Mark Gomelsky

Summary

Affiliation: University of Wyoming
Country: USA

Publications

  1. doi A zinc lock on GGDEF domain dimerization inhibits E. coli biofilms
    Mark Gomelsky
    Department of Molecular Biology, University of Wyoming, 1000 E University Avenue, Laramie, WY 82071, USA
    Structure 21:1067-8. 2013
  2. doi Light helps bacteria make important lifestyle decisions
    Mark Gomelsky
    Department of Molecular Biology, University of Wyoming, Laramie, WY 82071, USA
    Trends Microbiol 19:441-8. 2011
  3. ncbi BLUF: a novel FAD-binding domain involved in sensory transduction in microorganisms
    Mark Gomelsky
    Department of Molecular Biology, University of Wyoming, Laramie, WY 82071 3944, USA
    Trends Biochem Sci 27:497-500. 2002
  4. ncbi Identification and in vivo characterization of PpaA, a regulator of photosystem formation in Rhodobacter sphaeroides
    Larissa Gomelsky
    Department of Molecular Biology, University of Wyoming, Laramie, WY 82071 3944, USA
    Microbiology 149:377-88. 2003
  5. pmc Hierarchical regulation of photosynthesis gene expression by the oxygen-responsive PrrBA and AppA-PpsR systems of Rhodobacter sphaeroides
    Larissa Gomelsky
    Department of Molecular Biology, University of Wyoming, Laramie, WY 82071, USA
    J Bacteriol 190:8106-14. 2008
  6. ncbi Novel heme-based oxygen sensor with a revealing evolutionary history
    Oleg V Moskvin
    Department of Molecular Biology, University of Wyoming, Laramie, Wyoming 82071, USA
    J Biol Chem 282:28740-8. 2007
  7. pmc Transcriptome analysis of the Rhodobacter sphaeroides PpsR regulon: PpsR as a master regulator of photosystem development
    Oleg V Moskvin
    Department of Molecular Biology, University of Wyoming, Laramie, WY 82071, USA
    J Bacteriol 187:2148-56. 2005
  8. pmc The PpaA/AerR regulators of photosynthesis gene expression from anoxygenic phototrophic proteobacteria contain heme-binding SCHIC domains
    Oleg V Moskvin
    Department of Molecular Biology, University of Wyoming, Dept 3944, 1000 E University Ave, Laramie, WY 82071, USA
    J Bacteriol 192:5253-6. 2010
  9. pmc Natural and engineered photoactivated nucleotidyl cyclases for optogenetic applications
    Min Hyung Ryu
    Department of Molecular Biology, University of Wyoming, Laramie, Wyoming 82071, USA
    J Biol Chem 285:41501-8. 2010
  10. ncbi The PilZ domain is a receptor for the second messenger c-di-GMP: the PilZ domain protein YcgR controls motility in enterobacteria
    Dmitri A Ryjenkov
    Department of Molecular Biology, University of Wyoming, Laramie, Wyoming 82071, USA
    J Biol Chem 281:30310-4. 2006

