Research Topics
| Mark S GoldSummaryAffiliation: University of Florida Country: USA Publications
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Detail Information
Publications
Prescription opioid abuse and dependence among physicians: hypotheses and treatmentLisa J Merlo
Department of Psychiatry, University of Florida, Gainesville, FL 32610 0183, USA
Harv Rev Psychiatry 16:181-94. 2008..Given the extremely positive outcomes demonstrated by specialized programs for treating impaired professionals, it is recommended that their methods be disseminated and utilized in treatment centers for the general public...
Fentanyl abuse and dependence: further evidence for second hand exposure hypothesisMark S Gold
Department of Psychiatry, Division of Addiction Medicine, University of Florida College of Medicine, Gainesville, FL 32610 0183, USA
J Addict Dis 25:15-21. 2006..We are developing an animal model for second hand exposure and additional studies of the operating room and cardiac anesthesiologists are underway...- Occupational exposure and addictions for physicians: case studies and theoretical implicationsMark S Gold
University of Florida College of Medicine, Gainesville, FL, USA
Psychiatr Clin North Am 27:745-53. 2004..These studies should include biological measures, such as blood levels in exposed workers, and sensitive assays that quantitatively assess levels of exposure in the workplace... - Second-hand exposure to aerosolized intravenous anesthetics propofol and fentanyl may cause sensitization and subsequent opiate addiction among anesthesiologists and surgeonsPriscilla F McAuliffe
Department of Surgery, University of Florida College of Medicine, Gainesville, 32610, USA
Med Hypotheses 66:874-82. 2006..We conclude that the potential exists for chronic exposure to low levels of airborne intravenously administered drugs. Further studies are under way to determine the significance of this exposure... - Fentanyl and propofol exposure in the operating room: sensitization hypotheses and further dataLisa J Merlo
Department of Psychiatry, University of Florida College of Medicine, Gainesville, FL 32610 0183, USA
J Addict Dis 27:67-76. 2008..Suggestions for reducing secondhand exposure in the operating room are discussed... - Methods in drug abuse neuroproteomics: methamphetamine psychoproteomeFiras H Kobeissy
Department of Psychiatry, University of Florida, Gainesville, FL, USA
Methods Mol Biol 566:217-28. 2009..These methods and protocols are discussed in the paradigm of acute model of methamphetamine drug abuse and can be applied to other models of substance abuse such as to MDMA or cocaine... - Effects of fentanyl dose and exposure duration on the affective and somatic signs of fentanyl withdrawal in ratsJiang Liu
Department of Pharmaceutics, University of Florida, Gainesville, FL 32610, USA
Neuropharmacology 55:812-8. 2008..These studies suggest that the magnitude and duration of the negative affective signs of fentanyl withdrawal depend on the dose of fentanyl administered and not on the duration of fentanyl administration... - Methods in systems biology of experimental methamphetamine drug abuseFiras H Kobeissy
Department of Psychiatry, Center for Neuroproteomics and Biomarkers Research, McKnight Brain Institute of the University of Florida, Gainesville, FL, USA
Methods Mol Biol 662:303-16. 2010..These methods and protocols are discussed in the paradigm of the acute model of METH drug abuse and neuronal cell culture and can be applied on other models of substance abuse such as on MDMA or cocaine... - Methods in tobacco abuse: proteomic changes following second-hand smoke exposureJoy Guingab-Cagmat
Department of Psychiatry, Center for Neuroproteomics and Biomarkers Research at the Evelyn F and William L McKnight Brain Institute, Gainesville, FL, USA
Methods Mol Biol 829:329-48. 2012..Moreover, combining smoke exposure with proteomics can lead to the discovery of biomarkers that can be potentially useful tools in screening, early diagnosis, prevention, and treatment of diseases caused by SHS... - The effects of buprenorphine on fentanyl withdrawal in ratsAdrie W Bruijnzeel
Department of Psychiatry, McKnight Brain Institute, College of Medicine, University of Florida, 100 S Newell Dr, 100256, Gainesville, FL 32610 0244, USA
Psychopharmacology (Berl) 191:931-41. 2007..Fentanyl is a potent mu-opioid receptor agonist that is widely used for the treatment of severe chronic pain. Discontinuation of fentanyl administration has been shown to induce a negative emotional state... - Food addiction and obesity: evidence from bench to bedsideYijun Liu
Division of Global Tobacco, Alcohol, Obesity and Health Research, University of Florida, Department of Psychiatry and McKnight Brain Institute, PO Box 100256, Gainesville, FL 32610 0256, USA
J Psychoactive Drugs 42:133-45. 2010..The acquired drive for great food and relative weakness of the satiety signal would cause an imbalance between the drive and hunger/reward centers in the brain and their regulation... - The role of corticotropin-releasing factor-like peptides in cannabis, nicotine, and alcohol dependenceAdrie W Bruijnzeel
Department of Psychiatry, University of Florida, McKnight Brain Institute, 100 S Newell Dr PO Box 100256, Gainesville, FL 32610, USA
Brain Res Brain Res Rev 49:505-28. 2005.... 
