J M Gold

Summary

Affiliation: University of Maryland
Country: USA

Publications

  1. ncbi request reprint Cognitive correlates of job tenure among patients with severe mental illness
    James M Gold
    Maryland Psychiatric Research Center and the Center for Mental Health Services Research, Department of Psychiatry, University of Maryland, Baltimore 21228, USA
    Am J Psychiatry 159:1395-402. 2002
  2. pmc Negative symptoms of schizophrenia are associated with abnormal effort-cost computations
    James M Gold
    Department of Psychiatry, University of Maryland School of Medicine and Maryland Psychiatric Research Center, Baltimore, MD 21228, USA
    Biol Psychiatry 74:130-6. 2013
  3. doi request reprint Negative symptoms and the failure to represent the expected reward value of actions: behavioral and computational modeling evidence
    James M Gold
    Department of Psychiatry, Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore, MD 21228, USA
    Arch Gen Psychiatry 69:129-38. 2012
  4. pmc Turning it upside down: areas of preserved cognitive function in schizophrenia
    James M Gold
    Maryland Psychiatric Research Center, University of Maryland School of Medicine, PO Box 21247, Baltimore, MD 21228, USA
    Neuropsychol Rev 19:294-311. 2009
  5. pmc Reward processing in schizophrenia: a deficit in the representation of value
    James M Gold
    Maryland Psychiatric Research Center, Baltimore, MD 21228, USA
    Schizophr Bull 34:835-47. 2008
  6. ncbi request reprint Cognitive deficits as treatment targets in schizophrenia
    James M Gold
    Department of Psychiatry, University of Maryland Baltimore School of Medicine, Maryland Psychiatric Research Center, Baltimore, MD 21228, USA
    Schizophr Res 72:21-8. 2004
  7. ncbi request reprint Working memory for visual features and conjunctions in schizophrenia
    James M Gold
    Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore 21228, USA
    J Abnorm Psychol 112:61-71. 2003
  8. ncbi request reprint The family pictures test as a measure of impaired feature binding in schizophrenia
    James M Gold
    Maryland Psychiatric Research Center, PO Box 21247, Baltimore, MD 21228, USA
    J Clin Exp Neuropsychol 26:511-20. 2004
  9. pmc Reduced capacity but spared precision and maintenance of working memory representations in schizophrenia
    James M Gold
    Maryland Psychiatric Research Center, Baltimore, MD 21228, USA
    Arch Gen Psychiatry 67:570-7. 2010
  10. ncbi request reprint Intact attentional control of working memory encoding in schizophrenia
    James M Gold
    Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore, MD, USA
    J Abnorm Psychol 115:658-73. 2006

Detail Information

Publications76

  1. ncbi request reprint Cognitive correlates of job tenure among patients with severe mental illness
    James M Gold
    Maryland Psychiatric Research Center and the Center for Mental Health Services Research, Department of Psychiatry, University of Maryland, Baltimore 21228, USA
    Am J Psychiatry 159:1395-402. 2002
    ..The objective of the present study was to examine the cognitive predictors of vocational functioning in the context of a controlled clinical trial by comparing two approaches to vocational rehabilitation...
  2. pmc Negative symptoms of schizophrenia are associated with abnormal effort-cost computations
    James M Gold
    Department of Psychiatry, University of Maryland School of Medicine and Maryland Psychiatric Research Center, Baltimore, MD 21228, USA
    Biol Psychiatry 74:130-6. 2013
    ..On the basis of evidence of dysfunction in these systems in schizophrenia (SZ), we examined whether effort-cost computations were impaired in SZ patients and whether these deficits were associated with negative symptoms...
  3. doi request reprint Negative symptoms and the failure to represent the expected reward value of actions: behavioral and computational modeling evidence
    James M Gold
    Department of Psychiatry, Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore, MD 21228, USA
    Arch Gen Psychiatry 69:129-38. 2012
    ..Negative symptoms are a core feature of schizophrenia, but their pathogenesis remains unclear. Negative symptoms are defined by the absence of normal function. However, there must be a productive mechanism that leads to this absence...
  4. pmc Turning it upside down: areas of preserved cognitive function in schizophrenia
    James M Gold
    Maryland Psychiatric Research Center, University of Maryland School of Medicine, PO Box 21247, Baltimore, MD 21228, USA
    Neuropsychol Rev 19:294-311. 2009
    ..The documentation of preserved cognitive function in schizophrenia may serve to sharpen hypotheses about the biological mechanisms that are implicated in the illness...
