Ilan Goldberg

Summary

Affiliation: University of Rochester
Country: USA

Publications

  1. ncbi request reprint Prognostic significance of fragmented QRS complex for predicting the risk of recurrent cardiac events in patients with Q-wave myocardial infarction
    Grzegorz Pietrasik
    Heart Research Follow Up Program, Cardiology Division, Department of Medicine, University of Rochester Medical Center, Rochester, New York, USA
    Am J Cardiol 100:583-6. 2007
  2. doi request reprint Trigger-specific ion-channel mechanisms, risk factors, and response to therapy in type 1 long QT syndrome
    Ilan Goldenberg
    Cardiology Division, University of Rochester Medical Center, Rochester, New York 14642, USA
    Heart Rhythm 9:49-56. 2012
  3. pmc Does the lipid-lowering peroxisome proliferator-activated receptors ligand bezafibrate prevent colon cancer in patients with coronary artery disease?
    Alexander Tenenbaum
    Cardiac Rehabilitation Institute, Chaim Sheba Medical Center, Tel Hashomer, affiliated with Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    Cardiovasc Diabetol 7:18. 2008
  4. pmc Long-term effects of peroxisome proliferator-activated receptor ligand bezafibrate on N-terminal pro-B type natriuretic peptide in patients with advanced functional capacity impairment
    Koichi Node
    Department of Cardiovascular and Renal Medicine, Saga University Faculty of Medicine, Saga, Japan
    Cardiovasc Diabetol 8:5. 2009
  5. doi request reprint Long QT syndrome
    Ilan Goldenberg
    Cardiology Division, Department of Medicine, University of Rochester Medical Center, Rochester, New York 14642 8653, USA
    J Am Coll Cardiol 51:2291-300. 2008
  6. doi request reprint Implantable device therapy
    Ilan Goldenberg
    Cardiology Division of the Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA
    Prog Cardiovasc Dis 50:449-74. 2008
  7. doi request reprint Risk factors for aborted cardiac arrest and sudden cardiac death in children with the congenital long-QT syndrome
    Ilan Goldenberg
    Cardiology Division of the Department of Medicine, University of Rochester Medical Center, Rochester, NY 14642, USA
    Circulation 117:2184-91. 2008
  8. doi request reprint Long-QT syndrome after age 40
    Ilan Goldenberg
    Cardiology Division of the Department of Medicine, University of Rochester Medical Center, Rochester, NY 14642, USA
    Circulation 117:2192-201. 2008
  9. doi request reprint Risk stratification for primary implantation of a cardioverter-defibrillator in patients with ischemic left ventricular dysfunction
    Ilan Goldenberg
    Department of Medicine, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Am Coll Cardiol 51:288-96. 2008
  10. ncbi request reprint Polymorphism in the cholesteryl ester transfer protein gene and the risk of early onset myocardial infarction among cigarette smokers
    Ilan Goldenberg
    Cardiology Units of the Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA
    Ann Noninvasive Electrocardiol 12:364-74. 2007

Collaborators

Detail Information

Publications88

  1. ncbi request reprint Prognostic significance of fragmented QRS complex for predicting the risk of recurrent cardiac events in patients with Q-wave myocardial infarction
    Grzegorz Pietrasik
    Heart Research Follow Up Program, Cardiology Division, Department of Medicine, University of Rochester Medical Center, Rochester, New York, USA
    Am J Cardiol 100:583-6. 2007
    ..However, among patients with resolved Q waves, fragmented QRS was associated with increased risk of cardiac events. Fragmented QRS complex should not be neglected in patients with transient Q waves after myocardial infarction...
  2. doi request reprint Trigger-specific ion-channel mechanisms, risk factors, and response to therapy in type 1 long QT syndrome
    Ilan Goldenberg
    Cardiology Division, University of Rochester Medical Center, Rochester, New York 14642, USA
    Heart Rhythm 9:49-56. 2012
    ..Arrhythmic events in long-QT syndrome type 1 (LQT1) may be associated with exercise, acute arousal, or rest/sleep...
  3. pmc Does the lipid-lowering peroxisome proliferator-activated receptors ligand bezafibrate prevent colon cancer in patients with coronary artery disease?
    Alexander Tenenbaum
    Cardiac Rehabilitation Institute, Chaim Sheba Medical Center, Tel Hashomer, affiliated with Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
    Cardiovasc Diabetol 7:18. 2008
    ..Therefore, we proposed to investigate a possible preventive effect of bezafibrate on the development of colon cancer in patients with coronary artery disease during a 6-year follow-up...
  4. pmc Long-term effects of peroxisome proliferator-activated receptor ligand bezafibrate on N-terminal pro-B type natriuretic peptide in patients with advanced functional capacity impairment
    Koichi Node
    Department of Cardiovascular and Renal Medicine, Saga University Faculty of Medicine, Saga, Japan
    Cardiovasc Diabetol 8:5. 2009
    ..The current study aimed to investigate the long-term effects of bezafibrate on ProBNP level in patients with pre-existing CAD and advanced functional capacity impairment...