Methamphetamine- and trauma-induced brain injuries: comparative cellular and molecular neurobiological substratesMark S Gold
Center for Neuroproteomics and Biomarkers Research, McKnight Brain Institute of the University of Florida, Gainesville, Florida 32610, USA
Biol Psychiatry 66:118-27. 2009....- Identification of tyrosine nitration in UCH-L1 and GAPDHJoy D Guingab-Cagmat
Center of Innovative Research, Banyan Biomarkers, Inc, Alachua, FL, USA
Electrophoresis 32:1692-705. 2011..Targeted analysis of endogenous UCH-L1 and GAPDH nitration was then conducted in an in vivo second-hand smoke rat model to evaluate the utility of this approach... - Tobacco smoke exposure induces nicotine dependence in ratsElysia Small
Department of Psychiatry, College of Medicine, McKnight Brain Institute, University of Florida, 100 S Newell Dr, PO Box 100256, Gainesville, FL 32610, USA
Psychopharmacology (Berl) 208:143-58. 2010..Therefore, animal models are needed that allow the investigation of chronic exposure to the full spectrum of tobacco smoke constituents... - Methods in drug abuse models: comparison of different models of methamphetamine paradigmsFiras H Kobeissy
Division of Addiction Medicine, Department of Psychiatry, Center for Neuroproteomics and Biomarkers Research at the Evelyn F and William L McKnight Brain Institute, University of Florida, Gainesville, FL, USA
Methods Mol Biol 829:269-78. 2012..In comparing the models, this chapter briefly considers the METH-induced neurotoxic effects associated with each METH administration paradigm and the behavioral changes observed... - Methadone- and heroin-related deaths in FloridaNoni A Graham
University of Florida College of Medicine Department of Psychiatry, Division of Addiction Medicine, Evelyn F and William L McKnight Brain Institute, Gainesville, Florida 32610, USA
Am J Drug Alcohol Abuse 34:347-53. 2008..Treatment with methadone, for both pain and opioid dependence, should be preceded by an abuse liability evaluation. Attempts to minimize diversion should be implemented... - Reward circuitry dopaminergic activation regulates food and drug craving behaviorKenneth Blum
Department of Psychiatry, and McKnight Brain Institute, University of Florida, College of Medicine, Gainesville, Florida, USA
Curr Pharm Des 17:1158-67. 2011..Finally, utilizing the long term dopaminergic activation approach will ultimately lead to a common safe and effective modality to treat RDS behaviors including aberrant food and drug craving behaviors... - Psychiatric research: psychoproteomics, degradomics and systems biologyFiras H Kobeissy
McKnight Brain Institute, Department of Psychiatry, University of Florida College of Medicine, Gainesville, FL 32611, USA
Expert Rev Proteomics 5:293-314. 2008..Finally, we will discuss the emerging role of systems biology and its current use in the field of neuroscience and its integral role in establishing a comprehensive understanding of specific brain disorders and brain function in general... - Neuro-chemical activation of brain reward meso-limbic circuitry is associated with relapse prevention and drug hunger: a hypothesisKenneth Blum
Department of Psychiatry, University of Florida College of Medicine and McKnight Brain Institute, Gainesville, FL, USA
Med Hypotheses 76:576-84. 2011..The logical standard of care should focus on detoxifying, stabilizing and returning the patient to the pre-loss of control or pre-addiction neurochemical state... - Calpain- and caspase-mediated alphaII-spectrin and tau proteolysis in rat cerebrocortical neuronal cultures after ecstasy or methamphetamine exposureMatthew W Warren
Center for Traumatic Brain Injury Studies, Department of Neuroscience, McKnight Brain Institute of the University of Florida, Gainesville, FL, USA
Int J Neuropsychopharmacol 10:479-89. 2007..The ability of the protease inhibitors to reduce the damage caused by these drugs suggests that the treatment arsenal could include similar drugs as possible tools to combat the drug-induced neurotoxicity in vivo... - The mirage of impairing drug concentration thresholds: a rationale for zero tolerance per se driving under the influence of drugs lawsGary M Reisfield
