RUEBEN GONZALES

Summary

Affiliation: University of Texas
Country: USA

Publications

  1. ncbi request reprint The role of mesolimbic dopamine in the development and maintenance of ethanol reinforcement
    Rueben A Gonzales
    Department of Pharmacology, College of Pharmacy, The University of Texas at Austin, 1 University Station A1915, Austin, TX 78712 0125, USA
    Pharmacol Ther 103:121-46. 2004
  2. ncbi request reprint Effect of operant self-administration of 10% ethanol plus 10% sucrose on dopamine and ethanol concentrations in the nucleus accumbens
    William M Doyon
    Division of Pharmacology, College of Pharmacy, University of Texas, Austin, Texas 78712 0125, USA
    J Neurochem 93:1469-81. 2005
  3. pmc The dopamine response in the nucleus accumbens core-shell border differs from that in the core and shell during operant ethanol self-administration
    Elaina C Howard
    Department of Pharmacology, College of Pharmacy, The University of Texas at Austin, Austin, Texas 78712, USA
    Alcohol Clin Exp Res 33:1355-65. 2009
  4. ncbi request reprint Reduced basal and ethanol stimulation of striatal extracellular dopamine concentrations in dopamine D2 receptor knockout mice
    Martin O Job
    The University of Texas at Austin, PHAR Pharmacology, Austin, Texas 78712, USA
    Synapse 60:158-64. 2006
  5. pmc A 3-day exposure to 10% ethanol with 10% sucrose successfully initiates ethanol self-administration
    Jennifer Carrillo
    College of Pharmacy, Department of Pharmacology, The University of Texas at Austin, Austin, TX 78712, USA
    Alcohol 42:171-8. 2008
  6. ncbi request reprint Accumbal dopamine concentration during operant self-administration of a sucrose or a novel sucrose with ethanol solution
    William M Doyon
    Division of Pharmacology, College of Pharmacy, University of Texas at Austin, PHAR Pharmacology, 1 University Station A1915, Austin, TX 78712, USA
    Alcohol 34:261-71. 2004
  7. ncbi request reprint Dopamine activity in the nucleus accumbens during consummatory phases of oral ethanol self-administration
    William M Doyon
    Division of Pharmacology, College of Pharmacy, University of Texas, Austin, Texas 78712, USA
    Alcohol Clin Exp Res 27:1573-82. 2003
  8. pmc Role of 5-hydroxytryptamine2C receptors in Ca2+-dependent ethanol potentiation of GABA release onto ventral tegmental area dopamine neurons
    Jonathan W Theile
    Cell and Molecular Biology, College of Pharmacy, University of Texas, Austin, TX 78712 0125, USA
    J Pharmacol Exp Ther 329:625-33. 2009
  9. ncbi request reprint Characterization of probe and tissue factors that influence interpretation of quantitative microdialysis experiments for dopamine
    Amanda Tang
    Division of Pharmacology and Toxicology, College of Pharmacy, University of Texas at Austin, Austin, TX 78712, USA
    J Neurosci Methods 126:1-11. 2003
  10. pmc Mu (mu) opioid receptor regulation of ethanol-induced dopamine response in the ventral striatum: evidence of genotype specific sexual dimorphic epistasis
    Martin O Job
    Division of Pharmacology, College of Pharmacy, University of Texas, 1 University Station, Austin, TX 78712, USA
    Biol Psychiatry 62:627-34. 2007

