Research Topics
Genomes and Genes
| Joseph L GoldsteinSummaryAffiliation: University of Texas Southwestern Medical Center Country: USA Publications
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Detail Information
Publications
From fatty streak to fatty liver: 33 years of joint publications in the JCIJoseph L Goldstein
Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9046, USA
J Clin Invest 118:1220-2. 2008..In this retrospective, we review highlights from our 26 joint papers in the JCI, focusing on two papers that revealed the consequences of lipid accumulation with implications for atherosclerosis and steatohepatitis...
Surviving starvation: essential role of the ghrelin-growth hormone axisJ L Goldstein
Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9046, USA
Cold Spring Harb Symp Quant Biol 76:121-7. 2011..Thus, ghrelin lies at the center of a hormonal response that permits mice to survive an acute fast superimposed on chronic starvation...- The LDL receptorJoseph L Goldstein
Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390 9046, USA
Arterioscler Thromb Vasc Biol 29:431-8. 2009..The latter concept provides the mechanism by which statins selectively lower plasma LDL, reducing heart attacks and prolonging life... 
How a jolt and a bolt in a dentist's chair revolutionized cataract surgeryJoseph L Goldstein
Department of Molecular Genetics, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Room L5.238, Dallas, Texas 75390-9046, USA
Nat Med 10:1032-3. 2004- Protein sensors for membrane sterolsJoseph L Goldstein
Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
Cell 124:35-46. 2006..Here, we discuss recent advances that explain how cells employ an ensemble of membrane-embedded proteins to monitor sterol concentrations and adjust sterol synthesis and uptake... - Mutant mammalian cells as tools to delineate the sterol regulatory element-binding protein pathway for feedback regulation of lipid synthesisJoseph L Goldstein
Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9046, USA
Arch Biochem Biophys 397:139-48. 2002..Their cDNAs and genes were isolated by genetic complementation or by expression cloning. The somatic cell genetic approach described in this article should prove useful for unraveling other complex biochemical pathways in animal cells... - Insig required for sterol-mediated inhibition of Scap/SREBP binding to COPII proteins in vitroLi Ping Sun
Department of Molecular Genetics, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9046, USA
J Biol Chem 280:26483-90. 2005..This hexapeptide acts as a sterol-regulated ER sorting signal. These studies define the biochemical parameters responsible for regulated sorting of an ER membrane protein into COPII-coated vesicles... - Insig-dependent ubiquitination and degradation of mammalian 3-hydroxy-3-methylglutaryl-CoA reductase stimulated by sterols and geranylgeraniolNavdar Sever
Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9046, USA
J Biol Chem 278:52479-90. 2003.... - Insig-2, a second endoplasmic reticulum protein that binds SCAP and blocks export of sterol regulatory element-binding proteinsDaisuke Yabe
Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390 9046, USA
Proc Natl Acad Sci U S A 99:12753-8. 2002..The combined actions of insig-1 and -2 permit feedback regulation of cholesterol synthesis over a wide range of sterol concentrations... - Reconstitution of sterol-regulated endoplasmic reticulum-to-Golgi transport of SREBP-2 in insect cells by co-expression of mammalian SCAP and InsigsIrina Y Dobrosotskaya
Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9046
J Biol Chem 278:35837-43. 2003..They indicate that insect cells can respond to sterols when proper regulatory proteins are expressed... - Identification of surface residues on Niemann-Pick C2 essential for hydrophobic handoff of cholesterol to NPC1 in lysosomesMichael L Wang
Department of Molecular Genetics, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
Cell Metab 12:166-73. 2010..We refer to this transfer as a hydrophobic handoff and hypothesize that this handoff is essential for cholesterol export from lysosomes... - Overexpression of Insig-1 in the livers of transgenic mice inhibits SREBP processing and reduces insulin-stimulated lipogenesisLuke J Engelking
Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, 75390, USA
J Clin Invest 113:1168-75. 2004..These results provide in vivo support for the hypothesis that nSREBPs are essential for high levels of lipid synthesis in the liver and indicate that Insig's modulate nSREBP levels by binding and retaining SCAP in the ER... - Compensatory increase in fatty acid synthesis in adipose tissue of mice with conditional deficiency of SCAP in liverHiroshi Kuriyama
Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
Cell Metab 1:41-51. 2005..Plasma VLDL triglycerides are dramatically reduced in L-Scap- mice, underscoring the benefits of synthesizing FAs in fat rather than liver... - Accelerated degradation of HMG CoA reductase mediated by binding of insig-1 to its sterol-sensing domainNavdar Sever
Department of Molecular Genetics, University of Texas, Southwestern Medical Center, Dallas, TX 75390, USA
Mol Cell 11:25-33. 2003..Insig-1 appears to play an essential role in the sterol-mediated trafficking of two proteins with sterol-sensing domains, HMG CoA reductase and SCAP... - Schoenheimer effect explained--feedback regulation of cholesterol synthesis in mice mediated by Insig proteinsLuke J Engelking
Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9046, USA
J Clin Invest 115:2489-98. 2005..These studies indicate that the essential elements of the regulatory pathway for lipid synthesis function in liver as they do in cultured cells... - Liver-specific mRNA for Insig-2 down-regulated by insulin: implications for fatty acid synthesisDaisuke Yabe
Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390 9046, USA
Proc Natl Acad Sci U S A 100:3155-60. 2003..The insulin-mediated fall in Insig-2a may allow SREBP-1c to be processed, thereby allowing insulin to stimulate fatty acid synthesis, even under conditions in which hepatic cholesterol levels are elevated... - Amino acid substitution in NPC1 that abolishes cholesterol binding reproduces phenotype of complete NPC1 deficiency in miceXuefen Xie
Departments of Molecular Genetics and Pathology, University of Texas Southwestern Medical Center, Dallas, TX 75390 9046, USA
Proc Natl Acad Sci U S A 108:15330-5. 2011..The HPCD-mediated reduction of excess lysosomal enzymes may contribute to the ability of this drug to delay the progression of NPC disease in mice... - Sterol-regulated transport of SREBPs from endoplasmic reticulum to Golgi: oxysterols block transport by binding to InsigArun Radhakrishnan
Department of Molecular Genetics and Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
Proc Natl Acad Sci U S A 104:6511-8. 2007..These studies define Insigs as oxysterol-binding proteins, explaining the long-known ability of oxysterols to inhibit cholesterol synthesis in animal cells... - Sterol-regulated ubiquitination and degradation of Insig-1 creates a convergent mechanism for feedback control of cholesterol synthesis and uptakeYi Gong
Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
Cell Metab 3:15-24. 2006..When the new Insig-1 and cholesterol converge on Scap, Scap/SREBP binds to Insig-1, preventing ubiquitination. The Insig-1/Scap/SREBP complex accumulates in the ER, ready for liberation when the cell is again sterol deprived... - Membrane topology of human insig-1, a protein regulator of lipid synthesisJamison D Feramisco
Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9046, USA
J Biol Chem 279:8487-96. 2004..The membranous nature of Insig-1 is consistent with its sterol-dependent binding to hydrophobic sterol-sensing domains in SCAP and HMG CoA reductase... - Combined analysis of oligonucleotide microarray data from transgenic and knockout mice identifies direct SREBP target genesJay D Horton
Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390 9046, USA
Proc Natl Acad Sci U S A 100:12027-32. 2003.... - Identification of luminal Loop 1 of Scap protein as the sterol sensor that maintains cholesterol homeostasisMassoud Motamed
Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9046, USA
J Biol Chem 286:18002-12. 2011..These results indicate that luminal Loop 1 of Scap controls the conformation of cytosolic Loop 6, thereby determining whether cells produce cholesterol... - Regulated endoplasmic reticulum-associated degradation of a polytopic protein: p97 recruits proteasomes to Insig-1 before extraction from membranesYukio Ikeda
Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9046, USA
J Biol Chem 284:34889-900. 2009..These data suggest that p97 recruits proteasomes to polytopic ER proteins even before they are extracted from membranes... - The Scap/SREBP pathway is essential for developing diabetic fatty liver and carbohydrate-induced hypertriglyceridemia in animalsYoung Ah Moon
Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390 9046, USA
Cell Metab 15:240-6. 2012..Inhibition of SREBP activation has therapeutic potential for treatment of hypertriglyceridemia and fatty liver disease... - Structure of N-terminal domain of NPC1 reveals distinct subdomains for binding and transfer of cholesterolHyock Joo Kwon
Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390 9046, USA
