Research Topics
| J M GoldSummaryAffiliation: University of Maryland Country: USA Publications
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Publications
Negative symptoms and the failure to represent the expected reward value of actions: behavioral and computational modeling evidenceJames M Gold
Department of Psychiatry, Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore, MD 21228, USA
Arch Gen Psychiatry 69:129-38. 2012..Negative symptoms are a core feature of schizophrenia, but their pathogenesis remains unclear. Negative symptoms are defined by the absence of normal function. However, there must be a productive mechanism that leads to this absence...
The family pictures test as a measure of impaired feature binding in schizophreniaJames M Gold
Maryland Psychiatric Research Center, PO Box 21247, Baltimore, MD 21228, USA
J Clin Exp Neuropsychol 26:511-20. 2004..Such feature binding deficits likely implicate hippocampal dysfunction, consistent with neuroimaging evidence of structural and functional compromise of the medial temporal lobe in schizophrenia...- Cognitive correlates of job tenure among patients with severe mental illnessJames M Gold
Maryland Psychiatric Research Center and the Center for Mental Health Services Research, Department of Psychiatry, University of Maryland, Baltimore 21228, USA
Am J Psychiatry 159:1395-402. 2002..The objective of the present study was to examine the cognitive predictors of vocational functioning in the context of a controlled clinical trial by comparing two approaches to vocational rehabilitation... 
Reward processing in schizophrenia: a deficit in the representation of valueJames M Gold
Maryland Psychiatric Research Center, Baltimore, MD 21228, USA
Schizophr Bull 34:835-47. 2008..In contrast, patients often (but not always) approach normal performance levels on the slow learning achieved by the integration of reinforcement signals over many trials, thought to be mediated by the basal ganglia...- Clinical, functional, and intertask correlations of measures developed by the Cognitive Neuroscience Test Reliability and Clinical Applications for Schizophrenia ConsortiumJames M Gold
Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, PO Box 21247, Baltimore, MD 21228, USA
Schizophr Bull 38:144-52. 2012..These results suggest that the CNTRACS tasks measure discrete cognitive abilities, some of which relate to aspects of functional capacity/outcome in schizophrenia... - Intact attentional control of working memory encoding in schizophreniaJames M Gold
Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore, MD, USA
J Abnorm Psychol 115:658-73. 2006..These findings indicate that attention is not globally impaired in SC and make it possible to delineate more precisely the nature of the specific impairment of attention in this disorder... - Impaired top-down control of visual search in schizophreniaJames M Gold
Maryland Psychiatric Research Center, University of Maryland School of Medicine, PO Box 21247, Baltimore, Maryland 21228, United States
Schizophr Res 94:148-55. 2007..These results extend prior studies that have focused on aspects of executive control in complex tasks and suggest that a similar underlying deficit may also impact the performance of perceptual systems... - Cognitive deficits as treatment targets in schizophreniaJames M Gold
Department of Psychiatry, University of Maryland Baltimore School of Medicine, Maryland Psychiatric Research Center, Baltimore, MD 21228, USA
Schizophr Res 72:21-8. 2004..Thus, cognitive impairment appears to be a well-defined, reliable and distinct dimension of the illness... - Learning and forgetting in schizophreniaJ M Gold
National Institute of Mental Health Neuroscience Center, St Elizabeth s, Washington, D C, USA
J Abnorm Psychol 109:534-8. 2000..The results suggest a primary deficit in the initial acquisition of information rather than an accelerated rate of forgetting in schizophrenia... - Reduced capacity but spared precision and maintenance of working memory representations in schizophreniaJames M Gold
Maryland Psychiatric Research Center, Baltimore, MD 21228, USA
Arch Gen Psychiatry 67:570-7. 2010..Working memory deficits are considered a core feature of schizophrenia. Several recent integrative articles have offered mechanistic computational and neurobiological models of the origins of this cognitive deficit... - Repeatable battery for the assessment of neuropsychological status as a screening test in schizophrenia I: sensitivity, reliability, and validityJ M Gold
Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland at Baltimore, 21228, USA
Am J Psychiatry 156:1944-50. 1999..This newly published test takes 25 minutes to administer and was standardized on a U.S.-Census-matched adult population. The test provides a total score and five index scores, each with a mean value of 100 (SD = 15)... - Turning it upside down: areas of preserved cognitive function in schizophreniaJames M Gold
Maryland Psychiatric Research Center, University of Maryland School of Medicine, PO Box 21247, Baltimore, MD 21228, USA
Neuropsychol Rev 19:294-311. 2009..The documentation of preserved cognitive function in schizophrenia may serve to sharpen hypotheses about the biological mechanisms that are implicated in the illness... - Working memory for visual features and conjunctions in schizophreniaJames M Gold
Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore 21228, USA
J Abnorm Psychol 112:61-71. 2003..Thus, the WM impairment in schizophrenia appears to be a consequence of attentional deficits rather than a reduction in storage capacity... - Patients with schizophrenia demonstrate dissociation between affective experience and motivated behaviorErin A Heerey
Maryland Psychiatric Research Center, University of Maryland Baltimore, Baltimore, MD, USA
J Abnorm Psychol 116:268-78. 2007..These data suggest that the motivational deficits in schizophrenia reflect problems in the ability to translate experience into action... - Learning-related changes in brain activity following errors and performance feedback in schizophreniaSarah E Morris
VA Capitol Network VISN 5 Mental Illness Research, Education, and Clinical Center, 10 No Greene St, Baltimore, MD 21201, USA
Schizophr Res 99:274-85. 2008..These findings suggest that reward-related brain activity is weakened in schizophrenia, perhaps reflecting diminished sensitivity to whether ongoing events are better or worse than expected... - Prediction of neuropsychological performance by neurological signs in schizophreniaC Arango
Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore 21228, USA
Am J Psychiatry 156:1349-57. 1999.... - Initial phase 2 trial of a nicotinic agonist in schizophreniaRobert Freedman
Department of Psychiatry, Denver VA Medical Center and University of Colorado, Denver, CO 80262, USA
Am J Psychiatry 165:1040-7. 2008..The agent 3-(2,4-dimethoxybenzylidene) anabaseine (DMXB-A) is a partial alpha(7)-nicotinic agonist and can be taken orally. A phase 1 trial showed evidence for cognitive enhancement in schizophrenia... - Delay discounting in schizophreniaErin A Heerey
Maryland Psychiatric Research Center, University of Maryland, Baltimore, MD, USA
Cogn Neuropsychiatry 12:213-21. 2007..We used a delay discounting measure to test the degree to which patients make future-oriented decisions... - Overlooking the obvious: a meta-analytic comparison of digit symbol coding tasks and other cognitive measures in schizophreniaDwight Dickinson
VISN 5 Mental Illness Research, Education and Clinical Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD 21201, USA
Arch Gen Psychiatry 64:532-42. 2007..In focusing on potentially localizable cognitive impairments, the schizophrenia meta-analytic literature has overlooked the largest single impairment: on digit symbol coding tasks... - The Cognitive and Negative Symptoms in Schizophrenia Trial (CONSIST): the efficacy of glutamatergic agents for negative symptoms and cognitive impairmentsRobert W Buchanan
Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore, MD 21228, USA
Am J Psychiatry 164:1593-602. 2007..Agents that act at the glycine site of the N-methyl-D-aspartic acid (NMDA) glutamatergic receptor have been suggested as promising treatments for moderate to severe negative symptoms and cognitive impairments... - Decisional capacity for informed consent in schizophrenia researchW T Carpenter
Maryland Psychiatric Research Center and the Department of Psychiatry, University of Maryland, Baltimore 21228, USA
Arch Gen Psychiatry 57:533-8. 2000.... - Spatial working memory as a cognitive endophenotype of schizophrenia: assessing risk for pathophysiological dysfunctionAlice M Saperstein