  5. doi request reprint Long QT syndrome
    Ilan Goldenberg
    Cardiology Division, Department of Medicine, University of Rochester Medical Center, Rochester, New York 14642 8653, USA
    J Am Coll Cardiol 51:2291-300. 2008
    ..These new data may be used to improve risk stratification and for the development of gene-specific therapies that may reduce the risk of life-threatening cardiac events in patients with this inherited cardiac disorder...
  6. doi request reprint Implantable device therapy
    Ilan Goldenberg
    Cardiology Division of the Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA
    Prog Cardiovasc Dis 50:449-74. 2008
    ..In the present review we focus on current data regarding the clinical indications as well as the safety and efficacy of implantable device therapy, including ICD, CRT, and CRT-D...
  7. doi request reprint Risk factors for aborted cardiac arrest and sudden cardiac death in children with the congenital long-QT syndrome
    Ilan Goldenberg
    Cardiology Division of the Department of Medicine, University of Rochester Medical Center, Rochester, NY 14642, USA
    Circulation 117:2184-91. 2008
    ..However, specific risk factors for life-threatening cardiac events in children with this genetic disorder have not been identified...
  8. doi request reprint Long-QT syndrome after age 40
    Ilan Goldenberg
    Cardiology Division of the Department of Medicine, University of Rochester Medical Center, Rochester, NY 14642, USA
    Circulation 117:2192-201. 2008
    ....
  9. doi request reprint Risk stratification for primary implantation of a cardioverter-defibrillator in patients with ischemic left ventricular dysfunction
    Ilan Goldenberg
    Department of Medicine, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Am Coll Cardiol 51:288-96. 2008
    ..The study was designed to develop a simple risk stratification score for primary therapy with an implantable cardioverter-defibrillator (ICD)...
  10. ncbi request reprint Polymorphism in the cholesteryl ester transfer protein gene and the risk of early onset myocardial infarction among cigarette smokers
    Ilan Goldenberg
    Cardiology Units of the Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA
    Ann Noninvasive Electrocardiol 12:364-74. 2007
    ..We hypothesized that susceptibility to early onset myocardial infarction (MI) among cigarette smokers may be related to the presence of TaqIB polymorphism in the CETP gene...
  11. ncbi request reprint Inverse relationship of blood pressure levels to sudden cardiac mortality and benefit of the implantable cardioverter-defibrillator in patients with ischemic left ventricular dysfunction
    Ilan Goldenberg
    Cardiology Unit of the Department of Medicine, University of Rochester Medical Center, Rochester, New York, USA
    J Am Coll Cardiol 49:1427-33. 2007
    ....
  12. ncbi request reprint Treatment of arrhythmias and use of implantable cardioverter-defibrillators to improve survival in elderly patients with cardiac disease
    Ilan Goldenberg
    Heart Research Follow Up Program, Cardiology Unit, Department of Medicine, Box 653, University of Rochester Medical Center, Rochester, NY 14642, USA
    Clin Geriatr Med 23:205-19. 2007
    ....
  13. pmc Update on the use of fibrates: focus on bezafibrate
    Ilan Goldenberg
    Heart Institute, Shiba Medical Center Tel Hashomer, Israel
    Vasc Health Risk Manag 4:131-41. 2008
    ..In addition, recent data from subgroup analyses of the Bezafibrate Infarction Prevention trial, demonstrating several important metabolic and long-term cardiovascular effects of bezafibrate therapy, are detailed...
  14. doi request reprint Predictors of response to cardiac resynchronization therapy in the Multicenter Automatic Defibrillator Implantation Trial with Cardiac Resynchronization Therapy (MADIT-CRT)
    Ilan Goldenberg
    Heart Research Follow Up Program, Box 653, Cardiology Division, University of Rochester Medical Center, Rochester, NY 14642, USA
    Circulation 124:1527-36. 2011
    ..We hypothesized that combined assessment of factors that are associated with favorable reverse remodeling after cardiac resynchronization-defibrillator therapy (CRT-D) can be used to predict clinical response to the device...
  15. doi request reprint Reduction of the risk of recurring heart failure events with cardiac resynchronization therapy: MADIT-CRT (Multicenter Automatic Defibrillator Implantation Trial With Cardiac Resynchronization Therapy)
    Ilan Goldenberg
    Cardiology Division of the Department of Medicine, University of Rochester Medical Center, Rochester, New York, USA
    J Am Coll Cardiol 58:729-37. 2011
    ..The evaluation of the risk of recurring heart failure events (HFEs) was a pre-specified substudy of MADIT-CRT (Multicenter Automatic Defibrillator Implantation Trial with Cardiac Resynchronization Therapy)...
  16. pmc Risk for life-threatening cardiac events in patients with genotype-confirmed long-QT syndrome and normal-range corrected QT intervals
    Ilan Goldenberg
    Cardiology Division of Department of Medicine, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Am Coll Cardiol 57:51-9. 2011
    ..This study was designed to assess the clinical course and to identify risk factors for life-threatening events in patients with long-QT syndrome (LQTS) with normal corrected QT (QTc) intervals...