Department of Psychiatry, University of Florida College of Medicine, Gainesville, FL, USA
J Anal Toxicol 36:353-6. 2012..We propose specific legislation to address alcohol- and drug-impaired driving in the United States... - Qualitative versus quantitative methods in psychiatric researchMahdi Razafsha
Department of Psychiatry, Center for Neuroproteomics and Biomarkers Research at the Evelyn F and William L McKnight Brain Institute, University of Florida, Gainesville, FL, USA
Methods Mol Biol 829:49-62. 2012..By applying both methods of research, scientists can take advantage of interpretative characteristics of qualitative methods as well as experimental dimensions of quantitative methods... - Investigating the effects of low dose alcohol on neural timing using functional MRINelson J Klahr
Department of Psychiatry and McKnight Brain Institute, University of Florida, Gainesville, Florida 32610 0256, USA
J Magn Reson Imaging 34:1045-52. 2011..To examine human brain function related to the perception of short time intervals before and after ingesting a low dosage of alcohol (0.25 g/kg)... - Opiate prescription medication dependence and pain perceptionsNorman S Miller
University of Florida College of Medicine, Department of Psychiatry, Gainesville, FL, USA
J Addict Dis 26:65-71. 2007..Identification of addiction and detoxification is the proper approach to pain management in chronic opiate administration... - Alcohol consumption associated with collegiate American football pre-game festivitiesLisa J Merlo
Department of Psychiatry, University of Florida, Gainesville, FL 32610, USA
Drug Alcohol Depend 116:242-5. 2011.... - Food addiction and neuroimagingYi Zhang
Department of Psychiatry, McKnight Brain Institute, University of Florida, 100 Newell Drive, PO Box 100256, Gainesville, FL 32610, USA
Curr Pharm Des 17:1149-57. 2011.... - Psychoproteomic analysis of rat cortex following acute methamphetamine exposureFiras H Kobeissy
Center for Neuroproteomics and Biomarkers Research, Department of Psychiatry, College of Medicine, McKnight Brain Institute of the University of Florida, Gainesville, Florida 32610, USA
J Proteome Res 7:1971-83. 2008..Lastly, we used these differentially expressed protein subsets to construct a "psychoproteomic" spectrum map in an effort to uncover potential protein interactions relevant to acute METH neurotoxicity... - Tobacco and psychiatric dual disordersNoni A Graham
Public Health Research Group, Division of Addiction Medicine, University of Florida College of Medicine, Gainesville, FL 32610 0183, USA
J Addict Dis 26:5-12. 2007.... - Antagonism of CRF receptors prevents the deficit in brain reward function associated with precipitated nicotine withdrawal in ratsAdrie W Bruijnzeel
Department of Psychiatry, McKnight Brain Institute, University of Florida, Gainesville, FL 32610, USA
Neuropsychopharmacology 32:955-63. 2007..These data provide support for the hypothesis that a hyperactivity of brain CRF systems may at least partly mediate the initiation of the negative affective aspects of nicotine withdrawal... - Body mass index and alcohol useKatie D Kleiner
College of Medicine, University of Florida, Gainesville, FL 32610, USA
J Addict Dis 23:105-18. 2004..As BMI increases, lower rates of alcohol consumption are found. Overeating may compete with alcohol for brain reward sites, making alcohol ingestion less reinforcing... - Concurrent calpain and caspase-3 mediated proteolysis of alpha II-spectrin and tau in rat brain after methamphetamine exposure: a similar profile to traumatic brain injuryMatthew W Warren
University of Florida Department of Psychiatry, McKnight Brain Institute, University of Florida, Gainesville, FL 32610, USA
Life Sci 78:301-9. 2005..Use of calpain and caspase proteolytic inhibitors may be useful in preventing methamphetamine-induced neurotoxicity... - Problematic internet use: proposed classification and diagnostic criteriaNathan A Shapira
Department of Psychiatry, E f and W L McKnight Brain Institute, University of Florida, Gainesville, Florida 32610 0383, USA