Cell 137:1213-24. 2009.... - NPC2 facilitates bidirectional transfer of cholesterol between NPC1 and lipid bilayers, a step in cholesterol egress from lysosomesRodney E Infante
Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390 9046, USA
Proc Natl Acad Sci U S A 105:15287-92. 2008..These findings may explain how mutations in either protein can produce a similar clinical phenotype... - Ghrelin O-acyltransferase (GOAT) is essential for growth hormone-mediated survival of calorie-restricted miceTong Jin Zhao
Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
Proc Natl Acad Sci U S A 107:7467-72. 2010..Thus, an essential function of ghrelin in mice is elevation of GH levels during severe calorie restriction, thereby preserving blood glucose and preventing death... - Severe facial clefting in Insig-deficient mouse embryos caused by sterol accumulation and reversed by lovastatinLuke J Engelking
Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9046, USA
J Clin Invest 116:2356-65. 2006.... - Purified NPC1 protein: II. Localization of sterol binding to a 240-amino acid soluble luminal loopRodney E Infante
Department of Molecular Genetics, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390, USA
J Biol Chem 283:1064-75. 2008..Thus, the sterol binding site on luminal loop-1 is not essential for NPC1 function in fibroblasts, but it may function in other cells where NPC1 deficiency produces more complicated lipid abnormalities... - Sterol-regulated transport of SREBPs from endoplasmic reticulum to Golgi: Insig renders sorting signal in Scap inaccessible to COPII proteinsLi Ping Sun
Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
Proc Natl Acad Sci U S A 104:6519-26. 2007.... - Purified NPC1 protein. I. Binding of cholesterol and oxysterols to a 1278-amino acid membrane proteinRodney E Infante
Department of Molecular Genetics, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390, USA
J Biol Chem 283:1052-63. 2008..The availability of assays to measure NPC1 binding in vitro may further the understanding of ways in which oxysterols regulate intracellular lipid transport... - Intramembrane aspartic acid in SCAP protein governs cholesterol-induced conformational changeJamison D Feramisco
Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390 9046, USA
Proc Natl Acad Sci U S A 102:3242-7. 2005..These data identify an important functional residue in SCAP, and they provide genetic evidence that the conformation of SCAP dictates the rate of cholesterol synthesis in animal cells... - Crucial step in cholesterol homeostasis: sterols promote binding of SCAP to INSIG-1, a membrane protein that facilitates retention of SREBPs in ERTong Yang
Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas 75390, USA
Cell 110:489-500. 2002..Mutant SCAP(Y298C) fails to bind INSIG-1 and is resistant to sterol-mediated inhibition of ER exit. By facilitating sterol-dependent ER retention of SCAP, INSIG-1 plays a central role in cholesterol homeostasis... - Hair growth defects in Insig-deficient mice caused by cholesterol precursor accumulation and reversed by simvastatinBret M Evers
Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas, USA
J Invest Dermatol 130:1237-48. 2010..These findings have implications for several human genetic diseases in which mutations in cholesterol biosynthetic enzymes lead to accumulation of sterol precursors and multiple cutaneous abnormalities... - Cyclodextrin overcomes deficient lysosome-to-endoplasmic reticulum transport of cholesterol in Niemann-Pick type C cellsLina Abi-Mosleh
Department of Molecular Genetics, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9046, USA
Proc Natl Acad Sci U S A 106:19316-21. 2009..The buildup of cholesteryl esters in the cytosol is expected to be much less toxic than the buildup of free cholesterol in the lysosomes of patients with mutations in NPC1 or NPC2... - Cholesterol and 25-hydroxycholesterol inhibit activation of SREBPs by different mechanisms, both involving SCAP and InsigsChristopher M Adams
Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9046, USA
J Biol Chem 279:52772-80. 2004..These data imply that cholesterol interacts with SCAP directly by inducing it to bind to Insigs, whereas 25-HC works indirectly through a putative 25-HC sensor protein that elicits SCAP-Insig binding... - Juxtamembranous aspartic acid in Insig-1 and Insig-2 is required for cholesterol homeostasisYi Gong
Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390 9046, USA
Proc Natl Acad Sci U S A 103:6154-9. 2006..These studies identify a single amino acid residue that is crucial for the function of Insig proteins in regulating cholesterol homeostasis in mammalian cells... - Central role for liver X receptor in insulin-mediated activation of Srebp-1c transcription and stimulation of fatty acid synthesis in liverGuoxun Chen
Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390 9046, USA
Proc Natl Acad Sci U S A 101:11245-50. 2004..Nuclear SREBPs and nuclear factor Y play permissive roles... - Insulin stimulation of SREBP-1c processing in transgenic rat hepatocytes requires p70 S6-kinaseJoshua L Owen
Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
Proc Natl Acad Sci U S A 109:16184-9. 2012..Insulin stimulation of both processes is blocked by glucagon. The transgenic rat system will be useful in further defining the molecular mechanism for insulin stimulation of lipid synthesis in liver in normal and diabetic states... - Switch-like control of SREBP-2 transport triggered by small changes in ER cholesterol: a delicate balanceArun Radhakrishnan
Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390 9046, USA
Cell Metab 8:512-21. 2008..Cooperative interactions between cholesterol, Scap, and Insig create a sensitive switch that controls the cholesterol composition of cell membranes with remarkable precision... - Direct binding of cholesterol to the purified membrane region of SCAP: mechanism for a sterol-sensing domainArun Radhakrishnan
Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas 75390, USA
Mol Cell 15:259-68. 2004..The current studies show that cells control their cholesterol content through receptor-ligand interactions and not through changes in the physical properties of the membrane... - Profound hypoglycemia in starved, ghrelin-deficient mice is caused by decreased gluconeogenesis and reversed by lactate or fatty acidsRobert Lin Li
Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9046, USA
J Biol Chem 287:17942-50. 2012..In humans with anorexia nervosa or kwashiorkor, ghrelin and growth hormone are known to be elevated, just as they are in fat-depleted mice. We suggest that these two hormones prolong survival in starved humans as they do in mice... - Inhibition of ghrelin O-acyltransferase (GOAT) by octanoylated pentapeptidesJing Yang
Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390 9046, USA
Proc Natl Acad Sci U S A 105:10750-5. 2008..These insights may facilitate the future design of useful inhibitors of GOAT... - The SREBP pathway in Drosophila: regulation by palmitate, not sterolsAdam C Seegmiller
Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
Dev Cell 2:229-38. 2002..Instead, dSREBP processing is blocked by palmitic acid. These findings suggest that the ancestral SREBP pathway functions to maintain membrane integrity rather than to control cholesterol homeostasis... - LXR-SREBP-1c-phospholipid transfer protein axis controls very low density lipoprotein (VLDL) particle sizeHiroaki Okazaki
Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9046, USA
J Biol Chem 285:6801-10. 2010..In the absence of LDL receptors, the large VLDLs accumulate and produce massive hypertriglyceridemia... - SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liverJay D Horton
Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9046, USA
J Clin Invest 109:1125-31. 2002 - Cholesterol-induced conformational change in SCAP enhanced by Insig proteins and mimicked by cationic amphiphilesChristopher M Adams
Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390 9046, USA
Proc Natl Acad Sci U S A 100:10647-52. 2003..The effects of cationic amphiphiles raise the possibility that SCAP may monitor specifically the composition of the cytoplasmic leaflet of the ER membrane... - Identification of FBL2 as a geranylgeranylated cellular protein required for hepatitis C virus RNA replicationChunfu Wang
Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
Mol Cell 18:425-34. 2005..The current data indicate that geranylgeranylated FBL2 binds to NS5A in a reaction crucial for HCV RNA replication... - Ghrelin secretion stimulated by {beta}1-adrenergic receptors in cultured ghrelinoma cells and in fasted miceTong Jin Zhao
Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, 75390, USA
Proc Natl Acad Sci U S A 107:15868-73. 2010..We conclude that ghrelin secretion during fasting is induced by adrenergic agents released by sympathetic neurons and acting directly on beta(1) receptors on the ghrelin-secreting cells of the stomach... - Cholesterol addition to ER membranes alters conformation of SCAP, the SREBP escort protein that regulates cholesterol metabolismAndrew J Brown
Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
Mol Cell 10:237-45. 2002..These studies demonstrate an in vitro effect of cholesterol on the sterol regulatory machinery... - Bifurcation of insulin signaling pathway in rat liver: mTORC1 required for stimulation of lipogenesis, but not inhibition of gluconeogenesisShijie Li
Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390 9046, USA
Proc Natl Acad Sci U S A 107:3441-6. 2010..These results establish mTORC1 as an essential component in the insulin-regulated pathway for hepatic lipogenesis but not gluconeogenesis, and may help to resolve the paradox of selective insulin resistance in livers of diabetic rodents... - Accelerated fatty acid oxidation in muscle averts fasting-induced hepatic steatosis in SJL/J miceHong Ping Guan
Department of Molecular Genetics, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9046, USA
J Biol Chem 284:24644-52. 2009..We conclude that SJL/J mice express one or more variant genes that lead to enhanced FA uptake and oxidation in muscle, thereby sparing the liver from FA overload in the fasting state... - Structure of the LDL receptor extracellular domain at endosomal pHGabby Rudenko
Department of Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard Y4 206, Dallas, TX 75390, USA
Science 298:2353-8. 2002..We propose a mechanism for lipoprotein release in the endosome whereby the beta propeller functions as an alternate substrate for the ligand-binding domain, binding in a calcium-dependent way and promoting lipoprotein release... - Cholesterol feedback: from Schoenheimer's bottle to Scap's MELADLMichael S Brown
Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390 9046, USA
J Lipid Res 50:S15-27. 2009..In this article we review the major milestones in the cholesterol feedback story... - Identification of the acyltransferase that octanoylates ghrelin, an appetite-stimulating peptide hormoneJing Yang
Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
Cell 132:387-96. 2008..Identification of GOAT will facilitate the search for inhibitors that reduce appetite and diminish obesity in humans... - Diminished hepatic response to fasting/refeeding and liver X receptor agonists in mice with selective deficiency of sterol regulatory element-binding protein-1cGuosheng Liang
Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9046, USA
J Biol Chem 277:9520-8. 2002..Moreover, these mRNAs, as well as multiple other lipogenic mRNAs, showed a markedly blunted response to the LXR agonist T090137, indicating an essential role of SREBP-1c in the LXR response... - Biomedicine. Lowering LDL--not only how low, but how long?Michael S Brown
Department of Molecular Genetics, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 9046, USA
Science 311:1721-3. 2006 - Richard G.W. Anderson (1940-2011) and the birth of receptor-mediated endocytosisMichael S Brown
J Cell Biol 193:601-3. 2011..He died of glioblastoma multiforme six days before his 71st birthday... - Characterization of mouse short-chain aldehyde reductase (SCALD), an enzyme regulated by sterol regulatory element-binding proteinsAnne Kasus-Jacobi
Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9046, USA
J Biol Chem 278:32380-9. 2003.... - Disruption of hepatitis C virus RNA replication through inhibition of host protein geranylgeranylationJin Ye
Departments of Molecular Genetics and Microbiology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
Proc Natl Acad Sci U S A 100:15865-70. 2003..Inhibition of its geranylgeranylation affords a therapeutic strategy for treatment of HCV infection... - Selective versus total insulin resistance: a pathogenic paradoxMichael S Brown
Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
Cell Metab 7:95-6. 2008..In this issue of Cell Metabolism, Biddinger et al. (2008) show that mice with total hepatic insulin resistance exhibit hyperglycemia without hypertriglyceridemia-a state paradoxically less severe than selective insulin resistance... - Mevinolin and colestipol stimulate receptor-mediated clearance of low density lipoprotein from plasma in familial hypercholeserolemia heterozygotes. 1983David W Bilheimer
Atheroscler Suppl 5:61-5. 2004 - Presentation of the Kober Medal to Joseph L. Goldstein and Michael S. BrownDavid W Foster
J Clin Invest 110:S5-9. 2002 - Lowering plasma cholesterol by raising ldl receptors. 1981Michael S Brown
Atheroscler Suppl 5:57-9. 2004 - 60 years of winged victories for biomedical researchJoseph L Goldstein
Nat Med 11:1023-5. 2005 - Pioneers in cholesterol research capture America's top award in medicineMichael S Brown
J Investig Med 51:251. 2003 - Lasker awards 2003. Foreword: It's a grand year for celebrating scienceJoseph L Goldstein
Chair, Lasker Awards Jury
Nat Med 9:1237-8. 2003 - Acceptance remarks of Joseph L Goldstein and Michael S. Brown on the occasion of the presentation of the Kober Medal, 2002Joseph L Goldstein
J Clin Invest 110:S11-3. 2002 - Towering science: an ounce of creativity is worth a ton of impactJoseph L Goldstein
Nat Med 10:1015-7. 2004