Stefan M Gold

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Depression and immunity: inflammation and depressive symptoms in multiple sclerosis
    Stefan M Gold
    Cousins Center for Psychoneuroimmunology, Semel Institute for Neuroscience, 300 Medical Plaza, Suite 3109, Los Angeles, CA 90095, USA
    Neurol Clin 24:507-19. 2006
  2. pmc Immune modulation and increased neurotrophic factor production in multiple sclerosis patients treated with testosterone
    Stefan M Gold
    Department of Neurology, Neuroscience Research Building 1, 635 Charles E, Young Drive South, University of California Los Angeles, CA 90095, USA
    J Neuroinflammation 5:32. 2008
  3. pmc Depression and immunity: inflammation and depressive symptoms in multiple sclerosis
    Stefan M Gold
    Cousins Center for Psychoneuroimmunology, Semel Institute for Neuroscience, 300 Medical Plaza, Suite 3109, Los Angeles, CA 90095, USA
    Immunol Allergy Clin North Am 29:309-20. 2009
  4. ncbi request reprint Stress and disease progression in multiple sclerosis and its animal models
    Stefan M Gold
    Multiple Sclerosis Program, Department of Neurology and Cousins Center for Psychoneuroimmunology, UCLA School of Medicine, Los Angeles, CA 90095, USA, and University Hospital Hamburg Eppendorf, Germany
    Neuroimmunomodulation 13:318-26. 2006
  5. ncbi request reprint Endocrine and cytokine responses to standardized physical stress in multiple sclerosis
    Christoph Heesen
    Department of Neurology, University Hospital Eppendorf, Martinistrasse 53, D 20246 Hamburg, Germany
    Brain Behav Immun 17:473-81. 2003
  6. ncbi request reprint Altered cytokine responses to cognitive stress in multiple sclerosis patients with fatigue
    Christoph Heesen
    Department of Neurology, University Hospital Eppendorf, Martinistrasse 52, D 20246 Hamburg, Germany
    Mult Scler 11:51-7. 2005
  7. ncbi request reprint Hypothalamo-pituitary-adrenal axis activity predicts disease progression in multiple sclerosis
    Stefan M Gold
    Department of Neurology, University Hospital Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany
    J Neuroimmunol 165:186-91. 2005
  8. doi request reprint Responsiveness of patient-based and external rating scales in multiple sclerosis: head-to-head comparison in three clinical settings
    Stefan M Gold
    Department of Neurology, UCLA School of Medicine, Los Angeles, CA, USA
    J Neurol Sci 290:102-6. 2010
  9. ncbi request reprint The role of stress-response systems for the pathogenesis and progression of MS
    Stefan M Gold
    Multiple Sclerosis Program, Department of Neurology and Cousins Center for Psychoneuroimmunology, Neuropsychiatric Institute, UCLA School of Medicine, NRB1 Rm 479, 635 Charles E Young Drive South, Los Angeles, CA 90095, USA
    Trends Immunol 26:644-52. 2005
  10. pmc Estrogen treatment in multiple sclerosis
    Stefan M Gold
    Department of Neurology, Geffen School of Medicine, University of California Los Angeles, USA
    J Neurol Sci 286:99-103. 2009

