Joseph L Goldstein

Summary

Affiliation: University of Texas Southwestern Medical Center
Country: USA

Publications

  1. pmc From fatty streak to fatty liver: 33 years of joint publications in the JCI
    Joseph L Goldstein
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9046, USA
    J Clin Invest 118:1220-2. 2008
  2. doi request reprint Surviving starvation: essential role of the ghrelin-growth hormone axis
    J L Goldstein
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9046, USA
    Cold Spring Harb Symp Quant Biol 76:121-7. 2011
  3. pmc The LDL receptor
    Joseph L Goldstein
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390 9046, USA
    Arterioscler Thromb Vasc Biol 29:431-8. 2009
  4. ncbi request reprint Protein sensors for membrane sterols
    Joseph L Goldstein
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Cell 124:35-46. 2006
  5. ncbi request reprint How a jolt and a bolt in a dentist's chair revolutionized cataract surgery
    Joseph L Goldstein
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Room L5 238, Dallas, Texas 75390 9046, USA
    Nat Med 10:1032-3. 2004
  6. ncbi request reprint Mutant mammalian cells as tools to delineate the sterol regulatory element-binding protein pathway for feedback regulation of lipid synthesis
    Joseph L Goldstein
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9046, USA
    Arch Biochem Biophys 397:139-48. 2002
  7. ncbi request reprint Insig required for sterol-mediated inhibition of Scap/SREBP binding to COPII proteins in vitro
    Li Ping Sun
    Department of Molecular Genetics, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9046, USA
    J Biol Chem 280:26483-90. 2005
  8. ncbi request reprint Insig-dependent ubiquitination and degradation of mammalian 3-hydroxy-3-methylglutaryl-CoA reductase stimulated by sterols and geranylgeraniol
    Navdar Sever
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9046, USA
    J Biol Chem 278:52479-90. 2003
  9. pmc Insig-2, a second endoplasmic reticulum protein that binds SCAP and blocks export of sterol regulatory element-binding proteins
    Daisuke Yabe
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390 9046, USA
    Proc Natl Acad Sci U S A 99:12753-8. 2002
  10. ncbi request reprint Reconstitution of sterol-regulated endoplasmic reticulum-to-Golgi transport of SREBP-2 in insect cells by co-expression of mammalian SCAP and Insigs
    Irina Y Dobrosotskaya
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9046
    J Biol Chem 278:35837-43. 2003

Collaborators

Detail Information

Publications71

  1. pmc From fatty streak to fatty liver: 33 years of joint publications in the JCI
    Joseph L Goldstein
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9046, USA
    J Clin Invest 118:1220-2. 2008
    ..In this retrospective, we review highlights from our 26 joint papers in the JCI, focusing on two papers that revealed the consequences of lipid accumulation with implications for atherosclerosis and steatohepatitis...
  2. doi request reprint Surviving starvation: essential role of the ghrelin-growth hormone axis
    J L Goldstein
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9046, USA
    Cold Spring Harb Symp Quant Biol 76:121-7. 2011
    ..Thus, ghrelin lies at the center of a hormonal response that permits mice to survive an acute fast superimposed on chronic starvation...
  3. pmc The LDL receptor
    Joseph L Goldstein
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390 9046, USA
    Arterioscler Thromb Vasc Biol 29:431-8. 2009
    ..The latter concept provides the mechanism by which statins selectively lower plasma LDL, reducing heart attacks and prolonging life...
  4. ncbi request reprint Protein sensors for membrane sterols
    Joseph L Goldstein
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Cell 124:35-46. 2006
    ..Here, we discuss recent advances that explain how cells employ an ensemble of membrane-embedded proteins to monitor sterol concentrations and adjust sterol synthesis and uptake...
  5. ncbi request reprint How a jolt and a bolt in a dentist's chair revolutionized cataract surgery
    Joseph L Goldstein
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Room L5 238, Dallas, Texas 75390 9046, USA
    Nat Med 10:1032-3. 2004
  6. ncbi request reprint Mutant mammalian cells as tools to delineate the sterol regulatory element-binding protein pathway for feedback regulation of lipid synthesis
    Joseph L Goldstein
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9046, USA
    Arch Biochem Biophys 397:139-48. 2002
    ..Their cDNAs and genes were isolated by genetic complementation or by expression cloning. The somatic cell genetic approach described in this article should prove useful for unraveling other complex biochemical pathways in animal cells...
