Beatrice Golomb

Summary

Affiliation: University of California
Country: USA

Publications

  1. doi request reprint Reduction in blood pressure with statins: results from the UCSD Statin Study, a randomized trial
    Beatrice A Golomb
    Department of Medicine, University of California, San Diego, 9500 Gilman Dr, No 0995, La Jolla, CA 92093 0995, USA
    Arch Intern Med 168:721-7. 2008
  2. pmc Trans fat consumption and aggression
    Beatrice A Golomb
    Department of Medicine, University of California San Diego, San Diego, California, United States of America
    PLoS ONE 7:e32175. 2012
  3. doi request reprint What's in placebos: who knows? Analysis of randomized, controlled trials
    Beatrice A Golomb
    University of California, San Diego, School of Medicine, San Diego, California, USA
    Ann Intern Med 153:532-5. 2010
  4. doi request reprint Amyotrophic lateral sclerosis-like conditions in possible association with cholesterol-lowering drugs: an analysis of patient reports to the University of California, San Diego (UCSD) Statin Effects Study
    Beatrice A Golomb
    Department of Medicine, University of California, San Diego, California 92093 0995, USA
    Drug Saf 32:649-61. 2009
  5. pmc Statin adverse effects : a review of the literature and evidence for a mitochondrial mechanism
    Beatrice A Golomb
    Department of Medicine, University of California, San Diego, California 92093 0995, USA
    Am J Cardiovasc Drugs 8:373-418. 2008
  6. pmc Acetylcholinesterase inhibitors and Gulf War illnesses
    Beatrice Alexandra Golomb
    Department of Medicine, University of California, San Diego, CA 92093 0995, USA
    Proc Natl Acad Sci U S A 105:4295-300. 2008
  7. ncbi request reprint Physician response to patient reports of adverse drug effects: implications for patient-targeted adverse effect surveillance
    Beatrice A Golomb
    Department of Medicine, University of California San Diego, La Jolla, CA 92093 0995, USA
    Drug Saf 30:669-75. 2007
  8. ncbi request reprint Point subtraction aggression paradigm: validity of a brief schedule of use
    Beatrice A Golomb
    Department of Medicine, School of Medicine, University of California, San Diego, La Jolla, CA 92093 0995, USA
    Violence Vict 22:95-103. 2007
  9. ncbi request reprint Peripheral arterial disease: morbidity and mortality implications
    Beatrice A Golomb
    Department of Medicine, University of California, San Diego School of Medicine, 9500 Gilman Dr, La Jolla, CA 92093 0995, USA
    Circulation 114:688-99. 2006
  10. ncbi request reprint Low cholesterol and violent crime
    B A Golomb
    Department of Medicine, University of California, Los Angeles, CA 92093 0995, USA
    J Psychiatr Res 34:301-9. 2000

Research Grants

  1. STATINS AND NON-CARDIAC ENDPOINTS
    Beatrice Golomb; Fiscal Year: 2003
  2. Coenzyme Q10 in Aging: A Planning Grant
    Beatrice Golomb; Fiscal Year: 2005

