Fernando Gomez-Pinilla

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc The influence of exercise on cognitive abilities
    Fernando Gomez-Pinilla
    Department of Integrative Biology and Physiology, UCLA and Department of Neurosurgery, UCLA Brain Injury Research Center, Los Angeles, California, USA
    Compr Physiol 3:403-28. 2013
  2. ncbi request reprint A "deficient environment" in prenatal life may compromise systems important for cognitive function by affecting BDNF in the hippocampus
    F Gomez-Pinilla
    Division of Neurosurgery, Department of Physiology Science, UCLA, 621 Charles E Young Dr, Los Angeles, CA 90095, USA
    Exp Neurol 192:235-43. 2005
  3. pmc The influence of naturalistic experience on plasticity markers in somatosensory cortex and hippocampus: effects of whisker use
    Fernando Gomez-Pinilla
    Department of Integrative Biology and Physiology, UCLA Brain Injury Research Center, University of California, Los Angeles, CA 90095, USA
    Brain Res 1388:39-47. 2011
  4. pmc Brain foods: the effects of nutrients on brain function
    Fernando Gomez-Pinilla
    Department of Neurosurgery, University of California at Los Angeles School of Medicine, Los Angeles 90095, California, USA
    Nat Rev Neurosci 9:568-78. 2008
  5. ncbi request reprint Voluntary exercise induces a BDNF-mediated mechanism that promotes neuroplasticity
    Fernando Gomez-Pinilla
    Department of Physiological Science, Los Angeles, California 90095, USA
    J Neurophysiol 88:2187-95. 2002
  6. ncbi request reprint Exercise restores levels of neurotrophins and synaptic plasticity following spinal cord injury
    Zhe Ying
    Department of Physiological Science, UCLA, Los Angeles, CA 90095 1527, USA Division of Neurosurgery, UCLA Brain Injury Research Center, Los Angeles, CA 90095 1527, USA
    Exp Neurol 193:411-9. 2005
  7. ncbi request reprint The upregulation of plasticity-related proteins following TBI is disrupted with acute voluntary exercise
    Grace Sophia Griesbach
    Division of Neurosurgery, Department of Surgery, UCLA, Los Angeles, CA, USA
    Brain Res 1016:154-62. 2004
  8. ncbi request reprint Hippocampal BDNF mediates the efficacy of exercise on synaptic plasticity and cognition
    Shoshanna Vaynman
    Department of Physiological Science, UCLA, 621 Charles E Young Drive, Los Angeles, CA 90095, USA
    Eur J Neurosci 20:2580-90. 2004
  9. ncbi request reprint Differential effects of acute and chronic exercise on plasticity-related genes in the rat hippocampus revealed by microarray
    Raffaella Molteni
    Division of Neurosurgery, UCLA Brain Injury Research Center and Department of Physiological Science, UCLA, 621 Charles E Young Drive Los Angeles California 90095, USA
    Eur J Neurosci 16:1107-16. 2002
  10. ncbi request reprint Exercise induces BDNF and synapsin I to specific hippocampal subfields
    Shoshanna Vaynman
    Department of Physiological Science, UCLA, Los Angeles, California 90095, USA
    J Neurosci Res 76:356-62. 2004

Collaborators

Detail Information

Publications61

  1. pmc The influence of exercise on cognitive abilities
    Fernando Gomez-Pinilla
    Department of Integrative Biology and Physiology, UCLA and Department of Neurosurgery, UCLA Brain Injury Research Center, Los Angeles, California, USA
    Compr Physiol 3:403-28. 2013
    ..Therefore, exercise and dietary management appear as a noninvasive and effective strategy to counteract neurological and cognitive disorders...
  2. ncbi request reprint A "deficient environment" in prenatal life may compromise systems important for cognitive function by affecting BDNF in the hippocampus
    F Gomez-Pinilla
    Division of Neurosurgery, Department of Physiology Science, UCLA, 621 Charles E Young Dr, Los Angeles, CA 90095, USA
    Exp Neurol 192:235-43. 2005
    ..These findings have implications for disorders that involve a dysfunction in the BDNF system and are accompanied by cognitive deficits...