  17. ncbi request reprint Hereditary arrhythmia corner: learning from challenging patients. Family with suspect LQTS
    Ilan Goldenberg
    Cardiology Unit of the Department of Medicine, University of Rochester Medical Center, Rochester, NY 14642, USA
    Ann Noninvasive Electrocardiol 15:384-6. 2010
    ..The family history is significant for sudden deaths in several distant relatives. In addition, the mother's aunt had an abnormal ECG in the setting of multiple syncopal episodes. In the interim, she had been treated with beta-blockers...
  18. doi request reprint Long-term benefit of primary prevention with an implantable cardioverter-defibrillator: an extended 8-year follow-up study of the Multicenter Automatic Defibrillator Implantation Trial II
    Ilan Goldenberg
    Heart Research Follow Up Program, Box 653, University of Rochester Medical Center, Rochester, NY 14642, USA
    Circulation 122:1265-71. 2010
    ..5 years. However, currently there are no data on the long-term efficacy of primary defibrillator therapy...
  19. doi request reprint Relation between renal function and response to cardiac resynchronization therapy in Multicenter Automatic Defibrillator Implantation Trial--Cardiac Resynchronization Therapy (MADIT-CRT)
    Ilan Goldenberg
    Cardiology Unit, Department of Medicine, University of Rochester Medical Center, Rochester, New York, USA
    Heart Rhythm 7:1777-82. 2010
    ..Cardiorenal interactions have been shown to affect outcome in heart failure patients but were not related to response to cardiac resynchronization therapy (CRT)...
  20. doi request reprint Relation between renal function and outcomes in patients with non-ST-segment elevation acute coronary syndrome: real-world data from the European Public Health Outcome Research and Indicators Collection Project
    Ilan Goldenberg
    Neufeld Cardiac Research Institute, Sheba Medical Center, Tel Hashomer, 52621, Israel
    Arch Intern Med 170:888-95. 2010
    ..Clinical trials provide limited information about the outcome of patients with acute coronary syndromes (ACSs) and kidney disease (KD) owing to underrepresentation of this population in most studies...
  21. doi request reprint Beta-blocker efficacy in high-risk patients with the congenital long-QT syndrome types 1 and 2: implications for patient management
    Ilan Goldenberg
    Cardiology Division, Department of Medicine, University of Rochester Medical Center, Rochester, NY 14642, USA
    J Cardiovasc Electrophysiol 21:893-901. 2010
    ..However, limited data exist regarding the efficacy and limitations of this form of medical management within high-risk subsets of these populations...
  22. doi request reprint Relation of clinical benefit of raising high-density lipoprotein cholesterol to serum levels of low-density lipoprotein cholesterol in patients with coronary heart disease (from the Bezafibrate Infarction Prevention Trial)
    Ilan Goldenberg
    Heart Institute, Sheba Medical Center, Tel Hashomer, Israel
    Am J Cardiol 103:41-5. 2009
    ....
  23. doi request reprint Cumulative burden of atherosclerotic risk genotypes and the age at onset of a first myocardial infarction: a case-only carriership approach
    Ilan Goldenberg
    Cardiology Unit of the Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    Ann Noninvasive Electrocardiol 13:287-94. 2008
    ..We hypothesized that several genetic atherosclerotic single nucleotide polymorphisms (SNPs) may exert an additive effect on the earlier occurrence of coronary atherothrombotic disease after adjustment for clinical factors...
  24. ncbi request reprint Corrected QT variability in serial electrocardiograms in long QT syndrome: the importance of the maximum corrected QT for risk stratification
    Ilan Goldenberg
    Cardiology Division, Department of Medicine, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Am Coll Cardiol 48:1047-52. 2006
    ..We evaluated the incremental prognostic information provided by multiple corrected QT (QTc) measurements on serial electrocardiograms (ECGs) in patients with the inherited long QT syndrome (LQTS)...
  25. ncbi request reprint Relations among renal function, risk of sudden cardiac death, and benefit of the implanted cardiac defibrillator in patients with ischemic left ventricular dysfunction
    Ilan Goldenberg
    Cardiology Unit, Department of Medicine, University of Rochester Medical Center, Rochester, New York, USA
    Am J Cardiol 98:485-90. 2006
    ..Defibrillator therapy was associated with a significant survival benefit among the study patients with mild to moderate or no renal disease, but no benefit was shown among patients with more advanced renal dysfunction...
  26. ncbi request reprint Cigarette smoking and the risk of supraventricular and ventricular tachyarrhythmias in high-risk cardiac patients with implantable cardioverter defibrillators
    Ilan Goldenberg
    Cardiology Unit of the Department of Medicine, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Cardiovasc Electrophysiol 17:931-6. 2006
    ..Nicotine elevates serum catecholamine concentration and is therefore potentially arrhythmogenic. However, the effect of cigarette smoking on arrhythmic risk in coronary heart disease patients is not well established...
  27. ncbi request reprint Time dependence of defibrillator benefit after coronary revascularization in the Multicenter Automatic Defibrillator Implantation Trial (MADIT)-II
    Ilan Goldenberg
    Cardiology Unit, Department of Medicine, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Am Coll Cardiol 47:1811-7. 2006
    ....