Depress Anxiety 17:207-16. 2003..For these reasons, we propose specific diagnostic criteria that will allow for consistent identification and assist in further study of this behavior... - Calpain and caspase proteolytic markers co-localize with rat cortical neurons after exposure to methamphetamine and MDMAMatthew W Warren
Center for Traumatic Brain Injury Studies, Department of Neuroscience, McKnight Brain Institute of the University of Florida, Gainesville, FL 32610, USA
Acta Neuropathol 114:277-86. 2007..These findings support the hypothesis that calpains and caspases mediate PCD in cortical neurons following club drug abuse and, more importantly, appear to contribute to the neuropathology suffered by abusers... - Is speeding a form of gambling in adolescents?David S Husted
Department of Psychiatry, University of Florida College of Medicine, P O Box 100256, Gainesville, FL 32610 0256, USA
J Gambl Stud 22:209-19. 2006..Our data indicate a relationship between risky driving, gambling, and other risk-taking behaviors in adolescents, and support the hypothesis that speeding may be a form of gambling behavior in this age group... - Further developments in the neurobiology of food and addiction: update on the state of the scienceNicole M Avena
Department of Psychiatry, University of Florida, College of Medicine, Gainesville, Florida, USA
Nutrition 28:341-3. 2012.... - Overlaps in the nosology of substance abuse and overeating: the translational implications of "food addiction"Nicole M Avena
University of Florida, College of Medicine, Department of Psychiatry, Gainesville, FL 32610, USA
Curr Drug Abuse Rev 4:133-9. 2011..With this background and evidence in mind, we conclude this article with a discussion as to how "food addiction" research may translate into clinical strategies and pharmaceutical treatments useful in curtailing overeating... - Neurobiological mechanisms in addictive and psychiatric disordersAdrie W Bruijnzeel
Department of Psychiatry, University of Florida College of Medicine, P.O. Box 100183, Gainesville, FL 32610-0183, USA
Psychiatr Clin North Am 27:661-74. 2004..Conversely, professional treatment of pre-existing psychiatric disorders may decrease the use of illicit substances... - Drug withdrawal and hyperphagia: lessons from tobacco and other drugsPaula J Edge
Department of Psychiatry, College of Medicine and McKnight Brain Institute, University of Florida, Gainesville, FL 32610 0183, USA
Curr Pharm Des 17:1173-9. 2011..Additionally, prenatal programming for addiction is explored. Lessons from successful drug treatment are elucidated and potential pharmaceutical targets for hyperphagia and obesity are suggested... - Food addiction and cues in prader-willi syndromeKaren M von Deneen
From the Departments of Psychiatry and Neuroscience, McKnight Brain Institute The University of Florida, Gainesville, FL
J Addict Med 3:19-25. 2009..Appetite control is poor in PWS, thus food cues play a major role in its regulation. Hence, PWS may be the genetic model of choice for obesity... - Do dopaminergic gene polymorphisms affect mesolimbic reward activation of music listening response? Therapeutic impact on Reward Deficiency Syndrome (RDS)Kenneth Blum
Department of Psychiatry, University of Florida, College of Medicine and McKnight Brain Institute, Gainesville, Florida, USA
Med Hypotheses 74:513-20. 2010..Ross et al. [18] found that music therapy appears to be a novel motivational tool in a severely impaired inpatient sample of patients with co-occurring mental illness and addiction... - A marked increase in cocaine-related deaths in the State of Florida: precursor to an epidemic?Bruce A Goldberger
William R Maples Center for Forensic Medicine, Florida Emergency Mortuary Operations Response System, University of Florida College of Medicine, Department of Pathology, USA
J Addict Dis 26:113-6. 2007..Public health interventions are necessary to prevent another full-fledged epidemic... - Interaction of satiety and reward response to food stimulationG Andrew James
