Genomes and Genes
Michael L Gonzales
Affiliation: University of California
- The role of MeCP2 in brain development and neurodevelopmental disordersMichael L Gonzales
School of Medicine, Medical Microbiology and Immunology, University of California, Davis, One Shields Avenue, Davis, CA 95616, USA
Curr Psychiatry Rep 12:127-34. 2010..As MeCP2 occupies a central role in the pathogenesis of multiple neurodevelopmental disorders, continued investigation into MeCP2 function and regulatory pathways may show promise for developing broad-spectrum therapies...
- R-loop formation at Snord116 mediates topotecan inhibition of Ube3a-antisense and allele-specific chromatin decondensationWeston T Powell
Medical Microbiology and Immunology, Genome Center, Medical Investigation of Neurodevelopmental Disorders Institute, and Department of Molecular and Cellular Biology, University of California, Davis, CA 95616, USA
Proc Natl Acad Sci U S A 110:13938-43. 2013..Our study holds promise for targeted therapies to the Snord116 locus for both AS and PWS. ..
- Mice with an isoform-ablating Mecp2 exon 1 mutation recapitulate the neurologic deficits of Rett syndromeDag H Yasui
Department of Medical Microbiology and Immunology, UC Davis, Davis, CA, USA
Hum Mol Genet 23:2447-58. 2014..Furthermore, MeCP2-e1 exhibited enhanced stability compared with MeCP2-e2 in neurons. Therefore, MeCP2-e1 deficient mice implicate MeCP2-e1 as the sole contributor to RTT with non-redundant functions. ..
- Phosphorylation of distinct sites in MeCP2 modifies cofactor associations and the dynamics of transcriptional regulationMichael L Gonzales
Medical Microbiology and Immunology, Genome Center, University of California, Davis, California, USA
Mol Cell Biol 32:2894-903. 2012..These results demonstrate that phosphorylation is one of several factors that are important for interpreting the complexities of MeCP2 transcriptional modulation...