Department of Psychology, University of Maryland, College Park, 20742, USA
Schizophr Bull 32:498-506. 2006..This is particularly relevant for research efforts to identify pathophysiological components of the disease... - Neurocognitive effects of antipsychotic medications in patients with chronic schizophrenia in the CATIE TrialRichard S E Keefe
Department of Psychiatry, John Umstead Hospital, Duke University Medical Center, Durham, NC 27710, USA
Arch Gen Psychiatry 64:633-47. 2007..The relative effect of the second-generation (atypical) antipsychotic drugs and older agents on neurocognition has not been comprehensively determined... - No, it is not possible to be schizophrenic yet neuropsychologically normalChristopher M Wilk
Maryland Psychiatric Research Center, University of Maryland School of Medicine, Department of Psychiatry, Baltimore, MD 21228-0747, and Mental Illness Research, Education, and Clinical Center, Veterans Affairs Capital Health Care Network, USA
Neuropsychology 19:778-86. 2005..Thus, scoring in the normal range does not preclude neuropsychological abnormality in schizophrenia, confirming that neuropsychological impairment is a core feature of the illness... - Correlates of long-term unemployment among inner-city adults with serious and persistent mental illnessR W Goldberg
Department of Psychiatry, University of Maryland, Baltimore 21201, USA
Psychiatr Serv 52:101-3. 2001..The findings underscore the relevance of clinical and neurocognitive impairments to long-term unemployment and point to the need to critically reevaluate the effectiveness of traditional vocational rehabilitation services... - Correlates of insight in serious mental illnessR W Goldberg
Veterans Administration Capitol Healthcare Network Mental Illness Research, Education and Clinical Center, Department of Psychiatry, The University of Maryland, Baltimore, School of Medicine, 21201, USA
J Nerv Ment Dis 189:137-45. 2001..Findings also support a need for continued investigation of how mental illness is understood, experienced, and expressed across diverse groups of people living with mental illness... - Test-retest stability of the Repeatable Battery for the Assessment of Neuropsychological Status in schizophreniaChristopher M Wilk
Maryland Psychiatric Research Center, Sheppard Pratt Health System, Baltimore, 21228-0747, USA
Am J Psychiatry 159:838-44. 2002..These data may serve as an informative guide for using the RBANS to evaluate neuropsychological change on the level of the individual subject... - Evidence of exacerbated cognitive deficits in schizophrenia patients with comorbid diabetesDwight Dickinson
VISN 5 Mental Illness Research, Education, and Clinical Center, Baltimore, MD 21201, USA
Psychosomatics 49:123-31. 2008.... - Current progress in schizophrenia research: cognitive phenotypes of schizophrenia: attentionJames M Gold
Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, MD 21228, USA
J Nerv Ment Dis 190:638-9. 2002 - General and specific cognitive deficits in schizophreniaDwight Dickinson
Veterans Affairs Capitol Health Care Network, Mental Illness Research, Education, and Clinical Center, 10 North Greene Street, Suite 6A, Baltimore, MD 21201, USA
Biol Psychiatry 55:826-33. 2004.... - Impaired visual working memory consolidation in schizophreniaRebecca L Fuller
Maryland Psychiatric Research Center, University of Maryland School of Medicine, MD, USA
Neuropsychology 23:71-80. 2009..These data demonstrate abnormally prolonged WM consolidation in schizophrenia. This impairment may slow the formation of stable representations of the visual environment, impacting everyday visually guided behavior... - Norms and standardization of the Brief Assessment of Cognition in Schizophrenia (BACS)Richard S E Keefe
Department of Psychiatry, Box 3207, Duke University Medical Center, Durham, North Carolina 27710, USA
Schizophr Res 102:108-15. 2008..An education-correction factor was calculated and recommended only for non-schizophrenia patients. Eight different verbal memory tests were found to have equivalent levels of difficulty... - Generalization of training effects in schizophreniaA S Bellack
VA Capitol Network MIRECC, University of Maryland School of Medicine, 737 West Lombard Street, 21201, Baltimore, MD, USA