Collaborators

Detail Information

Publications28

  1. doi A zinc lock on GGDEF domain dimerization inhibits E. coli biofilms
    Mark Gomelsky
    Department of Molecular Biology, University of Wyoming, 1000 E University Avenue, Laramie, WY 82071, USA
    Structure 21:1067-8. 2013
    ..coli. The authors show that zinc ions bound to the CZB domain inhibit enzyme activity and reveal how zinc availability affects biofilm formation. ..
  2. doi Light helps bacteria make important lifestyle decisions
    Mark Gomelsky
    Department of Molecular Biology, University of Wyoming, Laramie, WY 82071, USA
    Trends Microbiol 19:441-8. 2011
    ..We also discuss how 'seeing' helps some pathogenic bacteria make another important choice, i.e. between environmental and host-associated lifestyles...
  3. ncbi BLUF: a novel FAD-binding domain involved in sensory transduction in microorganisms
    Mark Gomelsky
    Department of Molecular Biology, University of Wyoming, Laramie, WY 82071 3944, USA
    Trends Biochem Sci 27:497-500. 2002
    ..The predicted secondary structure reveals that the BLUF domain is a novel FAD-binding fold...
  4. ncbi Identification and in vivo characterization of PpaA, a regulator of photosystem formation in Rhodobacter sphaeroides
    Larissa Gomelsky
    Department of Molecular Biology, University of Wyoming, Laramie, WY 82071 3944, USA
    Microbiology 149:377-88. 2003
    ..It is suggested that PpaA binds a corrinoid cofactor and the availability or structure of this cofactor affects PpaA activity...
  5. pmc Hierarchical regulation of photosynthesis gene expression by the oxygen-responsive PrrBA and AppA-PpsR systems of Rhodobacter sphaeroides
    Larissa Gomelsky
    Department of Molecular Biology, University of Wyoming, Laramie, WY 82071, USA
    J Bacteriol 190:8106-14. 2008
    ....
  6. ncbi Novel heme-based oxygen sensor with a revealing evolutionary history
    Oleg V Moskvin
    Department of Molecular Biology, University of Wyoming, Laramie, Wyoming 82071, USA
    J Biol Chem 282:28740-8. 2007
    ..A phylogenetic analysis revealed that SCHIC domain proteins form a distinct cluster within a superfamily that includes vitamin B(12)-binding proteins and other proteins that may bind other kinds of tetrapyrroles...
  7. pmc Transcriptome analysis of the Rhodobacter sphaeroides PpsR regulon: PpsR as a master regulator of photosystem development
    Oleg V Moskvin
    Department of Molecular Biology, University of Wyoming, Laramie, WY 82071, USA
    J Bacteriol 187:2148-56. 2005
    ..It is revealed that the PrrBA and AppA-PpsR systems, believed to work independently, in fact interact and coordinately regulate photosystem development...
  8. pmc The PpaA/AerR regulators of photosynthesis gene expression from anoxygenic phototrophic proteobacteria contain heme-binding SCHIC domains
    Oleg V Moskvin
    Department of Molecular Biology, University of Wyoming, Dept 3944, 1000 E University Ave, Laramie, WY 82071, USA
    J Bacteriol 192:5253-6. 2010
    ..Here we show that the predicted SCHIC domain PpaA/AerR regulators also bind heme and respond to oxygen in vitro, despite their low sequence identity with AppA...
  9. pmc Natural and engineered photoactivated nucleotidyl cyclases for optogenetic applications
    Min Hyung Ryu
    Department of Molecular Biology, University of Wyoming, Laramie, Wyoming 82071, USA
    J Biol Chem 285:41501-8. 2010
    ....
  10. ncbi The PilZ domain is a receptor for the second messenger c-di-GMP: the PilZ domain protein YcgR controls motility in enterobacteria
    Dmitri A Ryjenkov
    Department of Molecular Biology, University of Wyoming, Laramie, Wyoming 82071, USA
    J Biol Chem 281:30310-4. 2006
    ..Therefore, biochemical and genetic evidence presented here establishes PilZ as a long sought after c-di-GMP-binding domain and YcgR as a c-di-GMP receptor affecting motility in enterobacteria...
  11. pmc The ubiquitous protein domain EAL is a cyclic diguanylate-specific phosphodiesterase: enzymatically active and inactive EAL domains
    Andrew J Schmidt
    Department of Molecular Biology, University of Wyoming, Laramie, 82071, USA
    J Bacteriol 187:4774-81. 2005
    ..The enzymatic inactivity of EAL domains may explain their coexistence with GGDEF domains in proteins possessing c-di-GMP synthase (diguanulate cyclase) activity...
  12. pmc Cyclic diguanylate is a ubiquitous signaling molecule in bacteria: insights into biochemistry of the GGDEF protein domain
    Dmitri A Ryjenkov
    Department of Molecular Biology, University of Wyoming, Dept 3944, 1000 E University Ave, Laramie, WY 82071, USA
    J Bacteriol 187:1792-8. 2005
    ..This study establishes that majority of GGDEF domain proteins are c-di-GMP specific, that c-di-GMP synthesis is a wide-spread phenomenon in Bacteria, and that it is highly regulated...
  13. doi Rhodobase, a meta-analytical tool for reconstructing gene regulatory networks in a model photosynthetic bacterium
    Oleg V Moskvin
    Department of Molecular Biology, University of Wyoming, Laramie, WY 82071, USA
    Biosystems 103:125-31. 2011
    ..The database of transcriptional profile correlations, the network visualization engine and the optimized search engine for transcription factor binding sites analysis are available at http://rhodobase.org...
  14. ncbi An unorthodox bacteriophytochrome from Rhodobacter sphaeroides involved in turnover of the second messenger c-di-GMP
    Marina Tarutina
    Department of Molecular Biology, University of Wyoming, Laramie, Wyoming 82071, USA
    J Biol Chem 281:34751-8. 2006
    ..BphG1 is potentially the first "bifunctional" enzyme capable of both c-di-GMP synthesis and hydrolysis. A model for the regulation of the "opposite" activities of BphG1 is presented...
  15. doi A post-translational, c-di-GMP-dependent mechanism regulating flagellar motility
    Xin Fang
