Todd Golde

Summary

Affiliation: University of Florida
Country: USA

Publications

  1. pmc Anti-aβ therapeutics in Alzheimer's disease: the need for a paradigm shift
    Todd E Golde
    Center for Translational Research in Neurodegenerative Disease and Department of Neuroscience, College of Medicine, University of Florida, 1275 Center Drive BMS J 483, P O Box 100159, Gainesville, FL 32610 0244, USA
    Neuron 69:203-13. 2011
  2. pmc Thinking laterally about neurodegenerative proteinopathies
    Todd E Golde
    Center for Translational Research in Neurodegenerative Disease, Department of Neuroscience, McKnight Brain Institute, College of Medicine, University of Florida, Gainesville, Florida 32610, USA
    J Clin Invest 123:1847-55. 2013
  3. pmc Notch signals in the endothelium and cancer "stem-like" cells: opportunities for cancer therapy
    Jian Wei Gu
    University of Mississippi Cancer Institute, Jackson, MS, USA
    Vasc Cell 4:7. 2012
  4. pmc Hippocampal expression of murine TNFα results in attenuation of amyloid deposition in vivo
    Paramita Chakrabarty
    Center for Translational Research in Neurodegenerative Disease, College of Medicine, University of Florida, 1275 Center Drive, Gainesville, PO Box 100159, FL 32610, USA
    Mol Neurodegener 6:16. 2011
  5. pmc Normal cognition in transgenic BRI2-Aβ mice
    Jungsu Kim
    Department of Neuroscience and Center for Translational Research in Neurodegenerative Disease, University of Florida, 1275 Center Drive, Gainesville, FL 32610, USA
    Mol Neurodegener 8:15. 2013
  6. pmc Expression of Fused in sarcoma mutations in mice recapitulates the neuropathology of FUS proteinopathies and provides insight into disease pathogenesis
    Christophe Verbeeck
    Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA
    Mol Neurodegener 7:53. 2012
  7. pmc A multigram chemical synthesis of the gamma-secretase inhibitor LY411575 and its diastereoisomers
    Abdul H Fauq
    Department of Neuroscience, Mayo Clinic Jacksonville, 4500 San Pablo Road, Jacksonville, FL 32224, USA
    Bioorg Med Chem Lett 17:6392-5. 2007
  8. ncbi request reprint Abeta40 inhibits amyloid deposition in vivo
    Jungsu Kim
    Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville, Florida 32224, USA
    J Neurosci 27:627-33. 2007
  9. pmc Age-related increase in amyloid plaque burden is associated with impairment in conditioned fear memory in CRND8 mouse model of amyloidosis
    Amanda Hanna
    Center for Translational Research in Neurodegenerative Disease and Department of Neuroscience, University of Florida, 1275 Center Dr, Gainesville, FL, 32610, USA
    Alzheimers Res Ther 4:21. 2012
  10. pmc Dysfunction of TGF-beta signaling in Alzheimer's disease
    Pritam Das
    Department of Neuroscience, College of Medicine, Mayo Clinic, Jacksonville, Florida 32224, USA
    J Clin Invest 116:2855-7. 2006

Collaborators

  • Pritam Das
  • Christopher Janus
  • David R Borchelt
  • Benoit I Giasson
  • Abdul H Fauq
  • Rosa Rademakers
  • Jungsu Kim
  • Amanda Hanna
  • Paramita Chakrabarty
  • Dennis W Dickson
  • Christophe Verbeeck
  • Jian Wei Gu
  • Carolina Ceballos-Diaz
  • Amelia March
  • Barbara Osborne
  • Paola Rizzo
  • Jannet Kocerha
  • Antonio Pannuti
  • Qiudong Deng
  • Dennis Dickson
  • Mariely DeJesus-Hernandez
  • Georgia Taylor
  • Kayleigh Iremonger
  • Thomas Kukar
  • Lucio Miele
  • Amanda Herring
  • Luisa Onstead
  • Craig Zwizinski
  • Eileen McGowan
  • Robert Price
  • Lisa Smithson
  • Suzanne Randle