Schizophr Res 48:255-62. 2001..56, P<0.05). The implications of these findings for rehabilitation programs were discussed, and recommendations were made for future research... - Patients with schizophrenia have a reduced neural response to both unpredictable and predictable primary reinforcersJames A Waltz
Department of Psychiatry, Maryland Psychiatric Research Center, University of Maryland School of Medicine, PO Box 21247, Baltimore, MD 21228, USA
Neuropsychopharmacology 34:1567-77. 2009..These results provide evidence that SZ patients show abnormal brain responses associated with the processing of a primary reinforcer, which may be a source of motivational deficits... - Abnormal responses to monetary outcomes in cortex, but not in the basal ganglia, in schizophreniaJames A Waltz
Department of Psychiatry, University of Maryland School of Medicine, Maryland Psychiatric Research Center, Baltimore, MD 21228, USA
Neuropsychopharmacology 35:2427-39. 2010.... - General and specific cognitive deficits in schizophrenia: Goliath defeats David?Dwight Dickinson
VA Capitol Health Care Network Mental Illness Research, Education and Clinical Center, Education and Clinical Center, Baltimore, Maryland 21201, USA
Biol Psychiatry 64:823-7. 2008..Current analyses sought to extend these findings... - Anticipatory vs. consummatory pleasure: what is the nature of hedonic deficits in schizophrenia?Gregory P Strauss
Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA
Psychiatry Res 187:36-41. 2011..74). These findings suggest that additional studies are needed using the TEPS, as well as other measures, to determine the nature of anhedonia in individuals with schizophrenia... - Cognitive rehabilitation for schizophrenia and the putative role of motivation and expectanciesDawn I Velligan
Department of Psychiatry, University of Texas Health Science Center at San Antonio, USA
Schizophr Bull 32:474-85. 2006..Although a number of current CR approaches address motivation to varying degrees, treating motivation as a primary target may be needed to maximize CR outcomes... - The Wisconsin Card Sorting impairment in schizophrenia is evident in the first four trialsKristen J Prentice
University of Maryland School of Medicine, Department of Psychiatry and Maryland Psychiatric Research Center, P O Box 21247, Baltimore, MD 21228, USA
Schizophr Res 106:81-7. 2008..In this study we tested the hypothesis that SZ patients, due to dysregulated error-processing mechanisms, are more fundamentally impaired in their on-line, trial-to-trial use of feedback to guide behavior... - Galantamine for the treatment of cognitive impairments in people with schizophreniaRobert W Buchanan
Department of Psychiatry, University of Maryland, Baltimore, MD, USA
Am J Psychiatry 165:82-9. 2008.... - A randomized double-blind trial of atomoxetine for cognitive impairments in 32 people with schizophreniaDeanna L Kelly
Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore, MD 21228, USA
J Clin Psychiatry 70:518-25. 2009..In animals, it has been shown to increase extracellular levels of acetylcholine and dopamine in cortical and hippocampal regions... - Probabilistic reversal learning impairments in schizophrenia: further evidence of orbitofrontal dysfunctionJames A Waltz
Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore, Maryland 21228, United States
Schizophr Res 93:296-303. 2007..Further studies are required to investigate the roles of dopaminergic systems in these impairments... - A randomized, controlled trial of computer-assisted cognitive remediation for schizophreniaDwight Dickinson
Mental Illness Research, Education and Clinical Center, VISN 5, VA Medical Center, Suite 6A BT MIRECC, 10 North Greene St, Baltimore, MD 21201, USA
Am J Psychiatry 167:170-80. 2010..The goal of the current study was to develop a broadly targeted computer-assisted cognitive remediation program and conduct a rigorous clinical trial in a large group of schizophrenia patients... - Olanzapine treatment of residual positive and negative symptomsRobert W Buchanan
Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland, Baltimore 21228, USA
Am J Psychiatry 162:124-9. 2005..The authors examined the comparative efficacy and safety of olanzapine and haloperidol in outpatients with partially responsive schizophrenia... - Optimistic bias in the perception of personal risk: patterns in schizophreniaKristen J Prentice