Collaborators

Detail Information

Publications25

  1. ncbi request reprint Depression and immunity: inflammation and depressive symptoms in multiple sclerosis
    Stefan M Gold
    Cousins Center for Psychoneuroimmunology, Semel Institute for Neuroscience, 300 Medical Plaza, Suite 3109, Los Angeles, CA 90095, USA
    Neurol Clin 24:507-19. 2006
    ..For example, an inflammatory depression may require different therapeutic approaches than a reactive depression in MS. Future research should aim to characterize these subtypes better with the goal of optimizing treatment...
  2. pmc Immune modulation and increased neurotrophic factor production in multiple sclerosis patients treated with testosterone
    Stefan M Gold
    Department of Neurology, Neuroscience Research Building 1, 635 Charles E, Young Drive South, University of California Los Angeles, CA 90095, USA
    J Neuroinflammation 5:32. 2008
    ..Evidence from basic and clinical studies suggests that testosterone has an immunomodulatory as well as a potential neuroprotective effect that could be beneficial in MS...
  3. pmc Depression and immunity: inflammation and depressive symptoms in multiple sclerosis
    Stefan M Gold
    Cousins Center for Psychoneuroimmunology, Semel Institute for Neuroscience, 300 Medical Plaza, Suite 3109, Los Angeles, CA 90095, USA
    Immunol Allergy Clin North Am 29:309-20. 2009
    ..This article reviews the current knowledge in the field and illustrates how the sickness behavior model may be applied to investigate depressive symptoms in inflammatory neurologic diseases...
  4. ncbi request reprint Stress and disease progression in multiple sclerosis and its animal models
    Stefan M Gold
    Multiple Sclerosis Program, Department of Neurology and Cousins Center for Psychoneuroimmunology, UCLA School of Medicine, Los Angeles, CA 90095, USA, and University Hospital Hamburg Eppendorf, Germany
    Neuroimmunomodulation 13:318-26. 2006
    ..These findings can be integrated into a biological model of stress response system alterations in MS...
  5. ncbi request reprint Endocrine and cytokine responses to standardized physical stress in multiple sclerosis
    Christoph Heesen
    Department of Neurology, University Hospital Eppendorf, Martinistrasse 53, D 20246 Hamburg, Germany
    Brain Behav Immun 17:473-81. 2003
    ..From these data we could not demonstrate a proinflammatory immune deviation in response to physical stress in MS. The observed trend of hyporesponsive TNFalpha and IL-10 responses in MS warrants further investigation...
  6. ncbi request reprint Altered cytokine responses to cognitive stress in multiple sclerosis patients with fatigue
    Christoph Heesen
    Department of Neurology, University Hospital Eppendorf, Martinistrasse 52, D 20246 Hamburg, Germany
    Mult Scler 11:51-7. 2005
    ..05). Overall, cognitive stress induces IFNgamma production in healthy controls but not in MS patients with fatigue. Furthermore, a reduced cardiac response might indicate an autonomic dysfunction in this group of patients...
  7. ncbi request reprint Hypothalamo-pituitary-adrenal axis activity predicts disease progression in multiple sclerosis
    Stefan M Gold
    Department of Neurology, University Hospital Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany
    J Neuroimmunol 165:186-91. 2005
    ..Furthermore, HPA axis activity correlated with progression ratings and cognitive impairment three years later. Tests of HPA axis activity may be useful biomarkers for disease progression in MS...
  8. doi request reprint Responsiveness of patient-based and external rating scales in multiple sclerosis: head-to-head comparison in three clinical settings
    Stefan M Gold
    Department of Neurology, UCLA School of Medicine, Los Angeles, CA, USA
    J Neurol Sci 290:102-6. 2010
    ..Responsiveness to health-related change of quality of life scales is thus an important property when these measures are to be used successfully in clinical trials...
  9. ncbi request reprint The role of stress-response systems for the pathogenesis and progression of MS
    Stefan M Gold
    Multiple Sclerosis Program, Department of Neurology and Cousins Center for Psychoneuroimmunology, Neuropsychiatric Institute, UCLA School of Medicine, NRB1 Rm 479, 635 Charles E Young Drive South, Los Angeles, CA 90095, USA
    Trends Immunol 26:644-52. 2005
    ..Here, we integrate findings from molecular, cellular, experimental, clinical and epidemiological research to describe the involvement of stress response systems in MS pathogenesis and progression...
  10. pmc Estrogen treatment in multiple sclerosis
    Stefan M Gold
    Department of Neurology, Geffen School of Medicine, University of California Los Angeles, USA
    J Neurol Sci 286:99-103. 2009
    ..A first pilot trial of oral estriol treatment showed encouraging results. There are now several phase II trials underway to further determine the efficacy of estrogen treatment in MS...
  11. ncbi request reprint Cognitive impairment in multiple sclerosis does not affect reliability and validity of self-report health measures
    Stefan M Gold
    Multiple Sclerosis Research Group, Department of Neurology, University Hospital Eppendorf, Hamburg, Germany
    Mult Scler 9:404-10. 2003
    ..The common pattern of poor correlation between self-rated and objective cognitive function thus appears to be a result of the patients' (adaptive or maladaptive) coping mechanisms rather than being due to inaccurate measurement...
  12. ncbi request reprint Oral terbutaline differentially affects cytokine (IL-10, IL-12, TNF, IFNg) release in multiple sclerosis patients and controls
    Christoph Heesen
    Department of Neurology, University Hospital Eppendorf, Martinistrasse 52, D 20246 Hamburg, Germany
    J Neuroimmunol 132:189-95. 2002