Research Grants

Collaborators

Detail Information

Publications15

  1. ncbi request reprint The role of mesolimbic dopamine in the development and maintenance of ethanol reinforcement
    Rueben A Gonzales
    Department of Pharmacology, College of Pharmacy, The University of Texas at Austin, 1 University Station A1915, Austin, TX 78712 0125, USA
    Pharmacol Ther 103:121-46. 2004
    ..Thus, anatomical, pharmacological, neurochemical, cellular, and behavioral studies are more clearly defining the role of mesolimbic dopamine in ethanol reinforcement...
  2. ncbi request reprint Effect of operant self-administration of 10% ethanol plus 10% sucrose on dopamine and ethanol concentrations in the nucleus accumbens
    William M Doyon
    Division of Pharmacology, College of Pharmacy, University of Texas, Austin, Texas 78712 0125, USA
    J Neurochem 93:1469-81. 2005
    ..The dopamine response may be related to the stimulus properties of ethanol presentation, which were strongest during consumption...
  3. pmc The dopamine response in the nucleus accumbens core-shell border differs from that in the core and shell during operant ethanol self-administration
    Elaina C Howard
    Department of Pharmacology, College of Pharmacy, The University of Texas at Austin, Austin, Texas 78712, USA
    Alcohol Clin Exp Res 33:1355-65. 2009
    ....
  4. ncbi request reprint Reduced basal and ethanol stimulation of striatal extracellular dopamine concentrations in dopamine D2 receptor knockout mice
    Martin O Job
    The University of Texas at Austin, PHAR Pharmacology, Austin, Texas 78712, USA
    Synapse 60:158-64. 2006
    ..In addition, the blunted ethanol-evoked DA response in the D2 knockouts may contribute, in part, to some of the behavioral deficits previously observed in response to ethanol...
  5. pmc A 3-day exposure to 10% ethanol with 10% sucrose successfully initiates ethanol self-administration
    Jennifer Carrillo
    College of Pharmacy, Department of Pharmacology, The University of Texas at Austin, Austin, TX 78712, USA
    Alcohol 42:171-8. 2008
    ..Blood alcohol concentrations were 4.5 mM 20 min after consumption began. We conclude that initiation and establishment of ethanol self-administration will occur using this modified sucrose-fading procedure...
  6. ncbi request reprint Accumbal dopamine concentration during operant self-administration of a sucrose or a novel sucrose with ethanol solution
    William M Doyon
    Division of Pharmacology, College of Pharmacy, University of Texas at Austin, PHAR Pharmacology, 1 University Station A1915, Austin, TX 78712, USA
    Alcohol 34:261-71. 2004
    ..In addition, oral self-administration of ethanol at 0.27 +/- 0.02 g/kg over 20 min is not sufficient for stimulation of dopamine activity in the nucleus accumbens...
  7. ncbi request reprint Dopamine activity in the nucleus accumbens during consummatory phases of oral ethanol self-administration
    William M Doyon
    Division of Pharmacology, College of Pharmacy, University of Texas, Austin, Texas 78712, USA
    Alcohol Clin Exp Res 27:1573-82. 2003
    ..Furthermore, we sought to define the relationship between ethanol in the brain and the accumbal dopamine response after oral self-administration of ethanol...
  8. pmc Role of 5-hydroxytryptamine2C receptors in Ca2+-dependent ethanol potentiation of GABA release onto ventral tegmental area dopamine neurons
    Jonathan W Theile
    Cell and Molecular Biology, College of Pharmacy, University of Texas, Austin, TX 78712 0125, USA
    J Pharmacol Exp Ther 329:625-33. 2009
    ..These observations suggest that an increase in Ca(2+) release from intracellular stores via 5-HT(2C) receptor activation is involved in the ethanol-induced enhancement of GABA release onto VTA-DA neurons...
  9. ncbi request reprint Characterization of probe and tissue factors that influence interpretation of quantitative microdialysis experiments for dopamine
    Amanda Tang
    Division of Pharmacology and Toxicology, College of Pharmacy, University of Texas at Austin, Austin, TX 78712, USA
    J Neurosci Methods 126:1-11. 2003
    ..These findings are consistent with a decrease in physiological viability of the dopamine nerve terminals surrounding the probe during a long-term experiment...
  10. pmc Mu (mu) opioid receptor regulation of ethanol-induced dopamine response in the ventral striatum: evidence of genotype specific sexual dimorphic epistasis
    Martin O Job
    Division of Pharmacology, College of Pharmacy, University of Texas, 1 University Station, Austin, TX 78712, USA
    Biol Psychiatry 62:627-34. 2007
    ..Mu (mu)-opioid (MOP) receptors modulate accumbal dopamine activity, but it is not clear whether MOP receptors are involved in the mechanism of ethanol-stimulated accumbal dopamine release...
  11. ncbi request reprint Ethanol preference is inversely correlated with ethanol-induced dopamine release in 2 substrains of C57BL/6 mice
    Vorani Ramachandra
    University of Texas at Austin, Pharmacology PHAR, Austin, Texas 78712, USA
    Alcohol Clin Exp Res 31:1669-76. 2007
    ..Differences in ethanol-induced dopamine release in the ventral striatum could contribute to this variability in drinking behavior as dopamine has been implicated in the reinforcing properties of ethanol...
  12. ncbi request reprint Effect of gender and estrous cycle on the pharmacokinetics of ethanol in the rat brain
    Donita L Robinson
    College of Pharmacy, University of Texas, Austin, Texas, USA
    Alcohol Clin Exp Res 26:165-72. 2002
    ..This study used quantitative microdialysis to measure ethanol pharmacokinetics in the nucleus accumbens after a moderate dose of ethanol, comparing males with females and females across the estrous cycle...
  13. ncbi request reprint Ethanol increases extracellular dopamine concentration in the ventral striatum in C57BL/6 mice
    Amanda Tang
    College of Pharmacy, University of Texas at Austin, USA
    Alcohol Clin Exp Res 27:1083-9. 2003
    ..Mesolimbic dopamine is thought to play a role in the reinforcing properties of ethanol, but ethanol-induced changes in extracellular dopamine in the ventral striatum have not been well characterized in mouse models...
  14. pmc Kappa-opioid receptor modulation of accumbal dopamine concentration during operant ethanol self-administration
    William M Doyon
    Department of Neuroscience, Baylor College of Medicine, Houston, TX 77030, USA
    Neuropharmacology 51:487-96. 2006
    ..Despite these neurochemical changes, NOR-BNI did not alter operant responding or ethanol intake, suggesting that the KOPr is not involved in ethanol-reinforced behavior under the limited conditions we studied...
  15. pmc Repeated ethanol intoxication induces behavioral sensitization in the absence of a sensitized accumbens dopamine response in C57BL/6J and DBA/2J mice
    Agustin Zapata
    Integrative Neuroscience Section, Behavioral Neuroscience Branch National Institute on Drug Abuse Intramural Research Program, Baltimore, MD 21224, USA
    Neuropsychopharmacology 31:396-405. 2006
    ..These results suggest that, at least in the case of ethanol, sensitization of the DA mesolimbic system may not be necessary for the development of behavioral sensitization...

