Research Topics
Species | F Gomez-PinillaSummaryAffiliation: University of California Country: USA Publications
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Publications
Alterations in BDNF and synapsin I within the occipital cortex and hippocampus after mild traumatic brain injury in the developing rat: reflections of injury-induced neuroplasticityGrace Sophia Griesbach
Division of Neurosurgery, Department of Surgery, UCLA School of Medicine, Los Angeles, California 90024 7039, USA
J Neurotrauma 19:803-14. 2002....
Natural mood foods: the actions of polyphenols against psychiatric and cognitive disordersFernando Gomez-Pinilla
Department of Integrative Biology and Physiology, University of California, 621 Charles E Young Drive, Los Angeles, CA 90095, USA
Nutr Neurosci 15:127-33. 2012..Examining the molecular basis underlying the link between food intake and brain function has presented the exciting possibility of using diet as a viable method to battle cognitive and psychiatric disorders...- 'Metabolic syndrome' in the brain: deficiency in omega-3 fatty acid exacerbates dysfunctions in insulin receptor signalling and cognitionRahul Agrawal
Department of Integrative Biology and Physiology, University of California Los Angeles UCLA, Los Angeles, CA 90095, USA
J Physiol 590:2485-99. 2012..Results showed that dietary n-3 fatty acid deficiency elevates the vulnerability to metabolic dysfunction and impaired cognitive functions by modulating insulin receptor signalling and synaptic plasticity... - Brain and spinal cord interaction: protective effects of exercise prior to spinal cord injuryFernando Gomez-Pinilla
Department of Integrative Biology and Physiology, University of California Los Angeles, Los Angeles, California, United States of America
PLoS ONE 7:e32298. 2012..In particular, exercise prior to the injury onset appears to foster protective mechanisms in the brain and spinal cord... - Afferent input modulates neurotrophins and synaptic plasticity in the spinal cordFernando Gomez-Pinilla
Department of Physiological Science, UCLA Brain Injury Research Center, Los Angeles, California 90095, USA
J Neurophysiol 92:3423-32. 2004..Combined, these results indicate that the level of supraspinal and muscle afferent input plays an important role in modulating the levels of BDNF and NT-3 in the spinal cord... - The influences of diet and exercise on mental health through hormesisFernando Gomez-Pinilla
Division of Neurosurgery, Brain Injury Research Center, UCLA Medical School, Los Angeles, CA 90095, USA
Ageing Res Rev 7:49-62. 2008..In particular, neurotrophins are emerging as main factors in the equation that may connect lifestyle factors and mental health... - BDNF and learning: Evidence that instrumental training promotes learning within the spinal cord by up-regulating BDNF expressionF Gomez-Pinilla
Division of Neurosurgery, UCLA Brain Injury Research Center, USA
Neuroscience 148:893-906. 2007..The findings indicate that instrumental training enables learning and elevates BDNF mRNA levels within the lumbar spinal cord. BDNF is both necessary, and sufficient, to produce the enabling effect... - Brain-derived neurotrophic factor functions as a metabotrophin to mediate the effects of exercise on cognitionFernando Gomez-Pinilla
Department of Physiological Science, UCLA Brain Injury Research Center, Los Angeles, CA, USA
Eur J Neurosci 28:2278-87. 2008..These findings suggest that the effects of exercise on synaptic plasticity and cognitive function involve elements of energy metabolism, and that BDNF seems to work at the interface between the two processes as a metabotrophin... - Differential effects of exercise and dietary docosahexaenoic acid on molecular systems associated with control of allostasis in the hypothalamus and hippocampusF Gomez-Pinilla
Department of Physiological Science, University of California Los Angeles, 621 Charles E Young Drive, Los Angeles, CA 90095, USA
