B L Golden

Summary

Affiliation: University of Colorado
Country: USA

Publications

  1. ncbi request reprint A preorganized active site in the crystal structure of the Tetrahymena ribozyme
    B L Golden
    Howard Hughes Medical Institute, Department of Chemistry and Biochemistry, University of Colorado, Boulder, CO 80309 0215, USA
    Science 282:259-64. 1998

Collaborators

Detail Information

Publications1

  1. ncbi request reprint A preorganized active site in the crystal structure of the Tetrahymena ribozyme
    B L Golden
    Howard Hughes Medical Institute, Department of Chemistry and Biochemistry, University of Colorado, Boulder, CO 80309 0215, USA
    Science 282:259-64. 1998
    ..The binding pockets for both the 5' splice site helix and guanosine are formed and oriented in the absence of these substrates. Thus, this large ribozyme is largely preorganized for catalysis, much like a globular protein enzyme...