Research Grants18

  1. Mu receptors and ethanol/dopamine interactions
    RUEBEN GONZALES; Fiscal Year: 2007
    ..Together, the proposed experiments will elucidate the role of mu opiate receptors in the modulation of mesolimbic dopamine activity by ethanol. ..
  2. NEUROCHEMICAL MECHANISMS OF ETHANOL SELF-ADMINISTRATION
    RUEBEN GONZALES; Fiscal Year: 2007
    ..Together the experiments proposed will provide new data on the role of dopamine in the early stages of the development of ethanol reinforcement in a behaviorally relevant context. ..
  3. NEUROCHEMICAL AND BEHAVIORAL CORRELATES OF ETOH EFFECTS
    RUEBEN GONZALES; Fiscal Year: 2007
    ..We will continue to focus on minority recruitment. The training program has an excellent record and will continue to focus on producing well qualified alcohol researchers. ..
  4. Modulation of Effects of Repeated Ethanol Administratio*
    RUEBEN GONZALES; Fiscal Year: 2005
    ..abstract_text> ..
  5. NEUROCHEMICAL MECHANISMS OF ETHANOL SELF-ADMINISTRATION
    RUEBEN GONZALES; Fiscal Year: 2002
    ..Increased understanding of the neurochemical mechanisms which underlie ethanol self-administration behavior may lead to new approaches for therapy of alcohol abuse and alcoholism. ..
  6. Mu receptors and ethanol/dopamine interactions
    RUEBEN GONZALES; Fiscal Year: 2009
    ..Together, the proposed experiments will elucidate the role of mu opiate receptors in the modulation of mesolimbic dopamine activity by ethanol. ..