  3. pmc The influence of naturalistic experience on plasticity markers in somatosensory cortex and hippocampus: effects of whisker use
    Fernando Gomez-Pinilla
    Department of Integrative Biology and Physiology, UCLA Brain Injury Research Center, University of California, Los Angeles, CA 90095, USA
    Brain Res 1388:39-47. 2011
    ..The critical action of experience on molecular substrates of plasticity seems to provide molecular basis for the design of experienced-based rehabilitative strategies to enhance brain function...
  4. pmc Brain foods: the effects of nutrients on brain function
    Fernando Gomez-Pinilla
    Department of Neurosurgery, University of California at Los Angeles School of Medicine, Los Angeles 90095, California, USA
    Nat Rev Neurosci 9:568-78. 2008
    ..Understanding the molecular basis of the effects of food on cognition will help us to determine how best to manipulate diet in order to increase the resistance of neurons to insults and promote mental fitness...
  5. ncbi request reprint Voluntary exercise induces a BDNF-mediated mechanism that promotes neuroplasticity
    Fernando Gomez-Pinilla
    Department of Physiological Science, Los Angeles, California 90095, USA
    J Neurophysiol 88:2187-95. 2002
    ..These results indicate that basal levels of neuromuscular activity are required to maintain normal levels of BDNF in the neuromuscular system and the potential for neuroplasticity...
  6. ncbi request reprint Exercise restores levels of neurotrophins and synaptic plasticity following spinal cord injury
    Zhe Ying
    Department of Physiological Science, UCLA, Los Angeles, CA 90095 1527, USA Division of Neurosurgery, UCLA Brain Injury Research Center, Los Angeles, CA 90095 1527, USA
    Exp Neurol 193:411-9. 2005
    ..These results are consistent with the concept that synaptic pathways under the regulatory role of BDNF induced by exercise can play a role in facilitating recovery of locomotion following spinal cord injury...
  7. ncbi request reprint The upregulation of plasticity-related proteins following TBI is disrupted with acute voluntary exercise
    Grace Sophia Griesbach
    Division of Neurosurgery, Department of Surgery, UCLA, Los Angeles, CA, USA
    Brain Res 1016:154-62. 2004
    ..These results indicate that intracellular signaling proteins are increased during the first week following FPI and that premature voluntary exercise may compromise plasticity...
  8. ncbi request reprint Hippocampal BDNF mediates the efficacy of exercise on synaptic plasticity and cognition
    Shoshanna Vaynman
    Department of Physiological Science, UCLA, 621 Charles E Young Drive, Los Angeles, CA 90095, USA
    Eur J Neurosci 20:2580-90. 2004
    ..These findings suggest a functional role for CREB under the control of BDNF in mediating the exercise-induced enhancement in learning and memory. Our results indicate that synapsin I might also contribute to this BDNF-mediated mechanism...
  9. ncbi request reprint Differential effects of acute and chronic exercise on plasticity-related genes in the rat hippocampus revealed by microarray
    Raffaella Molteni
    Division of Neurosurgery, UCLA Brain Injury Research Center and Department of Physiological Science, UCLA, 621 Charles E Young Drive Los Angeles California 90095, USA
    Eur J Neurosci 16:1107-16. 2002
    ..For example, the CaM-K signal system seems to be active during acute and chronic periods of exercise, while the MAP-K/ERK system seems more important during long-term exercise...
  10. ncbi request reprint Exercise induces BDNF and synapsin I to specific hippocampal subfields
    Shoshanna Vaynman
    Department of Physiological Science, UCLA, Los Angeles, California 90095, USA
    J Neurosci Res 76:356-62. 2004
    ..These results indicate that exercise induces plasticity of select hippocampal transsynaptic circuitry, possibly comprising a spatial restriction on synapsin I regulation by BDNF...
  11. pmc Voluntary exercise increases axonal regeneration from sensory neurons
    Raffaella Molteni
    Department of Neurosurgery, University of California, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 101:8473-8. 2004
    ....
  12. ncbi request reprint Time window for voluntary exercise-induced increases in hippocampal neuroplasticity molecules after traumatic brain injury is severity dependent
    Grace S Griesbach
    Division of Neurosurgery, University of California Los Angeles UCLA, Los Angeles, California, USA
    J Neurotrauma 24:1161-71. 2007
    ..These results indicate that the time window for exercise-induced increases in BDNF, synapsin I, and CREB is dependent on injury severity...
