Affiliation: University of Massachusetts Medical School
Country: USA


  1. Tran H, Ash A, Gore J, Darling C, Kiefe C, Goldberg R. Twenty-five year trends (1986-2011) in hospital incidence and case-fatality rates of ventricular tachycardia and ventricular fibrillation complicating acute myocardial infarction. Am Heart J. 2019;208:1-10 pubmed publisher
    ..Despite these encouraging trends, efforts remain needed to identify patients at risk for these serious ventricular arrhythmias so that preventive and treatment strategies might be implemented as necessary. ..
  2. Goldberg R, Tisminetzky M, Tran H, Yarzebski J, Lessard D, Gore J. Decade Long Trends (2001-2011) in the Incidence Rates of Initial Acute Myocardial Infarction. Am J Cardiol. 2019;123:206-211 pubmed publisher
    ..In conclusion, the incidence rates of initial AMI declined appreciably in residents of central Massachusetts who were hospitalized with AMI during the years under study. ..
  3. Tran H, Gore J, Darling C, Ash A, Kiefe C, Goldberg R. Hyperglycemia and risk of ventricular tachycardia among patients hospitalized with acute myocardial infarction. Cardiovasc Diabetol. 2018;17:136 pubmed publisher
    ..Efforts should be made to closely monitor and treat patients who develop hyperglycemia, especially early after hospital admission, to reduce their risk of VT. ..
  4. Tran H, Byatt N, Erskine N, Lessard D, Devereaux R, Saczynski J, et al. Impact of anxiety on the post-discharge outcomes of patients discharged from the hospital after an acute coronary syndrome. Int J Cardiol. 2019;278:28-33 pubmed publisher
    ..We identified patients with an anxiety disorder as being at greater risk for dying after hospital discharge for an ACS. Interventions may be more appropriately targeted to those with a history of, rather than acute symptoms of, anxiety. ..
  5. Tisminetzky M, Nguyen H, Gurwitz J, McManus D, Gore J, Singh S, et al. Magnitude and impact of multiple chronic conditions with advancing age in older adults hospitalized with acute myocardial infarction. Int J Cardiol. 2018;272:341-345 pubmed publisher
    ..The prevalence of multimorbidity among older adults hospitalized with AMI is high and associated with worse outcomes that should be considered in the management of this vulnerable population. ..
  6. Goldberg R, Nguyen H. Unlocking the Keys to Site Activation and Recruitment Success in a Randomized Controlled Trial. Stroke. 2017;48:2339-2340 pubmed publisher
  7. Erskine N, Gandek B, Tran H, Abu H, McManus D, Kiefe C, et al. Barriers to Healthcare Access and to Improvements in Health-Related Quality of Life After an Acute Coronary Syndrome (From TRACE-CORE). Am J Cardiol. 2018;122:1121-1127 pubmed publisher
    ..46, 95% CI 0.96, 2.22). Financial and other barriers to healthcare access may be associated with clinically meaningful declines in HRQOL after hospital discharge for an ACS. ..
  8. Hariri E, Tisminetzky M, Lessard D, Yarzebski J, Gore J, Goldberg R. Twenty-Five-Year (1986-2011) Trends in the Incidence and Death Rates of Stroke Complicating Acute Myocardial Infarction. Am J Med. 2018;131:1086-1094 pubmed publisher
    ..Although the incidence rates of acute stroke complicating acute myocardial infarction remained relatively stable during the years under study, the in-hospital mortality rates of those experiencing a stroke have not decreased. ..
  9. Fisher K, Stefan M, Darling C, Lessard D, Goldberg R. Impact of COPD on the mortality and treatment of patients hospitalized with acute decompensated heart failure: the Worcester Heart Failure Study. Chest. 2015;147:637-645 pubmed publisher
    ..Further research is required to understand the complex interactions of these diseases and ensure that patients with ADHF and COPD receive optimal treatment modalities. ..

More Information


  1. Tran H, Erskine N, Nguyen H, McManus D, Awad H, Kiefe C, et al. Increase in white blood cell count is associated with the development of atrial fibrillation after an acute coronary syndrome. Int J Cardiol. 2019;274:138-143 pubmed publisher
    ..Increase in the WBCC during hospitalization for an ACS should be further studied as a potentially simple predictor for new-onset AF in these patients. ..
  2. Goldberg R, Gurwitz J, Saczynski J, Hsu G, McManus D, Magid D, et al. Comparison of medication practices in patients with heart failure and preserved versus those with reduced ejection fraction (from the Cardiovascular Research Network [CVRN]). Am J Cardiol. 2013;111:1324-9 pubmed publisher
    ..In conclusion, the present results from a large, population-based sample suggest considerable variation in the previous and new use of different cardiac medication classes of drugs in patients with HF-PEF versus HF-REF. ..
