Brigitte N Gomperts

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Stem cells and chronic lung disease
    Brigitte N Gomperts
    Mattel Children s Hospital, Department of Pediatrics, Division of Pediatric Hematology, Oncology, David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA
    Annu Rev Med 58:285-98. 2007
  2. pmc Evolving concepts in lung carcinogenesis
    Brigitte N Gomperts
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA
    Semin Respir Crit Care Med 32:32-43. 2011
  3. pmc Molecular profiling of premalignant lesions in lung squamous cell carcinomas identifies mechanisms involved in stepwise carcinogenesis
    Aik T Ooi
    Mattel Children s Hospital, University of California, Los Angeles, 10833 Le Conte Avenue A2 410MDCC, Los Angeles, CA 90095
    Cancer Prev Res (Phila) 7:487-95. 2014
  4. pmc Quantification of cytokeratin 5 mRNA expression in the circulation of healthy human subjects and after lung transplantation
    Derek W Nickerson
    Mattel Children s Hospital at UCLA, Division of Hematology Oncology, Department of Pediatrics, David Geffen School of Medicine at UCLA, Los Angeles, California, United States of America
    PLoS ONE 4:e5925. 2009
  5. ncbi request reprint Lung cancer biomarkers: FISHing in the sputum for risk assessment and early detection
    Brigitte N Gomperts
    David Geffen School of Medicine, University of California at Los Angeles, 10833 Le Conte Avenue, Los Angeles, CA 90095, USA
    Cancer Prev Res (Phila) 3:420-3. 2010
  6. pmc IL-13 regulates cilia loss and foxj1 expression in human airway epithelium
    Brigitte N Gomperts
    Department of Pediatrics and Mattel Children s Hospital, University of California Los Angeles, Los Angeles, California 90095, USA
    Am J Respir Cell Mol Biol 37:339-46. 2007
  7. pmc Keratinocyte growth factor improves repair in the injured tracheal epithelium
    Brigitte N Gomperts
    UCLA Department of Pediatrics, Mattel Children s Hospital, 10833 Le Conte Avenue, A2 410 MDCC, Los Angeles, CA 90095, USA
    Am J Respir Cell Mol Biol 37:48-56. 2007
  8. pmc Isolation and in vitro characterization of basal and submucosal gland duct stem/progenitor cells from human proximal airways
    Ahmed E Hegab
    Department of Pediatrics, Mattel Children s Hospital, David Geffen School of Medicine, University of California, Los Angeles, CA, USA
    Stem Cells Transl Med 1:719-24. 2012
  9. pmc Novel stem/progenitor cell population from murine tracheal submucosal gland ducts with multipotent regenerative potential
    Ahmed E Hegab
    Department of Pediatrics, David Geffen School of Medicine at University of California Los Angeles, University of California Los Angeles School of Medicine, Los Angeles, California, USA
    Stem Cells 29:1283-93. 2011
  10. pmc Repair and regeneration of tracheal surface epithelium and submucosal glands in a mouse model of hypoxic-ischemic injury
    Ahmed E Hegab
    Department of Pediatrics, Mattel Children s Hospital, Los Angeles, California, USA
    Respirology 17:1101-13. 2012

Research Grants

  1. Cytokine Regulation of the Pulmonary Epithelium
    Brigitte Gomperts; Fiscal Year: 2007
  2. Progenitor Cells in Airway Repair
    Brigitte Gomperts; Fiscal Year: 2009
  3. Progenitor Cells in Airway Repair
    Brigitte N Gomperts; Fiscal Year: 2010