  5. pmc Reward processing in schizophrenia: a deficit in the representation of value
    James M Gold
    Maryland Psychiatric Research Center, Baltimore, MD 21228, USA
    Schizophr Bull 34:835-47. 2008
    ..In contrast, patients often (but not always) approach normal performance levels on the slow learning achieved by the integration of reinforcement signals over many trials, thought to be mediated by the basal ganglia...
  6. ncbi request reprint Cognitive deficits as treatment targets in schizophrenia
    James M Gold
    Department of Psychiatry, University of Maryland Baltimore School of Medicine, Maryland Psychiatric Research Center, Baltimore, MD 21228, USA
    Schizophr Res 72:21-8. 2004
    ..Thus, cognitive impairment appears to be a well-defined, reliable and distinct dimension of the illness...
  7. ncbi request reprint Working memory for visual features and conjunctions in schizophrenia
    James M Gold
    Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore 21228, USA
    J Abnorm Psychol 112:61-71. 2003
    ..Thus, the WM impairment in schizophrenia appears to be a consequence of attentional deficits rather than a reduction in storage capacity...
  8. ncbi request reprint The family pictures test as a measure of impaired feature binding in schizophrenia
    James M Gold
    Maryland Psychiatric Research Center, PO Box 21247, Baltimore, MD 21228, USA
    J Clin Exp Neuropsychol 26:511-20. 2004
    ..Such feature binding deficits likely implicate hippocampal dysfunction, consistent with neuroimaging evidence of structural and functional compromise of the medial temporal lobe in schizophrenia...
  9. pmc Reduced capacity but spared precision and maintenance of working memory representations in schizophrenia
    James M Gold
    Maryland Psychiatric Research Center, Baltimore, MD 21228, USA
    Arch Gen Psychiatry 67:570-7. 2010
    ..Working memory deficits are considered a core feature of schizophrenia. Several recent integrative articles have offered mechanistic computational and neurobiological models of the origins of this cognitive deficit...
  10. ncbi request reprint Intact attentional control of working memory encoding in schizophrenia
    James M Gold
    Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore, MD, USA
    J Abnorm Psychol 115:658-73. 2006
    ..These findings indicate that attention is not globally impaired in SC and make it possible to delineate more precisely the nature of the specific impairment of attention in this disorder...
  11. pmc Impaired top-down control of visual search in schizophrenia
    James M Gold
    Maryland Psychiatric Research Center, University of Maryland School of Medicine, PO Box 21247, Baltimore, Maryland 21228, United States
    Schizophr Res 94:148-55. 2007
    ..These results extend prior studies that have focused on aspects of executive control in complex tasks and suggest that a similar underlying deficit may also impact the performance of perceptual systems...
  12. pmc Clinical, functional, and intertask correlations of measures developed by the Cognitive Neuroscience Test Reliability and Clinical Applications for Schizophrenia Consortium
    James M Gold
    Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, PO Box 21247, Baltimore, MD 21228, USA
    Schizophr Bull 38:144-52. 2012
    ..These results suggest that the CNTRACS tasks measure discrete cognitive abilities, some of which relate to aspects of functional capacity/outcome in schizophrenia...
  13. ncbi request reprint Repeatable battery for the assessment of neuropsychological status as a screening test in schizophrenia I: sensitivity, reliability, and validity
    J M Gold
    Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland at Baltimore, 21228, USA
    Am J Psychiatry 156:1944-50. 1999
    ..This newly published test takes 25 minutes to administer and was standardized on a U.S.-Census-matched adult population. The test provides a total score and five index scores, each with a mean value of 100 (SD = 15)...
  14. ncbi request reprint Learning and forgetting in schizophrenia
    J M Gold
    National Institute of Mental Health Neuroscience Center, St Elizabeth s, Washington, D C, USA
    J Abnorm Psychol 109:534-8. 2000
    ..The results suggest a primary deficit in the initial acquisition of information rather than an accelerated rate of forgetting in schizophrenia...
  15. pmc Learning-related changes in brain activity following errors and performance feedback in schizophrenia
    Sarah E Morris
    VA Capitol Network VISN 5 Mental Illness Research, Education, and Clinical Center, 10 No Greene St, Baltimore, MD 21201, USA
    Schizophr Res 99:274-85. 2008
    ..These findings suggest that reward-related brain activity is weakened in schizophrenia, perhaps reflecting diminished sensitivity to whether ongoing events are better or worse than expected...