  28. ncbi request reprint QT interval: how to measure it and what is "normal"
    Ilan Goldenberg
    Cardiology Division, Department of Medicine, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Cardiovasc Electrophysiol 17:333-6. 2006
  29. ncbi request reprint Cost-effectiveness of implanted defibrillators in young people with inherited cardiac arrhythmias
    Ilan Goldenberg
    Department of Medicine, University of Rochester Medical Center, Rochester, New York 14642, USA
    Ann Noninvasive Electrocardiol 10:67-83. 2005
    ..However, data on the benefit and cost-effectiveness of device therapy in high-risk patients with inherited cardiac disorders are limited...
  30. ncbi request reprint Sudden cardiac death without structural heart disease: update on the long QT and Brugada syndromes
    Ilan Goldenberg
    Heart Research Follow Up Program, Box 653, University of Rochester Medical Center, Rochester, NY 14642, USA
    Curr Cardiol Rep 7:349-56. 2005
    ..In patients identified as high risk for arrhythmic mortality, the implantable cardioverter defibrillator is the most effective treatment and has been shown to provide near-complete protection during long-term follow-up...
  31. pmc Nephropathy induced by contrast media: pathogenesis, risk factors and preventive strategies
    Ilan Goldenberg
    Heart Institute, Sheba Medical Center, Tel Hashomer, Israel
    CMAJ 172:1461-71. 2005
    ..In this article, we review the current evidence on the causes, pathogenesis and clinical course of contrast-medium nephropathy as well as therapeutic approaches to its prevention evaluated in clinical trials...
  32. ncbi request reprint Clinical course and risk stratification of patients affected with the Jervell and Lange-Nielsen syndrome
    Ilan Goldenberg
    Division of Cardiology, Department of Medicine, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Cardiovasc Electrophysiol 17:1161-8. 2006
    ....
  33. ncbi request reprint Polymorphism in the angiotensinogen gene, hypertension, and ethnic differences in the risk of recurrent coronary events
    Ilan Goldenberg
    Cardiology Unit, Department of Medicine, University of Rochester School of Medicine and Dentistry, NY, USA
    Hypertension 48:693-9. 2006
    ..The presence of hypertension significantly augments the risk associated with this genetic mutation...
  34. ncbi request reprint Causes and consequences of heart failure after prophylactic implantation of a defibrillator in the multicenter automatic defibrillator implantation trial II
    Ilan Goldenberg
    Cardiology Unit, Department of Medicine, Heart Research Follow Up Program, Box 653, University of Rochester Medical Center, Rochester, NY 14642, USA
    Circulation 113:2810-7. 2006
    ..Implantable cardioverter-defibrillator (ICD) therapy may be associated with an increased risk for heart failure (HF). The present study evaluated the frequency, causes, and consequences of HF after ICD implantation...
  35. pmc Phenotypic variability in Caucasian and Japanese patients with matched LQT1 mutations
    Judy F Liu
    Cardiology Division of the Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY14642, USA
    Ann Noninvasive Electrocardiol 13:234-41. 2008
    ..We compared the clinical course of Caucasian and Japanese long QT type-1 (LQT1) patients who were matched for mutations in the KCNQ1 gene...
  36. ncbi request reprint Long QT syndrome in adults
    Andrew J Sauer
    Cardiology Unit of the Department of Medicine, University of Rochester Medical Center, Rochester, New York 14642 8653, USA
    J Am Coll Cardiol 49:329-37. 2007
    ....
  37. doi request reprint Reverse remodeling and the risk of ventricular tachyarrhythmias in the MADIT-CRT (Multicenter Automatic Defibrillator Implantation Trial-Cardiac Resynchronization Therapy)
    Alon Barsheshet
    Cardiology Division, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Am Coll Cardiol 57:2416-23. 2011
    ..We aimed to evaluate the relationship between echocardiographic response to cardiac resynchronization therapy (CRT) and the risk of subsequent ventricular tachyarrhythmias (VTAs)...
  38. pmc Genotype-specific QT correction for heart rate and the risk of life-threatening cardiac events in adolescents with congenital long-QT syndrome
    Alon Barsheshet
    Cardiology Division, University of Rochester Medical Center, Rochester, New York, USA
    Heart Rhythm 8:1207-13. 2011
    ..A prolonged QT interval corrected for heart rate (QTc) is a major risk factor in patients with long QT syndrome (LQTS). However, heart rate-related risk in this genetic disorder differs among genotypes...
  39. doi request reprint Predictors of long-term mortality in Multicenter Automatic Defibrillator Implantation Trial II (MADIT II) patients with implantable cardioverter-defibrillators
    Iwona Cygankiewicz
    Cardiology Division, University of Rochester Medical Center, Rochester, New York 14642, USA
    Heart Rhythm 6:468-73. 2009
    ..Data on long-term follow-up and factors influencing mortality in implantable cardioverter-defibrillator (ICD) recipients are limited...
  40. doi request reprint Efficacy of medical therapy for the reduction of heart failure events in patients with implanted cardioverter defibrillators
    Grzegorz Pietrasik
    Heart Research Follow Up Program, Cardiology Division, University of Rochester Medical Center, Rochester, New York, USA
    J Cardiovasc Electrophysiol 20:395-400. 2009
    ..There are limited data on the effect of the primary types of HF medications, angiotensin converting enzyme inhibitors (ACE-I), and beta-blockers on HF progression in ICD-treated patients...