  7. ncbi request reprint Insig required for sterol-mediated inhibition of Scap/SREBP binding to COPII proteins in vitro
    Li Ping Sun
    Department of Molecular Genetics, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9046, USA
    J Biol Chem 280:26483-90. 2005
    ..This hexapeptide acts as a sterol-regulated ER sorting signal. These studies define the biochemical parameters responsible for regulated sorting of an ER membrane protein into COPII-coated vesicles...
  8. ncbi request reprint Insig-dependent ubiquitination and degradation of mammalian 3-hydroxy-3-methylglutaryl-CoA reductase stimulated by sterols and geranylgeraniol
    Navdar Sever
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9046, USA
    J Biol Chem 278:52479-90. 2003
    ....
  9. pmc Insig-2, a second endoplasmic reticulum protein that binds SCAP and blocks export of sterol regulatory element-binding proteins
    Daisuke Yabe
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390 9046, USA
    Proc Natl Acad Sci U S A 99:12753-8. 2002
    ..The combined actions of insig-1 and -2 permit feedback regulation of cholesterol synthesis over a wide range of sterol concentrations...
  10. ncbi request reprint Reconstitution of sterol-regulated endoplasmic reticulum-to-Golgi transport of SREBP-2 in insect cells by co-expression of mammalian SCAP and Insigs
    Irina Y Dobrosotskaya
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9046
    J Biol Chem 278:35837-43. 2003
    ..They indicate that insect cells can respond to sterols when proper regulatory proteins are expressed...
  11. pmc Identification of surface residues on Niemann-Pick C2 essential for hydrophobic handoff of cholesterol to NPC1 in lysosomes
    Michael L Wang
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    Cell Metab 12:166-73. 2010
    ..We refer to this transfer as a hydrophobic handoff and hypothesize that this handoff is essential for cholesterol export from lysosomes...
  12. pmc Schoenheimer effect explained--feedback regulation of cholesterol synthesis in mice mediated by Insig proteins
    Luke J Engelking
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9046, USA
    J Clin Invest 115:2489-98. 2005
    ..These studies indicate that the essential elements of the regulatory pathway for lipid synthesis function in liver as they do in cultured cells...
  13. pmc Overexpression of Insig-1 in the livers of transgenic mice inhibits SREBP processing and reduces insulin-stimulated lipogenesis
    Luke J Engelking
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, 75390, USA
    J Clin Invest 113:1168-75. 2004
    ..These results provide in vivo support for the hypothesis that nSREBPs are essential for high levels of lipid synthesis in the liver and indicate that Insig's modulate nSREBP levels by binding and retaining SCAP in the ER...
  14. ncbi request reprint Compensatory increase in fatty acid synthesis in adipose tissue of mice with conditional deficiency of SCAP in liver
    Hiroshi Kuriyama
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Cell Metab 1:41-51. 2005
    ..Plasma VLDL triglycerides are dramatically reduced in L-Scap- mice, underscoring the benefits of synthesizing FAs in fat rather than liver...
  15. ncbi request reprint Accelerated degradation of HMG CoA reductase mediated by binding of insig-1 to its sterol-sensing domain
    Navdar Sever
    Department of Molecular Genetics, University of Texas, Southwestern Medical Center, Dallas, TX 75390, USA
    Mol Cell 11:25-33. 2003
    ..Insig-1 appears to play an essential role in the sterol-mediated trafficking of two proteins with sterol-sensing domains, HMG CoA reductase and SCAP...
  16. pmc Point mutation in luminal loop 7 of Scap protein blocks interaction with loop 1 and abolishes movement to Golgi
    Yinxin Zhang
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9046, USA
    J Biol Chem 288:14059-67. 2013
    ..These data suggest that Scap Loop 1 must interact with Loop 7 to maintain Loop 6 in the configuration that permits COPII binding. These results help explain the operation of Scap as a sterol sensor...
  17. pmc Liver-specific mRNA for Insig-2 down-regulated by insulin: implications for fatty acid synthesis
    Daisuke Yabe
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390 9046, USA
    Proc Natl Acad Sci U S A 100:3155-60. 2003
    ..The insulin-mediated fall in Insig-2a may allow SREBP-1c to be processed, thereby allowing insulin to stimulate fatty acid synthesis, even under conditions in which hepatic cholesterol levels are elevated...