  16. ncbi request reprint Patients with schizophrenia demonstrate dissociation between affective experience and motivated behavior
    Erin A Heerey
    Maryland Psychiatric Research Center, University of Maryland Baltimore, Baltimore, MD, USA
    J Abnorm Psychol 116:268-78. 2007
    ..These data suggest that the motivational deficits in schizophrenia reflect problems in the ability to translate experience into action...
  17. ncbi request reprint Prediction of neuropsychological performance by neurological signs in schizophrenia
    C Arango
    Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore 21228, USA
    Am J Psychiatry 156:1349-57. 1999
    ....
  18. pmc Delay discounting in schizophrenia
    Erin A Heerey
    Maryland Psychiatric Research Center, University of Maryland, Baltimore, MD, USA
    Cogn Neuropsychiatry 12:213-21. 2007
    ..We used a delay discounting measure to test the degree to which patients make future-oriented decisions...
  19. ncbi request reprint Overlooking the obvious: a meta-analytic comparison of digit symbol coding tasks and other cognitive measures in schizophrenia
    Dwight Dickinson
    VISN 5 Mental Illness Research, Education and Clinical Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Arch Gen Psychiatry 64:532-42. 2007
    ..In focusing on potentially localizable cognitive impairments, the schizophrenia meta-analytic literature has overlooked the largest single impairment: on digit symbol coding tasks...
  20. pmc Initial phase 2 trial of a nicotinic agonist in schizophrenia
    Robert Freedman
    Department of Psychiatry, Denver VA Medical Center and University of Colorado, Denver, CO 80262, USA
    Am J Psychiatry 165:1040-7. 2008
    ..The agent 3-(2,4-dimethoxybenzylidene) anabaseine (DMXB-A) is a partial alpha(7)-nicotinic agonist and can be taken orally. A phase 1 trial showed evidence for cognitive enhancement in schizophrenia...
  21. ncbi request reprint The Cognitive and Negative Symptoms in Schizophrenia Trial (CONSIST): the efficacy of glutamatergic agents for negative symptoms and cognitive impairments
    Robert W Buchanan
    Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore, MD 21228, USA
    Am J Psychiatry 164:1593-602. 2007
    ..Agents that act at the glycine site of the N-methyl-D-aspartic acid (NMDA) glutamatergic receptor have been suggested as promising treatments for moderate to severe negative symptoms and cognitive impairments...
  22. ncbi request reprint Decisional capacity for informed consent in schizophrenia research
    W T Carpenter
    Maryland Psychiatric Research Center and the Department of Psychiatry, University of Maryland, Baltimore 21228, USA
    Arch Gen Psychiatry 57:533-8. 2000
    ....
  23. pmc Spatial working memory as a cognitive endophenotype of schizophrenia: assessing risk for pathophysiological dysfunction
    Alice M Saperstein
    Department of Psychology, University of Maryland, College Park, 20742, USA
    Schizophr Bull 32:498-506. 2006
    ..This is particularly relevant for research efforts to identify pathophysiological components of the disease...
  24. ncbi request reprint Neurocognitive effects of antipsychotic medications in patients with chronic schizophrenia in the CATIE Trial
    Richard S E Keefe
    Department of Psychiatry, John Umstead Hospital, Duke University Medical Center, Durham, NC 27710, USA
    Arch Gen Psychiatry 64:633-47. 2007
    ..The relative effect of the second-generation (atypical) antipsychotic drugs and older agents on neurocognition has not been comprehensively determined...
  25. ncbi request reprint No, it is not possible to be schizophrenic yet neuropsychologically normal
    Christopher M Wilk
    Maryland Psychiatric Research Center, University of Maryland School of Medicine, Department of Psychiatry, Baltimore, MD 21228 0747, and Mental Illness Research, Education, and Clinical Center, Veterans Affairs Capital Health Care Network, USA
    Neuropsychology 19:778-86. 2005
    ..Thus, scoring in the normal range does not preclude neuropsychological abnormality in schizophrenia, confirming that neuropsychological impairment is a core feature of the illness...
