David Gomez-Varela

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc PMCA2 via PSD-95 controls calcium signaling by α7-containing nicotinic acetylcholine receptors on aspiny interneurons
    David Gomez-Varela
    Division of Biological Sciences, University of California, San Diego, La Jolla, California 92093 0357, USA
    J Neurosci 32:6894-905. 2012
  2. pmc Characterization of Eag1 channel lateral mobility in rat hippocampal cultures by single-particle-tracking with quantum dots
    David Gomez-Varela
    Department of Molecular Biology of Neuronal Signals, Max Planck Institute of Experimental Medicine, Gottingen, Germany
    PLoS ONE 5:e8858. 2010
  3. pmc A novel mechanism for nicotinic potentiation of glutamatergic synapses
    Andrew W Halff
    Neurobiology Section, Division of Biological Sciences, University of California San Diego, La Jolla, California 92093, and Max Planck Institute of Experimental Medicine, 37075 Gottingen, Germany
    J Neurosci 34:2051-64. 2014
  4. pmc Lateral mobility of presynaptic α7-containing nicotinic receptors and its relevance for glutamate release
    David Gomez-Varela
    Neurobiology Section, Division of Biological Sciences, University of California, San Diego, La Jolla, California 92093 0357, and Max Planck Institute of Experimental Medicine, D 37075 Goettingen, Germany
    J Neurosci 33:17062-71. 2013
  5. ncbi Different relevance of inactivation and F468 residue in the mechanisms of hEag1 channel blockage by astemizole, imipramine and dofetilide
    David Gomez-Varela
    Max Planck Institute of Experimental Medicine, Department of Molecular Biology of Neuronal Signals, Hermann Rein Str 3, 37075 Gottingen, Germany
    FEBS Lett 580:5059-66. 2006
  6. pmc Lateral mobility of nicotinic acetylcholine receptors on neurons is determined by receptor composition, local domain, and cell type
    Catarina C Fernandes
    Neurobiology Section, Division of Biological Sciences, University of California, San Diego, La Jolla, California 92093 0357, USA
    J Neurosci 30:8841-51. 2010
  7. ncbi Monoclonal antibody blockade of the human Eag1 potassium channel function exerts antitumor activity
    David Gomez-Varela
    Max Planck Institute of Experimental Medicine, Gottingen, Germany
    Cancer Res 67:7343-9. 2007
  8. doi Postsynaptic scaffolds for nicotinic receptors on neurons
    Robert A Neff
    Neurobiology Section, Division of Biological Sciences, University of California San Diego, La Jolla, CA 92093 0357, USA
    Acta Pharmacol Sin 30:694-701. 2009

Collaborators

Detail Information

Publications8

  1. pmc PMCA2 via PSD-95 controls calcium signaling by α7-containing nicotinic acetylcholine receptors on aspiny interneurons
    David Gomez-Varela
    Division of Biological Sciences, University of California, San Diego, La Jolla, California 92093 0357, USA
    J Neurosci 32:6894-905. 2012
    ..The PSD-95 link is required for PMCA2-mediated removal of α7-nAChR clusters. This three-component combination of PMCA2, PSD-95, and α7-nAChR offers a novel mechanism for tight control of calcium dynamics in neurons...
  2. pmc Characterization of Eag1 channel lateral mobility in rat hippocampal cultures by single-particle-tracking with quantum dots
    David Gomez-Varela
    Department of Molecular Biology of Neuronal Signals, Max Planck Institute of Experimental Medicine, Gottingen, Germany
    PLoS ONE 5:e8858. 2010
    ..The location-dependent constraints imposed by cytoskeletal elements together with the regulatory role of electrical activity strongly suggest a pivotal role for the mobility of voltage-gated ion channels in synaptic activity...
  3. pmc A novel mechanism for nicotinic potentiation of glutamatergic synapses
    Andrew W Halff
    Neurobiology Section, Division of Biological Sciences, University of California San Diego, La Jolla, California 92093, and Max Planck Institute of Experimental Medicine, 37075 Gottingen, Germany
    J Neurosci 34:2051-64. 2014
    ..These findings define a new avenue by which nicotinic signaling modulates synaptic mechanisms thought to subserve learning and memory. ..
  4. pmc Lateral mobility of presynaptic α7-containing nicotinic receptors and its relevance for glutamate release
    David Gomez-Varela
    Neurobiology Section, Division of Biological Sciences, University of California, San Diego, La Jolla, California 92093 0357, and Max Planck Institute of Experimental Medicine, D 37075 Goettingen, Germany
    J Neurosci 33:17062-71. 2013
    ..The results support a new homeostatic regulatory mechanism in which α7-nAChR restrain may be adjusted as needed at presynaptic sites via active zone proteins to maintain transmitter release capability. ..
  5. ncbi Different relevance of inactivation and F468 residue in the mechanisms of hEag1 channel blockage by astemizole, imipramine and dofetilide
    David Gomez-Varela
    Max Planck Institute of Experimental Medicine, Department of Molecular Biology of Neuronal Signals, Hermann Rein Str 3, 37075 Gottingen, Germany
    FEBS Lett 580:5059-66. 2006
    ..Together with measurements on recovery of blocking, our observations indicate that the mechanism of hEag1 blockage by each of these drugs is different, and suggest relevant structural differences between hEag1 and HERG channels...
  6. pmc Lateral mobility of nicotinic acetylcholine receptors on neurons is determined by receptor composition, local domain, and cell type
    Catarina C Fernandes
    Neurobiology Section, Division of Biological Sciences, University of California, San Diego, La Jolla, California 92093 0357, USA
    J Neurosci 30:8841-51. 2010
    ..The outcome is a system that could tailor nicotinic signaling capabilities to specific needs of individual locations...
  7. ncbi Monoclonal antibody blockade of the human Eag1 potassium channel function exerts antitumor activity
    David Gomez-Varela
    Max Planck Institute of Experimental Medicine, Gottingen, Germany
    Cancer Res 67:7343-9. 2007
    ..The particular antibody described here, as well as the technique developed to make additional functional antibodies to Eag1, makes it possible to evaluate the potential of the channel as a target for cancer therapy...
  8. doi Postsynaptic scaffolds for nicotinic receptors on neurons
    Robert A Neff
    Neurobiology Section, Division of Biological Sciences, University of California San Diego, La Jolla, CA 92093 0357, USA
    Acta Pharmacol Sin 30:694-701. 2009
    ..This review summarizes recent results in these areas and raises questions for the future about the mechanism and synaptic role of nAChR trafficking...