Research Topics
Genomes and Genes | Brigitte N GompertsSummaryAffiliation: University of California Country: USA Publications
Research Grants
| Collaborators
|
Detail Information
Publications
Stem cells and chronic lung diseaseBrigitte N Gomperts
Mattel Children s Hospital, Department of Pediatrics, Division of Pediatric Hematology, Oncology, David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA
Annu Rev Med 58:285-98. 2007..There is much excitement about the possibility of harnessing stem cells for repair and regeneration of the lungs. This review highlights current knowledge of this area and identifies gaps in our understanding of this complicated process...
Evolving concepts in lung carcinogenesisBrigitte N Gomperts
Department of Medicine, Division of Pulmonary and Critical Care Medicine, David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA
Semin Respir Crit Care Med 32:32-43. 2011....- Keratinocyte growth factor improves repair in the injured tracheal epitheliumBrigitte N Gomperts
UCLA Department of Pediatrics, Mattel Children s Hospital, 10833 Le Conte Avenue, A2 410 MDCC, Los Angeles, CA 90095, USA
Am J Respir Cell Mol Biol 37:48-56. 2007..KGF therefore appears to be an important growth factor for local resident progenitor epithelial cell repair and for mobilization and enhanced engraftment of CEPC to the injured proximal airway epithelium... - IL-13 regulates cilia loss and foxj1 expression in human airway epitheliumBrigitte N Gomperts
Department of Pediatrics and Mattel Children s Hospital, University of California Los Angeles, Los Angeles, California 90095, USA
Am J Respir Cell Mol Biol 37:339-46. 2007..These findings have important implications for the pathogenesis and treatment of airway diseases... 
Lung cancer biomarkers: FISHing in the sputum for risk assessment and early detectionBrigitte N Gomperts
David Geffen School of Medicine, University of California at Los Angeles, 10833 Le Conte Avenue, Los Angeles, CA 90095, USA
Cancer Prev Res (Phila) 3:420-3. 2010..The presently reported findings on FISH in sputum cells are an important contribution worthy of further investigation in defined clinical settings...- Novel stem/progenitor cell population from murine tracheal submucosal gland ducts with multipotent regenerative potentialAhmed E Hegab
Department of Pediatrics, David Geffen School of Medicine at University of California Los Angeles, University of California Los Angeles School of Medicine, Los Angeles, California, USA
Stem Cells 29:1283-93. 2011.... - Repair and regeneration of tracheal surface epithelium and submucosal glands in a mouse model of hypoxic-ischemic injuryAhmed E Hegab
Department of Pediatrics, Mattel Children s Hospital, Los Angeles, California, USA
Respirology 17:1101-13. 2012..We hypothesized that the repair and regeneration process of the surface epithelium and submucosal glands would occur in a reproducible pattern that could be followed by the expression of specific markers of epithelial cell types... - Circulating progenitor epithelial cells traffic via CXCR4/CXCL12 in response to airway injuryBrigitte N Gomperts
Department of Pediatrics, Mattel Children s Hospital, Los Angeles, CA 90095, USA
J Immunol 176:1916-27. 2006..These findings support a novel paradigm for the development of squamous metaplasia of the airway epithelium and for developing therapeutic strategies for circulating progenitor epithelial cells in airway diseases... - Isolation and in vitro characterization of Basal and submucosal gland duct stem/progenitor cells from human proximal airwaysAhmed E Hegab
Department of Pediatrics, Mattel Children s Hospital, David Geffen School of Medicine
Stem Cells Transl Med 1:719-24. 2012..In conclusion, we have developed methods to isolate basal and SMG duct cells from the surface epithelium and SMGs of human tracheas and have developed an in vitro model to characterize their self-renewal and differentiation... - IL-13 is pivotal in the fibro-obliterative process of bronchiolitis obliterans syndromeMichael P Keane
Department of Medicine, Division of Pulmonary and Critical Care Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
J Immunol 178:511-9. 2007..This supports the notion that IL-13 biological axis plays an important role during the pathogenesis of BOS independent of the IL-4 biological axis... - The role of CXC chemokines in pulmonary fibrosisRobert M Strieter
Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
J Clin Invest 117:549-56. 2007.... - Presence of a putative tumor-initiating progenitor cell population predicts poor prognosis in smokers with non-small cell lung cancerAik T Ooi