  41. doi request reprint Long QT syndrome in African-Americans
    Thomas Fugate
    Cardiology Division of the Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642 8653, USA
    Ann Noninvasive Electrocardiol 15:73-6. 2010
    ..We evaluated the risk factors and clinical course of Long QT syndrome (LQTS) in African-American patients...
  42. pmc Clinical aspects of type-1 long-QT syndrome by location, coding type, and biophysical function of mutations involving the KCNQ1 gene
    Arthur J Moss
    Cardiology Division, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA
    Circulation 115:2481-9. 2007
    ..We evaluated the effect of location, coding type, and biophysical function of KCNQ1 mutations on the clinical phenotype of this disorder...
  43. ncbi request reprint Pemphigus vulgaris is associated with the transporter associated with antigen processing (TAP) system
    Elena Slomov
    Tissue Typing Laboratory, Sheba Medical Center, Ramat Gan, and Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
    Hum Immunol 66:1213-22. 2005
    ..8% in the patients and 5.3 % in the controls. This association was found to be independent of HLA-DR. It is therefore likely that TAP2 genes are involved in susceptibility to development of PV...
  44. ncbi request reprint Long QT syndrome and pregnancy
    Rahul Seth
    Cardiology Division of the Department of Medicine, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Am Coll Cardiol 49:1092-8. 2007
    ..This study was designed to investigate the clinical course of women with long QT syndrome (LQTS) throughout their potential childbearing years...
  45. doi request reprint Relation of bundle branch block to long-term (four-year) mortality in hospitalized patients with systolic heart failure
    Alon Barsheshet
    Cardiology Division, University of Rochester Medical Center, New York, USA
    Am J Cardiol 107:540-4. 2011
    ..Deleterious effects of RBBB compared to LBBB appear to be more pronounced in patients with more advanced left ventricular dysfunction...
  46. doi request reprint Use of mutant-specific ion channel characteristics for risk stratification of long QT syndrome patients
    Christian Jons
    Cardiology Division, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Sci Transl Med 3:76ra28. 2011
    ..Our results indicate that genotype and biophysical phenotype analysis may be useful for risk stratification of LQT1 patients and suggest that slow channel activation is associated with an increased risk of cardiac events...
  47. pmc Mutation-specific risk in two genetic forms of type 3 long QT syndrome
    Judy F Liu
    Heart Research Follow Up Program, Cardiology Division, Department of Medicine, University of Rochester Medical Center, Rochester, New York, USA
    Am J Cardiol 105:210-3. 2010
    ..The findings highlight the importance of knowing the specific mutation in risk stratification of patients with long QT syndrome type 3...
  48. pmc Trigger-specific risk factors and response to therapy in long QT syndrome type 2
    James A Kim
    Cardiology Division, Department of Medicine, University of Rochester Medical Center, Rochester, New York, USA
    Heart Rhythm 7:1797-805. 2010
    ..Cardiac events in patients with long QT syndrome type 2 (LQT2) are predominately associated with sudden arousal. However, exercise-induced events also occur in this population...
  49. doi request reprint Risk of fatal arrhythmic events in long QT syndrome patients after syncope
    Christian Jons
    Cardiology Division of the Department of Medicine, University of Rochester Medical Center, Rochester, New York, USA
    J Am Coll Cardiol 55:783-8. 2010
    ..The aim of this study was to identify risk factors for fatal arrhythmias in long QT syndrome (LQTS) patients presenting with syncope...
  50. doi request reprint Long-term implications of cumulative right ventricular pacing among patients with an implantable cardioverter-defibrillator
    Alon Barsheshet
    Cardiology Division, University of Rochester Medical Center, Rochester, New York 14642, USA
    Heart Rhythm 8:212-8. 2011
    ..Limited data regarding the effect of right ventricular pacing (RVP) on long-term survival following implantable cardioverter-defibrillator (ICD) implantation are available...
  51. doi request reprint Response to preventive cardiac resynchronization therapy in patients with ischaemic and nonischaemic cardiomyopathy in MADIT-CRT
    Alon Barsheshet
    Cardiology Division, Heart Research Follow Up Program, University of Rochester Medical Center, Rochester, NY, USA
    Eur Heart J 32:1622-30. 2011
    ..We evaluated the outcome of patients enrolled in MADIT-CRT by ischaemic and non-ischaemic aetiology of cardiomyopathy (ICM and non-ICM, respectively)...
  52. doi request reprint Time-dependent benefit of preventive cardiac resynchronization therapy after myocardial infarction
    Alon Barsheshet
    Cardiology Division, Heart Research Follow Up Program, University of Rochester Medical Center, Rochester, NY, USA
    Eur Heart J 32:1614-21. 2011
    ..The present study was designed to evaluate the relationship between elapsed time from MI and the benefit of preventive CRT-D therapy in patients with ischaemic cardiomyopathy (ICM)...
  53. ncbi request reprint Risk of aborted cardiac arrest or sudden cardiac death during adolescence in the long-QT syndrome
    Jenny B Hobbs
    Cardiology Unit of the Department of Medicine, University of Rochester Medical Center, Rochester, NY, USA
    JAMA 296:1249-54. 2006
    ..Risk factors specific for aborted cardiac arrest and sudden cardiac death have not been investigated...