Maryland Psychiatric Research Center, P O Box 21247, Baltimore, MD 21228, USA
Am J Psychiatry 162:507-12. 2005..The authors investigated whether schizophrenia patients share the same optimistic biases frequently demonstrated by non-ill adults in their perceptions of personal risk... - Working memory consolidation is abnormally slow in schizophreniaRebecca L Fuller
Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore, MD 21228, USA
J Abnorm Psychol 114:279-90. 2005..Slowed consolidation may play an important and largely unrecognized role in schizophrenia... - Schizophrenia in translation: the presence of absence: habenular regulation of dopamine neurons and the encoding of negative outcomesPaul D Shepard
Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore, USA
Schizophr Bull 32:417-21. 2006..Collectively, these data suggest that the habenula may play a critical role in mediating the feedback-processing deficits of schizophrenia... - Impaired control of visual attention in schizophreniaRebecca L Fuller
Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore, MD 21228, USA
J Abnorm Psychol 115:266-75. 2006..This pattern of results indicates that the primary impairment of attention in schizophrenia lies in the control of attention and not in the selection processes that operate once attention has been directed to an object... - Neuropsychology of the deficit syndrome: new data and meta-analysis of findings to dateAlex S Cohen
Department of Psychology, University of Maryland, College Park, USA
Schizophr Bull 33:1201-12. 2007..The question of whether deficit patients exhibit a unique cognitive impairment profile will require a more sophisticated and rigorous examination of the neuropsychology of the deficit syndrome... - Selective reinforcement learning deficits in schizophrenia support predictions from computational models of striatal-cortical dysfunctionJames A Waltz
Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore, Maryland 21228, USA
Biol Psychiatry 62:756-64. 2007..We investigated whether fronto-striatal dysfunction in schizophrenia (SZ) is characterized by selective impairment in either reward- (Go) or punishment-driven (NoGo) learning... - Optimizing vs. matching: response strategy in a probabilistic learning task is associated with negative symptoms of schizophreniaZuzana Kasanova
Department of Psychiatry, Maryland Psychiatric Research Center, University of Maryland School of Medicine, PO Box 21247, Baltimore, MD 21228, USA
Schizophr Res 127:215-22. 2011..These data provide a rare example of a greater clinical impairment being associated with better behavioral performance... - Deficits in positive reinforcement learning and uncertainty-driven exploration are associated with distinct aspects of negative symptoms in schizophreniaGregory P Strauss
Department of Psychiatry and Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore, MD 21228, USA
Biol Psychiatry 69:424-31. 2011..The current study examines whether deficits in reinforcement learning and uncertainty-driven exploration predict specific negative symptom domains... - A randomized clinical trial of MK-0777 for the treatment of cognitive impairments in people with schizophreniaRobert W Buchanan
Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Maple and Locust Streets, Baltimore, MD 21228, USA
Biol Psychiatry 69:442-9. 2011..The current study was designed to further examine the efficacy and safety of MK-0777 for the treatment of cognitive impairments in schizophrenia... - Altered probabilistic learning and response biases in schizophrenia: behavioral evidence and neurocomputational modelingJames A Waltz
Department of Psychiatry, University of Maryland School of Medicine, MD Psychiatric Research Center, P O Box 21247, Baltimore, MD 21228, USA
Neuropsychology 25:86-97. 2011..Patients with schizophrenia (SZ) show reinforcement learning impairments related to both the gradual/procedural acquisition of reward contingencies, and the ability to use trial-to-trial feedback to make rapid behavioral adjustments... - Brief cognitive assessment in schizophrenia: normative data for the Repeatable Battery for the Assessment of Neuropsychological StatusChristopher M Wilk
Maryland Psychiatric Research Center, PO Box 21247, Baltimore, MD 21228-0747, USA
