Steve Goldman

Summary

Affiliation: University of Rochester
Country: USA

Publications

  1. ncbi Identification and isolation of multipotential neural progenitor cells from the subcortical white matter of the adult human brain
    Marta C Nunes
    Department of Neurology and Neuroscience, Cornell University Medical College, New York, New York, USA
    Nat Med 9:439-47. 2003
  2. ncbi Glial progenitor cell-based treatment and modeling of neurological disease
    Steven A Goldman
    Center for Translational Neuromedicine, University of Rochester Medical Center, Rochester, NY 14642, USA
    Science 338:491-5. 2012
  3. ncbi Disease targets and strategies for the therapeutic modulation of endogenous neural stem and progenitor cells
    S A Goldman
    Division of Cell and Gene Therapy, Departments of Neurology and Neurosurgery, University of Rochester Medical Center, Rochester, New York, USA
    Clin Pharmacol Ther 82:453-60. 2007
  4. ncbi A niche-defying feat: induced oligoneogenesis in the adult dentate gyrus
    Steven A Goldman
    Department of Neurology, University of Rochester Medical Center, Rochester, NY 14580, USA
    Cell Stem Cell 3:125-6. 2008
  5. ncbi Cell replacement therapy in neurological disease
    Steven A Goldman
    Division of Cell and Gene Therapy, Department of Neurology, University of Rochester Medical Center, 601 Elmwood Avenue, PO Box 645, Rochester, NY 14642, USA
    Philos Trans R Soc Lond B Biol Sci 361:1463-75. 2006
  6. ncbi Stem and progenitor cell-based therapy of the human central nervous system
    Steve Goldman
    Division of Cell and Gene Therapy, Department of Neurology, 601 Elmwood Ave, Box 645, University of Rochester Medical Center, Rochester, New York 14642, USA
    Nat Biotechnol 23:862-71. 2005
  7. ncbi Directed mobilization of endogenous neural progenitor cells: the intersection of stem cell biology and gene therapy
    Steven A Goldman
    University of Rochester Medical Center, Division of Cell and Gene Therapy, Department of Neurology, Rochester, NY 14642, USA
    Curr Opin Mol Ther 6:466-72. 2004
  8. ncbi Perivascular instruction of cell genesis and fate in the adult brain
    Steven A Goldman
    Department of Neurology and the Center for Translational Neuromedicine, University of Rochester Medical School, Rochester, New York, USA
    Nat Neurosci 14:1382-9. 2011
  9. ncbi Statin treatment of adult human glial progenitors induces PPAR gamma-mediated oligodendrocytic differentiation
    Fraser J Sim
    Department of Neurology, University of Rochester Medical Center, New York 14642, USA
    Glia 56:954-62. 2008
  10. ncbi Progenitor cells derived from the adult human subcortical white matter disperse and differentiate as oligodendrocytes within demyelinated lesions of the rat brain
    Martha S Windrem
    Department of Neurology and Neuroscience, Cornell University Medical College, New York, New York 10021, USA
    J Neurosci Res 69:966-75. 2002

Research Grants

  1. Induction of Striatal Regeneration in Huntington's Disease
    Steven Goldman; Fiscal Year: 2007
  2. Regulation of adult human oligodendrocyte progenitors
    Steven Goldman; Fiscal Year: 2007
  3. Angiogenic determinants of endogenous adult neurogenesis
    Steven Goldman; Fiscal Year: 2007
  4. Induction of Striatal Regeneration in Huntington's Disease
    Steven Goldman; Fiscal Year: 2009
  5. IDENTIFICATION & SELECTION OF ADULT NEURAL PRECURSORS
    Steven Goldman; Fiscal Year: 2003
  6. ISOLATION AND USE OF ADULT HUMAN OLIGODENDROCYTE PROGENI
    Steven Goldman; Fiscal Year: 2003
  7. Induction of Striatal Regeneration in Huntington's Disease
    Steven Goldman; Fiscal Year: 2009