Collaborators

Detail Information

Publications24

  1. ncbi request reprint Stem cells and chronic lung disease
    Brigitte N Gomperts
    Mattel Children s Hospital, Department of Pediatrics, Division of Pediatric Hematology, Oncology, David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA
    Annu Rev Med 58:285-98. 2007
    ..There is much excitement about the possibility of harnessing stem cells for repair and regeneration of the lungs. This review highlights current knowledge of this area and identifies gaps in our understanding of this complicated process...
  2. pmc Evolving concepts in lung carcinogenesis
    Brigitte N Gomperts
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA
    Semin Respir Crit Care Med 32:32-43. 2011
    ....
  3. pmc Molecular profiling of premalignant lesions in lung squamous cell carcinomas identifies mechanisms involved in stepwise carcinogenesis
    Aik T Ooi
    Mattel Children s Hospital, University of California, Los Angeles, 10833 Le Conte Avenue A2 410MDCC, Los Angeles, CA 90095
    Cancer Prev Res (Phila) 7:487-95. 2014
    ..Cancer Prev Res; 7(5); 487-95. ©2014 AACR. ..
  4. pmc Quantification of cytokeratin 5 mRNA expression in the circulation of healthy human subjects and after lung transplantation
    Derek W Nickerson
    Mattel Children s Hospital at UCLA, Division of Hematology Oncology, Department of Pediatrics, David Geffen School of Medicine at UCLA, Los Angeles, California, United States of America
    PLoS ONE 4:e5925. 2009
    ....
  5. ncbi request reprint Lung cancer biomarkers: FISHing in the sputum for risk assessment and early detection
    Brigitte N Gomperts
    David Geffen School of Medicine, University of California at Los Angeles, 10833 Le Conte Avenue, Los Angeles, CA 90095, USA
    Cancer Prev Res (Phila) 3:420-3. 2010
    ..The presently reported findings on FISH in sputum cells are an important contribution worthy of further investigation in defined clinical settings...
  6. pmc IL-13 regulates cilia loss and foxj1 expression in human airway epithelium
    Brigitte N Gomperts
    Department of Pediatrics and Mattel Children s Hospital, University of California Los Angeles, Los Angeles, California 90095, USA
    Am J Respir Cell Mol Biol 37:339-46. 2007
    ..These findings have important implications for the pathogenesis and treatment of airway diseases...
  7. pmc Keratinocyte growth factor improves repair in the injured tracheal epithelium
    Brigitte N Gomperts
    UCLA Department of Pediatrics, Mattel Children s Hospital, 10833 Le Conte Avenue, A2 410 MDCC, Los Angeles, CA 90095, USA
    Am J Respir Cell Mol Biol 37:48-56. 2007
    ..KGF therefore appears to be an important growth factor for local resident progenitor epithelial cell repair and for mobilization and enhanced engraftment of CEPC to the injured proximal airway epithelium...
  8. pmc Isolation and in vitro characterization of basal and submucosal gland duct stem/progenitor cells from human proximal airways
    Ahmed E Hegab
    Department of Pediatrics, Mattel Children s Hospital, David Geffen School of Medicine, University of California, Los Angeles, CA, USA
    Stem Cells Transl Med 1:719-24. 2012
    ..In conclusion, we have developed methods to isolate basal and SMG duct cells from the surface epithelium and SMGs of human tracheas and have developed an in vitro model to characterize their self-renewal and differentiation...
  9. pmc Novel stem/progenitor cell population from murine tracheal submucosal gland ducts with multipotent regenerative potential
    Ahmed E Hegab
    Department of Pediatrics, David Geffen School of Medicine at University of California Los Angeles, University of California Los Angeles School of Medicine, Los Angeles, California, USA
    Stem Cells 29:1283-93. 2011
    ....
  10. pmc Repair and regeneration of tracheal surface epithelium and submucosal glands in a mouse model of hypoxic-ischemic injury
    Ahmed E Hegab
    Department of Pediatrics, Mattel Children s Hospital, Los Angeles, California, USA
    Respirology 17:1101-13. 2012
    ..We hypothesized that the repair and regeneration process of the surface epithelium and submucosal glands would occur in a reproducible pattern that could be followed by the expression of specific markers of epithelial cell types...
  11. ncbi request reprint Circulating progenitor epithelial cells traffic via CXCR4/CXCL12 in response to airway injury
    Brigitte N Gomperts
    Department of Pediatrics, Mattel Children s Hospital, Los Angeles, CA 90095, USA
    J Immunol 176:1916-27. 2006
    ..These findings support a novel paradigm for the development of squamous metaplasia of the airway epithelium and for developing therapeutic strategies for circulating progenitor epithelial cells in airway diseases...
  12. pmc Presence of a putative tumor-initiating progenitor cell population predicts poor prognosis in smokers with non-small cell lung cancer
    Aik T Ooi
    Department of Pediatrics, Division of Hematology Oncology, Mattel Children s Hospital, University of California at Los Angeles, David Geffen School of Medicine at the University of California, Los Angeles, California, USA
    Cancer Res 70:6639-48. 2010
    ..This suggests that reparative K14+ progenitor cells may be tumor-initiating cells in this subgroup of smokers with NSCLC...
  13. pmc Aldehyde dehydrogenase activity enriches for proximal airway basal stem cells and promotes their proliferation
    Ahmed E Hegab
    1 Department of Pediatrics, Children s Discovery and Innovation Institute, David Geffen School of Medicine at UCLA, Mattel Children s Hospital, Los Angeles, California
    Stem Cells Dev 23:664-75. 2014