Collaborators

Detail Information

Publications25

  1. doi request reprint Reduction in blood pressure with statins: results from the UCSD Statin Study, a randomized trial
    Beatrice A Golomb
    Department of Medicine, University of California, San Diego, 9500 Gilman Dr, No 0995, La Jolla, CA 92093 0995, USA
    Arch Intern Med 168:721-7. 2008
    ..Some studies have suggested reductions in blood pressure (BP)with statin treatment, particularly in persons with hypertension. Randomized trial evidence is limited...
  2. pmc Trans fat consumption and aggression
    Beatrice A Golomb
    Department of Medicine, University of California San Diego, San Diego, California, United States of America
    PLoS ONE 7:e32175. 2012
    ..The relationship was upheld with adjustment for confounders, was preserved across sex, age, and ethnicity strata, and held cross-sectionally and prospectively...
  3. doi request reprint What's in placebos: who knows? Analysis of randomized, controlled trials
    Beatrice A Golomb
    University of California, San Diego, School of Medicine, San Diego, California, USA
    Ann Intern Med 153:532-5. 2010
    ..No regulations govern placebo composition. The composition of placebos can influence trial outcomes and merits reporting...
  4. doi request reprint Amyotrophic lateral sclerosis-like conditions in possible association with cholesterol-lowering drugs: an analysis of patient reports to the University of California, San Diego (UCSD) Statin Effects Study
    Beatrice A Golomb
    Department of Medicine, University of California, San Diego, California 92093 0995, USA
    Drug Saf 32:649-61. 2009
    ..The aim of the analysis presented here was to examine characteristics and natural history of reported statin-associated ALS-like conditions with attention to factors that may bear on the issue of causality...
  5. pmc Statin adverse effects : a review of the literature and evidence for a mitochondrial mechanism
    Beatrice A Golomb
    Department of Medicine, University of California, San Diego, California 92093 0995, USA
    Am J Cardiovasc Drugs 8:373-418. 2008
    ..Awareness and vigilance for AEs should be maintained to enable informed treatment decisions, treatment modification if appropriate, improved quality of patient care, and reduced patient morbidity...
  6. pmc Acetylcholinesterase inhibitors and Gulf War illnesses
    Beatrice Alexandra Golomb
    Department of Medicine, University of California, San Diego, CA 92093 0995, USA
    Proc Natl Acad Sci U S A 105:4295-300. 2008
    ..AChEi exposure satisfies Hill's presumptive criteria for causality, suggesting this exposure may be causally linked to excess health problems in GWV...
  7. ncbi request reprint Physician response to patient reports of adverse drug effects: implications for patient-targeted adverse effect surveillance
    Beatrice A Golomb
    Department of Medicine, University of California San Diego, La Jolla, CA 92093 0995, USA
    Drug Saf 30:669-75. 2007
    ..This information was used to assess whether a patient-targeted ADR surveillance approach may complement provider reporting, potentially fostering identification of additional patients with possible or probable ADRs...
  8. ncbi request reprint Point subtraction aggression paradigm: validity of a brief schedule of use
    Beatrice A Golomb
    Department of Medicine, School of Medicine, University of California, San Diego, La Jolla, CA 92093 0995, USA
    Violence Vict 22:95-103. 2007
    ..The PSAP-FS had satisfactory validity properties for use where group-level data are of interest...
  9. ncbi request reprint Peripheral arterial disease: morbidity and mortality implications
    Beatrice A Golomb
    Department of Medicine, University of California, San Diego School of Medicine, 9500 Gilman Dr, La Jolla, CA 92093 0995, USA
    Circulation 114:688-99. 2006
  10. ncbi request reprint Low cholesterol and violent crime
    B A Golomb
    Department of Medicine, University of California, Los Angeles, CA 92093 0995, USA
    J Psychiatr Res 34:301-9. 2000
    ..Psychosom. Med 1994;56:479-84.). In this study we test for the first time whether cholesterol level is related to commission of violent crimes against others in a large community cohort...
  11. ncbi request reprint A review of health-related quality-of-life measures in stroke
    B A Golomb
    RAND Health Sciences Program and Department of Medicine, University of California San Diego School of Medicine, La Jolla, California, USA
    Pharmacoeconomics 19:155-85. 2001
    ..Additional psychometric testing in stroke populations is needed for existing HR-QOL measures. In addition, stroke-targeted HR-QOL measures need to be developed and evaluated with patients with stroke...
  12. ncbi request reprint Severe irritability associated with statin cholesterol-lowering drugs
    B A Golomb
    Department of Medicine, University of California, San Diego, CA 92093 0995, USA
    QJM 97:229-35. 2004
    ..Although a link has been suggested between low or lowered cholesterol and irritability/aggression, less is known about possible links between irritability and statins...
  13. ncbi request reprint The UCSD Statin Study: a randomized controlled trial assessing the impact of statins on selected noncardiac outcomes
    Beatrice A Golomb
    Department of Medicine, University of California, San Diego School of Medicine, San Diego, CA 92093 0995, USA