  3. Goldberg R, Saczynski J, McManus D, Waring M, McManus R, Allison J, et al. Characteristics of contemporary patients discharged from the hospital after an acute coronary syndrome. Am J Med. 2015;128:1087-93 pubmed publisher
    ..Implications of the high psychosocial burden on various patient-related outcomes require investigation. ..
  4. Goldberg R, Darling C, Joseph B, Saczynski J, Chinali M, Lessard D, et al. Epidemiology of decompensated heart failure in a single community in the northeastern United States. Am J Cardiol. 2009;104:377-82 pubmed publisher
  5. Erskine N, Waring M, McManus D, Lessard D, Kiefe C, Goldberg R. Barriers to Healthcare Access and Long-Term Survival After an Acute Coronary Syndrome. J Gen Intern Med. 2018;33:1543-1550 pubmed publisher
    ..Patients with these barriers to follow-up care may benefit from more intensive follow-up and support. ..
  6. Helfand B, Maselli N, Lessard D, Yarzebski J, Gore J, McManus D, et al. Elevated serum glucose levels and survival after acute heart failure: a population-based perspective. Diab Vasc Dis Res. 2015;12:119-25 pubmed publisher
    ..Patients with elevated blood glucose levels at hospital admission are more likely to die acutely. After resolution of the acute illness, patients with previously diagnosed DM need careful monitoring and enhanced treatment. ..
  7. Waring M, McManus D, Lemon S, Gore J, Anatchkova M, McManus R, et al. Perceiving one's heart condition to be cured following hospitalization for acute coronary syndromes: Implications for patient-provider communication. Patient Educ Couns. 2016;99:455-461 pubmed publisher
    ..8, 95%CI: 1.9-12.0 vs medical management). One week post-discharge, 3 in 10 patients perceived their heart condition to be cured. Conversations with patients should frame ACS as a chronic disease and dispel cure perceptions. ..
  8. Goldberg R, Makam R, Yarzebski J, McManus D, Lessard D, Gore J. Decade-Long Trends (2001-2011) in the Incidence and Hospital Death Rates Associated with the In-Hospital Development of Cardiogenic Shock after Acute Myocardial Infarction. Circ Cardiovasc Qual Outcomes. 2016;9:117-25 pubmed publisher
    ..These encouraging trends in hospital survival are likely because of advances in the early recognition and aggressive management of patients who develop cardiogenic shock. ..
  9. Tisminetzky M, Coukos J, McManus D, Darling C, Joffe S, Gore J, et al. Decade-long trends in the magnitude, treatment, and outcomes of patients aged 30 to 54 years hospitalized with ST-segment elevation and non-ST-segment elevation myocardial infarction. Am J Cardiol. 2014;113:1606-10 pubmed publisher
    ..Patients with STEMI and NSTEMI had similar in-hospital outcomes and long-term survival. Trends in these and other important outcomes warrant continued monitoring. ..
  10. Tisminetzky M, McManus D, Erskine N, Saczynski J, Yarzebski J, Granillo E, et al. Thirty-day Hospital Readmissions in Patients with Non-ST-segment Elevation Acute Myocardial Infarction. Am J Med. 2015;128:760-5 pubmed publisher
    ..We identified several groups at higher risk for hospital readmission; further surveillance efforts and/or tailored educational and treatment approaches remain needed for these groups. ..
  11. Chen H, Gore J, Lapane K, Yarzebski J, Person S, Gurwitz J, et al. A 35-Year Perspective (1975 to 2009) into the Long-Term Prognosis and Hospital Management of Patients Discharged from the Hospital After a First Acute Myocardial Infarction. Am J Cardiol. 2015;116:24-9 pubmed publisher
    ..In conclusion, the increased use of invasive cardiac interventions and pharmacotherapies was associated with enhanced long-term survival in patients hospitalized for a first AMI. ..
  12. Zacharias M, Joffe S, Konadu E, Meyer T, Kiernan M, Lessard D, et al. Clinical epidemiology of heart failure with preserved ejection fraction (HFpEF) in comparatively young hospitalized patients. Int J Cardiol. 2016;202:918-21 pubmed publisher
    ..While HFpEF is predominantly a disease of old age, data from longitudinal studies remain needed to identify risk factors in younger individuals that may predispose them to the development of HFpEF. ..