  18. pmc Amino acid substitution in NPC1 that abolishes cholesterol binding reproduces phenotype of complete NPC1 deficiency in mice
    Xuefen Xie
    Departments of Molecular Genetics and Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9046, USA
    Proc Natl Acad Sci U S A 108:15330-5. 2011
    ..The HPCD-mediated reduction of excess lysosomal enzymes may contribute to the ability of this drug to delay the progression of NPC disease in mice...
  19. pmc Sterol-regulated transport of SREBPs from endoplasmic reticulum to Golgi: oxysterols block transport by binding to Insig
    Arun Radhakrishnan
    Department of Molecular Genetics and Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 104:6511-8. 2007
    ..These studies define Insigs as oxysterol-binding proteins, explaining the long-known ability of oxysterols to inhibit cholesterol synthesis in animal cells...
  20. pmc Combined analysis of oligonucleotide microarray data from transgenic and knockout mice identifies direct SREBP target genes
    Jay D Horton
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390 9046, USA
    Proc Natl Acad Sci U S A 100:12027-32. 2003
    ....
  21. pmc Identification of luminal Loop 1 of Scap protein as the sterol sensor that maintains cholesterol homeostasis
    Massoud Motamed
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9046, USA
    J Biol Chem 286:18002-12. 2011
    ..These results indicate that luminal Loop 1 of Scap controls the conformation of cytosolic Loop 6, thereby determining whether cells produce cholesterol...
  22. pmc Regulated endoplasmic reticulum-associated degradation of a polytopic protein: p97 recruits proteasomes to Insig-1 before extraction from membranes
    Yukio Ikeda
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9046, USA
    J Biol Chem 284:34889-900. 2009
    ..These data suggest that p97 recruits proteasomes to polytopic ER proteins even before they are extracted from membranes...
  23. ncbi request reprint Membrane topology of human insig-1, a protein regulator of lipid synthesis
    Jamison D Feramisco
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9046, USA
    J Biol Chem 279:8487-96. 2004
    ..The membranous nature of Insig-1 is consistent with its sterol-dependent binding to hydrophobic sterol-sensing domains in SCAP and HMG CoA reductase...
  24. ncbi request reprint Sterol-regulated ubiquitination and degradation of Insig-1 creates a convergent mechanism for feedback control of cholesterol synthesis and uptake
    Yi Gong
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Cell Metab 3:15-24. 2006
    ..When the new Insig-1 and cholesterol converge on Scap, Scap/SREBP binds to Insig-1, preventing ubiquitination. The Insig-1/Scap/SREBP complex accumulates in the ER, ready for liberation when the cell is again sterol deprived...
  25. pmc The Scap/SREBP pathway is essential for developing diabetic fatty liver and carbohydrate-induced hypertriglyceridemia in animals
    Young Ah Moon
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390 9046, USA
    Cell Metab 15:240-6. 2012
    ..Inhibition of SREBP activation has therapeutic potential for treatment of hypertriglyceridemia and fatty liver disease...
  26. pmc Structure of N-terminal domain of NPC1 reveals distinct subdomains for binding and transfer of cholesterol
    Hyock Joo Kwon
    Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390 9046, USA
    Cell 137:1213-24. 2009
    ....
  27. pmc NPC2 facilitates bidirectional transfer of cholesterol between NPC1 and lipid bilayers, a step in cholesterol egress from lysosomes
    Rodney E Infante
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390 9046, USA
    Proc Natl Acad Sci U S A 105:15287-92. 2008
    ..These findings may explain how mutations in either protein can produce a similar clinical phenotype...
  28. pmc Ghrelin O-acyltransferase (GOAT) is essential for growth hormone-mediated survival of calorie-restricted mice
    Tong Jin Zhao
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 107:7467-72. 2010
    ..Thus, an essential function of ghrelin in mice is elevation of GH levels during severe calorie restriction, thereby preserving blood glucose and preventing death...
  29. ncbi request reprint Purified NPC1 protein. I. Binding of cholesterol and oxysterols to a 1278-amino acid membrane protein
    Rodney E Infante
    Department of Molecular Genetics, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390, USA
    J Biol Chem 283:1052-63. 2008
    ..The availability of assays to measure NPC1 binding in vitro may further the understanding of ways in which oxysterols regulate intracellular lipid transport...
  30. ncbi request reprint Purified NPC1 protein: II. Localization of sterol binding to a 240-amino acid soluble luminal loop
    Rodney E Infante
    Department of Molecular Genetics, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390, USA
    J Biol Chem 283:1064-75. 2008
    ..Thus, the sterol binding site on luminal loop-1 is not essential for NPC1 function in fibroblasts, but it may function in other cells where NPC1 deficiency produces more complicated lipid abnormalities...