Collaborators

Detail Information

Publications40

  1. ncbi Identification and isolation of multipotential neural progenitor cells from the subcortical white matter of the adult human brain
    Marta C Nunes
    Department of Neurology and Neuroscience, Cornell University Medical College, New York, New York, USA
    Nat Med 9:439-47. 2003
    ..These experiments indicate that an abundant pool of mitotically competent neurogenic progenitor cells resides in the adult human white matter...
  2. ncbi Glial progenitor cell-based treatment and modeling of neurological disease
    Steven A Goldman
    Center for Translational Neuromedicine, University of Rochester Medical Center, Rochester, NY 14642, USA
    Science 338:491-5. 2012
    ....
  3. ncbi Disease targets and strategies for the therapeutic modulation of endogenous neural stem and progenitor cells
    S A Goldman
    Division of Cell and Gene Therapy, Departments of Neurology and Neurosurgery, University of Rochester Medical Center, Rochester, New York, USA
    Clin Pharmacol Ther 82:453-60. 2007
    ....
  4. ncbi A niche-defying feat: induced oligoneogenesis in the adult dentate gyrus
    Steven A Goldman
    Department of Neurology, University of Rochester Medical Center, Rochester, NY 14580, USA
    Cell Stem Cell 3:125-6. 2008
    ..The effect is specific to the hippocampal niche in vivo, indicating that cell-autonomous and niche-defined factors collaborate to instruct cell fate choices...
  5. ncbi Cell replacement therapy in neurological disease
    Steven A Goldman
    Division of Cell and Gene Therapy, Department of Neurology, University of Rochester Medical Center, 601 Elmwood Avenue, PO Box 645, Rochester, NY 14642, USA
    Philos Trans R Soc Lond B Biol Sci 361:1463-75. 2006
    ....
  6. ncbi Stem and progenitor cell-based therapy of the human central nervous system
    Steve Goldman
    Division of Cell and Gene Therapy, Department of Neurology, 601 Elmwood Ave, Box 645, University of Rochester Medical Center, Rochester, New York 14642, USA
    Nat Biotechnol 23:862-71. 2005
    ..Together, these may present the most compelling strategies and near-term disease targets for cell-based neurological therapy...
  7. ncbi Directed mobilization of endogenous neural progenitor cells: the intersection of stem cell biology and gene therapy
    Steven A Goldman
    University of Rochester Medical Center, Division of Cell and Gene Therapy, Department of Neurology, Rochester, NY 14642, USA
    Curr Opin Mol Ther 6:466-72. 2004
    ....
  8. ncbi Perivascular instruction of cell genesis and fate in the adult brain
    Steven A Goldman
    Department of Neurology and the Center for Translational Neuromedicine, University of Rochester Medical School, Rochester, New York, USA
    Nat Neurosci 14:1382-9. 2011
    ....
  9. ncbi Statin treatment of adult human glial progenitors induces PPAR gamma-mediated oligodendrocytic differentiation
    Fraser J Sim
    Department of Neurology, University of Rochester Medical Center, New York 14642, USA
    Glia 56:954-62. 2008
    ..Thus, statins may promote oligodendrocyte lineage commitment by parenchymal glial progenitor cells; this might reduce the available progenitor pool, and hence degrade the long-term regenerative competence of the adult white matter...
  10. ncbi Progenitor cells derived from the adult human subcortical white matter disperse and differentiate as oligodendrocytes within demyelinated lesions of the rat brain
    Martha S Windrem
    Department of Neurology and Neuroscience, Cornell University Medical College, New York, New York 10021, USA
    J Neurosci Res 69:966-75. 2002
    ..This being the case, they may constitute appropriate vectors for cell-based remyelination strategies...
  11. ncbi Prospective identification, isolation, and profiling of a telomerase-expressing subpopulation of human neural stem cells, using sox2 enhancer-directed fluorescence-activated cell sorting
    Su Wang
    Center for Translational Neuromedicine and the Department of Neurology, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Neurosci 30:14635-48. 2010
    ....
  12. ncbi Telomerase immortalization of neuronally restricted progenitor cells derived from the human fetal spinal cord
    Neeta S Roy
    Department of Neurology and Neuroscience, Cornell University Medical Center, New York, New York 10021, USA
    Nat Biotechnol 22:297-305. 2004
    ..The cells have survived >168 doublings in vitro, with karyotypic normalcy and without replicative senescence. hTERT overexpression thus permits the generation of progenitor lines able to give rise to phenotypically restricted neurons...
  13. ncbi Glia as neural progenitor cells
    Steve Goldman
    Department of Neurology, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Trends Neurosci 26:590-6. 2003
    ..It will also discuss the interactions of progenitor cells with their brethren that could specify their phenotype and fate, while defining the permissive niches for cell genesis in the adult CNS...
  14. ncbi Adenovirally expressed noggin and brain-derived neurotrophic factor cooperate to induce new medium spiny neurons from resident progenitor cells in the adult striatal ventricular zone