Detail Information

Publications10

  1. pmc Anti-aβ therapeutics in Alzheimer's disease: the need for a paradigm shift
    Todd E Golde
    Center for Translational Research in Neurodegenerative Disease and Department of Neuroscience, College of Medicine, University of Florida, 1275 Center Drive BMS J 483, P O Box 100159, Gainesville, FL 32610 0244, USA
    Neuron 69:203-13. 2011
    ..In this perspective, we discuss why it is imperative to resolve this dilemma and suggest ways for moving forward in the hopes of enhancing the development of truly effective AD therapeutics...
  2. pmc Thinking laterally about neurodegenerative proteinopathies
    Todd E Golde
    Center for Translational Research in Neurodegenerative Disease, Department of Neuroscience, McKnight Brain Institute, College of Medicine, University of Florida, Gainesville, Florida 32610, USA
    J Clin Invest 123:1847-55. 2013
    ....
  3. pmc Notch signals in the endothelium and cancer "stem-like" cells: opportunities for cancer therapy
    Jian Wei Gu
    University of Mississippi Cancer Institute, Jackson, MS, USA
    Vasc Cell 4:7. 2012
    ..Understanding how Notch interacts with other factors that control endothelial cell functions and angiogenesis in cancers could pave the way to innovative therapeutic strategies that simultaneously target angiogenesis and CSC...
  4. pmc Hippocampal expression of murine TNFα results in attenuation of amyloid deposition in vivo
    Paramita Chakrabarty
    Center for Translational Research in Neurodegenerative Disease, College of Medicine, University of Florida, 1275 Center Drive, Gainesville, PO Box 100159, FL 32610, USA
    Mol Neurodegener 6:16. 2011
    ..Whether such an enhanced microglial response actually clears preexisting deposits without causing bystander neurotoxicity remains an open question...
  5. pmc Normal cognition in transgenic BRI2-Aβ mice
    Jungsu Kim
    Department of Neuroscience and Center for Translational Research in Neurodegenerative Disease, University of Florida, 1275 Center Drive, Gainesville, FL 32610, USA
    Mol Neurodegener 8:15. 2013
    ..BRI2-Aβ mice produce high levels of Aβ peptides and BRI2-Aβ1-42 mice develop amyloid pathology that is similar to the pathology observed in mutant human APP transgenic models...
  6. pmc Expression of Fused in sarcoma mutations in mice recapitulates the neuropathology of FUS proteinopathies and provides insight into disease pathogenesis
    Christophe Verbeeck
    Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA
    Mol Neurodegener 7:53. 2012
    ..In this paper we report the development of somatic brain transgenic (SBT) mice using recombinant adeno-associated virus (rAAV) to investigate how FUS mutations lead to neurodegeneration...
  7. pmc A multigram chemical synthesis of the gamma-secretase inhibitor LY411575 and its diastereoisomers
    Abdul H Fauq
    Department of Neuroscience, Mayo Clinic Jacksonville, 4500 San Pablo Road, Jacksonville, FL 32224, USA
    Bioorg Med Chem Lett 17:6392-5. 2007
    ..Starting from the resolved aminolactams 5a and 5b, all four diastereomers were produced in enantiomerically pure form...
  8. ncbi request reprint Abeta40 inhibits amyloid deposition in vivo
    Jungsu Kim
    Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville, Florida 32224, USA
    J Neurosci 27:627-33. 2007
    ....
  9. pmc Age-related increase in amyloid plaque burden is associated with impairment in conditioned fear memory in CRND8 mouse model of amyloidosis
    Amanda Hanna
    Center for Translational Research in Neurodegenerative Disease and Department of Neuroscience, University of Florida, 1275 Center Dr, Gainesville, FL, 32610, USA
    Alzheimers Res Ther 4:21. 2012
    ....
  10. pmc Dysfunction of TGF-beta signaling in Alzheimer's disease
    Pritam Das
    Department of Neuroscience, College of Medicine, Mayo Clinic, Jacksonville, Florida 32224, USA
    J Clin Invest 116:2855-7. 2006
    ..Collectively, these data suggest that dysfunction of the TGF-beta/TbetaRII signaling axis in the AD brain may accelerate Abeta deposition and neurodegeneration...

Research Grants21

  1. Immune-Mediated Mechanisms Underlying CNS Abeta Clearance
    Todd Golde; Fiscal Year: 2005
    ..The proposed studies aim to further explore the potential mechanism by which immunization works and the possible limitations of the immunization approach. ..
  2. Gamma Secretases in Alzheimers Disease
    Todd Golde; Fiscal Year: 2007
    ..of other aspartyl proteases? 3) What are the structural similarities between the active sites of PSH and PS? Do PSHs possess an initial substrate docking site as PS apparently does? And 4) Does SPP/PSH3 indeed act alone (and as a dimer)? ..
  3. In situ therapeutic anti-AB delivery/adenoviral vectors
    Todd Golde; Fiscal Year: 2004
    ..abstract_text> ..
  4. IMMUNE-MEDIATED MECHANISMS UNDERLAYING CNS AB CLEARANCE
    Todd Golde; Fiscal Year: 2002
    ....
  5. Y-SECRETASES IN ALZHEIMER'S DISEASE
    Todd Golde; Fiscal Year: 2002
    ..3. Purify gamma-secretase using affinity based approaches to identify candidate candidate gamma-secretases that will then be screened for gamma-activity by sense and antisense expression studies. ..
  6. Immune-Mediated Mechanisms Underlying CNS Abeta Clearance
    Todd E Golde; Fiscal Year: 2010
    ..These studies may provide the scientific rationale for the development of novel forms of immunotherapy for AD. ..