  26. ncbi request reprint Correlates of insight in serious mental illness
    R W Goldberg
    Veterans Administration Capitol Healthcare Network Mental Illness Research, Education and Clinical Center, Department of Psychiatry, The University of Maryland, Baltimore, School of Medicine, 21201, USA
    J Nerv Ment Dis 189:137-45. 2001
    ..Findings also support a need for continued investigation of how mental illness is understood, experienced, and expressed across diverse groups of people living with mental illness...
  27. ncbi request reprint Correlates of long-term unemployment among inner-city adults with serious and persistent mental illness
    R W Goldberg
    Department of Psychiatry, University of Maryland, Baltimore 21201, USA
    Psychiatr Serv 52:101-3. 2001
    ..The findings underscore the relevance of clinical and neurocognitive impairments to long-term unemployment and point to the need to critically reevaluate the effectiveness of traditional vocational rehabilitation services...
  28. ncbi request reprint Test-retest stability of the Repeatable Battery for the Assessment of Neuropsychological Status in schizophrenia
    Christopher M Wilk
    Maryland Psychiatric Research Center, Sheppard Pratt Health System, Baltimore, 21228 0747, USA
    Am J Psychiatry 159:838-44. 2002
    ..This study examined the test-retest stability of the RBANS in individual patients with schizophrenia relative to a healthy comparison group...
  29. pmc Impaired visual working memory consolidation in schizophrenia
    Rebecca L Fuller
    Maryland Psychiatric Research Center, University of Maryland School of Medicine, MD, USA
    Neuropsychology 23:71-80. 2009
    ..These data demonstrate abnormally prolonged WM consolidation in schizophrenia. This impairment may slow the formation of stable representations of the visual environment, impacting everyday visually guided behavior...
  30. ncbi request reprint Current progress in schizophrenia research: cognitive phenotypes of schizophrenia: attention
    James M Gold
    Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, MD 21228, USA
    J Nerv Ment Dis 190:638-9. 2002
  31. doi request reprint Norms and standardization of the Brief Assessment of Cognition in Schizophrenia (BACS)
    Richard S E Keefe
    Department of Psychiatry, Box 3207, Duke University Medical Center, Durham, North Carolina 27710, USA
    Schizophr Res 102:108-15. 2008
    ..An education-correction factor was calculated and recommended only for non-schizophrenia patients. Eight different verbal memory tests were found to have equivalent levels of difficulty...
  32. doi request reprint Evidence of exacerbated cognitive deficits in schizophrenia patients with comorbid diabetes
    Dwight Dickinson
    VISN 5 Mental Illness Research, Education, and Clinical Center, Baltimore, MD 21201, USA
    Psychosomatics 49:123-31. 2008
    ....
  33. ncbi request reprint General and specific cognitive deficits in schizophrenia
    Dwight Dickinson
    Veterans Affairs Capitol Health Care Network, Mental Illness Research, Education, and Clinical Center, 10 North Greene Street, Suite 6A, Baltimore, MD 21201, USA
    Biol Psychiatry 55:826-33. 2004
    ..The issue has implications for assessment practice, intervention design, and the exploration of schizophrenia genetics...
  34. ncbi request reprint Generalization of training effects in schizophrenia
    A S Bellack
    VA Capitol Network MIRECC, University of Maryland School of Medicine, 737 West Lombard Street, 21201, Baltimore, MD, USA
    Schizophr Res 48:255-62. 2001
    ..56, P<0.05). The implications of these findings for rehabilitation programs were discussed, and recommendations were made for future research...
  35. pmc Patients with schizophrenia have a reduced neural response to both unpredictable and predictable primary reinforcers
    James A Waltz
    Department of Psychiatry, Maryland Psychiatric Research Center, University of Maryland School of Medicine, PO Box 21247, Baltimore, MD 21228, USA
    Neuropsychopharmacology 34:1567-77. 2009
    ..These results provide evidence that SZ patients show abnormal brain responses associated with the processing of a primary reinforcer, which may be a source of motivational deficits...
  36. doi request reprint A randomized, controlled trial of computer-assisted cognitive remediation for schizophrenia
    Dwight Dickinson
    Mental Illness Research, Education and Clinical Center, VISN 5, VA Medical Center, Suite 6A BT MIRECC, 10 North Greene St, Baltimore, MD 21201, USA
    Am J Psychiatry 167:170-80. 2010
    ..The goal of the current study was to develop a broadly targeted computer-assisted cognitive remediation program and conduct a rigorous clinical trial in a large group of schizophrenia patients...