    ..Our findings might reflect a disturbed autonomic control of the immune system in MS...
  13. pmc Smaller cornu ammonis 2-3/dentate gyrus volumes and elevated cortisol in multiple sclerosis patients with depressive symptoms
    Stefan M Gold
    Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine at UCLA, Los Angeles, California, USA
    Biol Psychiatry 68:553-9. 2010
    ..We examined the role of subregional hippocampal volume for depression in relapsing-remitting multiple sclerosis...
  14. doi request reprint The XX sex chromosome complement in mice is associated with increased spontaneous lupus compared with XY
    Manda V Sasidhar
    Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, California 90095, USA
    Ann Rheum Dis 71:1418-22. 2012
    ..This may be caused by sex hormones, sex chromosomes or both. This report uses a transgenic mouse model to investigate how sex chromosome complement, not confounded by differences in gonadal type, might contribute to lupus pathogenesis...
  15. doi request reprint Sex-related factors in multiple sclerosis susceptibility and progression
    Rhonda R Voskuhl
    Department of Neurology, University of California Los Angeles, Neuroscience Research Building 1, Room 475D, 635 Charles Young Drive South, Los Angeles, CA 90095, USA
    Nat Rev Neurol 8:255-63. 2012
    ....
  16. pmc Estrogen and testosterone therapies in multiple sclerosis
    Stefan M Gold
    Department of Neurology, Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA
    Prog Brain Res 175:239-51. 2009
    ..In this paper, we review the preclinical and clinical evidence for sex hormone treatments in MS and discuss potential mechanisms of action...
  17. pmc Estrogen treatment decreases matrix metalloproteinase (MMP)-9 in autoimmune demyelinating disease through estrogen receptor alpha (ERalpha)
    Stefan M Gold
    Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Lab Invest 89:1076-83. 2009
    ..In conclusion, estriol acting through ERalpha to reduce MMP-9 from immune cells is one mechanism potentially underlying the estriol-mediated reduction in enhancing lesions in MS and inflammatory lesions in EAE...
  18. ncbi request reprint Testosterone replacement therapy for the treatment of neurological and neuropsychiatric disorders
    Stefan M Gold
    Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles 90095, USA
    Curr Opin Investig Drugs 7:625-30. 2006
    ..Further study of the therapeutic potential of testosterone is warranted in neurological and neuropsychiatric diseases...
  19. ncbi request reprint Basal serum levels and reactivity of nerve growth factor and brain-derived neurotrophic factor to standardized acute exercise in multiple sclerosis and controls
    Stefan M Gold
    Department of Neurology, University Hospital Hamburg Eppendorf, Martinistrasse 52, 20246, Hamburg, Germany
    J Neuroimmunol 138:99-105. 2003
    ..We conclude that moderate exercise can be used to induce neutrophin production in humans. This may mediate beneficial effects of physical exercise in MS reported recently...
  20. pmc Cortical atrophy in experimental autoimmune encephalomyelitis: in vivo imaging
    Allan MacKenzie-Graham
    University of California, Los Angeles, Los Angeles, CA, USA 091593 Z 10
    Neuroimage 60:95-104. 2012
    ..This is the first report of progressive cortical atrophy in vivo in a mouse model of MS...
  21. ncbi request reprint Cognitive impairment correlates with hypothalamo-pituitary-adrenal axis dysregulation in multiple sclerosis
    Christoph Heesen
    Department of Neurology, University Hospital Eppendorf, Martinistrasse 52, D 20246 Hamburg, Germany
    Psychoneuroendocrinology 27:505-17. 2002
    ..We conclude that the observed dysregulation is more likely a secondary effect of the extent of brain damage rather than primarily involved in the pathogenesis of MS...
  22. ncbi request reprint [The concept of allostasis and allostatic load: psychoneuroimmunological findings]
    Karl Heinz Schulz
    Institut und Poliklinik für Medizinische Psychologie, Zentrum fur Psychosoziale Medizin
    Psychother Psychosom Med Psychol 55:452-61. 2005
    ..When using allostatic load as a heuristic model, one needs to consider that stress mediators and outcomes are interconnected in a non-linear network...
  23. ncbi request reprint Hypertension and hypothalamo-pituitary-adrenal axis hyperactivity affect frontal lobe integrity
    Stefan M Gold
    Center for Brain Health, HN 400, New York University School of Medicine, 550 First Avenue, New York, New York 10016, USA
    J Clin Endocrinol Metab 90:3262-7. 2005
    ..Future studies assessing the impact of hypertension on the brain should include cortisol assessments...
  24. ncbi request reprint Impact of aerobic training on immune-endocrine parameters, neurotrophic factors, quality of life and coordinative function in multiple sclerosis
    Karl Heinz Schulz
    Institute of Medical Psychology and Transplantation Center, University Hospital Eppendorf, Martinistrasse 52, S3520246 Hamburg, Germany
    J Neurol Sci 225:11-8. 2004
    ..In summary, low-level aerobic training in MS improves not only quality of life but also coordinative function and physical fitness...
  25. ncbi request reprint Higher Beck depression scores predict delayed epinephrine recovery after acute psychological stress independent of baseline levels of stress and mood
    Stefan M Gold
    Biobehavioral Medicine Program, Derald H Ruttenberg Cancer Center, Mount Sinai School of Medicine, 1425 Madison Avenue, Box 1130, New York, NY 10029 6574, USA
    Biol Psychol 67:261-73. 2004
    ..No differences were found in norepinephrine responses. Elevations in BDI scores within the normal range may selectively predict slower physiological recovery following acute stress...