    Eva Chmielnicki
    Department of Neurology and Neuroscience, Cornell University Medical College, New York, New York 10021, USA
    J Neurosci 24:2133-42. 2004
    ....
  15. ncbi Stem cell-based strategies for treating pediatric disorders of myelin
    Steven A Goldman
    Division of Cell and Gene Therapy and Center for Translational Neuromedicine, Department of Neurology and Neurosurgery, University of Rochester Medical Center, Rochester, NY 14642, USA
    Hum Mol Genet 17:R76-83. 2008
    ....
  16. ncbi Induced neurogenesis by endogenous progenitor cells in the adult mammalian brain
    Eva Chmielnicki
    Department of Neurology and Neuroscience, Cornell University Medical College, 1300 York Ave, Room E607, New York, NY 10021, USA
    Prog Brain Res 138:451-64. 2002
  17. ncbi Interview. From canaries to the clinic
    Steven A Goldman
    Regen Med 3:655-9. 2008
  18. ncbi Neonatal chimerization with human glial progenitor cells can both remyelinate and rescue the otherwise lethally hypomyelinated shiverer mouse
    Martha S Windrem
    Department of Neurology, University of Rochester Medical Center, Rochester, NY 14642, USA
    Cell Stem Cell 2:553-65. 2008
    ..These data demonstrate that the neonatal transplantation of human glial progenitor cells can effectively treat disorders of congenital and perinatal hypomyelination...
  19. ncbi Functional engraftment of human ES cell-derived dopaminergic neurons enriched by coculture with telomerase-immortalized midbrain astrocytes
    Neeta S Roy
    Department of Neurology, Weill Medical College of Cornell University, New York, New York 10021, USA
    Nat Med 12:1259-68. 2006
    ..Yet these data also mandate caution in the clinical application of HES cell-derived grafts, given their potential for phenotypic instability and undifferentiated expansion...
  20. ncbi Complementary patterns of gene expression by human oligodendrocyte progenitors and their environment predict determinants of progenitor maintenance and differentiation
    Fraser J Sim
    Department of Neurology, University of Rochester Medical Center, NY 14642, USA
    Ann Neurol 59:763-79. 2006
    ..As such, they provide targets by which to productively mobilize resident progenitor cells of the adult human brain...
  21. ncbi Enhancer-specified GFP-based FACS purification of human spinal motor neurons from embryonic stem cells
    Neeta Singh Roy
    Department of Neurology, Cornell University Medical College, NYC, NY 10021, USA
    Exp Neurol 196:224-34. 2005
    ..These results suggest the utility of promoter/enhancer-based FACS for the isolation of specific phenotypes from hES cell populations as a means of purifying clinically appropriate vectors for cell therapy...
  22. ncbi Neural progenitor cells of the adult brain
    Steven A Goldman
    Department of Neurology, University of Rochester Medical Center, 601 Elmwood Avenue, MRBX, Box 645, Rochester, NY 14642, USA
    Novartis Found Symp 265:66-80; discussion 82-97. 2005
    ....
  23. ncbi Fetal and adult human oligodendrocyte progenitor cell isolates myelinate the congenitally dysmyelinated brain
    Martha S Windrem
    Department of Neurology and Neuroscience, Cornell University Medical College, 1300 York Ave, New York, New York 10021, USA
    Nat Med 10:93-7. 2004
    ..Both fetal and adult OPC phenotypes mediated the extensive and robust myelination of congenitally dysmyelinated host brain, although their differences suggested their use for different disease targets...
  24. ncbi Purinergic signaling regulates neural progenitor cell expansion and neurogenesis
    Jane H C Lin
    Department of Cell Biology, New York Medical College, Valhalla, NY, USA
    Dev Biol 302:356-66. 2007
    ..As a result, progenitor cell-derived neurogenesis is thus associated with regions of both active purinergic signaling and modulation thereof...
  25. ncbi Neurology and the stem cell debate
    Steven A Goldman
    Neurology 64:1675-6. 2005
  26. ncbi Large stem cell grafts could lead to erroneous interpretations of behavioral results?
    Steven A Goldman
    Nat Med 13:118-9. 2007
  27. ncbi Human embryonic stem cell-derived motor neurons expressing SOD1 mutants exhibit typical signs of motor neuron degeneration linked to ALS
    Saravanan Karumbayaram
    Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Dis Model Mech 2:189-95. 2009
    ..These genetically manipulated hESC-derived motor neurons can facilitate and advance the study of disease-specific cellular pathways, and serve as a model system to test new therapeutic approaches...
  28. ncbi Fate determination of adult human glial progenitor cells
    Fraser J Sim
    Center for Translational Neuromedicine, and the Department of Neurology, University of Rochester Medical Center, Rochester, NY, USA
    Neuron Glia Biol 5:45-55. 2009
    ....
  29. ncbi Retrovirally mediated telomerase immortalization of neural progenitor cells
    Neeta S Roy
    Department of Neurology, Weill Medical College of Cornell University, New York, New York 10021, USA
    Nat Protoc 2:2815-25. 2007
    ....