  54. pmc Long QT syndrome in patients over 40 years of age: increased risk for LQTS-related cardiac events in patients with coronary disease
    Edward Sze
    Cardiology Division, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642 8653, USA
    Ann Noninvasive Electrocardiol 13:327-31. 2008
    ....
  55. ncbi request reprint Clopidogrel resistance is associated with increased risk of recurrent atherothrombotic events in patients with acute myocardial infarction
    Shlomi Matetzky
    Heart Institute, Sheba Medical Center, Tel Hashomer, Israel
    Circulation 109:3171-5. 2004
    ..Although clopidogrel reduces the risk of cardiovascular episodes after coronary events and stenting, a substantial number of incidents continue to occur...
  56. doi request reprint Predictors of long-term (4-year) mortality in elderly and young patients with acute heart failure
    Alon Barsheshet
    Heart Institute, Sheba Medical Center, Tel Hashomer and Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
    Eur J Heart Fail 12:833-40. 2010
    ..The present study was designed to identify and compare predictors of short- and long-term mortality in elderly and young patients hospitalized with acute heart failure (HF)...
  57. doi request reprint Mutations in conserved amino acids in the KCNQ1 channel and risk of cardiac events in type-1 long-QT syndrome
    Christian Jons
    Cardiology Division, Department of Medicine, University of Rochester Medical Center, Rochester, New York, USA
    J Cardiovasc Electrophysiol 20:859-65. 2009
    ..The purpose of this study was to investigate whether KCNQ1 mutations in highly conserved amino acid residues within the voltage-gated potassium channel family are associated with an increased risk of cardiac events...
  58. pmc Risk of recurrent cardiac events after onset of menopause in women with congenital long-QT syndrome types 1 and 2
    Jonathan Buber
    Leviev Heart Center, Sheba Medical Center, Tel Hashomer, Israel
    Circulation 123:2784-91. 2011
    ..We hypothesized that the hormonal changes associated with menopause may affect clinical risk in this population...
  59. doi request reprint Risk factors for recurrent heart failure events in the Multicenter Automatic Defibrillator Implantation Trial II (MADIT-II)
    Edward Sze
    Cardiology Unit of the Department of Medicine, University of Rochester Medical Center, Rochester, New York, USA
    J Cardiovasc Electrophysiol 21:1217-23. 2010
    ..Risk Factors for Recurrent Heart Failure...
  60. ncbi request reprint Polymorphisms in the paraoxonase and endothelial nitric oxide synthase genes and the risk of early-onset myocardial infarction
    Brian Morray
    Cardiology Unit, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA
    Am J Cardiol 99:1100-5. 2007
    ..15, p = 0.01, respectively). In conclusion, our findings suggest that high-risk genotypes of the PON1 Q192R and eNOS E298D polymorphisms are independently associated with a significantly earlier occurrence of coronary events...
  61. ncbi request reprint Obesity as a risk factor for sustained ventricular tachyarrhythmias in MADIT II patients
    Grzegorz Pietrasik
    Heart Research Follow Up Program, Cardiology Division, University of Rochester Medical Center, Rochester, New York, USA
    J Cardiovasc Electrophysiol 18:181-4. 2007
    ..The aim of this study was to evaluate the risk of ventricular tachyarrhythmias and sudden death by BMI in patients after myocardial infarction with severe left ventricular dysfunction...
  62. doi request reprint Usefulness of combining serum uric acid and C-reactive protein for risk stratification of patients with coronary artery disease (Bezafibrate Infarction Prevention [BIP] study)
    Yafim Brodov
    Heart Institute, Sheba Medical Center, Tel Hashomer and Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel
    Am J Cardiol 104:194-8. 2009
    ..66, 1.07 to 2.59). In conclusion, combined assessment of UA and CRP levels provides incremental information for risk stratification of patients with CAD with low levels of a single marker...
  63. doi request reprint Risk of cardiac events in patients with asthma and long-QT syndrome treated with beta(2) agonists
    Princy Thottathil
    Cardiology Division of the Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA
    Am J Cardiol 102:871-4. 2008
    ..14, p = 0.05). In conclusion, beta(2)-agonist therapy was associated with an increased risk for cardiac events in patients with asthma with LQTS, and this risk was diminished in patients receiving beta blockers...
  64. pmc Influence of diabetes mellitus on outcome in patients over 40 years of age with the long QT syndrome
    Gregory Ouellet
    Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA
    Am J Cardiol 105:87-9. 2010
    ..In conclusion, diabetes and prolonged QTc interval contributed independent mortality risks in adult patients with LQTS, with no interaction between these 2 risk factors...
  65. ncbi request reprint Effectiveness of the implantable cardioverter defibrillator in blacks versus whites (from MADIT-II)
    Gabriel Vorobiof
    Heart Research Follow Up Program, Cardiology Division, Department of Medicine, University of Rochester Medical Center, Rochester, New York, USA
    Am J Cardiol 98:1383-6. 2006
    ..In conclusion, ICD therapy in MADIT-II was associated with a reduction in total mortality, cardiac death, and sudden cardiac death in whites but not in blacks...