  13. Awad H, Tisminetzky M, Metry D, McManus D, Yarzebski J, Gore J, et al. Magnitude, treatment, and impact of diabetes mellitus in patients hospitalized with non-ST segment elevation myocardial infarction: A community-based study. Diab Vasc Dis Res. 2016;13:13-20 pubmed publisher
    ..Diabetic patients presenting with non-ST segment elevation myocardial infarction remain at high risk of developing significant clinical complications during hospitalization. ..
  14. Tisminetzky M, Gurwitz J, McManus D, Saczynski J, Erskine N, Waring M, et al. Multiple Chronic Conditions and Psychosocial Limitations in Patients Hospitalized with an Acute Coronary Syndrome. Am J Med. 2016;129:608-14 pubmed publisher
    ..This emphasizes the challenge of caring for these patients, which extends well beyond acute coronary syndrome management. ..
  15. Tran H, Lessard D, Tisminetzky M, Yarzebski J, Granillo E, Gore J, et al. Trends in Length of Hospital Stay and the Impact on Prognosis of Early Discharge After a First Uncomplicated Acute Myocardial Infarction. Am J Cardiol. 2018;121:397-402 pubmed publisher
  16. Chen H, Tisminetzky M, Yarzebski J, Gore J, Goldberg R. Decade-Long Trends in the Frequency of 90-Day Rehospitalizations After Hospital Discharge for Acute Myocardial Infarction. Am J Cardiol. 2016;117:743-8 pubmed publisher
    ..In conclusion, the likelihood of subsequent 90-day rehospitalizations remained frequent, and we did not observe a significant decrease in these rates during the years under study. ..
  17. Tisminetzky M, Gurwitz J, Chen H, Erskine N, Yarzebski J, Gore J, et al. Identification and Characteristics of Low-Risk Survivors of an Acute Myocardial Infarction. Am J Cardiol. 2016;117:1552-1557 pubmed publisher
  18. Allison J, Nguyen H, Ha D, Chiriboga G, Ly H, Tran H, et al. Culturally adaptive storytelling method to improve hypertension control in Vietnam - "We talk about our hypertension": study protocol for a feasibility cluster-randomized controlled trial. Trials. 2016;17:26 pubmed publisher (registration date June 22, 2015). ..
  19. Makam R, Erskine N, Yarzebski J, Lessard D, Lau J, Allison J, et al. Decade Long Trends (2001-2011) in Duration of Pre-Hospital Delay Among Elderly Patients Hospitalized for an Acute Myocardial Infarction. J Am Heart Assoc. 2016;5:e002664 pubmed publisher
    ..The lack of improvement in the timeliness of patients' care-seeking behavior during the years under study remains of considerable clinical and public health concern. ..
  20. Tran H, Waring M, McManus D, Erskine N, Do V, Kiefe C, et al. Underuse of Effective Cardiac Medications Among Women, Middle-Aged Adults, and Racial/Ethnic Minorities With Coronary Artery Disease (from the National Health and Nutrition Examination Survey 2005 to 2014). Am J Cardiol. 2017;120:1223-1229 pubmed publisher
    ..Continued targeted efforts are needed to increase the receipt of effective cardiac medications among all US adults with CAD, especially those aged 45 to 64 years, women, and racial/ethnic minorities. ..
  21. Goldberg R, Spencer F, Gore J, Lessard D, Yarzebski J. Thirty-year trends (1975 to 2005) in the magnitude of, management of, and hospital death rates associated with cardiogenic shock in patients with acute myocardial infarction: a population-based perspective. Circulation. 2009;119:1211-9 pubmed publisher
    ..Given the high death rates associated with this clinical complication, monitoring future trends in the incidence and death rates and the factors associated with an increased risk for developing cardiogenic shock remains warranted. ..
  22. Tisminetzky M, Wang T, Gurwitz J, Kaltenbach L, McManus D, Gore J, et al. Magnitude and Characteristics of Patients Who Survived an Acute Myocardial Infarction. J Am Heart Assoc. 2017;6: pubmed publisher
    ..URL: Unique identifier: NCT01088503. ..
  23. Nguyen H, Yarzebski J, Lessard D, Gore J, McManus D, Goldberg R. Ten-Year (2001-2011) Trends in the Incidence Rates and Short-Term Outcomes of Early Versus Late Onset Cardiogenic Shock After Hospitalization for Acute Myocardial Infarction. J Am Heart Assoc. 2017;6: pubmed publisher
    ..Interventions focused on preventing or treating prehospital and late CS are needed to improve in-hospital survival after acute myocardial infarction. ..