Department of Pediatrics, Division of Hematology Oncology, Mattel Children s Hospital, University of California at Los Angeles, David Geffen School of Medicine at the University of California, Los Angeles, California, USA
Cancer Res 70:6639-48. 2010..This suggests that reparative K14+ progenitor cells may be tumor-initiating cells in this subgroup of smokers with NSCLC... - Quantification of cytokeratin 5 mRNA expression in the circulation of healthy human subjects and after lung transplantationDerek W Nickerson
Mattel Children s Hospital at UCLA, Division of Hematology Oncology, Department of Pediatrics, David Geffen School of Medicine at UCLA, Los Angeles, California, United States of America
PLoS ONE 4:e5925. 2009.... - CXCR2/CXCR2 ligand biology during lung transplant ischemia-reperfusion injuryJohn A Belperio
Department of Medicine, Division of Pulmonary and Critical Care Medicine, David Geffen School of Medicine, University of California, Los Angeles, 90095, USA
J Immunol 175:6931-9. 2005.... - Enriching the molecular definition of the airway "field of cancerization:" establishing new paradigms for the patient at risk for lung cancerBrigitte N Gomperts
1Division of Hematology Oncology, Department of Pediatrics, Mattel Children s Hospital at the University of California, Los Angeles UCLA, Los Angeles, CA, USA
Cancer Prev Res (Phila) 6:4-7. 2013..In addition to increasing our understanding of lung cancer biology, studying the field of cancerization has the potential to identify biomarkers from samples obtained in a minimally invasive manner... - Fibrocytes in lung diseaseBrigitte N Gomperts
Mattel Children s Hospital, Department of Pediatrics, Division of Pediatric Hematology Oncology, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, California, USA
J Leukoc Biol 82:449-56. 2007..Fibrocytes have been shown to contribute to a number of fibrotic disorders, and here, we review their involvement in lung diseases including pulmonary fibrosis, asthma, and vascular remodeling... - CXC chemokines in angiogenesisRobert M Strieter
Department of Medicine, Division of Pulmonary and Critical Care Medicine, David Geffen School of Medicine at UCLA, 900 Veteran Avenue, 14 154 Warren Hall, Los Angeles, CA 90095 1786, USA
Cytokine Growth Factor Rev 16:593-609. 2005..This review will discuss the biology of these angiogenic and angiostatic CXC chemokines and discuss their disparate angiogenic activity in the context of a variety of disorders... - Circulating progenitor cells in chronic lung diseaseBorna Mehrad
University of Virginia, Division of Pulmonary and Critical Care Medicine, Department of Medicine, Box 800546, Charlottesville, VA 22908, USA
Expert Rev Respir Med 1:157-65. 2007..In this review, we summarize the current understanding of the biology of adult circulating progenitors as related to lung disease... - Chemokine-directed metastasisBrigitte N Gomperts
Department of Pediatrics, University of California, Los Angeles, School of Medicine, Los Angeles 90095-1786, USA
Contrib Microbiol 13:170-90. 2006..Here, we review the importance of chemokines, especially CXC chemokines in regulating angiogenesis, tumor cell invasion and metastases; and demonstrate why they can be seen as important therapeutic targets for intervention in cancer... - B-acute lymphoblastic leukemia and cystinuria in a patient with duplication 22q11.21 detected by chromosomal microarray analysisVivian Y Chang
Division of Hematology Oncology, David Geffen School of Medicine, University of California, Los Angeles, California, USA
Pediatr Blood Cancer 56:470-3. 2011..2 syndrome. In this era of advanced genomics, this technology has become an important method for helping to determine the molecular basis of diseases, best treatments and ultimately patient outcomes... - Foxj1 regulates basal body anchoring to the cytoskeleton of ciliated pulmonary epithelial cellsBrigitte N Gomperts
Developmental Biology Research Unit, The Edward R Mallinckrodt Department of Pediatrics, Washington University School of Medicine, St Louis, MO 63110, USA
J Cell Sci 117:1329-37. 2004..In the absence of Foxj1, decreased calpastatin expression with decreased ezrin and EBP-50 results in an inability of basal bodies to anchor to the apical cytoskeleton and subsequent failure of axonemal formation...
Research Grants
- Cytokine Regulation of the Pulmonary EpitheliumBrigitte Gomperts; Fiscal Year: 2007..RSV infection in wild type and STAT-6-/- mice will be used as a model to examine regulation of foxj1, the apical cytoskeleton and the signal transduction pathways involved in abnormal mucociliary clearance in response to RSV infection. ..
- Progenitor Cells in Airway RepairBrigitte N Gomperts; Fiscal Year: 2010..We plan to test this hypothesis in preclinical models and in lung transplant patient samples. ..