  31. pmc Severe facial clefting in Insig-deficient mouse embryos caused by sterol accumulation and reversed by lovastatin
    Luke J Engelking
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9046, USA
    J Clin Invest 116:2356-65. 2006
    ....
  32. pmc Intramembrane aspartic acid in SCAP protein governs cholesterol-induced conformational change
    Jamison D Feramisco
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390 9046, USA
    Proc Natl Acad Sci U S A 102:3242-7. 2005
    ..These data identify an important functional residue in SCAP, and they provide genetic evidence that the conformation of SCAP dictates the rate of cholesterol synthesis in animal cells...
  33. ncbi request reprint Crucial step in cholesterol homeostasis: sterols promote binding of SCAP to INSIG-1, a membrane protein that facilitates retention of SREBPs in ER
    Tong Yang
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas 75390, USA
    Cell 110:489-500. 2002
    ..Mutant SCAP(Y298C) fails to bind INSIG-1 and is resistant to sterol-mediated inhibition of ER exit. By facilitating sterol-dependent ER retention of SCAP, INSIG-1 plays a central role in cholesterol homeostasis...
  34. pmc Sterol-regulated transport of SREBPs from endoplasmic reticulum to Golgi: Insig renders sorting signal in Scap inaccessible to COPII proteins
    Li Ping Sun
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 104:6519-26. 2007
    ....
  35. pmc Central role for liver X receptor in insulin-mediated activation of Srebp-1c transcription and stimulation of fatty acid synthesis in liver
    Guoxun Chen
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390 9046, USA
    Proc Natl Acad Sci U S A 101:11245-50. 2004
    ..Nuclear SREBPs and nuclear factor Y play permissive roles...
  36. pmc Juxtamembranous aspartic acid in Insig-1 and Insig-2 is required for cholesterol homeostasis
    Yi Gong
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390 9046, USA
    Proc Natl Acad Sci U S A 103:6154-9. 2006
    ..These studies identify a single amino acid residue that is crucial for the function of Insig proteins in regulating cholesterol homeostasis in mammalian cells...
  37. ncbi request reprint Cholesterol and 25-hydroxycholesterol inhibit activation of SREBPs by different mechanisms, both involving SCAP and Insigs
    Christopher M Adams
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9046, USA
    J Biol Chem 279:52772-80. 2004
    ..These data imply that cholesterol interacts with SCAP directly by inducing it to bind to Insigs, whereas 25-HC works indirectly through a putative 25-HC sensor protein that elicits SCAP-Insig binding...
  38. pmc Hair growth defects in Insig-deficient mice caused by cholesterol precursor accumulation and reversed by simvastatin
    Bret M Evers
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas, USA
    J Invest Dermatol 130:1237-48. 2010
    ..These findings have implications for several human genetic diseases in which mutations in cholesterol biosynthetic enzymes lead to accumulation of sterol precursors and multiple cutaneous abnormalities...
  39. pmc Cyclodextrin overcomes deficient lysosome-to-endoplasmic reticulum transport of cholesterol in Niemann-Pick type C cells
    Lina Abi-Mosleh
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9046, USA
    Proc Natl Acad Sci U S A 106:19316-21. 2009
    ..The buildup of cholesteryl esters in the cytosol is expected to be much less toxic than the buildup of free cholesterol in the lysosomes of patients with mutations in NPC1 or NPC2...
  40. pmc Insulin stimulation of SREBP-1c processing in transgenic rat hepatocytes requires p70 S6-kinase
    Joshua L Owen
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 109:16184-9. 2012
    ..Insulin stimulation of both processes is blocked by glucagon. The transgenic rat system will be useful in further defining the molecular mechanism for insulin stimulation of lipid synthesis in liver in normal and diabetic states...
  41. pmc Switch-like control of SREBP-2 transport triggered by small changes in ER cholesterol: a delicate balance
    Arun Radhakrishnan
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390 9046, USA
    Cell Metab 8:512-21. 2008
    ..Cooperative interactions between cholesterol, Scap, and Insig create a sensitive switch that controls the cholesterol composition of cell membranes with remarkable precision...