Schizophr Res 70:175-86. 2004..CONCLUSIONS: The RBANS is an efficient screening tool for assessing cognitive impairment in patients with SC thereby making it a useful instrument for clinical and research applications... - A comparison of cognitive structure in schizophrenia patients and healthy controls using confirmatory factor analysisDwight Dickinson
Department of Psychiatry, University of Maryland School of Medicine, BT MIRECC, Baltimore, 21201, USA
Schizophr Res 85:20-9. 2006..Cognitive ability, as reflected in test performance, appears to be more unitary in schizophrenia than in healthy subjects. This finding may have measurement and treatment implications... - Less unique variance than meets the eye: overlap among traditional neuropsychological dimensions in schizophreniaDwight Dickinson
VISN 5 Mental Illness Research, Education and Clinical Center, Baltimore, MD 21201, USA
Schizophr Bull 34:423-34. 2008..The ability of such batteries to reveal cognitive domain-specific treatment effects in schizophrenia may be much more limited than is generally assumed... - Changing patterns of brain activation during maze learningJ D Van Horn
Clinical Brain Disorders Branch, NIMH, Neuroscience Center at St Elizabeth s Hospital, William A White Building, SE, Washington, DC 20032, USA
Brain Res 793:29-38. 1998.... - Factor structure of the Wechsler Adult Intelligence Scale-III in schizophreniaDwight Dickinson
Veterans Affairs Capitol Health Care Network Mental Illness Research, Education and Clinical Center, Baltimore, MD 21201, USA
Assessment 9:171-80. 2002.... - The translation of cognitive paradigms for patient researchSteven J Luck
Center for Mind and Brain, University of California, Davis, CA 95618, USA
Schizophr Bull 34:629-44. 2008..Finally, we present examples of 2 experiments, one of which exemplifies our recommendations regarding measurement issues and was a success and one of which was a painful but informative failure... - The speed of visual attention in schizophrenia: electrophysiological and behavioral evidenceSteven J Luck
Department of Psychology, University of Iowa, Iowa City, 52242 1407, USA
Schizophr Res 85:174-95. 2006.... - Functional co-primary measures for clinical trials in schizophrenia: results from the MATRICS Psychometric and Standardization StudyMichael F Green
Semel Institute for Neuroscience and Human Behavior, UCLA, 300 Medical Plaza, Rm 2263, Los Angeles, CA 90095 6968, USA
Am J Psychiatry 165:221-8. 2008..e., a co-primary) that is considered functionally meaningful. The goal of the current study was to describe steps to evaluate four potential co-primary measures for psychometric properties and validity... - The MATRICS Consensus Cognitive Battery, part 2: co-norming and standardizationRobert S Kern
Department of Psychology, Geffen School of Medicine, University of California, Los Angeles CA 90073, USA
Am J Psychiatry 165:214-20. 2008..S. community sample with the battery administered as a unit... - The MATRICS Consensus Cognitive Battery, part 1: test selection, reliability, and validityKeith H Nuechterlein
Department of Psychology, UCLA Semel Institute for Neuroscience and Human Behavior, 300 Medical Plaza, Rm 2251, Los Angeles, CA 90095 6968, USA
Am J Psychiatry 165:203-13. 2008.... - Baseline neurocognitive deficits in the CATIE schizophrenia trialRichard S E Keefe
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
Neuropsychopharmacology 31:2033-46. 2006..Multiple analyses suggested that a broad cognitive deficit characterizes this sample. These deficits are modestly related to negative symptoms and essentially independent of positive symptom severity... - Neurocognitive assessment in the Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) project schizophrenia trial: development, methodology, and rationaleRichard S E Keefe
Neurocognitive Assessment Unit, Duke University Medical Center, Durham, NC 27710, USA
Schizophr Bull 29:45-55. 2003.... - The Brief Assessment of Cognition in Schizophrenia: reliability, sensitivity, and comparison with a standard neurocognitive batteryRichard S E Keefe
Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, P O Box 3270, Durham, NC 27710, USA
Schizophr Res 68:283-97. 2004..76) and healthy controls (r=0.90). These psychometric properties make the BACS a promising tool for assessing cognition repeatedly in patients with schizophrenia, especially in clinical trials of cognitive enhancement... - Another view of therapy for cognition in schizophreniaWilliam T Carpenter