  13. pmc Dietary omega-3 deficiency from gestation increases spinal cord vulnerability to traumatic brain injury-induced damage
    Zhe Ying
    Department of Integrative Biology and Physiology, University of California Los Angeles, Los Angeles, California, United States of America
    PLoS ONE 7:e52998. 2012
    ..Results emphasize the comprehensive action of TBI across the neuroaxis, and the critical role of dietary n-3 as a means to build resistance against the effects of TBI...
  14. pmc Effects of diet and/or exercise in enhancing spinal cord sensorimotor learning
    M Selvan Joseph
    Department of Integrative Biology and Physiology, University of California Los Angeles, Los Angeles, California, United States of America
    PLoS ONE 7:e41288. 2012
    ....
  15. pmc Brain-derived neurotrophic factor functions as a metabotrophin to mediate the effects of exercise on cognition
    Fernando Gomez-Pinilla
    Department of Physiological Science, UCLA Brain Injury Research Center, Los Angeles, CA, USA
    Eur J Neurosci 28:2278-87. 2008
    ..These findings suggest that the effects of exercise on synaptic plasticity and cognitive function involve elements of energy metabolism, and that BDNF seems to work at the interface between the two processes as a metabotrophin...
  16. pmc TBI and sex: crucial role of progesterone protecting the brain in an omega-3 deficient condition
    Ethika Tyagi
    Department of Integrative Biology and Physiology, UCLA, Los Angeles, CA 90095, USA
    Exp Neurol 253:41-51. 2014
    ..These results reveal the importance of n-3 preconditioning during early life and the efficacy of progesterone therapy during adulthood to counteract weaknesses in neuronal and behavioral plasticity...
  17. ncbi request reprint Omega-3 fatty acids supplementation restores mechanisms that maintain brain homeostasis in traumatic brain injury
    Aiguo Wu
    Department of Physiological Science, University of California at Los Angeles UCLA, Los Angeles, California 90095, USA
    J Neurotrauma 24:1587-95. 2007
    ..In addition, results show the capacity of omega-3 fatty acids to counteract some of the effects of TBI by normalizing levels of molecular systems associated with energy homeostasis...
  18. pmc The salutary effects of DHA dietary supplementation on cognition, neuroplasticity, and membrane homeostasis after brain trauma
    Aiguo Wu
    Department of Integrative Biology and Physiology, University of California at Los Angeles UCLA, Los Angeles, California 90095, USA
    J Neurotrauma 28:2113-22. 2011
    ..The overall results emphasize the potential of dietary DHA to counteract broad and fundamental aspects of TBI pathology that may translate into preserved cognitive capacity...
  19. pmc The combined effects of exercise and foods in preventing neurological and cognitive disorders
    Fernando Gomez-Pinilla
    Dept of Integrative Biology and Physiology, and Dept of Neurosurgery, University of California Los Angeles, Los Angeles, CA 90095, USA
    Prev Med 52:S75-80. 2011
    ..New evidence indicates that exercise, in combination with dietary factors, exerts its effects by affecting molecular events related to the management of energy metabolism and synaptic plasticity...
  20. ncbi request reprint Alterations in BDNF and synapsin I within the occipital cortex and hippocampus after mild traumatic brain injury in the developing rat: reflections of injury-induced neuroplasticity
    Grace Sophia Griesbach
    Division of Neurosurgery, Department of Surgery, UCLA School of Medicine, Los Angeles, California 90024 7039, USA
    J Neurotrauma 19:803-14. 2002
    ....
  21. ncbi request reprint Voluntary exercise increases neurotrophin-3 and its receptor TrkC in the spinal cord
    Zhe Ying
    Department of Physiological Science, UCLA, 621 Charles E Young Dr, Los Angeles, CA 90095, USA
    Brain Res 987:93-9. 2003
    ....
  22. pmc Exercise-induced improvement in cognitive performance after traumatic brain injury in rats is dependent on BDNF activation
    Grace Sophia Griesbach
    Department of Neurosurgery, David Geffen School of Medicine, UCLA, Los Angeles, CA 90095 7039, USA
    Brain Res 1288:105-15. 2009
    ..These studies provide evidence that BDNF has a major role in exercise's cognitive effects in traumatically injured brain...