Neuroscience 168:130-7. 2010..The results harmonize with the concept that exercise and dietary DHA exert specific actions on the hypothalamus and hippocampus, with implications for the regulations of brain plasticity and cognitive function... - Exercise impacts brain-derived neurotrophic factor plasticity by engaging mechanisms of epigenetic regulationF Gomez-Pinilla
Department of Integrative Biology and Physiology, University of California Los Angeles, Los Angeles, CA, USA
Eur J Neurosci 33:383-90. 2011..Reported information about the impact of a behavior, inherently involved in the daily human routine, on the epigenome opens exciting new directions and therapeutic opportunities in the war against neurological and psychiatric disorders... - The influence of dietary factors in central nervous system plasticity and injury recoveryFernando Gomez-Pinilla
Department of Neurosurgery, University of California Los Angeles Brain Injury Research Center, Los Angeles, CA 90095, USA
PM R 3:S111-6. 2011..Therefore, exercise and dietary management appear as a noninvasive and effective strategy to help counteract neurologic and cognitive disorders... - Collaborative effects of diet and exercise on cognitive enhancementFernando Gomez-Pinilla
Department of Integrative Biology and Physiology, University of California Los Angeles, Los Angeles, CA 90095, USA
Nutr Health 20:165-9. 2011..Omega 3 fatty acids and curcumin elevate levels of molecules important for synaptic plasticity such as brain-derived neurotrophic factor (BDNF), thus benefiting normal brain function and recovery events following brain insults... - Diazepam induces FGF-2 mRNA in the hippocampus and striatumF Gomez-Pinilla
Department of Physiological Science, University of California, Los Angeles, Los Angeles, CA 90095, USA
Brain Res Bull 53:283-9. 2000..These results indicate that diazepam treatment up-regulates FGF-2 expression in select regions of the brain and suggest that GABA may promote neuroplasticity in concert with FGF-2... - The combined effects of exercise and foods in preventing neurological and cognitive disordersFernando Gomez-Pinilla
Dept of Integrative Biology and Physiology, and Dept of Neurosurgery, University of California Los Angeles, Los Angeles, CA 90095, USA
Prev Med 52:S75-80. 2011..New evidence indicates that exercise, in combination with dietary factors, exerts its effects by affecting molecular events related to the management of energy metabolism and synaptic plasticity... - Voluntary exercise induces a BDNF-mediated mechanism that promotes neuroplasticityFernando Gomez-Pinilla
Department of Physiological Science, Los Angeles, California 90095, USA
J Neurophysiol 88:2187-95. 2002..These results indicate that basal levels of neuromuscular activity are required to maintain normal levels of BDNF in the neuromuscular system and the potential for neuroplasticity... - Voluntary exercise following traumatic brain injury: brain-derived neurotrophic factor upregulation and recovery of functionG S Griesbach
David Geffen School of Medicine at UCLA, Division of Neurosurgery, Los Angeles, CA 90095 7039, USA
Neuroscience 125:129-39. 2004..However, when exercise is administered to soon after TBI, the molecular response to exercise is disrupted and recovery may be delayed... - Coupling energy metabolism with a mechanism to support brain-derived neurotrophic factor-mediated synaptic plasticityS Vaynman
Department of Physiological Science, UCLA, Los Angeles, CA 90095, USA
Neuroscience 139:1221-34. 2006..Our results reveal a fundamental mechanism by which key elements of energy metabolism may modulate the substrates of hippocampal synaptic plasticity... - Insulin-like growth factor I interfaces with brain-derived neurotrophic factor-mediated synaptic plasticity to modulate aspects of exercise-induced cognitive functionQ Ding
Department of Physiological Science, UCLA, 621 Charles E Young Drive, Los Angeles, CA 90095, USA
Neuroscience 140:823-33. 2006..Our results illustrate a possible mechanism by which insulin-like growth factor-I interfaces with the brain-derived neurotrophic factor system to mediate exercise-induced synaptic and cognitive plasticity... - Docosahexaenoic acid dietary supplementation enhances the effects of exercise on synaptic plasticity and cognitionA Wu