  37. pmc Abnormal responses to monetary outcomes in cortex, but not in the basal ganglia, in schizophrenia
    James A Waltz
    Department of Psychiatry, University of Maryland School of Medicine, Maryland Psychiatric Research Center, Baltimore, MD 21228, USA
    Neuropsychopharmacology 35:2427-39. 2010
    ....
  38. ncbi request reprint Galantamine for the treatment of cognitive impairments in people with schizophrenia
    Robert W Buchanan
    Department of Psychiatry, University of Maryland, Baltimore, MD, USA
    Am J Psychiatry 165:82-9. 2008
    ....
  39. pmc Anticipatory vs. consummatory pleasure: what is the nature of hedonic deficits in schizophrenia?
    Gregory P Strauss
    Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA
    Psychiatry Res 187:36-41. 2011
    ..74). These findings suggest that additional studies are needed using the TEPS, as well as other measures, to determine the nature of anhedonia in individuals with schizophrenia...
  40. doi request reprint General and specific cognitive deficits in schizophrenia: Goliath defeats David?
    Dwight Dickinson
    VA Capitol Health Care Network Mental Illness Research, Education and Clinical Center, Education and Clinical Center, Baltimore, Maryland 21201, USA
    Biol Psychiatry 64:823-7. 2008
    ..Current analyses sought to extend these findings...
  41. ncbi request reprint A randomized double-blind trial of atomoxetine for cognitive impairments in 32 people with schizophrenia
    Deanna L Kelly
    Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore, MD 21228, USA
    J Clin Psychiatry 70:518-25. 2009
    ..In animals, it has been shown to increase extracellular levels of acetylcholine and dopamine in cortical and hippocampal regions...
  42. pmc Probabilistic reversal learning impairments in schizophrenia: further evidence of orbitofrontal dysfunction
    James A Waltz
    Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore, Maryland 21228, United States
    Schizophr Res 93:296-303. 2007
    ..Further studies are required to investigate the roles of dopaminergic systems in these impairments...
  43. ncbi request reprint Olanzapine treatment of residual positive and negative symptoms
    Robert W Buchanan
    Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland, Baltimore 21228, USA
    Am J Psychiatry 162:124-9. 2005
    ..The authors examined the comparative efficacy and safety of olanzapine and haloperidol in outpatients with partially responsive schizophrenia...
  44. ncbi request reprint Optimistic bias in the perception of personal risk: patterns in schizophrenia
    Kristen J Prentice
    Maryland Psychiatric Research Center, P O Box 21247, Baltimore, MD 21228, USA
    Am J Psychiatry 162:507-12. 2005
    ..The authors investigated whether schizophrenia patients share the same optimistic biases frequently demonstrated by non-ill adults in their perceptions of personal risk...
  45. ncbi request reprint Working memory consolidation is abnormally slow in schizophrenia
    Rebecca L Fuller
    Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore, MD 21228, USA
    J Abnorm Psychol 114:279-90. 2005
    ..Slowed consolidation may play an important and largely unrecognized role in schizophrenia...
  46. pmc Cognitive rehabilitation for schizophrenia and the putative role of motivation and expectancies
    Dawn I Velligan
    Department of Psychiatry, University of Texas Health Science Center at San Antonio, USA
    Schizophr Bull 32:474-85. 2006
    ..Although a number of current CR approaches address motivation to varying degrees, treating motivation as a primary target may be needed to maximize CR outcomes...
  47. pmc Schizophrenia in translation: the presence of absence: habenular regulation of dopamine neurons and the encoding of negative outcomes
    Paul D Shepard
    Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore, USA
    Schizophr Bull 32:417-21. 2006
    ..Collectively, these data suggest that the habenula may play a critical role in mediating the feedback-processing deficits of schizophrenia...
  48. ncbi request reprint Impaired control of visual attention in schizophrenia
    Rebecca L Fuller
    Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore, MD 21228, USA
    J Abnorm Psychol 115:266-75. 2006
    ..This pattern of results indicates that the primary impairment of attention in schizophrenia lies in the control of attention and not in the selection processes that operate once attention has been directed to an object...
