Research Topics
Species | M S GolubSummaryAffiliation: University of California Country: USA Publications
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Publications
Cognitive testing (delayed non-match to sample) during oral treatment of female adolescent monkeys with the estrogenic pesticide methoxychlorMari S Golub
California Regional Primate Research Center, University of California Davis, Davis, CA 95616, USA
Neurotoxicol Teratol 24:87-92. 2002..Further investigation will be needed to identify the impairment leading to this performance deficit...
Influence of prenatal iron deficiency and MAOA genotype on response to social challenge in rhesus monkey infantsM S Golub
Department of Environmental Toxicology California National Primate Research Center, University of California, Davis, Davis, CA, USA
Genes Brain Behav 11:278-90. 2012..Nutrition/genotype interactions may shed new light on behavioral consequences of nutritional deprivation during brain development...- Effects of exogenous estrogenic agents on pubertal growth and reproductive system maturation in female rhesus monkeysMari S Golub
Department of Internal Medicine, California National Primate Research Center, University of California, Davis 95616, USA
Toxicol Sci 74:103-13. 2003..Long-term consequences of this disruption of pubertal development are being studied in this cohort of monkeys as adults... - Behavioral characteristics of a nervous system-specific erbB4 knock-out mouseMari S Golub
Department of Internal Medicine, CNPRC, University of California, Davis, CA 95616, USA
Behav Brain Res 153:159-70. 2004..These findings were interpreted based on more detailed analysis of the behavioral data and considerations of the complex nature and multiple roles of the neuregulin/erbB4 system in the nervous system... - Endocrine disruption and cognitive function in adolescent female rhesus monkeysMari S Golub
California National Primate Research Center, Rm 1925, University of California, Davis, One Shields Avenue, Davis, CA 95616, USA
Neurotoxicol Teratol 26:799-809. 2004..Differential effects of the two agents at the estrogen receptor subtypes (ER alpha and ER beta) may be relevant to the differential behavioral outcomes... - Endocrine disruption in adolescence: immunologic, hematologic, and bone effects in monkeysMari S Golub
Department of Internal Medicine, University of California, Davis, Davis, California 95616, USA
Toxicol Sci 82:598-607. 2004..Disruption in these systems during puberty could alter adolescent risk for anemia and infectious disease and subsequent adult risk for diseases such as osteoporosis, heart disease, and autoimmune disease... - Neurobehavioral evaluation of rhesus monkey infants fed cow's milk formula, soy formula, or soy formula with added manganeseMari S Golub
Department of Internal Medicine, CNPRC, Rm 1925, University of California, One Shields Ave, Davis, CA 95616, USA
Neurotoxicol Teratol 27:615-27. 2005..This experiment suggests that components of soy formula, including Mn, may influence brain development as reflected in behavioral measures... - Behavioral consequences of developmental iron deficiency in infant rhesus monkeysMari S Golub
Department of Environmental Toxicology, CNRPC, Room 1925, University of California, Davis, One Shields Avenue, Davis, CA 95616, United States
Neurotoxicol Teratol 28:3-17. 2006.... - Movement disorders in the Hfe knockout mouseMari S Golub
Murine Behavior Assessment Laboratory, Mutant Mouse Regional Resource Center, University of California, Davis Davis, California 95616, USA
Nutr Neurosci 8:239-44. 2005..Iron accumulation in brain was not detected by histopathology. These data suggest that a motor syndrome may be associated with HHH that could be further understood through the Hfe(-/-) mouse model... - Diet-induced iron deficiency anemia and pregnancy outcome in rhesus monkeysMari S Golub
University of California, Davis, Davis, CA 95616, USA
Am J Clin Nutr 83:647-56. 2006..Iron deficiency anemia (IDA) is relatively common in the third trimester of pregnancy, but causal associations with low birth weight and compromised neonatal iron status are difficult to establish in human populations... - Iron deprivation during fetal development changes the behavior of juvenile rhesus monkeysMari S Golub
Department of Environmental Toxicology, University of California, Davis, CA 95616, USA
J Nutr 137:979-84. 2007..This finding may be relevant to individual differences in temperament or to behavior disorders in children involving reduced inhibitory control... - Behavioral consequences of ovarian atrophy and estrogen replacement in the APPswe mouseMari S Golub
Murine Behavioral Assessment Laboratory, University of California, One Shields Avenue, Davis, CA 95616, United States
Neurobiol Aging 29:1512-23. 2008.... - Iron deficiency anemia and affective response in rhesus monkey infantsMari S Golub
Department of Environmental Toxicology, University of California, Davis, CA 95616, USA
Dev Psychobiol 51:47-59. 2009..IDA females did not differ from controls. Adrenocortical response was not significantly affected. These findings may be relevant to functional deficits in human infants with IDA that influence later behavior... 