  23. pmc Controlled contusion injury alters molecular systems associated with cognitive performance
    Grace Sophia Griesbach
    Department of Neurosurgery, University of California, Los Angeles, California 90024 7039, USA
    J Neurosci Res 87:795-805. 2009
    ..In addition, the delayed increase in the expression of BDNF and synapsin I within the cortex contralateral to CCI may reflect restorative processes in areas homotypical to the injury...
  24. pmc Brain and spinal cord interaction: protective effects of exercise prior to spinal cord injury
    Fernando Gomez-Pinilla
    Department of Integrative Biology and Physiology, University of California Los Angeles, Los Angeles, California, United States of America
    PLoS ONE 7:e32298. 2012
    ..In particular, exercise prior to the injury onset appears to foster protective mechanisms in the brain and spinal cord...
  25. ncbi request reprint Exercise normalizes levels of MAG and Nogo-A growth inhibitors after brain trauma
    Gabriela Chytrova
    Department of Physiological Science, UCLA, 621 Charles E Young Drive, Los Angeles, CA 90095, USA
    Eur J Neurosci 27:1-11. 2008
    ..These results indicate that exercise promotes a permissive cellular environment for repair after TBI, in a process in which BDNF plays a central role...
  26. pmc A pyrazole curcumin derivative restores membrane homeostasis disrupted after brain trauma
    Sandeep Sharma
    Department of Integrative Biology and Physiology, University of California, LA, CA 90095, USA
    Exp Neurol 226:191-9. 2010
    ....
  27. pmc Diet and cognition: interplay between cell metabolism and neuronal plasticity
    Fernando Gomez-Pinilla
    Department of Integrative Biology and Physiology and Department of Neurosurgery, University of California, Los Angeles, California, USA
    Curr Opin Clin Nutr Metab Care 16:726-33. 2013
    ..To discuss studies in humans and animals revealing the ability of foods to benefit the brain: new information with regards to mechanisms of action and the treatment of neurological and psychiatric disorders...
  28. pmc Vulnerability imposed by diet and brain trauma for anxiety-like phenotype: implications for post-traumatic stress disorders
    Ethika Tyagi
    Department of Integrative Biology and Physiology, University of California Los Angeles, Los Angeles, CA, USA
    PLoS ONE 8:e57945. 2013
    ..These results provide novel evidence for the capacity of maladaptive dietary habits to lower the threshold for neurological disorders in response to challenges...
  29. pmc Exercise decreases myelin-associated glycoprotein expression in the spinal cord and positively modulates neuronal growth
    Cristina A Ghiani
    Jane and Terry Semel Institute for Neuroscience and Human Behavior, Department of Neurobiology and Psychiatry, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA 90095, USA
    Glia 55:966-75. 2007
    ..Overall, these results show that exercise promotes a permissive cellular environment for axonal growth in the adult spinal cord requiring BDNF action...
  30. pmc Vitamin E protects against oxidative damage and learning disability after mild traumatic brain injury in rats
    - Aiguo Wu
    University of California at Los Angeles, Los Angeles, California 90095, USA
    Neurorehabil Neural Repair 24:290-8. 2010
    ..The elevation of superoxide dismutase (SOD) and Sir2 (silent information regulator 2) play an important role in resistance to oxidative stress...
  31. ncbi request reprint A saturated-fat diet aggravates the outcome of traumatic brain injury on hippocampal plasticity and cognitive function by reducing brain-derived neurotrophic factor
    A Wu
    Department of Physiological Science, University of California at Los Angeles, 621 Charles E Young Drive, Los Angeles, CA H 1450, USA
    Neuroscience 119:365-75. 2003
    ..The results suggest that FPI and diet impose a risk factor to the molecular machinery in charge of maintaining neuronal function under homeostatic and challenging situations...
  32. doi request reprint Coupling energy homeostasis with a mechanism to support plasticity in brain trauma
    Rahul Agrawal
    Department of Integrative Biology and Physiology, UCLA, Los Angeles, CA 90095, USA
    Biochim Biophys Acta 1842:535-46. 2014
    ..Overall, the results emphasize the interactive action of metabolic and plasticity signals for supporting neurological health. ..