Department of Physiological Science, University of California at Los Angeles, 621 Charles E Young Drive, Los Angeles, CA 90095, USA
Neuroscience 155:751-9. 2008..These results indicate that the DHA diet enhanced the effects of exercise on cognition and BDNF-related synaptic plasticity, a capacity that may be used to promote mental health and reduce risk of neurological disorders... - Interplay between brain-derived neurotrophic factor and signal transduction modulators in the regulation of the effects of exercise on synaptic-plasticityS Vaynman
Department of Physiological Science, UCLA, 621 Charles E. Young Drive, Los Angeles, CA 90095, USA
Neuroscience 122:647-57. 2003..Since these molecules have a well-described association to BDNF action, our results illustrate a basic mechanism through which exercise may promote synaptic-plasticity in the adult brain... - The select action of hippocampal calcium calmodulin protein kinase II in mediating exercise-enhanced cognitive functionS Vaynman
Department of Physiological Science, UCLA, 621 Charles E Young Drive, Los Angeles, CA 90095, USA
Neuroscience 144:825-33. 2007..These findings indicate that hippocampal CAMKII may have a refined role in mediating the effects of exercise on cognition, selectively functioning to regulate memory retention... - BDNF-exercise interactions in the recovery of symmetrical stepping after a cervical hemisection in ratsZ Ying
Department of Physiological Science, University of California, Los Angeles, CA 90095 1527, USA
Neuroscience 155:1070-8. 2008..The results indicate that BDNF levels play an important role in shaping the synaptic plasticity and in defining the level of recovery of locomotor performance after a SCI... - Learning upregulates brain-derived neurotrophic factor messenger ribonucleic acid: a mechanism to facilitate encoding and circuit maintenance?J P Kesslak
Institute for Brain Aging and Department of Neurology, University of California, Irvine 92697 4540, USA
Behav Neurosci 112:1012-9. 1998..Furthermore, behaviors such as physical activity and learning may help maintain and protect neurons at risk in aging and neurodegenerative disease via increased BDNF expression... - Spatial learning induces neurotrophin receptor and synapsin I in the hippocampusF Gomez-Pinilla
Department of Physiological Science, UCLA, Los Angeles, CA 90095 1527, USA
Brain Res 904:13-9. 2001..Behavioral regulation of neurotrophins may provide a molecular basis for the enhanced cognitive function associated with active lifestyles, and guide development of strategies to promote neural healing after CNS injury or disease... - Voluntary exercise or amphetamine treatment, but not the combination, increases hippocampal brain-derived neurotrophic factor and synapsin I following cortical contusion injury in ratsG S Griesbach
Division of Neurosurgery, Department of Surgery, David Geffen School of Medicine at UCLA, Box 957039, Los Angeles, CA 90095 7039, USA
Neuroscience 154:530-40. 2008..These results indicate that, whereas exercise or AMPH treatment alone may induce plasticity and reduce oxidative stress after TBI, combining these treatments may cancel each other's therapeutic effects... - Dietary curcumin supplementation counteracts reduction in levels of molecules involved in energy homeostasis after brain traumaS Sharma
Department of Physiological Science, UCLA, 621 Charles E Young Drive, Los Angeles, CA 90095, USA
Neuroscience 161:1037-44. 2009..These studies may foster a new line of therapeutic treatments for TBI patients by endogenous upregulation of molecules important for functional recovery... - A saturated-fat diet aggravates the outcome of traumatic brain injury on hippocampal plasticity and cognitive function by reducing brain-derived neurotrophic factorA Wu
Department of Physiological Science, University of California at Los Angeles, 621 Charles E Young Drive, Los Angeles, CA H-1450, USA
