B L Golden
Affiliation: University of Colorado
- A preorganized active site in the crystal structure of the Tetrahymena ribozymeB L Golden
Howard Hughes Medical Institute, Department of Chemistry and Biochemistry, University of Colorado, Boulder, CO 80309 0215, USA
Science 282:259-64. 1998..The binding pockets for both the 5' splice site helix and guanosine are formed and oriented in the absence of these substrates. Thus, this large ribozyme is largely preorganized for catalysis, much like a globular protein enzyme...