University of Florida College of Medicine, Department of Psychiatry, Gainesville, FL 32610-0256, USA
J Addict Dis 23:23-37. 2004..We review the interaction between central satiety signals and reward responses to food stimuli and discuss the implications of this research for understanding the causes of obesity... - Are physicians and medical students prepared to educate patients about alcohol consumption?Kimberly Frost-Pineda
Department of Psychiatry, University of Florida College of Medicine, USA
J Addict Dis 23:1-13. 2004.... - Changes in leptin, ghrelin, growth hormone and neuropeptide-Y after an acute model of MDMA and methamphetamine exposure in ratsFiras H Kobeissy
University of Florida College of Medicine, Gainesville, FL 32610, USA
Addict Biol 13:15-25. 2008..Future studies should be performed to see how chronic, low dose drug administration would affect hormone levels and try to answer questions about the physiological mechanisms involved in the anorexic paradigm observed in drug use... - PATHOS: a brief screening application for assessing sexual addictionPatrick J Carnes
Pine Grove Behavioral Health Services, University of Southern Mississippi, Hattiesburg, MS, USA
J Addict Med 6:29-34. 2012..Sexual addiction is estimated to afflict up to 3% to 6% of the population. However, many clinicians lack clear criteria for detecting potential cases... - From bedside to bench and back again: a 30-year sagaMark S Gold
Department of Psychiatry, College of Medicine, University of Florida, Gainesville, FL 32611, USA
Physiol Behav 104:157-61. 2011..The Gold lab is investigating working models for pathological attachment to eating and food addiction. New pharmacological treatments which interfere with food reinforcement may be the next step... - Marijuana and tobacco: a major connection?Laura Michelle Tullis
University of Florida, P O Box 100183, Gainesville, FL 32610 0183, USA
J Addict Dis 22:51-62. 2003..Our research with university students is suggesting that cigarette-smoking initiation often follows or coincides with marijuana... - Women tipping the scale during pregnancy: a special population for obesity interventions, treatments and clinical trialsNancy S Hardt
Obstetrics Gynecology and Pathology, Department of Psychiatry Division of Addiction Medicine, University of Florida, Gainesville, FL 32610 0183, USA
Curr Pharm Des 17:1143-4. 2011..In order to prevent obesity in women and their offspring, clinical interventions and trials need to be developed for women before and in between pregnancies... - Performance enhancing, non-prescription use of Ritalin: a comparison with amphetamines and cocaineStanislay I Svetlov
Department of Physiological Sciences, University of Florida, Gainesville, FL 32610, USA
J Addict Dis 26:1-6. 2007..In this mini-review, we discuss psychopharmacological and behavioral aspects, and outline neurochemical mechanisms that may provoke Ritalin abuse, addiction and adverse effects compared to amphetamines and cocaine... - The Salted Food Addiction Hypothesis may explain overeating and the obesity epidemicJames A Cocores
Department of Psychiatry, University of Florida College of Medicine and McKnight Brain Institute, Gainesville, FL, USA
Med Hypotheses 73:892-9. 2009.... - Crossroads of pain and addictionJohn A Bailey
Pain and Addiction Medicine in the Division of Addiction Medicine, Department of Psychiatry, University of Florida s Springhill Health Center, Gainesville, FL32606, USA
Pain Med 11:1803-18. 2010..Similarly, addiction medicine programs often offer little training in pain management. What follows is a review of the intersection between these two specialties from the perspective of clinicians that practice both... - Caffeine content of decaffeinated coffeeRachel R McCusker
Department of Pathology, Immunology and Laboratory Medicine, University of Florida College of Medicine, Gainesville, Florida 32610-0275, USA
J Anal Toxicol 30:611-3. 2006..Additionally, further exploration is merited for the possible physical dependence potential of low doses of caffeine such as those concentrations found in decaffeinated coffee... - Adolescent drug addiction treatment and weight gainCandace C Hodgkins