    Department of Molecular Biology, University of Wyoming, Laramie, WY 82071, USA
    Mol Microbiol 76:1295-305. 2010
    ....
  16. pmc Construction and validation of the Rhodobacter sphaeroides 2.4.1 DNA microarray: transcriptome flexibility at diverse growth modes
    Christopher T Pappas
    Department of Molecular Biology, University of Wyoming, 1000 E University Ave, Dept 3944, Laramie, WY 82071, USA
    J Bacteriol 186:4748-58. 2004
    ..sphaeroides genechip as a powerful and reliable tool for studying unprecedented metabolic versatility of this bacterium...
  17. ncbi c-di-GMP signaling regulates E. coli O157:H7 adhesion to colonic epithelium
    Jia Hu
    Department of Animal Science, University of Wyoming, Laramie, WY 82071, USA
    Vet Microbiol 164:344-51. 2013
    ..Collectively, data indicated that c-di-GMP signaling positively regulates E. coli O157:H7 intestinal epithelial cell and tissue colonization and expression of associated adhesion factors...
  18. pmc GIL, a new c-di-GMP-binding protein domain involved in regulation of cellulose synthesis in enterobacteria
    Xin Fang
    Department of Molecular Biology, University of Wyoming, Laramie, WY, 82071, USA
    Mol Microbiol 93:439-52. 2014
    ..It appears that cellulose production in enterobacteria is controlled by a two-tiered c-di-GMP-dependent system involving BcsE and the PilZ domain containing glycosyltransferase BcsA. ..
  19. pmc Engineering adenylate cyclases regulated by near-infrared window light
    Min Hyung Ryu
    Department of Molecular Biology, University of Wyoming, Laramie, WY 82071
    Proc Natl Acad Sci U S A 111:10167-72. 2014
    ..The insights derived from this study can be applied to the engineering of other homodimeric bacteriophytochromes, which will further expand the optogenetic toolset. ..
  20. ncbi Earliest changes in the left ventricular transcriptome postmyocardial infarction
    Mark H Harpster
    Department of Molecular Biology, University of Wyoming, Laramie, 82071, USA
    Mamm Genome 17:701-15. 2006
    ..ARG1: was the single-most highly induced transcript in the database (121-fold in IF region) and its induction in heart has not been previously reported...
  21. ncbi A single flavoprotein, AppA, integrates both redox and light signals in Rhodobacter sphaeroides
    Stephan Braatsch
    Institut fur Mikrobiologie und Molekularbiologie, Universitat Giessen, Germany
    Mol Microbiol 45:827-36. 2002
    ..capsulatus, is known to participate in the redox-dependent control of photosynthesis gene expression. Thus, AppA is the first example of a protein with dual sensing capabilities that integrates both redox and light signals...
  22. pmc Transcriptome and physiological responses to hydrogen peroxide of the facultatively phototrophic bacterium Rhodobacter sphaeroides
    Tanja Zeller
    Institut fur Mikrobiologie und Molekularbiologie, University of Giessen, Germany
    J Bacteriol 187:7232-42. 2005
    ..The transcription of the AppA-PpsR-dependent genes was down at 30 min, apparently due to the significant decrease in appA mRNA...
  23. pmc Structure of a bacterial BLUF photoreceptor: insights into blue light-mediated signal transduction
    Astrid Jung
    Max Planck Institute for Medical Research, Department of Biomolecular Mechanisms, Jahnstrasse 29, 69120 Heidelberg, Germany
    Proc Natl Acad Sci U S A 102:12350-5. 2005
    ..The structure suggests a unique photochemical signaling switch in which the absorption of light induces a structural change in the rim surrounding the hook, thereby changing the protein interface between BLUF and the output domain...
  24. pmc Responses of the Rhodobacter sphaeroides transcriptome to blue light under semiaerobic conditions
    Stephan Braatsch
    Institut fur Mikrobiologie und Molekularbiologie, Universitat Giessen, Giesse, Germany
    J Bacteriol 186:7726-35. 2004
    ..The identified transcriptome responses provided a framework for deciphering blue-light-dependent signal transduction pathways in R. sphaeroides...
  25. pmc A staphylococcal GGDEF domain protein regulates biofilm formation independently of cyclic dimeric GMP
    Linda M Holland
    School of Biomolecular and Biomedical Science, Ardmore House, University College Dublin, Belfield, Dublin 4, Ireland
    J Bacteriol 190:5178-89. 2008
    ..Our data raise the possibility that staphylococci cannot synthesize c-di-GMP and have only remnants of a c-di-GMP signaling pathway...
  26. ncbi The flagellar sigma factor FliA regulates adhesion and invasion of Crohn disease-associated Escherichia coli via a cyclic dimeric GMP-dependent pathway
    Laurent Claret
    université Clermont 1, Pathogenie Bacterienne Intestinale, Institut National de la Recherche Agronomique, Unité Sous Contrat 2018 USC INRA 2018, Clermont Ferrand F 63001, France
    J Biol Chem 282:33275-83. 2007
    ..These findings show that in the AIEC strain LF82, FliA is a key regulatory component linking flagellar and type 1 pili synthesis and that its effect on type 1 pili is mediated, at least in part, via a c-di-GMP-dependent pathway...
  27. ncbi C-di-GMP: the dawning of a novel bacterial signalling system
    Ute Romling
    Microbiology and Tumor Biology Center, Karolinska Institutet, Box 280, SE 17177 Stockholm, Sweden
    Mol Microbiol 57:629-39. 2005
    ..The accumulated data clearly indicate that a novel ubiquitous signalling system in bacteria has been discovered...
  28. pmc Regulation of hydrogen peroxide-dependent gene expression in Rhodobacter sphaeroides: regulatory functions of OxyR
    Tanja Zeller
    Institut fur Mikrobiologie und Molekularbiologie, University of Giessen, Giessen, Germany
    J Bacteriol 189:3784-92. 2007
    ..The role of reduced OxyR as an activator is shown for the first time. Our data reveal that the OxyR-mediated response is fast and transient. In addition, we found that additional regulatory pathways are involved in the H(2)O(2) response...