DARREL GOLL

Summary

Affiliation: University of Arizona
Country: USA

Publications

  1. ncbi Myofibrillar protein turnover: the proteasome and the calpains
    D E Goll
    Muscle Biology Group, University of Arizona, Tucson, AZ 85721, USA
    J Anim Sci 86:E19-35. 2008
  2. ncbi The calpain system
    Darrell E Goll
    Muscle Biology Group, University of Arizona, Tucson, AZ 85721, USA
    Physiol Rev 83:731-801. 2003
  3. ncbi Autolysis of mu- and m-calpain from bovine skeletal muscle
    P Cottin
    Muscle Biology Group, University of Arizona, Tucson 85721, USA
    Biol Chem 382:767-76. 2001
  4. ncbi Changes in the calpains and calpastatin during postmortem storage of bovine muscle
    M L Boehm
    Muscle Biology Group, University of Arizona, Tucson 85721, USA
    J Anim Sci 76:2415-34. 1998
  5. doi Effect of two dietary concentrate levels on tenderness, calpain and calpastatin activities, and carcass merit in Waguli and Brahman steers
    R M Ibrahim
    Department of Animal Sciences, University of Arizona, Tucson 85721, USA
    J Anim Sci 86:1426-33. 2008
  6. ncbi A BODIPY fluorescent microplate assay for measuring activity of calpains and other proteases
    V F Thompson
    Muscle Biology Group, University of Arizona, Tucson, Arizona, 85721, USA
    Anal Biochem 279:170-8. 2000
  7. ncbi Effect of mu-calpain on m-calpain
    V F Thompson
    Muscle Biology Group, University of Arizona, Tucson, AZ 85721, USA
    Biochem Biophys Res Commun 267:495-9. 2000
  8. ncbi Isolation and characterization of mu-calpain, m-calpain, and calpastatin from postmortem muscle. I. Initial steps
    J P Camou
    Muscle Biology Group, University of Arizona, Tucson 85721, USA
    J Anim Sci 85:3400-14. 2007
  9. ncbi Effect of postmortem storage on activity of mu- and m-calpain in five bovine muscles
    J P Camou
    Muscle Biology Group, University of Arizona, Tucson 85721, USA
    J Anim Sci 85:2670-81. 2007
  10. ncbi Effect of monoclonal antibodies specific for the 28-kDa subunit on catalytic properties of the calpains
    J Cong
    Muscle Biology Group, University of Arizona, Tucson 85721
    J Biol Chem 268:25740-7. 1993

Research Grants

Collaborators

Detail Information

Publications11

  1. ncbi Myofibrillar protein turnover: the proteasome and the calpains
    D E Goll
    Muscle Biology Group, University of Arizona, Tucson, AZ 85721, USA
    J Anim Sci 86:E19-35. 2008
    ..It seems that both the calpains and the proteasome are responsible for myofibrillar protein turnover, but the mechanism is still unknown...
  2. ncbi The calpain system
    Darrell E Goll
    Muscle Biology Group, University of Arizona, Tucson, AZ 85721, USA
    Physiol Rev 83:731-801. 2003
    ..Deregulated calpain activity following loss of Ca2+ homeostasis results in tissue damage in response to events such as myocardial infarcts, stroke, and brain trauma...
  3. ncbi Autolysis of mu- and m-calpain from bovine skeletal muscle
    P Cottin
    Muscle Biology Group, University of Arizona, Tucson 85721, USA
    Biol Chem 382:767-76. 2001
    ..By incubating the calpains at Ca2+ concentrations below those required for half-maximal activity, it is possible to show that unautolyzed calpains degrade a beta-casein substrate, proving that unautolyzed calpains are active proteases...
  4. ncbi Changes in the calpains and calpastatin during postmortem storage of bovine muscle
    M L Boehm
    Muscle Biology Group, University of Arizona, Tucson 85721, USA
    J Anim Sci 76:2415-34. 1998
    ..Unless postmortem muscle contains some factor that enables micro-calpain in this muscle to be proteolytically active, it is not clear whether micro-calpain could be responsible for any appreciable postmortem myofibrillar proteolysis...
  5. doi Effect of two dietary concentrate levels on tenderness, calpain and calpastatin activities, and carcass merit in Waguli and Brahman steers
    R M Ibrahim
    Department of Animal Sciences, University of Arizona, Tucson 85721, USA
    J Anim Sci 86:1426-33. 2008
    ..In conclusion, LM muscle from the Waguli steers had a high degree of marbling, lower shear force values, and low calpastatin activity, all of which are related to more tender meat...
  6. ncbi A BODIPY fluorescent microplate assay for measuring activity of calpains and other proteases
    V F Thompson
    Muscle Biology Group, University of Arizona, Tucson, Arizona, 85721, USA
    Anal Biochem 279:170-8. 2000
    ..The BODIPY-FL-casein assay is a general assay for proteolytic activity and can be used with any protease that cleaves casein...
  7. ncbi Effect of mu-calpain on m-calpain
    V F Thompson
    Muscle Biology Group, University of Arizona, Tucson, AZ 85721, USA
    Biochem Biophys Res Commun 267:495-9. 2000
    ....
  8. ncbi Isolation and characterization of mu-calpain, m-calpain, and calpastatin from postmortem muscle. I. Initial steps
    J P Camou
    Muscle Biology Group, University of Arizona, Tucson 85721, USA
    J Anim Sci 85:3400-14. 2007
    ..Hence, loss of calpastatin activity in postmortem muscle is due to its degradation, but the cause of the loss of mu-calpain activity remains unknown...
  9. ncbi Effect of postmortem storage on activity of mu- and m-calpain in five bovine muscles
    J P Camou
    Muscle Biology Group, University of Arizona, Tucson 85721, USA
    J Anim Sci 85:2670-81. 2007
    ..Because neither mu- nor m-calpain is proteolytically active at pH 5.8 after being incubated at pH 5.8 for 24 h, other proteolytic systems such as the caspases may contribute to postmortem proteolysis in addition to the calpains...
  10. ncbi Effect of monoclonal antibodies specific for the 28-kDa subunit on catalytic properties of the calpains
    J Cong
    Muscle Biology Group, University of Arizona, Tucson 85721
    J Biol Chem 268:25740-7. 1993
    ....
  11. ncbi The bovine calpastatin gene promoter and a new N-terminal region of the protein are targets for cAMP-dependent protein kinase activity
    M Cong
    Department of Biochemistry, University of Arizona, Tucson, Arizona 85721, USA
    J Biol Chem 273:660-6. 1998
    ..Deletion analysis indicates that at least one cAMP-responsive element resides within 102 nucleotides of transcription initiation...

Research Grants2

  1. Role of Phosphorylation in Regulating Calpain Activity
    DARREL GOLL; Fiscal Year: 2007
    ..The studies use mass spectrometry and Western analysis to monitor calpain phosphorylation and enzyme assays to monitor catalytic properties of the calpains. ..