Recent studies of iron deficiency during brain development in nonhuman primatesMari S Golub
Brain Mind and Behavior Unit, California National Primate Research Center, University of California, Davis, CA, USA
Biofactors 36:111-6. 2010..Further work in this model, including integration with studies in humans and in laboratory rodents, is ongoing...- Long-term consequences of developmental exposure to aluminum in a suboptimal diet for growth and behavior of Swiss Webster miceM S Golub
Department of Internal Medicine, California Regional Primate Research Center, University of California, Davis, 1 Shields Avenue, Davis, CA 95616, USA
Neurotoxicol Teratol 23:365-72. 2001..The data suggest that developmental Al exposure under normal, but less than optimal, dietary conditions can lead to subtle but long-term effects on growth and brain function in adulthood... - Activity and attention in zinc-deprived adolescent monkeysM S Golub
Department of Internal Medicine, University of California, Davis 95616, USA
Am J Clin Nutr 64:908-15. 1996..These data support previous findings that activity and attention can be affected during early stages of zinc deprivation before the onset of growth retardation... - Aluminum alters iron and manganese uptake and regulation of surface transferrin receptors in primary rat oligodendrocyte culturesM S Golub
Department of Internal Medicine, University of California, Davis 95616, USA
Brain Res 719:72-7. 1996..60 and 0.46 x 10(5) after incubations with equivalent amounts of apo-, Fe-, and Al-Tf respectively. The data suggest that Al-Tf down-regulates surface Tf receptors on oligodendrocytes and can limit Fe and Mn uptake through this mechanism... - Changes in plasma alpha 1-acid glycoprotein and albumin concentrations during late pregnancy in rhesus monkeysM S Golub
California Regional Primate Research Center, University of California, Davis 95616, USA
Clin Chim Acta 262:29-37. 1997..The data suggest that AAGP and albumin concentrations are jointly but inversely regulated by physiological or hormonal conditions that precede delivery... - Aluminum effects on operant performance and food motivation of miceM S Golub
Department of Internal Medicine, University of California, Davis, 95616, USA
Neurotoxicol Teratol 20:421-7. 1998..Aluminum may bias performance of food-motivated tasks by influencing food motivation... - Effects of dietary aluminum on pubertal miceM S Golub
Department of Internal Medicine, University of California, Davis 95616, USA
Neurotoxicol Teratol 21:595-602. 1999..Neither exposure influenced auditory startle amplitude. The period after puberty was sensitive to dietary Al exposure, but affected variables apparently recovered when exposure continued into young adulthood... - Behavioral and hematologic consequences of marginal iron-zinc nutrition in adolescent monkeys and the effect of a powdered beef supplementM S Golub
Departments of Internal Medicine and Nutrition, California Regional Primate Research Center, University of California, Davis 95616, USA
Am J Clin Nutr 70:1059-68. 1999..The adolescent growth spurt and menarche increase iron and zinc needs and could precipitate functional deficiencies if dietary sources are inadequate... - Morphometric studies of myelination in the spinal cord of mice exposed developmentally to aluminumM S Golub
Department of Internal Medicine, University of California, Davis 95616, USA
Neurotoxicology 20:953-9. 1999..The density of myelinated axons was greater in some areas for the Al-treated group. The data indicate that dietary aluminum exposure can interfere with myelination in the spinal cord... - Aluminum uptake and effects on transferrin mediated iron uptake in primary cultures of rat neurons, astrocytes and oligodendrocytesM S Golub
Department of Internal Medicine, University of California, Davis, 95616, USA
Neurotoxicology 20:961-70. 1999..Such effects could contribute to Al-induced neurotoxicity if they result in altered myelin formation or maintenance... 