  42. ncbi request reprint Direct binding of cholesterol to the purified membrane region of SCAP: mechanism for a sterol-sensing domain
    Arun Radhakrishnan
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas 75390, USA
    Mol Cell 15:259-68. 2004
    ..The current studies show that cells control their cholesterol content through receptor-ligand interactions and not through changes in the physical properties of the membrane...
  43. pmc Inhibition of ghrelin O-acyltransferase (GOAT) by octanoylated pentapeptides
    Jing Yang
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390 9046, USA
    Proc Natl Acad Sci U S A 105:10750-5. 2008
    ..These insights may facilitate the future design of useful inhibitors of GOAT...
  44. pmc Profound hypoglycemia in starved, ghrelin-deficient mice is caused by decreased gluconeogenesis and reversed by lactate or fatty acids
    Robert Lin Li
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9046, USA
    J Biol Chem 287:17942-50. 2012
    ..In humans with anorexia nervosa or kwashiorkor, ghrelin and growth hormone are known to be elevated, just as they are in fat-depleted mice. We suggest that these two hormones prolong survival in starved humans as they do in mice...
  45. pmc SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver
    Jay D Horton
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9046, USA
    J Clin Invest 109:1125-31. 2002
  46. ncbi request reprint The SREBP pathway in Drosophila: regulation by palmitate, not sterols
    Adam C Seegmiller
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Dev Cell 2:229-38. 2002
    ..Instead, dSREBP processing is blocked by palmitic acid. These findings suggest that the ancestral SREBP pathway functions to maintain membrane integrity rather than to control cholesterol homeostasis...
  47. pmc LXR-SREBP-1c-phospholipid transfer protein axis controls very low density lipoprotein (VLDL) particle size
    Hiroaki Okazaki
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9046, USA
    J Biol Chem 285:6801-10. 2010
    ..In the absence of LDL receptors, the large VLDLs accumulate and produce massive hypertriglyceridemia...
  48. pmc Cholesterol-induced conformational change in SCAP enhanced by Insig proteins and mimicked by cationic amphiphiles
    Christopher M Adams
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390 9046, USA
    Proc Natl Acad Sci U S A 100:10647-52. 2003
    ..The effects of cationic amphiphiles raise the possibility that SCAP may monitor specifically the composition of the cytoplasmic leaflet of the ER membrane...
  49. ncbi request reprint Cholesterol addition to ER membranes alters conformation of SCAP, the SREBP escort protein that regulates cholesterol metabolism
    Andrew J Brown
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Mol Cell 10:237-45. 2002
    ..These studies demonstrate an in vitro effect of cholesterol on the sterol regulatory machinery...
  50. pmc Ghrelin secretion stimulated by {beta}1-adrenergic receptors in cultured ghrelinoma cells and in fasted mice
    Tong Jin Zhao
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, 75390, USA
    Proc Natl Acad Sci U S A 107:15868-73. 2010
    ..We conclude that ghrelin secretion during fasting is induced by adrenergic agents released by sympathetic neurons and acting directly on beta(1) receptors on the ghrelin-secreting cells of the stomach...
  51. pmc Bifurcation of insulin signaling pathway in rat liver: mTORC1 required for stimulation of lipogenesis, but not inhibition of gluconeogenesis
    Shijie Li
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390 9046, USA
    Proc Natl Acad Sci U S A 107:3441-6. 2010
    ..These results establish mTORC1 as an essential component in the insulin-regulated pathway for hepatic lipogenesis but not gluconeogenesis, and may help to resolve the paradox of selective insulin resistance in livers of diabetic rodents...
  52. ncbi request reprint Identification of FBL2 as a geranylgeranylated cellular protein required for hepatitis C virus RNA replication
    Chunfu Wang
    Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Mol Cell 18:425-34. 2005
    ..The current data indicate that geranylgeranylated FBL2 binds to NS5A in a reaction crucial for HCV RNA replication...
  53. pmc Use of mutant 125I-perfringolysin O to probe transport and organization of cholesterol in membranes of animal cells
    Akash Das
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390 9046, USA
    Proc Natl Acad Sci U S A 110:10580-5. 2013
    ..Using three different mutant cell lines, we show that this transport requires receptor-mediated uptake of LDL, hydrolysis of LDL-cholesteryl esters in lysosomes, and transfer of the liberated cholesterol to the plasma membrane. ..
