Research Topics
| Mark GomelskySummaryAffiliation: University of Wyoming Country: USA Publications
| Collaborators
|
Detail Information
Publications
Light helps bacteria make important lifestyle decisionsMark Gomelsky
Department of Molecular Biology, University of Wyoming, Laramie, WY 82071, USA
Trends Microbiol 19:441-8. 2011..We also discuss how 'seeing' helps some pathogenic bacteria make another important choice, i.e. between environmental and host-associated lifestyles...
BLUF: a novel FAD-binding domain involved in sensory transduction in microorganismsMark Gomelsky
Department of Molecular Biology, University of Wyoming, Laramie, WY 82071 3944, USA
Trends Biochem Sci 27:497-500. 2002..The predicted secondary structure reveals that the BLUF domain is a novel FAD-binding fold...- Identification and in vivo characterization of PpaA, a regulator of photosystem formation in Rhodobacter sphaeroidesLarissa Gomelsky
Department of Molecular Biology, University of Wyoming, Laramie, WY 82071 3944, USA
Microbiology 149:377-88. 2003..It is suggested that PpaA binds a corrinoid cofactor and the availability or structure of this cofactor affects PpaA activity... 
Hierarchical regulation of photosynthesis gene expression by the oxygen-responsive PrrBA and AppA-PpsR systems of Rhodobacter sphaeroidesLarissa Gomelsky
Department of Molecular Biology, University of Wyoming, Laramie, WY 82071, USA
J Bacteriol 190:8106-14. 2008....- Novel heme-based oxygen sensor with a revealing evolutionary historyOleg V Moskvin
Department of Molecular Biology, University of Wyoming, Laramie, Wyoming 82071, USA
J Biol Chem 282:28740-8. 2007..A phylogenetic analysis revealed that SCHIC domain proteins form a distinct cluster within a superfamily that includes vitamin B(12)-binding proteins and other proteins that may bind other kinds of tetrapyrroles... - Transcriptome analysis of the Rhodobacter sphaeroides PpsR regulon: PpsR as a master regulator of photosystem developmentOleg V Moskvin
Department of Molecular Biology, University of Wyoming, Laramie, WY 82071, USA
J Bacteriol 187:2148-56. 2005..It is revealed that the PrrBA and AppA-PpsR systems, believed to work independently, in fact interact and coordinately regulate photosystem development... - Natural and engineered photoactivated nucleotidyl cyclases for optogenetic applicationsMin Hyung Ryu
Department of Molecular Biology, University of Wyoming, Laramie, Wyoming 82071, USA
J Biol Chem 285:41501-8. 2010.... - The PpaA/AerR regulators of photosynthesis gene expression from anoxygenic phototrophic proteobacteria contain heme-binding SCHIC domainsOleg V Moskvin
Department of Molecular Biology, University of Wyoming, Dept 3944, 1000 E University Ave, Laramie, WY 82071, USA
J Bacteriol 192:5253-6. 2010..Here we show that the predicted SCHIC domain PpaA/AerR regulators also bind heme and respond to oxygen in vitro, despite their low sequence identity with AppA... - The PilZ domain is a receptor for the second messenger c-di-GMP: the PilZ domain protein YcgR controls motility in enterobacteriaDmitri A Ryjenkov
Department of Molecular Biology, University of Wyoming, Laramie, Wyoming 82071, USA
J Biol Chem 281:30310-4. 2006..Therefore, biochemical and genetic evidence presented here establishes PilZ as a long sought after c-di-GMP-binding domain and YcgR as a c-di-GMP receptor affecting motility in enterobacteria... - Rhodobase, a meta-analytical tool for reconstructing gene regulatory networks in a model photosynthetic bacteriumOleg V Moskvin
Department of Molecular Biology, University of Wyoming, Laramie, WY 82071, USA
Biosystems 103:125-31. 2011..The database of transcriptional profile correlations, the network visualization engine and the optimized search engine for transcription factor binding sites analysis are available at http://rhodobase.org... - An unorthodox bacteriophytochrome from Rhodobacter sphaeroides involved in turnover of the second messenger c-di-GMPMarina Tarutina
Department of Molecular Biology, University of Wyoming, Laramie, Wyoming 82071, USA
J Biol Chem 281:34751-8. 2006..BphG1 is potentially the first "bifunctional" enzyme capable of both c-di-GMP synthesis and hydrolysis. A model for the regulation of the "opposite" activities of BphG1 is presented... - The ubiquitous protein domain EAL is a cyclic diguanylate-specific phosphodiesterase: enzymatically active and inactive EAL domainsAndrew J Schmidt
Department of Molecular Biology, University of Wyoming, Laramie, 82071, USA
J Bacteriol 187:4774-81. 2005..The enzymatic inactivity of EAL domains may explain their coexistence with GGDEF domains in proteins possessing c-di-GMP synthase (diguanulate cyclase) activity... - A post-translational, c-di-GMP-dependent mechanism regulating flagellar motilityXin Fang
