Elena A Goncharova

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. pmc mTOR and vascular remodeling in lung diseases: current challenges and therapeutic prospects
    Elena A Goncharova
    1University of Pennsylvania Perelman School of Medicine, Translational Research Laboratories, Rm 1214, 125 South 31st St, Philadelphia, PA 19104, USA
    FASEB J 27:1796-807. 2013
  2. pmc Differential effects of formoterol on thrombin- and PDGF-induced proliferation of human pulmonary arterial vascular smooth muscle cells
    Elena A Goncharova
    Pulmonary, Allergy and Critical Care Division, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA
    Respir Res 13:109. 2012
  3. pmc Signal transducer and activator of transcription 3 is required for abnormal proliferation and survival of TSC2-deficient cells: relevance to pulmonary lymphangioleiomyomatosis
    Elena A Goncharova
    Pulmonary, Allergy, and Critical Care Division, Airways Biology Initiative, Department of Medicine, University of Pennsylvania, TRL, Room 1214, 125 South 31st St, Philadelphia, PA 19104, USA
    Mol Pharmacol 76:766-77. 2009
  4. ncbi request reprint Interferon beta augments tuberous sclerosis complex 2 (TSC2)-dependent inhibition of TSC2-null ELT3 and human lymphangioleiomyomatosis-derived cell proliferation
    Elena A Goncharova
    Department of Medicine, University of Pennsylvania, TRL Suite 1200, 125 South 31st Street, Philadelphia, PA 19104, USA
    Mol Pharmacol 73:778-88. 2008
  5. pmc Abnormal growth of smooth muscle-like cells in lymphangioleiomyomatosis: Role for tumor suppressor TSC2
    Elena A Goncharova
    Pulmonary, Allergy and Critical Care Division, Department of Medicine, University of Pennsylvania, 421 Curie Boulevard, BRB II III, Philadelphia, PA 19104 6160, USA
    Am J Respir Cell Mol Biol 34:561-72. 2006
  6. pmc Modulation of cell migration and invasiveness by tumor suppressor TSC2 in lymphangioleiomyomatosis
    Elena A Goncharova
    Department of Medicine, University of Pennsylvania, BRB II III, 421 Curie Blvd, Philadelphia, PA 19104, USA
    Am J Respir Cell Mol Biol 34:473-80. 2006
  7. ncbi request reprint Src is necessary and sufficient for human airway smooth muscle cell proliferation and migration
    Vera P Krymskaya
    Pulmonary, Allergy and Critical Care Division, Department of Medicine, University of Pennsylvania, 421 Curie Blvd, BRB II III, Philadelphia, PA 19104 6160, USA
    FASEB J 19:428-30. 2005
  8. ncbi request reprint Tuberin regulates p70 S6 kinase activation and ribosomal protein S6 phosphorylation. A role for the TSC2 tumor suppressor gene in pulmonary lymphangioleiomyomatosis (LAM)
    Elena A Goncharova
    Pulmonary, Allergy, and Critical Care Division, Department of Medicine, University of Pennsylvania, 421 Curie Boulevard, 847 BRB II III, Philadelphia, PA 19104, USA
    J Biol Chem 277:30958-67. 2002
  9. pmc Interferons modulate mitogen-induced protein synthesis in airway smooth muscle
    Elena A Goncharova
    Pulmonary, Allergy, and Critical Care Division, Airway Biology Initiative, Department of Medicine, Cardiovascular Institute, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Am J Physiol Lung Cell Mol Physiol 299:L25-35. 2010
  10. ncbi request reprint PI3K is required for proliferation and migration of human pulmonary vascular smooth muscle cells
    Elena A Goncharova
    Pulmonary, Allergy, and Critical Care Division, Department of Medicine, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104 6160, USA
    Am J Physiol Lung Cell Mol Physiol 283:L354-63. 2002