Neuroscience 119:365-75. 2003..The results suggest that FPI and diet impose a risk factor to the molecular machinery in charge of maintaining neuronal function under homeostatic and challenging situations... - Differential regulation by exercise of BDNF and NT-3 in rat spinal cord and skeletal muscleF Gomez-Pinilla
Department of Physiological Science, UCLA, Los Angeles, CA 90095 1527, USA
Eur J Neurosci 13:1078-84. 2001..These results show that neuromuscular activity has specific effects on the BDNF and NT-3 systems, and that repetitive exercise affects the magnitude and stability of these responses... - Vitamin E protects against oxidative damage and learning disability after mild traumatic brain injury in rats- Aiguo Wu
University of California at Los Angeles, Los Angeles, California 90095, USA
Neurorehabil Neural Repair 24:290-8. 2010..The elevation of superoxide dismutase (SOD) and Sir2 (silent information regulator 2) play an important role in resistance to oxidative stress... - Exercise influences hippocampal plasticity by modulating brain-derived neurotrophic factor processingQ Ding
Department of Integrative Biology and Physiology, UCLA Brain Injury Research Center, University of California, Los Angeles, CA 90095, USA
Neuroscience 192:773-80. 2011..These results indicate that the effects of exercise on hippocampal plasticity are dependent on BDNF processing and subsequent TrkB signaling, with important implications for neuronal function... - Voluntary exercise increases oligodendrogenesis in spinal cordW Krityakiarana
Intellectual and Developmental Disability Research Center, Semel Institute for Neuroscience and Human Behavior Department of Neurobiology, David Geffen, School of Medicine at UCLA, Los Angeles, California 90095, USA
Int J Neurosci 120:280-90. 2010..These results suggest that voluntary exercise positively influences oligodendrogenesis in the intact spinal cord, emphasizing the beneficial effects of voluntary exercise as a possible co-treatment for spinal cord injury... - Exercise normalizes levels of MAG and Nogo-A growth inhibitors after brain traumaGabriela Chytrova
Department of Physiological Science, UCLA, 621 Charles E Young Drive, Los Angeles, CA 90095, USA
Eur J Neurosci 27:1-11. 2008..These results indicate that exercise promotes a permissive cellular environment for repair after TBI, in a process in which BDNF plays a central role... - A pyrazole curcumin derivative restores membrane homeostasis disrupted after brain traumaSandeep Sharma
Department of Integrative Biology and Physiology, University of California, LA, CA 90095, USA
Exp Neurol 226:191-9. 2010.... - A "deficient environment" in prenatal life may compromise systems important for cognitive function by affecting BDNF in the hippocampusF Gomez-Pinilla
Division of Neurosurgery, Department of Physiology Science, UCLA, 621 Charles E Young Dr, Los Angeles, CA 90095, USA
Exp Neurol 192:235-43. 2005..These findings have implications for disorders that involve a dysfunction in the BDNF system and are accompanied by cognitive deficits... - Exercise-induced improvement in cognitive performance after traumatic brain injury in rats is dependent on BDNF activationGrace Sophia Griesbach
Department of Neurosurgery, David Geffen School of Medicine, UCLA, Los Angeles, CA 90095 7039, USA
Brain Res 1288:105-15. 2009..These studies provide evidence that BDNF has a major role in exercise's cognitive effects in traumatically injured brain... - The upregulation of plasticity-related proteins following TBI is disrupted with acute voluntary exerciseGrace Sophia Griesbach
Division of Neurosurgery, Department of Surgery, UCLA, Los Angeles, CA, USA
Brain Res 1016:154-62. 2004..These results indicate that intracellular signaling proteins are increased during the first week following FPI and that premature voluntary exercise may compromise plasticity... - Controlled contusion injury alters molecular systems associated with cognitive performanceGrace Sophia Griesbach
Department of Neurosurgery, University of California, Los Angeles, California 90024 7039, USA
