F Gomez-Pinilla

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Differential regulation by exercise of BDNF and NT-3 in rat spinal cord and skeletal muscle
    F Gomez-Pinilla
    Department of Physiological Science, UCLA, Los Angeles, CA 90095 1527, USA
    Eur J Neurosci 13:1078-84. 2001
  2. ncbi request reprint Exercise reverses the harmful effects of consumption of a high-fat diet on synaptic and behavioral plasticity associated to the action of brain-derived neurotrophic factor
    R Molteni
    Department of Physiological Science, Brain Injury Research Center, University of California at Los Angeles, 621 Charles E Young Drive, Los Angeles, CA 90095, USA
    Neuroscience 123:429-40. 2004
  3. ncbi request reprint Voluntary exercise following traumatic brain injury: brain-derived neurotrophic factor upregulation and recovery of function
    G S Griesbach
    David Geffen School of Medicine at UCLA, Division of Neurosurgery, Los Angeles, CA 90095 7039, USA
    Neuroscience 125:129-39. 2004
  4. ncbi request reprint A high-fat, refined sugar diet reduces hippocampal brain-derived neurotrophic factor, neuronal plasticity, and learning
    R Molteni
    Department of Physiological Science, University of California at Los Angeles, 621 Charles E Young Drive, 90095, USA
    Neuroscience 112:803-14. 2002
  5. ncbi request reprint Insulin-like growth factor I interfaces with brain-derived neurotrophic factor-mediated synaptic plasticity to modulate aspects of exercise-induced cognitive function
    Q Ding
    Department of Physiological Science, UCLA, 621 Charles E Young Drive, Los Angeles, CA 90095, USA
    Neuroscience 140:823-33. 2006
  6. ncbi request reprint Coupling energy metabolism with a mechanism to support brain-derived neurotrophic factor-mediated synaptic plasticity
    S Vaynman
    Department of Physiological Science, UCLA, Los Angeles, CA 90095, USA
    Neuroscience 139:1221-34. 2006
  7. doi request reprint Exercise facilitates the action of dietary DHA on functional recovery after brain trauma
    A Wu
    Department of Integrative Biology and Physiology, University of California at Los Angeles, 621 Charles E Young Drive, Los Angeles, CA 90095, USA
    Neuroscience 248:655-63. 2013
  8. ncbi request reprint Spatial learning induces neurotrophin receptor and synapsin I in the hippocampus
    F Gomez-Pinilla
    Department of Physiological Science, UCLA, Los Angeles, CA 90095 1527, USA
    Brain Res 904:13-9. 2001
  9. pmc Docosahexaenoic acid dietary supplementation enhances the effects of exercise on synaptic plasticity and cognition
    A Wu
    Department of Physiological Science, University of California at Los Angeles, 621 Charles E Young Drive, Los Angeles, CA 90095, USA
    Neuroscience 155:751-9. 2008
  10. ncbi request reprint Interplay between brain-derived neurotrophic factor and signal transduction modulators in the regulation of the effects of exercise on synaptic-plasticity
    S Vaynman
    Department of Physiological Science, UCLA, 621 Charles E Young Drive, Los Angeles, CA 90095, USA
    Neuroscience 122:647-57. 2003