  66. doi request reprint Effectiveness of Cardiac Resynchronization Therapy by QRS Morphology in the Multicenter Automatic Defibrillator Implantation Trial-Cardiac Resynchronization Therapy (MADIT-CRT)
    Wojciech Zareba
    Cardiology Division, University of Rochester, Rochester, NY, USA
    Circulation 123:1061-72. 2011
    ....
  67. doi request reprint Cardiac resynchronization therapy is more effective in women than in men: the MADIT-CRT (Multicenter Automatic Defibrillator Implantation Trial with Cardiac Resynchronization Therapy) trial
    Aysha Arshad
    Cardiology Division, St Luke s and Roosevelt Hospitals and Columbia University, New York, New York, USA
    J Am Coll Cardiol 57:813-20. 2011
    ....
  68. pmc Risk factors for recurrent syncope and subsequent fatal or near-fatal events in children and adolescents with long QT syndrome
    Judy F Liu
    Heart Research Follow Up Program, Cardiology Division, Department of Medicine, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Am Coll Cardiol 57:941-50. 2011
    ..We aimed to identify risk factors for recurrent syncope in children and adolescents with congenital long QT syndrome (LQTS)...
  69. doi request reprint Serum uric acid for risk stratification of patients with coronary artery disease
    Yafim Brodov
    Heart Institute, Sheba Medical Center, Tel Hashomer, Israel
    Cardiology 114:300-5. 2009
    ..It is known that SUA levels are influenced by renal function. We aimed to assess the predictive value of SUA while taking into account patients' renal function...
  70. pmc Risk of syncope in family members who are genotype-negative for a family-associated long-QT syndrome mutation
    Alon Barsheshet
    Cardiology Division, University of Rochester Medical Center, Rochester, NY 14642, USA
    Circ Cardiovasc Genet 4:491-9. 2011
    ..The present study was designed to assess the clinical course of individuals who are found negative for the LQTS-causing mutation in their families...
  71. ncbi request reprint HLA-G is associated with pemphigus vulgaris in Jewish patients
    Ephraim Gazit
    Tissue Typing Laboratory, Sheba Medical Center, Tel Hashomer, Israel
    Hum Immunol 65:39-46. 2004
    ..The latter is probably associated with the efficiency of transcription of this gene. Taken together, the results suggest that HLA-G is associated with PV in Jewish patients...
  72. ncbi request reprint Primary angioplasty with routine stenting compared with thrombolytic therapy in elderly patients with acute myocardial infarction
    Ilan Goldenberg
    Heart Institute, Sheba Medical Center, Tel Hashomer, Israel
    Am Heart J 145:862-7. 2003
    ..These studies, however, were performed before the contemporary widespread use of intracoronary stents and glycoprotien IIb/IIIa antagonists...
  73. doi request reprint Reversible acute kidney injury following contrast exposure and the risk of long-term mortality
    Ilan Goldenberg
    Heart Institute, Sheba Medical Center, Tel Hashomer, Israel
    Am J Nephrol 29:136-44. 2009
    ..However, data regarding the long-term prognostic implications of reversible AKI following contrast exposure are limited...
  74. doi request reprint Relation of body mass index to sudden cardiac death and the benefit of implantable cardioverter-defibrillator in patients with left ventricular dysfunction after healing of myocardial infarction
    Bonnie Choy
    Cardiology Unit, Department of Medicine, University of Rochester Medical Center, Rochester, New York, USA
    Am J Cardiol 105:581-6. 2010
    ..In conclusion, our findings suggest an independent inverse association between BMI values and risk of all-cause mortality and SCD in patients after myocardial infarction with left ventricular dysfunction enrolled in the MADIT-II trial...
  75. ncbi request reprint Pemphigus vulgaris in Jewish patients is associated with HLA-A region genes: mapping by microsatellite markers
    Elena Slomov
    Tissue Typing Laboratory, Sheba Medical Center, Ramat Gan, Israel
    Hum Immunol 64:771-9. 2003
    ..Activation/suppression of these genes might act as the trigger mechanism that starts the autoimmune destructive process...
  76. doi request reprint Genetics of sudden cardiac death
    Alon Barsheshet
    Heart Research Follow Up Program, University of Rochester Medical Center, Rochester, NY 14642, USA
    Curr Cardiol Rep 13:364-76. 2011
    ..This paper reviews the current data regarding genotype-phenotype correlations and the role of clinical genetic testing in diagnosis, prognosis, and management of inheritable disorders leading to sudden cardiac death...
  77. doi request reprint Time dependence of life-threatening ventricular tachyarrhythmias after coronary revascularization in MADIT-CRT
    Alon Barsheshet
    Cardiology Division, University of Rochester Medical Center, Rochester, New York 14642, USA
    Heart Rhythm 7:1421-7. 2010
    ..Coronary revascularization (CR) may confer electrical stability in patients with ischemic cardiomyopathy. However, data regarding the effect of CR on the development of ventricular tachyarrhythmias in this population are limited...