J Neurosci Res 87:795-805. 2009..In addition, the delayed increase in the expression of BDNF and synapsin I within the cortex contralateral to CCI may reflect restorative processes in areas homotypical to the injury... - Exercise decreases myelin-associated glycoprotein expression in the spinal cord and positively modulates neuronal growthCristina A Ghiani
Jane and Terry Semel Institute for Neuroscience and Human Behavior, Department of Neurobiology and Psychiatry, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA 90095, USA
Glia 55:966-75. 2007..Overall, these results show that exercise promotes a permissive cellular environment for axonal growth in the adult spinal cord requiring BDNF action... - Omega-3 fatty acids supplementation restores mechanisms that maintain brain homeostasis in traumatic brain injuryAiguo Wu
Department of Physiological Science, University of California at Los Angeles UCLA, Los Angeles, California 90095, USA
J Neurotrauma 24:1587-95. 2007..In addition, results show the capacity of omega-3 fatty acids to counteract some of the effects of TBI by normalizing levels of molecular systems associated with energy homeostasis... - Traumatic brain injury induced neuroprotection of retinal ganglion cells to optic nerve crushGuy J Ben Simon
Jules Stein Eye Institute and Department of Ophthalmology, David Geffen School of Medicine at UCLA, Los Angeles, California, USA
J Neurotrauma 23:1072-82. 2006..This neuroprotective effect, which appears unrelated to retinal BDNF, is inhibited by high-dose MP, commonly used clinically to treat traumatic optic neuropathy... - Suppression of hippocampal plasticity-related gene expression by sleep deprivation in ratsRuben Guzman-Marin
Research Service (151A3, V. A. Greater Los Angeles Healthcare System, 16111 Plummer Street, North Hills CA 91343, USA
J Physiol 575:807-19. 2006..Stepwise regression analysis suggested that loss of REM sleep underlies the effects of SD on hippocampal BDNF, Synapsin I and CREB mRNA levels, whereas loss of NREM sleep underlies the effects on CAMKII mRNA... - Revenge of the "sit": how lifestyle impacts neuronal and cognitive health through molecular systems that interface energy metabolism with neuronal plasticityShoshanna Vaynman
Department of Neurosurgery and Physiological Science and Brain Injury Research Center, UCLA School of Medicine, Los Angeles, California 90095, USA
J Neurosci Res 84:699-715. 2006..The ability of exercise and diet to impact systems that promote cell survival and plasticity may be applicable for combating the deleterious effects of disease and ageing on brain health and cognition... - Exercise differentially regulates synaptic proteins associated to the function of BDNFShoshanna S Vaynman
Department of Physiological Science, UCLA, 621 Charles E Young Drive, Los Angeles, CA 90095, USA
Brain Res 1070:124-30. 2006..Blocking BDNF abrogated the exercise-induced increases in synapsin I and synatophysin, revealing that exercise regulates select properties of synaptic transmission under the direction of BDNF... - The interplay between oxidative stress and brain-derived neurotrophic factor modulates the outcome of a saturated fat diet on synaptic plasticity and cognitionAiguo Wu
Department of Physiological Science, University of California at Los Angeles, 621 Charles E. Young Drive, Los Angeles, California 90095, USA
Eur J Neurosci 19:1699-707. 2004.... - Exercise affects energy metabolism and neural plasticity-related proteins in the hippocampus as revealed by proteomic analysisQinxue Ding
Department of Neurosurgery, Brain Injury Research Centre, UCLA, 621 Charles E. Young Drive, Los Angeles, CA 90095, USA
Eur J Neurosci 24:1265-76. 2006.... - Oxidative stress modulates Sir2alpha in rat hippocampus and cerebral cortexAiguo Wu
Department of Physiological Science, University of California at Los Angeles, 621 Charles E. Young Drive, Los Angeles, CA 90095, USA