Collaborators

Detail Information

Publications21

  1. ncbi request reprint Differential regulation by exercise of BDNF and NT-3 in rat spinal cord and skeletal muscle
    F Gomez-Pinilla
    Department of Physiological Science, UCLA, Los Angeles, CA 90095 1527, USA
    Eur J Neurosci 13:1078-84. 2001
    ..These results show that neuromuscular activity has specific effects on the BDNF and NT-3 systems, and that repetitive exercise affects the magnitude and stability of these responses...
  2. ncbi request reprint Exercise reverses the harmful effects of consumption of a high-fat diet on synaptic and behavioral plasticity associated to the action of brain-derived neurotrophic factor
    R Molteni
    Department of Physiological Science, Brain Injury Research Center, University of California at Los Angeles, 621 Charles E Young Drive, Los Angeles, CA 90095, USA
    Neuroscience 123:429-40. 2004
    ..Results unveil a possible molecular mechanism by which lifestyle factors can interact at a molecular level, and provide information for potential therapeutic applications to decrease the risk imposed by certain lifestyles...
  3. ncbi request reprint Voluntary exercise following traumatic brain injury: brain-derived neurotrophic factor upregulation and recovery of function
    G S Griesbach
    David Geffen School of Medicine at UCLA, Division of Neurosurgery, Los Angeles, CA 90095 7039, USA
    Neuroscience 125:129-39. 2004
    ..However, when exercise is administered to soon after TBI, the molecular response to exercise is disrupted and recovery may be delayed...
  4. ncbi request reprint A high-fat, refined sugar diet reduces hippocampal brain-derived neurotrophic factor, neuronal plasticity, and learning
    R Molteni
    Department of Physiological Science, University of California at Los Angeles, 621 Charles E Young Drive, 90095, USA
    Neuroscience 112:803-14. 2002
    ..Our results indicate that a popularly consumed diet can influence crucial aspects of neuronal and behavioral plasticity associated with the function of BDNF...
  5. ncbi request reprint Insulin-like growth factor I interfaces with brain-derived neurotrophic factor-mediated synaptic plasticity to modulate aspects of exercise-induced cognitive function
    Q Ding
    Department of Physiological Science, UCLA, 621 Charles E Young Drive, Los Angeles, CA 90095, USA
    Neuroscience 140:823-33. 2006
    ..Our results illustrate a possible mechanism by which insulin-like growth factor-I interfaces with the brain-derived neurotrophic factor system to mediate exercise-induced synaptic and cognitive plasticity...
  6. ncbi request reprint Coupling energy metabolism with a mechanism to support brain-derived neurotrophic factor-mediated synaptic plasticity
    S Vaynman
    Department of Physiological Science, UCLA, Los Angeles, CA 90095, USA
    Neuroscience 139:1221-34. 2006
    ..Our results reveal a fundamental mechanism by which key elements of energy metabolism may modulate the substrates of hippocampal synaptic plasticity...
  7. doi request reprint Exercise facilitates the action of dietary DHA on functional recovery after brain trauma
    A Wu
    Department of Integrative Biology and Physiology, University of California at Los Angeles, 621 Charles E Young Drive, Los Angeles, CA 90095, USA
    Neuroscience 248:655-63. 2013
    ..It is our contention that strategies that take advantage of the combined applications of diet and exercise may have additional effects to the injured brain. ..
  8. ncbi request reprint Spatial learning induces neurotrophin receptor and synapsin I in the hippocampus
    F Gomez-Pinilla
    Department of Physiological Science, UCLA, Los Angeles, CA 90095 1527, USA
    Brain Res 904:13-9. 2001
    ..Behavioral regulation of neurotrophins may provide a molecular basis for the enhanced cognitive function associated with active lifestyles, and guide development of strategies to promote neural healing after CNS injury or disease...
  9. pmc Docosahexaenoic acid dietary supplementation enhances the effects of exercise on synaptic plasticity and cognition
    A Wu
    Department of Physiological Science, University of California at Los Angeles, 621 Charles E Young Drive, Los Angeles, CA 90095, USA
    Neuroscience 155:751-9. 2008
    ..These results indicate that the DHA diet enhanced the effects of exercise on cognition and BDNF-related synaptic plasticity, a capacity that may be used to promote mental health and reduce risk of neurological disorders...
  10. ncbi request reprint Interplay between brain-derived neurotrophic factor and signal transduction modulators in the regulation of the effects of exercise on synaptic-plasticity
    S Vaynman
    Department of Physiological Science, UCLA, 621 Charles E Young Drive, Los Angeles, CA 90095, USA
    Neuroscience 122:647-57. 2003
    ..Since these molecules have a well-described association to BDNF action, our results illustrate a basic mechanism through which exercise may promote synaptic-plasticity in the adult brain...
  11. pmc The select action of hippocampal calcium calmodulin protein kinase II in mediating exercise-enhanced cognitive function
    S Vaynman
    Department of Physiological Science, UCLA, 621 Charles E Young Drive, Los Angeles, CA 90095, USA
    Neuroscience 144:825-33. 2007