Gateway Community Services, Inc, 555 Stockton Street, Jacksonville, FL 32224, USA
J Addict Dis 23:55-65. 2004..Furthermore, significant interactions between tobacco use and primary substance use disorder with weight gain was demonstrated by multivariate analysis of variance... - The relationship between obesity and drug useMatthew W Warren
Am J Psychiatry 164:1268; author reply 1268-9. 2007 - Opioid treatment for chronic back pain and its association with addictionRobert L DuPont
Ann Intern Med 147:349; author reply 349-50. 2007 - Increased assessment and monitoring needed for patients receiving methadoneLisa J Merlo
Am J Med 121:e23; author repply e25. 2008 - Response to "Comorbid psychiatric diagnoses and their association with cocaine-induced psychosis in cocaine-dependent subjects"Lisa J Merlo
Am J Addict 17:247-8; author reply 249-50. 2008 - Ecstasy toxicity: a comparison to methamphetamine and traumatic brain injuryMatthew W Warren
College of Medicine, University of Florida, Gainsville, FL 32610, USA
J Addict Dis 25:115-23. 2006..Neurotoxicity is still evident after 72 hours. Furthermore, apoptosis of the liver is seen 72 hours after ecstasy use. Use of protease inhibitors may be useful in preventing ecstasy-induced toxicity... - Methamphetamine causes microglial activation in the brains of human abusersYoshimoto Sekine
Molecular Neuropsychiatry Branch, National Institute on Drug Abuse, Intramural Research Program, National Institutes of Health, Department of Health and Human Services, Baltimore, Maryland 21224, USA
J Neurosci 28:5756-61. 2008..These results suggest that chronic self-administration of methamphetamine can cause reactive microgliosis in the brains of human methamphetamine abusers, a level of activation that appears to subside over longer periods of abstinence... - Depression-related improvement with vardenafil for erectile responseMark S Gold
Am J Psychiatry 163:1449. 2006 - Symptoms of ADHD or marijuana use?Noni A Graham
Am J Psychiatry 164:973; author reply 973-4. 2007 - Naltrexone augments the effects of nicotine replacement therapy in female smokersJoanne A Byars
University of Florida, Gainesviile, FL 32610, USA
J Addict Dis 24:49-60. 2005..7% (11/12) and for P + NRT + PT was 50% (6/12). CONCLUSION: Naltrexone combined with NRT and psychosocial therapy appears to have a positive cessation effect on women and may be a new treatment option for recidivist female smokers... - Physician suicide and drug abuseMark S Gold
Am J Psychiatry 162:1390; author reply 1390. 2005 - Socioeconomic inequities often translate into health inequalitiesSarah Vinson
J Natl Med Assoc 98:816-7. 2006 - Regarding "Is cigarette smoking a gateway to alcohol and illicit drug use disorders? A study of youths with and without attention deficit hyperactivity disorder"Mark S Gold
Biol Psychiatry 60:1166; author reply 1166. 2006 - Speed, cocaine, and other psychostimulants death ratesMark S Gold
Am J Cardiol 100:1184. 2007 - Brief intervention for medical inpatients with unhealthy alcohol useLisa J Merlo
Ann Intern Med 147:589-90; author reply 590. 2007 - Effects of sustained gamma-hydroxybutyrate treatments on spontaneous and evoked firing activity of locus coeruleus norepinephrine neuronsSteven T Szabo
Laboratory of Molecular Pathophysiology, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, USA
Biol Psychiatry 55:934-9. 2004..Enhanced norepinephrine activity during withdrawal may be related to symptoms of anxiety on rapid termination of this drug in abusers... - Can drug design inhibit abuse?John J Coleman
Prescription Drug Research Center, Fairfax, Virginia 22030, USA
J Psychoactive Drugs 37:343-62. 2005..In every instance, drugs employing abuse-resistant designs were found to have significantly lower levels of abuse than comparator drugs without such designs... - Physicians and drug screeningMark S Gold
J Adolesc Health 39:154-5; author reply 155. 2006 - Problem doctors: is there a system-level solution?Mark S Gold
Ann Intern Med 144:861-2; author reply 863. 2006