Eur J Neurosci 23:2573-80. 2006..The present results show that oxidative stress and energy homeostasis associated with the consumption of the high-fat diet are critical for the regulation of Sir2alpha, with important implications for mechanisms of neural repair... - Dietary curcumin counteracts the outcome of traumatic brain injury on oxidative stress, synaptic plasticity, and cognitionAiguo Wu
Department of Physiological Science, University of California at Los Angeles, 621 Charles E. Young Drive, 90095, USA
Exp Neurol 197:309-17. 2006..The fact that oxidative stress is an intrinsic component of the neurological sequel of TBI and other insults indicates that dietary antioxidant therapy is a realistic approach to promote protective mechanisms in the injured brain... - License to run: exercise impacts functional plasticity in the intact and injured central nervous system by using neurotrophinsShoshanna Vaynman
Department of Neurosurgery and Physiological Science, and Brain Injury Research Center, UCLA School of Medicine, Los Angeles, CA 90095, USA
Neurorehabil Neural Repair 19:283-95. 2005.... - Hippocampal BDNF mediates the efficacy of exercise on synaptic plasticity and cognitionShoshanna Vaynman
Department of Physiological Science, UCLA, 621 Charles E. Young Drive, Los Angeles, CA 90095, USA
Eur J Neurosci 20:2580-90. 2004..These findings suggest a functional role for CREB under the control of BDNF in mediating the exercise-induced enhancement in learning and memory. Our results indicate that synapsin I might also contribute to this BDNF-mediated mechanism... - Neurobiology of exerciseRod K Dishman
Department of Exercise Science, The University of Georgia, Ramsey Center, 330 River Road, Athens, GA 30602 6554, USA
Obesity (Silver Spring) 14:345-56. 2006.... - Dietary omega-3 fatty acids normalize BDNF levels, reduce oxidative damage, and counteract learning disability after traumatic brain injury in ratsAiguo Wu
Department of Physiological Science, University of California at Los Angeles, 90095, USA
J Neurotrauma 21:1457-67. 2004..These results imply that omega-3 enriched dietary supplements can provide protection against reduced plasticity and impaired learning ability after traumatic brain injury... - Expression of heat shock protein (HSP)-25 and HSP-32 in the rat spinal cord reconstructed with NeurogelStéphane Woerly
Organogel Canada Ltee, 1400 Parc Technologique Blvd, GIP 4R7, Quebec, Quebec, Canada
Neurochem Res 30:721-35. 2005..In conclusion, Neurogel reconstruction of the spine during the acute phase considerably reduces secondary damage resulting in a rapid and stable regenerative response... - The influence of diet and physical activity on brain repair and neurosurgical outcomeFernando Gomez-Pinilla
Surg Neurol 70:333-5; discussion 335-6. 2008
Research Grants
- Neurotrophins Support Spinal Cord Learning and RehabilitationFernando Gomez Pinilla; Fiscal Year: 2010..Success in the proposed investigations should provide new strategies for the development of treatments to improve functional recovery after spinal cord injury. ..
- Restoration of Homeostasis After Brain TraumaFernando Gomez Pinilla; Fiscal Year: 2009..A positive outcome of these studies would open a new line of therapeutic treatments for TBI patients by endogenous up-regulation of neurotrophins. ..
- Activity-Induced Recovery Following Brain TraumaFernando Gomez Pinilla; Fiscal Year: 2007..Therefore, the unique aspect of our proposal is to evaluate experience as a modulator of neuronal plasticity that can be used to enhance functional recovery following TBI. ..
- NEUROTROPHIN REGULATION IN THE SPINAL CORDFernando Gomez Pinilla; Fiscal Year: 2003..abstract_text> ..
- PHYSICAL ACTIVITY INDUCES NEUROTROPHIC FACTORSFernando Gomez Pinilla; Fiscal Year: 2002..Thirdly, the PI will determine whether locomotor deficit caused by degeneration of large muscle afferents (by using high doses of pyridoxine) can be countered by daily locomotion induction of neurotrophins. ..
- Restoration of Homeostasis After Brain TraumaFernando Gomez Pinilla; Fiscal Year: 2010..Our design relies on the powerful action of select dietary factors and exercise to modulate membrane physiology, synaptic function, and to enhance cognitive abilities. ..