Collaborators

Detail Information

Publications23

  1. pmc mTOR and vascular remodeling in lung diseases: current challenges and therapeutic prospects
    Elena A Goncharova
    1University of Pennsylvania Perelman School of Medicine, Translational Research Laboratories, Rm 1214, 125 South 31st St, Philadelphia, PA 19104, USA
    FASEB J 27:1796-807. 2013
    ..Goncharova, E. A. mTOR and vascular remodeling in lung diseases: current challenges and therapeutic prospects...
  2. pmc Differential effects of formoterol on thrombin- and PDGF-induced proliferation of human pulmonary arterial vascular smooth muscle cells
    Elena A Goncharova
    Pulmonary, Allergy and Critical Care Division, Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA
    Respir Res 13:109. 2012
    ..The goals of this study were to examine effects of racemic formoterol and its enantiomers on PAVSM cell proliferation as it relates to COPD-associated PH...
  3. pmc Signal transducer and activator of transcription 3 is required for abnormal proliferation and survival of TSC2-deficient cells: relevance to pulmonary lymphangioleiomyomatosis
    Elena A Goncharova
    Pulmonary, Allergy, and Critical Care Division, Airways Biology Initiative, Department of Medicine, University of Pennsylvania, TRL, Room 1214, 125 South 31st St, Philadelphia, PA 19104, USA
    Mol Pharmacol 76:766-77. 2009
    ..Thus, STAT3 may provide a novel therapeutic target for diseases associated with TSC1/TSC2 dysfunction...
  4. ncbi request reprint Interferon beta augments tuberous sclerosis complex 2 (TSC2)-dependent inhibition of TSC2-null ELT3 and human lymphangioleiomyomatosis-derived cell proliferation
    Elena A Goncharova
    Department of Medicine, University of Pennsylvania, TRL Suite 1200, 125 South 31st Street, Philadelphia, PA 19104, USA
    Mol Pharmacol 73:778-88. 2008
    ....
  5. pmc Abnormal growth of smooth muscle-like cells in lymphangioleiomyomatosis: Role for tumor suppressor TSC2
    Elena A Goncharova
    Pulmonary, Allergy and Critical Care Division, Department of Medicine, University of Pennsylvania, 421 Curie Boulevard, BRB II III, Philadelphia, PA 19104 6160, USA
    Am J Respir Cell Mol Biol 34:561-72. 2006
    ..Loss of TSC2 GAP activity or disruption of the TSC1/TSC2 complex dysregulates S6K1 activation, which leads to abnormal cell proliferation associated with LAM disease...
  6. pmc Modulation of cell migration and invasiveness by tumor suppressor TSC2 in lymphangioleiomyomatosis
    Elena A Goncharova
    Department of Medicine, University of Pennsylvania, BRB II III, 421 Curie Blvd, Philadelphia, PA 19104, USA
    Am J Respir Cell Mol Biol 34:473-80. 2006
    ....
  7. ncbi request reprint Src is necessary and sufficient for human airway smooth muscle cell proliferation and migration
    Vera P Krymskaya
    Pulmonary, Allergy and Critical Care Division, Department of Medicine, University of Pennsylvania, 421 Curie Blvd, BRB II III, Philadelphia, PA 19104 6160, USA
    FASEB J 19:428-30. 2005
    ....
  8. ncbi request reprint Tuberin regulates p70 S6 kinase activation and ribosomal protein S6 phosphorylation. A role for the TSC2 tumor suppressor gene in pulmonary lymphangioleiomyomatosis (LAM)
    Elena A Goncharova
    Pulmonary, Allergy, and Critical Care Division, Department of Medicine, University of Pennsylvania, 421 Curie Boulevard, 847 BRB II III, Philadelphia, PA 19104, USA
    J Biol Chem 277:30958-67. 2002
    ..These data demonstrate that tuberin negatively regulates the activity of S6 and p70S6K specifically, and suggest a potential mechanism for abnormal cell growth in LAM...
  9. pmc Interferons modulate mitogen-induced protein synthesis in airway smooth muscle
    Elena A Goncharova
    Pulmonary, Allergy, and Critical Care Division, Airway Biology Initiative, Department of Medicine, Cardiovascular Institute, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Am J Physiol Lung Cell Mol Physiol 299:L25-35. 2010
    ....
  10. ncbi request reprint PI3K is required for proliferation and migration of human pulmonary vascular smooth muscle cells
    Elena A Goncharova
    Pulmonary, Allergy, and Critical Care Division, Department of Medicine, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104 6160, USA
    Am J Physiol Lung Cell Mol Physiol 283:L354-63. 2002
    ..These results demonstrate that PI3K signaling is both necessary and sufficient to mediate human PVSM cell proliferation and migration and suggest that the activation of PI3K may play an important role in vascular remodeling...
  11. ncbi request reprint Vascular endothelial growth factor-induced secretion of fibronectin is ERK dependent