    Control Clin Trials 25:178-202. 2004
    ..If effects (favorable or unfavorable) are identified, we will seek to ascertain whether there are baseline variables that predict who will be most susceptible to these favorable or adverse noncardiac effects (i.e., effect modification)...
  14. ncbi request reprint Insulin sensitivity markers: predictors of accidents and suicides in Helsinki Heart Study screenees
    Beatrice A Golomb
    Department of Psychology, University of Southern California, Los Angeles, USA
    J Clin Epidemiol 55:767-73. 2002
    ..01 (1.19-3.38) and 2.24 (1.20-4.17), respectively. We speculate that insulin sensitivity may relate to these outcomes through low central serotonin activity...
  15. pmc Nerve gas antidotes
    John Smythies
    Center for Brain and Cognition, UCSD, La Jolla, CA 92093 0109, USA
    J R Soc Med 97:32. 2004
  16. doi request reprint Lipid lowering: what and when to monitor
    Michael H Criqui
    Division of Preventive Medicine, Department of Family and Preventive Medicine, University of California, San Diego, La Jolla, CA 92093, USA
    Lancet 372:516-7. 2008
  17. ncbi request reprint Chronic venous disease in an ethnically diverse population: the San Diego Population Study
    Michael H Criqui
    Department of Family and Preventive Medicine, School of Medicine, University of California, San Diego, San Diego, CA 92093, USA
    Am J Epidemiol 158:448-56. 2003
    ..7%, 0.6%, and 1.3% for legs visibly and functionally normal. However, visible disease did not invariably predict functional disease, or vice versa, and venous thrombotic events occurred in the absence of either...
  18. ncbi request reprint The modern spectrum of rhabdomyolysis: drug toxicity revealed by creatine kinase screening
    Leslie A Linares
    Scripps Mercy Hospital, San Diego, CA 92103, USA
    Curr Drug Saf 4:181-7. 2009
    ..This study describes the current etiologies, demographic characteristics, incidence of acute renal insufficiency and correlation between peak creatine kinase (CK) and peak creatinine in hospitalized patients with rhabdomyolysis...
  19. doi request reprint Statin-associated muscle-related adverse effects: a case series of 354 patients
    Stephanie Cham
    Department of Medicine, University of California San Diego School of Medicine, La Jolla, California 92093 0995, USA
    Pharmacotherapy 30:541-53. 2010
    ..To characterize the properties and natural history of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor (statin)-associated muscle-related adverse effects (MAEs)...
  20. ncbi request reprint Psychological correlates of battle and nonbattle injury among Operation Iraqi Freedom veterans
    Andrew J MacGregor
    Naval Health Research Center, San Diego, CA, USA
    Mil Med 174:224-31. 2009
    ..More research is needed to further define this relationship by examining potential mechanisms and addressing the possible contributing effect of combat exposure...
  21. ncbi request reprint Exertional leg pain in patients with and without peripheral arterial disease
    Jimmy C Wang
    University of California, School of Medicine, San Diego, CA, USA
    Circulation 112:3501-8. 2005
    ..Although exertional leg pain is a hallmark of peripheral arterial disease (PAD) and can occur in persons without PAD, symptom variation has received inadequate attention...
  22. doi request reprint Statin-associated adverse cognitive effects: survey results from 171 patients
    Marcella A Evans
    Department of Medicine, University of California San Diego, La Jolla, California 92093 0995, USA
    Pharmacotherapy 29:800-11. 2009
    ..To characterize the adverse cognitive effects of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins)...
  23. doi request reprint Prevalence and psychological correlates of traumatic brain injury in operation iraqi freedom
    Andrew J MacGregor
    Naval Health Research Center, San Diego, California 92106, USA
    J Head Trauma Rehabil 25:1-8. 2010
    ..To describe the prevalence and psychological correlates of traumatic brain injury (TBI) among injured male combatants in the Iraq conflict...
  24. ncbi request reprint Conceptual foundations of the UCSD Statin Study: a randomized controlled trial assessing the impact of statins on cognition, behavior, and biochemistry
    Beatrice Alexandra Golomb
    Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA
    Arch Intern Med 164:153-62. 2004
    ..However, there has been persistent controversy regarding possible favorable or adverse effects of statins or of cholesterol reduction on cognition, mood, and behavior (including aggressive or violent behavior)...
  25. ncbi request reprint Implications of statin adverse effects in the elderly
    Beatrice Alexandra Golomb
    Expert Opin Drug Saf 4:389-97. 2005
    ..Because the risk for AEs is unattended by evidence of net benefit to the person, the use of statins in the elderly should be undertaken, if at all, with circumspection and close scrutiny for adverse effects...

Research Grants6

  1. STATINS AND NON-CARDIAC ENDPOINTS
    Beatrice Golomb; Fiscal Year: 2003
    ....
  2. Coenzyme Q10 in Aging: A Planning Grant
    Beatrice Golomb; Fiscal Year: 2005
    ..Thus there is strong conceptual as well as clinical rationale for assessing whether Q10 provides QOL & functional benefits in aging and whether it protects against untoward events associated with age. ..