  49. pmc The Wisconsin Card Sorting impairment in schizophrenia is evident in the first four trials
    Kristen J Prentice
    University of Maryland School of Medicine, Department of Psychiatry and Maryland Psychiatric Research Center, P O Box 21247, Baltimore, MD 21228, USA
    Schizophr Res 106:81-7. 2008
    ..In this study we tested the hypothesis that SZ patients, due to dysregulated error-processing mechanisms, are more fundamentally impaired in their on-line, trial-to-trial use of feedback to guide behavior...
  50. pmc Neuropsychology of the deficit syndrome: new data and meta-analysis of findings to date
    Alex S Cohen
    Department of Psychology, University of Maryland, College Park, USA
    Schizophr Bull 33:1201-12. 2007
    ..The question of whether deficit patients exhibit a unique cognitive impairment profile will require a more sophisticated and rigorous examination of the neuropsychology of the deficit syndrome...
  51. pmc Selective reinforcement learning deficits in schizophrenia support predictions from computational models of striatal-cortical dysfunction
    James A Waltz
    Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore, Maryland 21228, USA
    Biol Psychiatry 62:756-64. 2007
    ..We investigated whether fronto-striatal dysfunction in schizophrenia (SZ) is characterized by selective impairment in either reward- (Go) or punishment-driven (NoGo) learning...
  52. pmc A randomized clinical trial of MK-0777 for the treatment of cognitive impairments in people with schizophrenia
    Robert W Buchanan
    Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Maple and Locust Streets, Baltimore, MD 21228, USA
    Biol Psychiatry 69:442-9. 2011
    ..The current study was designed to further examine the efficacy and safety of MK-0777 for the treatment of cognitive impairments in schizophrenia...
  53. pmc Optimizing vs. matching: response strategy in a probabilistic learning task is associated with negative symptoms of schizophrenia
    Zuzana Kasanova
    Department of Psychiatry, Maryland Psychiatric Research Center, University of Maryland School of Medicine, PO Box 21247, Baltimore, MD 21228, USA
    Schizophr Res 127:215-22. 2011
    ..These data provide a rare example of a greater clinical impairment being associated with better behavioral performance...
  54. pmc Deficits in positive reinforcement learning and uncertainty-driven exploration are associated with distinct aspects of negative symptoms in schizophrenia
    Gregory P Strauss
    Department of Psychiatry and Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore, MD 21228, USA
    Biol Psychiatry 69:424-31. 2011
    ..The current study examines whether deficits in reinforcement learning and uncertainty-driven exploration predict specific negative symptom domains...
  55. pmc Altered probabilistic learning and response biases in schizophrenia: behavioral evidence and neurocomputational modeling
    James A Waltz
    Department of Psychiatry, University of Maryland School of Medicine, MD Psychiatric Research Center, P O Box 21247, Baltimore, MD 21228, USA
    Neuropsychology 25:86-97. 2011
    ..Patients with schizophrenia (SZ) show reinforcement learning impairments related to both the gradual/procedural acquisition of reward contingencies, and the ability to use trial-to-trial feedback to make rapid behavioral adjustments...
  56. ncbi request reprint A comparison of cognitive structure in schizophrenia patients and healthy controls using confirmatory factor analysis
    Dwight Dickinson
    Department of Psychiatry, University of Maryland School of Medicine, BT MIRECC, Baltimore, 21201, USA
    Schizophr Res 85:20-9. 2006
    ..Cognitive ability, as reflected in test performance, appears to be more unitary in schizophrenia than in healthy subjects. This finding may have measurement and treatment implications...
  57. ncbi request reprint Brief cognitive assessment in schizophrenia: normative data for the Repeatable Battery for the Assessment of Neuropsychological Status
    Christopher M Wilk
    Maryland Psychiatric Research Center, PO Box 21247, Baltimore, MD 21228 0747, USA
    Schizophr Res 70:175-86. 2004
    ..Prior studies have established the clinical validity and test-retest reliability of the RBANS in SC...
  58. pmc Less unique variance than meets the eye: overlap among traditional neuropsychological dimensions in schizophrenia
    Dwight Dickinson
    VISN 5 Mental Illness Research, Education and Clinical Center, Baltimore, MD 21201, USA
    Schizophr Bull 34:423-34. 2008
    ..The ability of such batteries to reveal cognitive domain-specific treatment effects in schizophrenia may be much more limited than is generally assumed...