  30. ncbi Neurocytoma is a tumor of adult neuronal progenitor cells
    Fraser J Sim
    Department of Neurology, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Neurosci 26:12544-55. 2006
    ..This strategy of comparing the gene expression of tumor cells to that of the purified native progenitors from which they derive may provide a focused approach to identifying transcripts important to stem and progenitor cell oncogenesis...
  31. ncbi Induction of neostriatal neurogenesis slows disease progression in a transgenic murine model of Huntington disease
    Sung Rae Cho
    Department of Neurology, University of Rochester Medical Center, Rochester, New York, USA
    J Clin Invest 117:2889-902. 2007
    ..Thus, BDNF and Noggin induced striatal neuronal regeneration, delayed motor impairment, and extended survival in R6/2 mice, suggesting a new therapeutic strategy in Huntington disease...
  32. ncbi Glial progenitor-based repair of demyelinating neurological diseases
    H Michael Keyoung
    Department of Neurological Surgery, University of California, San Francisco, 505 Parnassus Avenue, M779, PO Box 0470, San Francisco, CA 94143 0470, USA
    Neurosurg Clin N Am 18:93-104, x. 2007
    ..Given the relative availability and homogeneity of human oligodendrocyte progenitor cells, the disorders of myelin formation and maintenance may be especially compelling targets for cell-based neurologic therapy...
  33. ncbi P2X7 receptor inhibition improves recovery after spinal cord injury
    Xiaohai Wang
    Department of Neurosurgery, Center for Aging and Developmental Biology, University of Rochester Medical Center, Rochester, New York 14642, USA
    Nat Med 10:821-7. 2004
    ..P2X7R antagonists inhibit this process, reducing both the histological extent and functional sequelae of acute SCI...
  34. ncbi Testosterone-induced matrix metalloproteinase activation is a checkpoint for neuronal addition to the adult songbird brain
    Dae Hee Kim
    Department of Neurology, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Neurosci 28:208-16. 2008
    ..These data suggest that the androgenic induction of endothelial MMP2 is a critical regulator of neuronal addition to the adult HVC, and as such comprises an important regulatory step in adult neurogenesis...
  35. ncbi Coordinated interaction of neurogenesis and angiogenesis in the adult songbird brain
    Abner Louissaint
    Department of Neurology and Neuroscience, Cornell University Medical Center, 1300 York Avenue, New York, NY 10021, USA
    Neuron 34:945-60. 2002
    ..These findings suggest a causal interaction between testosterone-induced angiogenesis and neurogenesis in the adult forebrain...
  36. ncbi Whole genome analysis of human neural stem cells derived from embryonic stem cells and stem and progenitor cells isolated from fetal tissue
    Soojung Shin
    Stem Cells and Regenerative Medicine, Invitrogen, Carlsbad, California, USA
    Stem Cells 25:1298-306. 2007
    ..Disclosure of potential conflicts of interest is found at the end of this article...
  37. ncbi Angiogenic inhibition reduces germinal matrix hemorrhage
    Praveen Ballabh
    Department of Pediatrics, New York Medical College Westchester Medical Center, Valhalla, New York 10595, USA
    Nat Med 13:477-85. 2007
    ..Thus, by suppressing germinal matrix angiogenesis, prenatal celecoxib or ZD6474 treatment may be able to reduce both the incidence and severity of GMH in susceptible premature infants...
  38. ncbi New roles for astrocytes: redefining the functional architecture of the brain
    Maiken Nedergaard
    Department of Cell Biology, New York Medical College, Valhalla, NY 10595, USA
    Trends Neurosci 26:523-30. 2003
    ..By these means, astrocytes might establish the functional as well as the structural architecture of the adult brain...
  39. ncbi Nitric oxide negatively regulates mammalian adult neurogenesis
    Michael A Packer
    Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
    Proc Natl Acad Sci U S A 100:9566-71. 2003
    ....
  40. ncbi Erythropoietin strikes a new cord
    Steven A Goldman
    Nat Med 8:785-7. 2002

Research Grants26

  1. Induction of Striatal Regeneration in Huntington's Disease
    Steven Goldman; Fiscal Year: 2007
    ....
  2. Regulation of adult human oligodendrocyte progenitors
    Steven Goldman; Fiscal Year: 2007
    ..abstract_text> ..
  3. Angiogenic determinants of endogenous adult neurogenesis
    Steven Goldman; Fiscal Year: 2007
    ....
  4. Induction of Striatal Regeneration in Huntington's Disease
    Steven Goldman; Fiscal Year: 2009
    ....
  5. IDENTIFICATION & SELECTION OF ADULT NEURAL PRECURSORS
    Steven Goldman; Fiscal Year: 2003
    ..If this work is successful, we may soon need to consider how best to train newly generated networks of replacement neurons and glia to assume lost functions, in diseases as diverse as stroke, trauma, and the neurodegenerations. ..
  6. ISOLATION AND USE OF ADULT HUMAN OLIGODENDROCYTE PROGENI
    Steven Goldman; Fiscal Year: 2003
    ..abstract_text> ..
  7. Induction of Striatal Regeneration in Huntington's Disease
    Steven Goldman; Fiscal Year: 2009
    ....