  33. ncbi request reprint Afferent input modulates neurotrophins and synaptic plasticity in the spinal cord
    Fernando Gomez-Pinilla
    Department of Physiological Science, UCLA Brain Injury Research Center, Los Angeles, California 90095, USA
    J Neurophysiol 92:3423-32. 2004
    ..Combined, these results indicate that the level of supraspinal and muscle afferent input plays an important role in modulating the levels of BDNF and NT-3 in the spinal cord...
  34. pmc High-fat diet transition reduces brain DHA levels associated with altered brain plasticity and behaviour
    Sandeep Sharma
    Dept Integrative Biology and Physiology, UCLA, Los Angeles, CA 90095, USA
    Sci Rep 2:431. 2012
    ..Brain DHA contents were significantly associated with the levels of anxiety-like behavior in these rats...
  35. ncbi request reprint Oxidative stress modulates Sir2alpha in rat hippocampus and cerebral cortex
    Aiguo Wu
    Department of Physiological Science, University of California at Los Angeles, 621 Charles E Young Drive, Los Angeles, CA 90095, USA
    Eur J Neurosci 23:2573-80. 2006
    ..The present results show that oxidative stress and energy homeostasis associated with the consumption of the high-fat diet are critical for the regulation of Sir2alpha, with important implications for mechanisms of neural repair...
  36. pmc Dietary therapy to promote neuroprotection in chronic spinal cord injury
    Langston T Holly
    Department of Neurosurgery, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 6901, USA
    J Neurosurg Spine 17:134-40. 2012
    ....
  37. pmc Omega-3 fatty acid deficiency during brain maturation reduces neuronal and behavioral plasticity in adulthood
    Harsharan Singh Bhatia
    Department of Integrative Biology and Physiology, University of California Los Angeles, Los Angeles, California, United States of America
    PLoS ONE 6:e28451. 2011
    ..Adequate levels of dietary DHA seem crucial for building long-term neuronal resilience for optimal brain performance and aiding in the battle against neurological disorders...
  38. ncbi request reprint Exercise differentially regulates synaptic proteins associated to the function of BDNF
    Shoshanna S Vaynman
    Department of Physiological Science, UCLA, 621 Charles E Young Drive, Los Angeles, CA 90095, USA
    Brain Res 1070:124-30. 2006
    ..Blocking BDNF abrogated the exercise-induced increases in synapsin I and synatophysin, revealing that exercise regulates select properties of synaptic transmission under the direction of BDNF...
  39. pmc Voluntary exercise may engage proteasome function to benefit the brain after trauma
    Zsofia Szabo
    Department of Physiological Science, Brain Injury Research Center, UCLA, Los Angeles, California 90095, USA
    Brain Res 1341:25-31. 2010
    ..The overall results indicate that the action of exercise interfaces with that of brain injury on molecular systems involved with protein fate and function, which may be significant for synaptic plasticity...
  40. pmc Exercise contributes to the effects of DHA dietary supplementation by acting on membrane-related synaptic systems
    Gabriela Chytrova
    Department of Physiological Science, UCLA, 621 Charles E Young Drive, Los Angeles, CA 90095, USA
    Brain Res 1341:32-40. 2010
    ..The overall findings reveal a mechanism by which exercise can interact with the function of DHA dietary enrichment to elevate the capacity of the adult brain for axonal growth, synaptic plasticity, and cognitive function...
  41. ncbi request reprint Revenge of the "sit": how lifestyle impacts neuronal and cognitive health through molecular systems that interface energy metabolism with neuronal plasticity
    Shoshanna Vaynman
    Department of Neurosurgery and Physiological Science and Brain Injury Research Center, UCLA School of Medicine, Los Angeles, California 90095, USA
    J Neurosci Res 84:699-715. 2006
    ..The ability of exercise and diet to impact systems that promote cell survival and plasticity may be applicable for combating the deleterious effects of disease and ageing on brain health and cognition...
  42. ncbi request reprint Insulin-like growth factor I interfaces with brain-derived neurotrophic factor-mediated synaptic plasticity to modulate aspects of exercise-induced cognitive function
    Q Ding
    Department of Physiological Science, UCLA, 621 Charles E Young Drive, Los Angeles, CA 90095, USA
    Neuroscience 140:823-33. 2006
    ..Our results illustrate a possible mechanism by which insulin-like growth factor-I interfaces with the brain-derived neurotrophic factor system to mediate exercise-induced synaptic and cognitive plasticity...
