Stephen J Gold
Affiliation: University of Texas Southwestern Medical Center
- Regulation of regulators of G protein signaling mRNA expression in rat brain by acute and chronic electroconvulsive seizuresStephen J Gold
Department of Psychiatry and Center for Basic Neuroscience, The University of Texas Southwestern Medical Center at Dallas, Texas 75390, USA
J Neurochem 82:828-38. 2002..These studies demonstrate subtype-, time-, and region-specific regulation of RGS proteins by ECS, adaptations that may contribute to the antidepressant effects of this treatment...
- Regulation of RGS proteins by chronic morphine in rat locus coeruleusStephen J Gold
Department of Psychiatry, The University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd, Dallas TX 75390, USA
Eur J Neurosci 17:971-80. 2003....
- Regulator of G-protein signaling 10 promotes dopaminergic neuron survival via regulation of the microglial inflammatory responseJae Kyung Lee
Department of Physiology, The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9040, USA
J Neurosci 28:8517-28. 2008..RGS10 emerges as a novel drug target for prevention of nigrostriatal pathway degeneration, the neuropathological hallmark of PD...
- RGS9-2 negatively modulates L-3,4-dihydroxyphenylalanine-induced dyskinesia in experimental Parkinson's diseaseStephen J Gold
Department of Psychiatry, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390, USA
J Neurosci 27:14338-48. 2007..However, the findings also suggest that increasing RGS9-2 expression and/or function in PD patients may only be a suitable therapeutic strategy to control involuntary movements induced by nonselective DA agonist such as L-dopa...
- In situ hybridization analysis of RGS mRNA regulation and behavioral phenotyping of RGS mutant miceStephen J Gold
Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas 75390, USA
Methods Enzymol 389:205-29. 2004..These protocols should provide valuable guidance for investigators to establish these methodologies independently in their own laboratories and, over time, increase our understanding of RGS function in vivo...
- Essential role for RGS9 in opiate actionVenetia Zachariou
Department of Psychiatry and Center for Basic Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX 75390 9070, USA
Proc Natl Acad Sci U S A 100:13656-61. 2003....
- Chronic cold exposure increases RGS7 expression and decreases alpha(2)-autoreceptor-mediated inhibition of noradrenergic locus coeruleus neuronsHank P Jedema
Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA 15261, USA
Eur J Neurosci 27:2433-43. 2008....
- Neurobiology of depressionEric J Nestler
Department of Psychiatry and Center for Basic Neuroscience, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
Neuron 34:13-25. 2002..A neurobiologic understanding of depression also requires identification of the genes that make individuals vulnerable or resistant to the syndrome. These advances will fundamentally improve the treatment and prevention of depression...
- Regional, cellular, and subcellular localization of RGS10 in rodent brainJeff L Waugh
Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9070, USA
J Comp Neurol 481:299-313. 2005..Moreover, enrichment of RGS10 in transcriptionally active regions of the nucleus suggests an unforeseen role of RGS10 in modulating gene expression...
- RGS9 modulates dopamine signaling in the basal gangliaZia Rahman
Department of Psychiatry and Center for Basic Neuroscience, The University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
Neuron 38:941-52. 2003....
- Brain-derived neurotrophic factor is essential for opiate-induced plasticity of noradrenergic neuronsSchahram Akbarian
Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142, USA
J Neurosci 22:4153-62. 2002..Therefore, a BDNF-signaling pathway originating from non-noradrenergic sources is essential for opiate-induced molecular adaptations of the noradrenergic system...
- RGS9-2 is a negative modulator of mu-opioid receptor functionKassi Psifogeorgou
Department of Basic Sciences, Faculty of Medicine, University of Crete, Heraklion, Crete, Greece
J Neurochem 103:617-25. 2007..Our data indicate that RGS9-2 plays an essential role in opiate actions, by negatively modulating MOR downstream signaling as well as the rate of MOR endocytosis...
- Acute amphetamine down-regulates RGS4 mRNA and protein expression in rat forebrain: distinct roles of D1 and D2 dopamine receptorsMarek Schwendt
Department of Neurosciences, Medical University of South Carolina, Charleston, South Carolina 29425, USA
J Neurochem 96:1606-15. 2006....
- Motor coordination deficits in mice lacking RGS9Jacqueline Blundell
Department of Neurology, The University of Texas Southwestern Medical Center, Dallas, TX, 75390 8813, USA
Brain Res 1190:78-85. 2008..These studies are the first to describe a role for RGS9-2 in motor coordination and working memory and implicate RGS9-2 as a potential therapeutic target for motor and cognitive dysfunction...
- Differentially regulated expression of endogenous RGS4 and RGS7Andrejs M Krumins
Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9041, USA
J Biol Chem 279:2593-9. 2004..Although we searched without finding evidence for regulation of RGS4 proteolysis, the possibility remains that alterations in the degradation of this protein could provide a means to promptly alter patterns of signal transduction...