Department of Molecular Biology, University of Wyoming, Laramie, WY 82071, USA
Mol Microbiol 76:1295-305. 2010.... - Construction and validation of the Rhodobacter sphaeroides 2.4.1 DNA microarray: transcriptome flexibility at diverse growth modesChristopher T Pappas
Department of Molecular Biology, University of Wyoming, 1000 E. University Ave, Dept. 3944, Laramie, WY 82071, USA
J Bacteriol 186:4748-58. 2004..sphaeroides genechip as a powerful and reliable tool for studying unprecedented metabolic versatility of this bacterium... - Cyclic diguanylate is a ubiquitous signaling molecule in bacteria: insights into biochemistry of the GGDEF protein domainDmitri A Ryjenkov
Department of Molecular Biology, University of Wyoming, Dept 3944, 1000 E University Ave, Laramie, WY 82071, USA
J Bacteriol 187:1792-8. 2005..This study establishes that majority of GGDEF domain proteins are c-di-GMP specific, that c-di-GMP synthesis is a wide-spread phenomenon in Bacteria, and that it is highly regulated... - Earliest changes in the left ventricular transcriptome postmyocardial infarctionMark H Harpster
Department of Molecular Biology, University of Wyoming, Laramie, 82071, USA
Mamm Genome 17:701-15. 2006..ARG1: was the single-most highly induced transcript in the database (121-fold in IF region) and its induction in heart has not been previously reported... - Structure of a bacterial BLUF photoreceptor: insights into blue light-mediated signal transductionAstrid Jung
Max Planck Institute for Medical Research, Department of Biomolecular Mechanisms, Jahnstrasse 29, 69120 Heidelberg, Germany
Proc Natl Acad Sci U S A 102:12350-5. 2005..The structure suggests a unique photochemical signaling switch in which the absorption of light induces a structural change in the rim surrounding the hook, thereby changing the protein interface between BLUF and the output domain... - Responses of the Rhodobacter sphaeroides transcriptome to blue light under semiaerobic conditionsStephan Braatsch
, , Giesse, Germany
J Bacteriol 186:7726-35. 2004..The identified transcriptome responses provided a framework for deciphering blue-light-dependent signal transduction pathways in R. sphaeroides... - A single flavoprotein, AppA, integrates both redox and light signals in Rhodobacter sphaeroidesStephan Braatsch
, , Germany
Mol Microbiol 45:827-36. 2002..capsulatus, is known to participate in the redox-dependent control of photosynthesis gene expression. Thus, AppA is the first example of a protein with dual sensing capabilities that integrates both redox and light signals... - Transcriptome and physiological responses to hydrogen peroxide of the facultatively phototrophic bacterium Rhodobacter sphaeroidesTanja Zeller
, University of Giessen, Germany
J Bacteriol 187:7232-42. 2005..The transcription of the AppA-PpsR-dependent genes was down at 30 min, apparently due to the significant decrease in appA mRNA... - A staphylococcal GGDEF domain protein regulates biofilm formation independently of cyclic dimeric GMPLinda M Holland
School of Biomolecular and Biomedical Science, Ardmore House, University College Dublin, Belfield, Dublin 4, Ireland
J Bacteriol 190:5178-89. 2008..Our data raise the possibility that staphylococci cannot synthesize c-di-GMP and have only remnants of a c-di-GMP signaling pathway... - Regulation of hydrogen peroxide-dependent gene expression in Rhodobacter sphaeroides: regulatory functions of OxyRTanja Zeller
Institut fur Mikrobiologie und Molekularbiologie, University of Giessen, Giessen, Germany
J Bacteriol 189:3784-92. 2007..The role of reduced OxyR as an activator is shown for the first time. Our data reveal that the OxyR-mediated response is fast and transient. In addition, we found that additional regulatory pathways are involved in the H(2)O(2) response... - C-di-GMP: the dawning of a novel bacterial signalling systemUte Romling
Microbiology and Tumor Biology Center, Karolinska Institutet, Box 280, SE 17177 Stockholm, Sweden
Mol Microbiol 57:629-39. 2005..The accumulated data clearly indicate that a novel ubiquitous signalling system in bacteria has been discovered... - The flagellar sigma factor FliA regulates adhesion and invasion of Crohn disease-associated Escherichia coli via a cyclic dimeric GMP-dependent pathwayLaurent Claret
université Clermont 1, Pathogenie Bacterienne Intestinale, Institut National de la Recherche Agronomique, Unité Sous Contrat 2018 USC INRA 2018, Clermont Ferrand F 63001, France
J Biol Chem 282:33275-83. 2007..These findings show that in the AIEC strain LF82, FliA is a key regulatory component linking flagellar and type 1 pili synthesis and that its effect on type 1 pili is mediated, at least in part, via a c-di-GMP-dependent pathway...