  43. ncbi request reprint The interplay between oxidative stress and brain-derived neurotrophic factor modulates the outcome of a saturated fat diet on synaptic plasticity and cognition
    Aiguo Wu
    Department of Physiological Science, University of California at Los Angeles, 621 Charles E Young Drive, Los Angeles, California 90095, USA
    Eur J Neurosci 19:1699-707. 2004
    ....
  44. pmc Natural mood foods: the actions of polyphenols against psychiatric and cognitive disorders
    Fernando Gomez-Pinilla
    Department of Integrative Biology and Physiology, University of California, 621 Charles E Young Drive, Los Angeles, CA 90095, USA
    Nutr Neurosci 15:127-33. 2012
    ..Examining the molecular basis underlying the link between food intake and brain function has presented the exciting possibility of using diet as a viable method to battle cognitive and psychiatric disorders...
  45. pmc Brain and spinal cord interaction: a dietary curcumin derivative counteracts locomotor and cognitive deficits after brain trauma
    Aiguo Wu
    University of California at Los Angeles, Los Angeles, CA, USA
    Neurorehabil Neural Repair 25:332-42. 2011
    ..Moreover, there are no current efficient treatments that can counteract the broad pathology associated with TBI...
  46. ncbi request reprint Exercise affects energy metabolism and neural plasticity-related proteins in the hippocampus as revealed by proteomic analysis
    Qinxue Ding
    Department of Neurosurgery, Brain Injury Research Centre, UCLA, 621 Charles E Young Drive, Los Angeles, CA 90095, USA
    Eur J Neurosci 24:1265-76. 2006
    ....
  47. ncbi request reprint Interplay between brain-derived neurotrophic factor and signal transduction modulators in the regulation of the effects of exercise on synaptic-plasticity
    S Vaynman
    Department of Physiological Science, UCLA, 621 Charles E Young Drive, Los Angeles, CA 90095, USA
    Neuroscience 122:647-57. 2003
    ..Since these molecules have a well-described association to BDNF action, our results illustrate a basic mechanism through which exercise may promote synaptic-plasticity in the adult brain...
  48. pmc The influences of diet and exercise on mental health through hormesis
    Fernando Gomez-Pinilla
    Division of Neurosurgery, Brain Injury Research Center, UCLA Medical School, Los Angeles, CA 90095, USA
    Ageing Res Rev 7:49-62. 2008
    ..In particular, neurotrophins are emerging as main factors in the equation that may connect lifestyle factors and mental health...
  49. pmc Collaborative effects of diet and exercise on cognitive enhancement
    Fernando Gomez-Pinilla
    Department of Integrative Biology and Physiology, University of California Los Angeles, Los Angeles, CA 90095, USA
    Nutr Health 20:165-9. 2011
    ..Omega 3 fatty acids and curcumin elevate levels of molecules important for synaptic plasticity such as brain-derived neurotrophic factor (BDNF), thus benefiting normal brain function and recovery events following brain insults...
  50. pmc The influence of dietary factors in central nervous system plasticity and injury recovery
    Fernando Gomez-Pinilla
    Department of Neurosurgery, University of California Los Angeles Brain Injury Research Center, Los Angeles, CA 90095, USA
    PM R 3:S111-6. 2011
    ..Therefore, exercise and dietary management appear as a noninvasive and effective strategy to help counteract neurologic and cognitive disorders...
  51. pmc The select action of hippocampal calcium calmodulin protein kinase II in mediating exercise-enhanced cognitive function
    S Vaynman
    Department of Physiological Science, UCLA, 621 Charles E Young Drive, Los Angeles, CA 90095, USA
    Neuroscience 144:825-33. 2007
    ..These findings indicate that hippocampal CAMKII may have a refined role in mediating the effects of exercise on cognition, selectively functioning to regulate memory retention...
  52. pmc Hypothalamic stimulation enhances hippocampal BDNF plasticity in proportion to metabolic rate
    Zhe Ying
    Department of Integrative Biology and Physiology, University of California, Los Angeles, CA 90095, USA
    Brain Stimul 5:642-6. 2012
    ..Energy metabolism is emerging as a driving force for cellular events underlying cognitive processing. The hypothalamus integrates metabolic signals with the function of centers related to cognitive processing such as the hippocampus...