Biol Psychiatry 51:969-71. 2002 - The construct of attention in schizophreniaSteven J Luck
University of California at Davis, Davis, California, USA
Biol Psychiatry 64:34-9. 2008.... - Approaching a consensus cognitive battery for clinical trials in schizophrenia: the NIMH-MATRICS conference to select cognitive domains and test criteriaMichael F Green
Neuropsychiatric Institute, Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California, USA
Biol Psychiatry 56:301-7. 2004..The results from this meeting constitute the initial steps for reaching a consensus cognitive battery for clinical trials in schizophrenia... - Identification of separable cognitive factors in schizophreniaKeith H Nuechterlein
Department of Psychiatry and Biobehavioral Sciences, Geffen School of Medicine at UCLA, USA
Schizophr Res 72:29-39. 2004..These separable cognitive dimensions also have broader relevance to future research aimed at understanding the nature and structure of core cognitive deficits in schizophrenia... - Decision-making impairments in the context of intact reward sensitivity in schizophreniaErin A Heerey
School of Psychology, Bangor University, Gwynedd, United Kingdom
Biol Psychiatry 64:62-9. 2008..An alternate explanation is that sensitivity to rewards is intact but that poor integration of affective with cognitive information impairs the ability to use this information to guide behavior... - Enuresis as a premorbid developmental marker of schizophreniaThomas M Hyde
Clinical Brain Disorders Branch, NIMH DIRP NIH, Bethesda, MD 20892, USA
Brain 131:2489-98. 2008..These findings add to the evidence implicating prefrontal dysmaturation in this disorder, potentially related to genetic risk factors... - One-year double-blind study of the neurocognitive efficacy of olanzapine, risperidone, and haloperidol in schizophreniaRichard S E Keefe
Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, NC 27710, USA
Schizophr Res 81:1-15. 2006..Haloperidol-treated patients improved only on domains of learning/memory. However, patients able to remain in treatment for the entire 52 weeks benefited more from olanzapine or risperidone treatment than haloperidol treatment... - Social/communication skills, cognition, and vocational functioning in schizophreniaDwight Dickinson
Schizophr Bull 33:1213-20. 2007....
Research Grants
- 4/5-Cognitive Neuroscience Task Reliability & Clinical Applications ConsortiumJames Gold; Fiscal Year: 2009..Thus, we need to improve our methods for detecting and enhancing cognitive function in schizophrenia in order to help individuals with this illness lead more productive and fulfilling lives. ..
- Clinical and Computational Studies of Dopamine Function in SchizophreniaJames M Gold; Fiscal Year: 2010....
- Cognitive Neuroscience of Attention and Working Memory in SchizophreniaSteven J Luck; Fiscal Year: 2010..This research program is designed to increase understanding of the specific processes that are involved in these important areas of cognitive impairment. ..
- 4/5-Cognitive Neuroscience Task Reliability & Clinical Applications ConsortiumJames M Gold; Fiscal Year: 2010..Thus, we need to improve our methods for detecting and enhancing cognitive function in schizophrenia in order to help individuals with this illness lead more productive and fulfilling lives. ..
- Dopaminergic Mechanisms of Reward in SchizophreniaJames Gold; Fiscal Year: 2007..If successful, the proposed work is designed to establish the conceptual foundation and preliminary data needed to support individual RO1 applications and a Translational Center. ..
- Cognitive Neuroscience of Attention in SchizophreniaJames Gold; Fiscal Year: 2005....
- WORK OUTCOME IN SCHIZOPHRENIA--BRAIN FUNCTION/STRUCTUREJames Gold; Fiscal Year: 2002..Abnormalities present in both good and poor outcome groups are arguably fundamental features of the illness. ..
- 4/5-Cognitive Neuroscience Task Reliability & Clinical Applications ConsortiumJames M Gold; Fiscal Year: 2010..Thus, we need to improve our methods for detecting and enhancing cognitive function in schizophrenia in order to help individuals with this illness lead more productive and fulfilling lives. ..