  78. ncbi request reprint Current smoking, smoking cessation, and the risk of sudden cardiac death in patients with coronary artery disease
    Ilan Goldenberg
    Heart Institute, The Chaim Sheba Medical Center, Tel Hashomer 52621, Israel
    Arch Intern Med 163:2301-5. 2003
    ..We, therefore, evaluated the effect of cigarette smoking on SCD risk in a large cohort of patients with established CAD...
  79. ncbi request reprint Relation between on-treatment increments in serum high-density lipoprotein cholesterol levels and cardiac mortality in patients with coronary heart disease (from the Bezafibrate Infarction Prevention trial)
    Ilan Goldenberg
    Heart Institute, Sheba Medical Center, Tel Hashomer, Israel
    Am J Cardiol 97:466-71. 2006
    ..In appropriately selected patients, monitoring short-term response to bezafibrate therapy through change in HDL cholesterol may indicate the potential long-term benefit of the drug...
  80. doi request reprint Long-term benefit of high-density lipoprotein cholesterol-raising therapy with bezafibrate: 16-year mortality follow-up of the bezafibrate infarction prevention trial
    Ilan Goldenberg
    Heart Institute, Sheba Medical Center, Tel Hashomer, Israel
    Arch Intern Med 169:508-14. 2009
    ..We hypothesized that the degree of HDL-C response to bezafibrate is independently associated with subsequent long-term mortality...
  81. doi request reprint Secondary prevention with bezafibrate therapy for the treatment of dyslipidemia: an extended follow-up of the BIP trial
    Ilan Goldenberg
    Heart Institute, Sheba Medical Center, Tel Hashomer, Israel
    J Am Coll Cardiol 51:459-65. 2008
    ..This study was designed to evaluate the long-term cardiovascular benefit of bezafibrate therapy in coronary heart disease patients enrolled in the BIP (Bezafibrate Infarction Prevention) trial...
  82. ncbi request reprint Oral acetylcysteine as an adjunct to saline hydration for the prevention of contrast-induced nephropathy following coronary angiography. A randomized controlled trial and review of the current literature
    Ilan Goldenberg
    Heart Institute, Sheba Medical Center, Tel Hashomer, Israel
    Eur Heart J 25:212-8. 2004
    ..To determine laboratory and clinical benefit of oral acetylcysteine, as an adjunct to saline hydration, in chronic renal insufficiency patients undergoing coronary angiography...
  83. ncbi request reprint Association of elevated homocysteine levels with a higher risk of recurrent coronary events and mortality in patients with acute myocardial infarction
    Shlomi Matetzky
    Heart Institute, Sheba Medical Center, Tel Hashomer, Israel
    Arch Intern Med 163:1933-7. 2003
    ..Despite the prothrombotic and proinflammatory effects associated with elevated homocysteine levels, only limited data exist regarding the effect of homocysteine levels on outcome of patients with acute myocardial infarction...
  84. ncbi request reprint Effect of elevated homocysteine levels on clinical restenosis following percutaneous coronary intervention
    Israel Hodish
    Heart Institute, Sheba Medical Center, Tel Hashomer 52621, Israel
    Cardiology 97:214-7. 2002
    ..14 +/- 11 micromol/l, p = 0.77). There was no correlation between homocysteine levels and time to restenosis (r(2) = 0.06, p = 0.35). In conclusion, elevated homocysteine levels do not predict a higher incidence of restenosis after PCI...
  85. ncbi request reprint Peroxisome proliferator-activated receptor ligand bezafibrate for prevention of type 2 diabetes mellitus in patients with coronary artery disease
    Alexander Tenenbaum
    Cardiac Rehabilitation Institute, Chaim Sheba Medical Center, Tel Hashomer, 52621 Israel
    Circulation 109:2197-202. 2004
    ..2-year follow-up period...
  86. ncbi request reprint Risk factors for sudden cardiac death in patients with chronic renal insufficiency and left ventricular dysfunction
    Michel Chonchol
    Division of Renal Diseases and Hypertension, University of Colorado Health Sciences Center, Denver, Colo 80262, USA
    Am J Nephrol 27:7-14. 2007
    ..It is, however, unclear if the risk and risk factors of SCD in these patients is modulated by the coexistence of mild chronic renal insufficiency...
  87. ncbi request reprint Decrease in triglyceride level by bezafibrate is related to reduction of recurrent coronary events: a Bezafibrate Infarction Prevention substudy
    Moti Haim
    Cardiology Department, Rabin Medical Center, Petach Tikva, Sackler School of Medicine, Tel Aviv University, Israel
    Coron Artery Dis 17:455-61. 2006
    ..Fibrates were reported to be effective in reducing recurrent coronary events in coronary heart disease patients with elevated triglycerides. It is not known whether this effect is related to the extent of triglyceride reduction...
  88. ncbi request reprint Serologic testing for celiac disease in young adults--a cost-effect analysis
    Yael Yagil
    Medical Services and Supply Center, Medical Corps, Israeli Defense Forces, Israel
    Dig Dis Sci 50:796-805. 2005
    ..From a cost-effect perspective, implemented screening procedures need to be dependent on subgroup: low-risk, clinical follow-up; and high-risk, serological testing for EMA and, only if positive, possibly a small-bowel biopsy...