    ..These findings indicate that hippocampal CAMKII may have a refined role in mediating the effects of exercise on cognition, selectively functioning to regulate memory retention...
  12. pmc BDNF-exercise interactions in the recovery of symmetrical stepping after a cervical hemisection in rats
    Z Ying
    Department of Physiological Science, University of California, Los Angeles, CA 90095 1527, USA
    Neuroscience 155:1070-8. 2008
    ..The results indicate that BDNF levels play an important role in shaping the synaptic plasticity and in defining the level of recovery of locomotor performance after a SCI...
  13. pmc Voluntary exercise or amphetamine treatment, but not the combination, increases hippocampal brain-derived neurotrophic factor and synapsin I following cortical contusion injury in rats
    G S Griesbach
    Division of Neurosurgery, Department of Surgery, David Geffen School of Medicine at UCLA, Box 957039, Los Angeles, CA 90095 7039, USA
    Neuroscience 154:530-40. 2008
    ..These results indicate that, whereas exercise or AMPH treatment alone may induce plasticity and reduce oxidative stress after TBI, combining these treatments may cancel each other's therapeutic effects...
  14. pmc Exercise impacts brain-derived neurotrophic factor plasticity by engaging mechanisms of epigenetic regulation
    F Gomez-Pinilla
    Department of Integrative Biology and Physiology, University of California Los Angeles, Los Angeles, CA, USA
    Eur J Neurosci 33:383-90. 2011
    ..Reported information about the impact of a behavior, inherently involved in the daily human routine, on the epigenome opens exciting new directions and therapeutic opportunities in the war against neurological and psychiatric disorders...
  15. pmc Dietary curcumin supplementation counteracts reduction in levels of molecules involved in energy homeostasis after brain trauma
    S Sharma
    Department of Physiological Science, UCLA, 621 Charles E Young Drive, Los Angeles, CA 90095, USA
    Neuroscience 161:1037-44. 2009
    ..These studies may foster a new line of therapeutic treatments for TBI patients by endogenous upregulation of molecules important for functional recovery...
  16. pmc Exercise influences hippocampal plasticity by modulating brain-derived neurotrophic factor processing
    Q Ding
    Department of Integrative Biology and Physiology, UCLA Brain Injury Research Center, University of California, Los Angeles, CA 90095, USA
    Neuroscience 192:773-80. 2011
    ..These results indicate that the effects of exercise on hippocampal plasticity are dependent on BDNF processing and subsequent TrkB signaling, with important implications for neuronal function...
  17. pmc Differential effects of exercise and dietary docosahexaenoic acid on molecular systems associated with control of allostasis in the hypothalamus and hippocampus
    F Gomez-Pinilla
    Department of Physiological Science, University of California Los Angeles, 621 Charles E Young Drive, Los Angeles, CA 90095, USA
    Neuroscience 168:130-7. 2010
    ..The results harmonize with the concept that exercise and dietary DHA exert specific actions on the hypothalamus and hippocampus, with implications for the regulations of brain plasticity and cognitive function...
  18. pmc Voluntary exercise increases oligodendrogenesis in spinal cord
    W Krityakiarana
    Intellectual and Developmental Disability Research Center, Semel Institute for Neuroscience and Human Behavior Department of Neurobiology, David Geffen, School of Medicine at UCLA, Los Angeles, California 90095, USA
    Int J Neurosci 120:280-90. 2010
    ..These results suggest that voluntary exercise positively influences oligodendrogenesis in the intact spinal cord, emphasizing the beneficial effects of voluntary exercise as a possible co-treatment for spinal cord injury...
  19. ncbi request reprint A "deficient environment" in prenatal life may compromise systems important for cognitive function by affecting BDNF in the hippocampus
    F Gomez-Pinilla
    Division of Neurosurgery, Department of Physiology Science, UCLA, 621 Charles E Young Dr, Los Angeles, CA 90095, USA
    Exp Neurol 192:235-43. 2005
    ..These findings have implications for disorders that involve a dysfunction in the BDNF system and are accompanied by cognitive deficits...
  20. ncbi request reprint Diazepam induces FGF-2 mRNA in the hippocampus and striatum
    F Gomez-Pinilla
    Department of Physiological Science, University of California, Los Angeles, Los Angeles, CA 90095, USA
    Brain Res Bull 53:283-9. 2000
    ..These results indicate that diazepam treatment up-regulates FGF-2 expression in select regions of the brain and suggest that GABA may promote neuroplasticity in concert with FGF-2...
  21. ncbi request reprint A saturated-fat diet aggravates the outcome of traumatic brain injury on hippocampal plasticity and cognitive function by reducing brain-derived neurotrophic factor
    A Wu
    Department of Physiological Science, University of California at Los Angeles, 621 Charles E Young Drive, Los Angeles, CA H 1450, USA
    Neuroscience 119:365-75. 2003
    ..The results suggest that FPI and diet impose a risk factor to the molecular machinery in charge of maintaining neuronal function under homeostatic and challenging situations...