  59. ncbi request reprint Changing patterns of brain activation during maze learning
    J D Van Horn
    Clinical Brain Disorders Branch, NIMH, Neuroscience Center at St Elizabeth s Hospital, William A White Building, SE, Washington, DC 20032, USA
    Brain Res 793:29-38. 1998
    ....
  60. ncbi request reprint Factor structure of the Wechsler Adult Intelligence Scale-III in schizophrenia
    Dwight Dickinson
    Veterans Affairs Capitol Health Care Network Mental Illness Research, Education and Clinical Center, Baltimore, MD 21201, USA
    Assessment 9:171-80. 2002
    ....
  61. ncbi request reprint Another view of therapy for cognition in schizophrenia
    William T Carpenter
    Biol Psychiatry 51:969-71. 2002
  62. ncbi request reprint The Brief Assessment of Cognition in Schizophrenia: reliability, sensitivity, and comparison with a standard neurocognitive battery
    Richard S E Keefe
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, P O Box 3270, Durham, NC 27710, USA
    Schizophr Res 68:283-97. 2004
    ..76) and healthy controls (r=0.90). These psychometric properties make the BACS a promising tool for assessing cognition repeatedly in patients with schizophrenia, especially in clinical trials of cognitive enhancement...
  63. ncbi request reprint Neurocognitive assessment in the Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) project schizophrenia trial: development, methodology, and rationale
    Richard S E Keefe
    Neurocognitive Assessment Unit, Duke University Medical Center, Durham, NC 27710, USA
    Schizophr Bull 29:45-55. 2003
    ....
  64. ncbi request reprint Approaching a consensus cognitive battery for clinical trials in schizophrenia: the NIMH-MATRICS conference to select cognitive domains and test criteria
    Michael F Green
    Neuropsychiatric Institute, Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California, USA
    Biol Psychiatry 56:301-7. 2004
    ..The results from this meeting constitute the initial steps for reaching a consensus cognitive battery for clinical trials in schizophrenia...
  65. ncbi request reprint Identification of separable cognitive factors in schizophrenia
    Keith H Nuechterlein
    Department of Psychiatry and Biobehavioral Sciences, Geffen School of Medicine at UCLA, USA
    Schizophr Res 72:29-39. 2004
    ..These separable cognitive dimensions also have broader relevance to future research aimed at understanding the nature and structure of core cognitive deficits in schizophrenia...
  66. pmc Social/communication skills, cognition, and vocational functioning in schizophrenia
    Dwight Dickinson
    Schizophr Bull 33:1213-20. 2007
    ....
  67. ncbi request reprint Baseline neurocognitive deficits in the CATIE schizophrenia trial
    Richard S E Keefe
    Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA
    Neuropsychopharmacology 31:2033-46. 2006
    ..Multiple analyses suggested that a broad cognitive deficit characterizes this sample. These deficits are modestly related to negative symptoms and essentially independent of positive symptom severity...
  68. doi request reprint Functional co-primary measures for clinical trials in schizophrenia: results from the MATRICS Psychometric and Standardization Study
    Michael F Green
    Semel Institute for Neuroscience and Human Behavior, UCLA, 300 Medical Plaza, Rm 2263, Los Angeles, CA 90095 6968, USA
    Am J Psychiatry 165:221-8. 2008
    ..e., a co-primary) that is considered functionally meaningful. The goal of the current study was to describe steps to evaluate four potential co-primary measures for psychometric properties and validity...
  69. doi request reprint The MATRICS Consensus Cognitive Battery, part 2: co-norming and standardization
    Robert S Kern
    Department of Psychology, Geffen School of Medicine, University of California, Los Angeles CA 90073, USA
    Am J Psychiatry 165:214-20. 2008
    ..S. community sample with the battery administered as a unit...
  70. doi request reprint The MATRICS Consensus Cognitive Battery, part 1: test selection, reliability, and validity
    Keith H Nuechterlein
    Department of Psychology, UCLA Semel Institute for Neuroscience and Human Behavior, 300 Medical Plaza, Rm 2251, Los Angeles, CA 90095 6968, USA
    Am J Psychiatry 165:203-13. 2008
    ....
  71. pmc The construct of attention in schizophrenia
    Steven J Luck
    University of California at Davis, Davis, California, USA
    Biol Psychiatry 64:34-9. 2008
    ....