  54. pmc Accelerated fatty acid oxidation in muscle averts fasting-induced hepatic steatosis in SJL/J mice
    Hong Ping Guan
    Department of Molecular Genetics, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9046, USA
    J Biol Chem 284:24644-52. 2009
    ..We conclude that SJL/J mice express one or more variant genes that lead to enhanced FA uptake and oxidation in muscle, thereby sparing the liver from FA overload in the fasting state...
  55. pmc Cholesterol feedback: from Schoenheimer's bottle to Scap's MELADL
    Michael S Brown
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390 9046, USA
    J Lipid Res 50:S15-27. 2009
    ..In this article we review the major milestones in the cholesterol feedback story...
  56. doi request reprint Identification of the acyltransferase that octanoylates ghrelin, an appetite-stimulating peptide hormone
    Jing Yang
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Cell 132:387-96. 2008
    ..Identification of GOAT will facilitate the search for inhibitors that reduce appetite and diminish obesity in humans...
  57. ncbi request reprint Structure of the LDL receptor extracellular domain at endosomal pH
    Gabby Rudenko
    Department of Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard Y4 206, Dallas, TX 75390, USA
    Science 298:2353-8. 2002
    ..We propose a mechanism for lipoprotein release in the endosome whereby the beta propeller functions as an alternate substrate for the ligand-binding domain, binding in a calcium-dependent way and promoting lipoprotein release...
  58. ncbi request reprint Diminished hepatic response to fasting/refeeding and liver X receptor agonists in mice with selective deficiency of sterol regulatory element-binding protein-1c
    Guosheng Liang
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9046, USA
    J Biol Chem 277:9520-8. 2002
    ..Moreover, these mRNAs, as well as multiple other lipogenic mRNAs, showed a markedly blunted response to the LXR agonist T090137, indicating an essential role of SREBP-1c in the LXR response...
  59. ncbi request reprint Biomedicine. Lowering LDL--not only how low, but how long?
    Michael S Brown
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9046, USA
    Science 311:1721-3. 2006
  60. pmc Richard G.W. Anderson (1940-2011) and the birth of receptor-mediated endocytosis
    Michael S Brown
    J Cell Biol 193:601-3. 2011
    ..He died of glioblastoma multiforme six days before his 71st birthday...
  61. ncbi request reprint Characterization of mouse short-chain aldehyde reductase (SCALD), an enzyme regulated by sterol regulatory element-binding proteins
    Anne Kasus-Jacobi
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9046, USA
    J Biol Chem 278:32380-9. 2003
    ....
  62. doi request reprint Selective versus total insulin resistance: a pathogenic paradox
    Michael S Brown
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Cell Metab 7:95-6. 2008
    ..In this issue of Cell Metabolism, Biddinger et al. (2008) show that mice with total hepatic insulin resistance exhibit hyperglycemia without hypertriglyceridemia-a state paradoxically less severe than selective insulin resistance...
  63. pmc Disruption of hepatitis C virus RNA replication through inhibition of host protein geranylgeranylation
    Jin Ye
    Departments of Molecular Genetics and Microbiology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 100:15865-70. 2003
    ..Inhibition of its geranylgeranylation affords a therapeutic strategy for treatment of HCV infection...
  64. ncbi request reprint Mevinolin and colestipol stimulate receptor-mediated clearance of low density lipoprotein from plasma in familial hypercholeserolemia heterozygotes. 1983
    David W Bilheimer
    Atheroscler Suppl 5:61-5. 2004
  65. ncbi request reprint Lowering plasma cholesterol by raising ldl receptors. 1981
    Michael S Brown
    Atheroscler Suppl 5:57-9. 2004
  66. ncbi request reprint Presentation of the Kober Medal to Joseph L. Goldstein and Michael S. Brown
    David W Foster
    J Clin Invest 110:S5-9. 2002
  67. ncbi request reprint Lasker awards 2003. Foreword: It's a grand year for celebrating science
    Joseph L Goldstein
    Chair, Lasker Awards Jury
    Nat Med 9:1237-8. 2003
  68. ncbi request reprint 60 years of winged victories for biomedical research
    Joseph L Goldstein
    Nat Med 11:1023-5. 2005
  69. ncbi request reprint Acceptance remarks of Joseph L Goldstein and Michael S. Brown on the occasion of the presentation of the Kober Medal, 2002
    Joseph L Goldstein
    J Clin Invest 110:S11-3. 2002
  70. ncbi request reprint Towering science: an ounce of creativity is worth a ton of impact
    Joseph L Goldstein
    Nat Med 10:1015-7. 2004