcriptional and proteomic profiling in a cellular model of DYT1 dystonia
    J N Martin
    Graduate Program in Genetics, The University of Iowa, Iowa City, IA, USA
    Neuroscience 164:563-72. 2009
    ..In conclusion, our results argue against the hypothesis of transcriptional dysregulation in DYT1 dystonia, suggesting potential alternative pathogenic pathways...
  4. pmc The ubiquitin ligase F-box/G-domain protein 1 promotes the degradation of the disease-linked protein torsinA through the ubiquitin-proteasome pathway and macroautophagy
    K L Gordon
    Graduate Program of Neuroscience, University of Iowa, Iowa City, IA 52242, USA
    Neuroscience 224:160-71. 2012
    ..In summary, our studies support a non-essential role for FBG1 on the degradation of torsinA and uncover a novel link of FBG1 to the autophagy pathway...
  5. ncbi Silencing primary dystonia: lentiviral-mediated RNA interference therapy for DYT1 dystonia
    Pedro Gonzalez-Alegre
    Department of Neurology, Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA
    J Neurosci 25:10502-9. 2005
    ..These results support the potential use of viral-mediated RNAi as a therapy for DYT1 dystonia and establish the basis for preclinical testing in animal models of the disease...
  6. ncbi Therapeutic RNA interference for neurodegenerative diseases: From promise to progress
    Pedro Gonzalez-Alegre
    Department of Neurology, 2 RCP, Carver College of Medicine at The University of Iowa, Iowa City, IA 52242, United States
    Pharmacol Ther 114:34-55. 2007
    ..Finally, the different preclinical trials of therapeutic RNAi completed in disease models will be summarized, stressing the experimental questions that need to be addressed before planning application in human disease...
  7. doi Descriptions of cervical dystonia by Sir Charles Bell
    Pedro Gonzalez-Alegre
    Department of Neurology, University of Iowa Hospitals and Clinics, Iowa City, Iowa 52242 1101, USA
    Mov Disord 25:257-9. 2010
    ....
  8. ncbi Monomelic parkinsonian tremor caused by contralateral substantia nigra stroke
    Pedro Gonzalez-Alegre
    Department of Neurology, University of Iowa College of Medicine, Iowa, USA
    Parkinsonism Relat Disord 13:182-4. 2007
    ....
  9. ncbi Silencing neurodegenerative disease: bringing RNA interference to the clinic
    Edgardo Rodriguez-Lebron
    Department of Neurology, Carver College of Medicine, University of Iowa, Iowa City, IA 52242 1101, USA
    Expert Rev Neurother 6:223-33. 2006
    ..This review summarizes the advances in the design of therapeutic RNAi for neurodegenerative diseases and discusses some of the experimental steps required to bring this therapy to human clinical trials...
  10. pmc Lethal toxicity caused by expression of shRNA in the mouse striatum: implications for therapeutic design
    J N Martin
    Graduate Program in Genetics, University of Iowa, Iowa City, IA, USA
    Gene Ther 18:666-73. 2011
    ..Furthermore, the genetic background of rodents modifies their sensitivity to this form of toxicity, a factor that should be taken into consideration in the design of preclinical therapeutic RNAi trials...
  11. pmc Consequences of the DYT1 mutation on torsinA oligomerization and degradation
    K L Gordon
    Interdisciplinary Graduate Program in Neuroscience, Carver College of Medicine, The University of Iowa, Iowa City, IA 52242, USA
    Neuroscience 157:588-95. 2008
    ....
  12. ncbi The inherited dystonias
    Pedro Gonzalez-Alegre
    Department of Neurology, Carver College of Medicine at The University of Iowa, Iowa City 52242, USA
    Semin Neurol 27:151-8. 2007
    ..Finally, a brief summary of the most significant recent advances in this field will focus on those aspects most helpful to the clinician...
  13. ncbi Technology insight: therapeutic RNA interference--how far from the neurology clinic?
    Pedro Gonzalez-Alegre
    University of Iowa, Iowa City, IA, USA
    Nat Clin Pract Neurol 3:394-404. 2007
    ....
  14. pmc Delineation of the motor disorder of Lesch-Nyhan disease
    H A Jinnah
    Department of Neurology, University of Maryland School of Medicine, Baltimore, MD, USA
    Brain 129:1201-17. 2006
    ..Explanations for the differing observations available in the literature are provided, along with a summary of how the motor disorder of LND relates to current understanding of its pathophysiology involving the basal ganglia...
  15. ncbi Toward therapy for DYT1 dystonia: allele-specific silencing of mutant TorsinA
    Pedro Gonzalez-Alegre
    Department of Neurology, University of Iowa College of Medicine, Iowa City, IA 52242, USA
    Ann Neurol 53:781-7. 2003
    ..Our siRNA studies demonstrate allele-specific targeting of a dominant neurogenetic disease gene and suggest the broad therapeutic potential of siRNA for DYT1 dystonia and other dominantly inherited neurological diseases...
  16. ncbi RNA interference in neuroscience: progress and challenges
    Victor M Miller
    Department of Neurology, University of Iowa Roy J and Lucille A Carver College of Medicine, Iowa City, IA 52242 1101, USA
    Cell Mol Neurobiol 25:1195-207. 2005
    ..We then describe the methods developed to manipulate RNAi in the laboratory and its applications to neuroscience. Finally, we focus on the potential therapeutic application of RNAi to neurological disease...
  17. doi Lentivirus-mediated RNA interference in mammalian neurons
    Scott Q Harper
    Department of Pediatrics, Ohio State University, Center for Gene Therapy, Columbus, OH, USA
    Methods Mol Biol 442:95-112. 2008
    ..We provide a practical approach to accomplish siRNA-mediated silencing of the disease-linked protein torsinA in primary neuronal cultures through the generation of lentiviral vectors expressing shRNAs...
  18. ncbi RNAi gets its prize
    Henry Paulson
    Lancet Neurol 5:997-9. 2006
  19. ncbi Isolated high-frequency jaw tremor relieved by botulinum toxin injections
    Pedro Gonzalez-Alegre
    Department of Neurology, University of Iowa College of Medicine, Iowa City, Iowa 52242 1101, USA
    Mov Disord 21:1049-50. 2006
    ..We encountered a similar patient with intermittent rapid focal jaw tremor that was successfully treated with botulinum toxin injections to the masseters...
  20. pmc Idiopathic brachial neuritis
    Pedro Gonzalez-Alegre
    Department of Neurology, University of Iowa College of Medicine, Iowa City 52242, USA
    Iowa Orthop J 22:81-5. 2002
    ..We present a case of idiopathic brachial neuritis and discuss important aspects of the disease and difficulties in reaching the correct diagnosis...