    ..These studies could lead to the development of novel strategies for altering ABSC proliferation in the airway epithelium. ..
  14. ncbi request reprint IL-13 is pivotal in the fibro-obliterative process of bronchiolitis obliterans syndrome
    Michael P Keane
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
    J Immunol 178:511-9. 2007
    ..This supports the notion that IL-13 biological axis plays an important role during the pathogenesis of BOS independent of the IL-4 biological axis...
  15. pmc The role of CXC chemokines in pulmonary fibrosis
    Robert M Strieter
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
    J Clin Invest 117:549-56. 2007
    ....
  16. ncbi request reprint CXCR2/CXCR2 ligand biology during lung transplant ischemia-reperfusion injury
    John A Belperio
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, David Geffen School of Medicine, University of California, Los Angeles, 90095, USA
    J Immunol 175:6931-9. 2005
    ....
  17. pmc Enriching the molecular definition of the airway "field of cancerization:" establishing new paradigms for the patient at risk for lung cancer
    Brigitte N Gomperts
    1Division of Hematology Oncology, Department of Pediatrics, Mattel Children s Hospital at the University of California, Los Angeles UCLA, Los Angeles, CA, USA
    Cancer Prev Res (Phila) 6:4-7. 2013
    ..In addition to increasing our understanding of lung cancer biology, studying the field of cancerization has the potential to identify biomarkers from samples obtained in a minimally invasive manner...
  18. ncbi request reprint Dynamic Changes in Intracellular ROS Levels Regulate Airway Basal Stem Cell Homeostasis through Nrf2-Dependent Notch Signaling
    Manash K Paul
    Department of Pediatrics, Mattel Children s Hospital, University of California, Los Angeles, Los Angeles, CA 90095, USA
    Cell Stem Cell 15:199-214. 2014
    ..This redox-mediated regulation of lung stem cell function has significant implications for stem cell biology, repair of lung injuries, and diseases such as cancer. ..
  19. ncbi request reprint Fibrocytes in lung disease
    Brigitte N Gomperts
    Mattel Children s Hospital, Department of Pediatrics, Division of Pediatric Hematology Oncology, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, California, USA
    J Leukoc Biol 82:449-56. 2007
    ..Fibrocytes have been shown to contribute to a number of fibrotic disorders, and here, we review their involvement in lung diseases including pulmonary fibrosis, asthma, and vascular remodeling...
  20. ncbi request reprint CXC chemokines in angiogenesis
    Robert M Strieter
    Department of Medicine, Division of Pulmonary and Critical Care Medicine, David Geffen School of Medicine at UCLA, 900 Veteran Avenue, 14 154 Warren Hall, Los Angeles, CA 90095 1786, USA
    Cytokine Growth Factor Rev 16:593-609. 2005
    ..This review will discuss the biology of these angiogenic and angiostatic CXC chemokines and discuss their disparate angiogenic activity in the context of a variety of disorders...
  21. pmc Circulating progenitor cells in chronic lung disease
    Borna Mehrad
    University of Virginia, Division of Pulmonary and Critical Care Medicine, Department of Medicine, Box 800546, Charlottesville, VA 22908, USA
    Expert Rev Respir Med 1:157-65. 2007
    ..In this review, we summarize the current understanding of the biology of adult circulating progenitors as related to lung disease...
  22. ncbi request reprint Chemokine-directed metastasis
    Brigitte N Gomperts
    Department of Pediatrics, University of California, Los Angeles, School of Medicine, Los Angeles 90095 1786, USA
    Contrib Microbiol 13:170-90. 2006
    ..Here, we review the importance of chemokines, especially CXC chemokines in regulating angiogenesis, tumor cell invasion and metastases; and demonstrate why they can be seen as important therapeutic targets for intervention in cancer...
  23. doi request reprint B-acute lymphoblastic leukemia and cystinuria in a patient with duplication 22q11.21 detected by chromosomal microarray analysis
    Vivian Y Chang
    Division of Hematology Oncology, David Geffen School of Medicine, University of California, Los Angeles, California, USA
    Pediatr Blood Cancer 56:470-3. 2011
    ..2 syndrome. In this era of advanced genomics, this technology has become an important method for helping to determine the molecular basis of diseases, best treatments and ultimately patient outcomes...
  24. ncbi request reprint Foxj1 regulates basal body anchoring to the cytoskeleton of ciliated pulmonary epithelial cells
    Brigitte N Gomperts
    Developmental Biology Research Unit, The Edward R Mallinckrodt Department of Pediatrics, Washington University School of Medicine, St Louis, MO 63110, USA
    J Cell Sci 117:1329-37. 2004
    ..In the absence of Foxj1, decreased calpastatin expression with decreased ezrin and EBP-50 results in an inability of basal bodies to anchor to the apical cytoskeleton and subsequent failure of axonemal formation...

Research Grants4

  1. Cytokine Regulation of the Pulmonary Epithelium
    Brigitte Gomperts; Fiscal Year: 2007
    ..RSV infection in wild type and STAT-6-/- mice will be used as a model to examine regulation of foxj1, the apical cytoskeleton and the signal transduction pathways involved in abnormal mucociliary clearance in response to RSV infection. ..
  2. Progenitor Cells in Airway Repair
    Brigitte Gomperts; Fiscal Year: 2009
    ..We plan to test this hypothesis in preclinical models and in lung transplant patient samples. ..
  3. Progenitor Cells in Airway Repair
    Brigitte N Gomperts; Fiscal Year: 2010
    ..We plan to test this hypothesis in preclinical models and in lung transplant patient samples. ..