Adolescent health and the environmentM S Golub
California Regional Primate Research Center, University of California Davis, 95616 USA
Environ Health Perspect 108:355-62. 2000..Screening methodologies that would identify toxic effects unique to adolescence would also be valuable...- Adolescent growth and maturation in zinc-deprived rhesus monkeys [see comment]M S Golub
Department of Internal Medicine, University of California, Davis 95616, USA
Am J Clin Nutr 64:274-82. 1996..Food intake was slightly higher in the zinc-deficient group than in controls. These data confirm that adolescent growth and maturation are vulnerable to disruption by moderate dietary zinc deprivation in nonhuman primates... - Lifelong feeding of a high aluminum diet to miceM S Golub
Department of Internal Medicine, CRPRC, Rm 1925, University of California, 95616, Davis, CA, USA
Toxicology 150:107-17. 2000..Swiss Webster and C57BL/6J mice do not appear to provide useful models for studying Al-induced neurodegenerative changes in aging... - Twelve-month evaluation of rhesus monkey dams and infants after relaxin (hRlx-2) infusion in late pregnancyM S Golub
Department of Internal Medicine, University of California, Davis 95616, USA
Reprod Toxicol 10:29-36. 1996..Conclusions concerning adverse effects are limited by the small sample size... - Complex, multimodal behavioral profile of the Homer1 knockout mouseP J Jaubert
Children s Center for Environmental Health and Department of Neurological Surgery, University of California Davis, CA 95616, USA
Genes Brain Behav 6:141-54. 2007..The results indicate an extensive range of disrupted behaviors that should contribute to the understanding of the Homer1 gene in brain development and behavior... - Influence of dietary aluminum on cytokine production by mitogen-stimulated spleen cells from Swiss Webster miceM S Golub
Department of Internal Medicine, School of Medicine, University of California, Davis 95616
Immunopharmacol Immunotoxicol 15:605-19. 1993..These findings suggest a deficit in immune effector cell function after long term in vivo aluminum exposure... - Visual recognition memory and auditory brainstem response in infant rhesus monkeys exposed perinatally to environmental tobacco smokeMari S Golub
Department of Environmental Toxicology, University of California, Davis, CA 95616, USA
Brain Res 1151:102-6. 2007..These preliminary results support the view that perinatal ETS exposure has adverse effects on cognitive function and indicate further that rhesus monkeys may provide a valuable nonhuman primate model for investigating this link... - Developmental aluminum toxicity in mice can be modulated by low concentrations of minerals (Fe, Zn, P, Ca, Mg) in the dietMari S Golub
Department of Internal Medicine, University of California, Davis, CA 95616, USA
Biol Trace Elem Res 93:213-26. 2003..A basal diet was also used in which the NRC diet was supplemented with ascorbic acid, which promotes Al absorption. No modification of Al toxicity was seen with ascorbic acid supplementation... - Public health implications of altered puberty timingMari S Golub
Department of Environmental Toxicology, University of California, Davis, California, USA
Pediatrics 121:S218-30. 2008.... - "Natural" progesterone: information on fetal effectsMari S Golub
Reproductive and Cancer Hazard Assessment Branch, Office of Environmental Health Hazard Assessment, California Environmental Protection Agency, Sacramento, California, USA
Birth Defects Res B Dev Reprod Toxicol 77:455-70. 2006..However, progesterone itself has come into use as a therapeutic agent only recently with the development of an orally bioavailable "micronized" preparation... - Environmental factors and puberty timing: expert panel research needsGermaine M Buck Louis
Epidemiology Branch, Division of Epidemiology, Statistics and Prevention Research, National Institute of Child Health and Human Development, 6100 Executive Blvd, Room 7B03, Rockville, MD 20852, USA
Pediatrics 121:S192-207. 2008..Coupled with comparative species studies, such research may provide insight regarding the causal ordering of events that underlie pubertal onset and progression and their role in the pathway of adult-onset disease...