Michael L Gonzales

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc The role of MeCP2 in brain development and neurodevelopmental disorders
    Michael L Gonzales
    School of Medicine, Medical Microbiology and Immunology, University of California, Davis, One Shields Avenue, Davis, CA 95616, USA
    Curr Psychiatry Rep 12:127-34. 2010
  2. pmc R-loop formation at Snord116 mediates topotecan inhibition of Ube3a-antisense and allele-specific chromatin decondensation
    Weston T Powell
    Medical Microbiology and Immunology, Genome Center, Medical Investigation of Neurodevelopmental Disorders Institute, and Department of Molecular and Cellular Biology, University of California, Davis, CA 95616, USA
    Proc Natl Acad Sci U S A 110:13938-43. 2013
  3. pmc Mice with an isoform-ablating Mecp2 exon 1 mutation recapitulate the neurologic deficits of Rett syndrome
    Dag H Yasui
    Department of Medical Microbiology and Immunology, UC Davis, Davis, CA, USA
    Hum Mol Genet 23:2447-58. 2014
  4. pmc Phosphorylation of distinct sites in MeCP2 modifies cofactor associations and the dynamics of transcriptional regulation
    Michael L Gonzales
    Medical Microbiology and Immunology, Genome Center, University of California, Davis, California, USA
    Mol Cell Biol 32:2894-903. 2012

Collaborators

Detail Information

Publications4

  1. pmc The role of MeCP2 in brain development and neurodevelopmental disorders
    Michael L Gonzales
    School of Medicine, Medical Microbiology and Immunology, University of California, Davis, One Shields Avenue, Davis, CA 95616, USA
    Curr Psychiatry Rep 12:127-34. 2010
    ..As MeCP2 occupies a central role in the pathogenesis of multiple neurodevelopmental disorders, continued investigation into MeCP2 function and regulatory pathways may show promise for developing broad-spectrum therapies...
  2. pmc R-loop formation at Snord116 mediates topotecan inhibition of Ube3a-antisense and allele-specific chromatin decondensation
    Weston T Powell
    Medical Microbiology and Immunology, Genome Center, Medical Investigation of Neurodevelopmental Disorders Institute, and Department of Molecular and Cellular Biology, University of California, Davis, CA 95616, USA
    Proc Natl Acad Sci U S A 110:13938-43. 2013
    ..Our study holds promise for targeted therapies to the Snord116 locus for both AS and PWS. ..
  3. pmc Mice with an isoform-ablating Mecp2 exon 1 mutation recapitulate the neurologic deficits of Rett syndrome
    Dag H Yasui
    Department of Medical Microbiology and Immunology, UC Davis, Davis, CA, USA
    Hum Mol Genet 23:2447-58. 2014
    ..Furthermore, MeCP2-e1 exhibited enhanced stability compared with MeCP2-e2 in neurons. Therefore, MeCP2-e1 deficient mice implicate MeCP2-e1 as the sole contributor to RTT with non-redundant functions. ..
  4. pmc Phosphorylation of distinct sites in MeCP2 modifies cofactor associations and the dynamics of transcriptional regulation
    Michael L Gonzales
    Medical Microbiology and Immunology, Genome Center, University of California, Davis, California, USA
    Mol Cell Biol 32:2894-903. 2012
    ..These results demonstrate that phosphorylation is one of several factors that are important for interpreting the complexities of MeCP2 transcriptional modulation...