    Altaf S Kazi
    Pulmonary, Allergy, and Critical Care Division, Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Am J Physiol Lung Cell Mol Physiol 286:L539-45. 2004
    ..We conclude that ASM-derived VEGF, through modulation of the extracellular matrix, may play an important role in airway remodeling seen in asthma...
  12. pmc β2-adrenergic receptor agonists modulate human airway smooth muscle cell migration via vasodilator-stimulated phosphoprotein
    Elena A Goncharova
    Airways Biology Initiative, Division of Pulmonary, Allergy, and Critical Care, Department of Medicine, University of Pennsylvania, Philadelphia, 19104, USA
    Am J Respir Cell Mol Biol 46:48-54. 2012
    ....
  13. ncbi request reprint Phosphatidylinositol 3-kinase but not tuberin is required for PDGF-induced cell migration
    Carla Irani
    Pulmonary, Allergy, and Critical Care Division, Department of Medicine, University of Pennsylvania, 421 Curie Blvd, Philadelphia, PA 19104, USA
    Am J Physiol Lung Cell Mol Physiol 282:L854-62. 2002
    ..These data suggest that PI 3-kinase is required for growth factor-induced cell migration and loss of tuberin appears to have little effect on cell migration...
  14. pmc mTORC2 is required for proliferation and survival of TSC2-null cells
    Elena A Goncharova
    Pulmonary, Allergy and Critical Care Division, Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Mol Cell Biol 31:2484-98. 2011
    ....
  15. ncbi request reprint Cyclic AMP-mobilizing agents and glucocorticoids modulate human smooth muscle cell migration
    Elena A Goncharova
    Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104 6160, USA
    Am J Respir Cell Mol Biol 29:19-27. 2003
    ..Collectively, these findings demonstrate that cAMP-mobilizing agents and steroids modulate human smooth muscle cell migration, likely by distinct mechanisms...
  16. ncbi request reprint Assays for in vitro monitoring of proliferation of human airway smooth muscle (ASM) and human pulmonary arterial vascular smooth muscle (VSM) cells
    Elena A Goncharova
    Pulmonary, Allergy and Critical Care Division, Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Nat Protoc 1:2905-8. 2006
    ..Although using radiolabeled [3H]thymidine incorporation is a limitation, the greatest benefit of the assay is providing reliable and statistically significant data...
  17. pmc Prevention of alveolar destruction and airspace enlargement in a mouse model of pulmonary lymphangioleiomyomatosis (LAM)
    Elena A Goncharova
    Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Sci Transl Med 4:154ra134. 2012
    ....
  18. pmc mTOR is required for pulmonary arterial vascular smooth muscle cell proliferation under chronic hypoxia
    Vera P Krymskaya
    Pulmonary, Allergy, and Critical Care Division, Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    FASEB J 25:1922-33. 2011
    ....
  19. pmc DHEA-S inhibits human neutrophil and human airway smooth muscle migration
    Cynthia J Koziol-White
    Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Biochim Biophys Acta 1822:1638-42. 2012
    ..These studies demonstrate direct effects of DHEA-S on cell migration, thereby suggesting that DHEA-S may attenuate airway inflammation and cell migration...
  20. ncbi request reprint Assays for in vitro monitoring of human airway smooth muscle (ASM) and human pulmonary arterial vascular smooth muscle (VSM) cell migration
    Elena A Goncharova
    Department of Medicine, Pulmonary, Allergy and Critical Care Division, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Nat Protoc 1:2933-9. 2006
    ....
  21. ncbi request reprint Pulmonary lymphangioleiomyomatosis (LAM): progress and current challenges
    Elena A Goncharova
    Department of Medicine, University of Pennsylvania, Pennsylvania, USA
    J Cell Biochem 103:369-82. 2008
    ..In this review, we will summarize the progress made in our understanding of TSC1/TSC2 cellular signaling and the molecular mechanisms of LAM; we will also highlight some of the lesser explored directions and challenges in LAM research...
  22. pmc PI3K/mTORC1 activation in hamartoma syndromes: therapeutic prospects
    Vera P Krymskaya
    Department of Medicine, and Abramson Cancer Center, University of Pennsylvania, Philadelphia, Pennsylvania 19104 3403, USA
    Cell Cycle 8:403-13. 2009
    ....
  23. pmc Folliculin, the product of the Birt-Hogg-Dube tumor suppressor gene, interacts with the adherens junction protein p0071 to regulate cell-cell adhesion
    Doug A Medvetz
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    PLoS ONE 7:e47842. 2012
    ....