  53. pmc 'Metabolic syndrome' in the brain: deficiency in omega-3 fatty acid exacerbates dysfunctions in insulin receptor signalling and cognition
    Rahul Agrawal
    Department of Integrative Biology and Physiology, University of California Los Angeles UCLA, Los Angeles, CA 90095, USA
    J Physiol 590:2485-99. 2012
    ..Results showed that dietary n-3 fatty acid deficiency elevates the vulnerability to metabolic dysfunction and impaired cognitive functions by modulating insulin receptor signalling and synaptic plasticity...
  54. ncbi request reprint License to run: exercise impacts functional plasticity in the intact and injured central nervous system by using neurotrophins
    Shoshanna Vaynman
    Department of Neurosurgery and Physiological Science, and Brain Injury Research Center, UCLA School of Medicine, Los Angeles, CA 90095, USA
    Neurorehabil Neural Repair 19:283-95. 2005
    ....
  55. ncbi request reprint Coupling energy metabolism with a mechanism to support brain-derived neurotrophic factor-mediated synaptic plasticity
    S Vaynman
    Department of Physiological Science, UCLA, Los Angeles, CA 90095, USA
    Neuroscience 139:1221-34. 2006
    ..Our results reveal a fundamental mechanism by which key elements of energy metabolism may modulate the substrates of hippocampal synaptic plasticity...
  56. ncbi request reprint Voluntary exercise following traumatic brain injury: brain-derived neurotrophic factor upregulation and recovery of function
    G S Griesbach
    David Geffen School of Medicine at UCLA, Division of Neurosurgery, Los Angeles, CA 90095 7039, USA
    Neuroscience 125:129-39. 2004
    ..However, when exercise is administered to soon after TBI, the molecular response to exercise is disrupted and recovery may be delayed...
  57. pmc Voluntary exercise or amphetamine treatment, but not the combination, increases hippocampal brain-derived neurotrophic factor and synapsin I following cortical contusion injury in rats
    G S Griesbach
    Division of Neurosurgery, Department of Surgery, David Geffen School of Medicine at UCLA, Box 957039, Los Angeles, CA 90095 7039, USA
    Neuroscience 154:530-40. 2008
    ..These results indicate that, whereas exercise or AMPH treatment alone may induce plasticity and reduce oxidative stress after TBI, combining these treatments may cancel each other's therapeutic effects...
  58. ncbi request reprint Traumatic brain injury induced neuroprotection of retinal ganglion cells to optic nerve crush
    Guy J Ben Simon
    Jules Stein Eye Institute and Department of Ophthalmology, David Geffen School of Medicine at UCLA, Los Angeles, California, USA
    J Neurotrauma 23:1072-82. 2006
    ..This neuroprotective effect, which appears unrelated to retinal BDNF, is inhibited by high-dose MP, commonly used clinically to treat traumatic optic neuropathy...
  59. ncbi request reprint Deterioration of plasticity and metabolic homeostasis in the brain of the UCD-T2DM rat model of naturally occurring type-2 diabetes
    Rahul Agrawal
    Department of Integrative Biology and Physiology, University of California, Los Angeles, CA, USA
    Biochim Biophys Acta 1842:1313-23. 2014
    ....
  60. doi request reprint Dietary strategy to repair plasma membrane after brain trauma: implications for plasticity and cognition
    Aiguo Wu
    1University of California at Los Angeles, Los Angeles, CA, USA
    Neurorehabil Neural Repair 28:75-84. 2014
    ..Damage to the plasma membrane is a prevalent but often neglected aspect of traumatic brain injury (TBI), which can impair neuronal signaling and hamper neurological recovery...
  61. ncbi request reprint Attenuated plasticity in neurons and astrocytes in the mouse model of Sanfilippo syndrome type B
    Hong Hua Li
    Department of Biological Chemistry, University of California, Los Angeles, Los Angeles, California, USA
    J Neurosci Res 69:30-8. 2002
    ..Our results showed important alterations in the expression of several genes involved in the maintenance of neuroplasticity in the MPS III B. This in turn may result in reduction of neuronal health and brain function...