  72. pmc Decision-making impairments in the context of intact reward sensitivity in schizophrenia
    Erin A Heerey
    School of Psychology, Bangor University, Gwynedd, United Kingdom
    Biol Psychiatry 64:62-9. 2008
    ..An alternate explanation is that sensitivity to rewards is intact but that poor integration of affective with cognitive information impairs the ability to use this information to guide behavior...
  73. ncbi request reprint The speed of visual attention in schizophrenia: electrophysiological and behavioral evidence
    Steven J Luck
    Department of Psychology, University of Iowa, Iowa City, 52242 1407, USA
    Schizophr Res 85:174-95. 2006
    ....
  74. ncbi request reprint One-year double-blind study of the neurocognitive efficacy of olanzapine, risperidone, and haloperidol in schizophrenia
    Richard S E Keefe
    Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, NC 27710, USA
    Schizophr Res 81:1-15. 2006
    ..Haloperidol-treated patients improved only on domains of learning/memory. However, patients able to remain in treatment for the entire 52 weeks benefited more from olanzapine or risperidone treatment than haloperidol treatment...
  75. pmc Enuresis as a premorbid developmental marker of schizophrenia
    Thomas M Hyde
    Clinical Brain Disorders Branch, NIMH DIRP NIH, Bethesda, MD 20892, USA
    Brain 131:2489-98. 2008
    ..These findings add to the evidence implicating prefrontal dysmaturation in this disorder, potentially related to genetic risk factors...
  76. pmc The translation of cognitive paradigms for patient research
    Steven J Luck
    Center for Mind and Brain, University of California, Davis, CA 95618, USA
    Schizophr Bull 34:629-44. 2008
    ..Finally, we present examples of 2 experiments, one of which exemplifies our recommendations regarding measurement issues and was a success and one of which was a painful but informative failure...

Research Grants21

  1. Clinical and Computational Studies of Dopamine Function in Schizophrenia
    James Gold; Fiscal Year: 2009
    ....
  2. Cognitive Neuroscience of Attention and Working Memory in Schizophrenia
    James Gold; Fiscal Year: 2009
    ..This research program is designed to increase understanding of the specific processes that are involved in these important areas of cognitive impairment. ..
  3. 4/5-Cognitive Neuroscience Task Reliability & Clinical Applications Consortium
    James Gold; Fiscal Year: 2009
    ..Thus, we need to improve our methods for detecting and enhancing cognitive function in schizophrenia in order to help individuals with this illness lead more productive and fulfilling lives. ..
  4. Clinical and Computational Studies of Dopamine Function in Schizophrenia
    James M Gold; Fiscal Year: 2010
    ....
  5. Cognitive Neuroscience of Attention and Working Memory in Schizophrenia
    Steven J Luck; Fiscal Year: 2010
    ..This research program is designed to increase understanding of the specific processes that are involved in these important areas of cognitive impairment. ..
  6. 4/5-Cognitive Neuroscience Task Reliability & Clinical Applications Consortium
    James M Gold; Fiscal Year: 2010
    ..Thus, we need to improve our methods for detecting and enhancing cognitive function in schizophrenia in order to help individuals with this illness lead more productive and fulfilling lives. ..
  7. Dopaminergic Mechanisms of Reward in Schizophrenia
    James Gold; Fiscal Year: 2007
    ..If successful, the proposed work is designed to establish the conceptual foundation and preliminary data needed to support individual RO1 applications and a Translational Center. ..
  8. Cognitive Neuroscience of Attention in Schizophrenia
    James Gold; Fiscal Year: 2005
    ....
  9. WORK OUTCOME IN SCHIZOPHRENIA--BRAIN FUNCTION/STRUCTURE
    James Gold; Fiscal Year: 1999
    ..Abnormalities present in both good and poor outcome groups are arguably fundamental features of the illness. ..
  10. WORK OUTCOME IN SCHIZOPHRENIA--BRAIN FUNCTION/STRUCTURE
    James Gold; Fiscal Year: 2000
    ..Abnormalities present in both good and poor outcome groups are arguably fundamental features of the illness. ..
  11. WORK OUTCOME IN SCHIZOPHRENIA--BRAIN FUNCTION/STRUCTURE
    James Gold; Fiscal Year: 2001
    ..Abnormalities present in both good and poor outcome groups are arguably fundamental features of the illness. ..
  12. Cognitive Neuroscience of Attention in Schizophrenia
    James Gold; Fiscal Year: 2001
    ....
  13. Cognitive Neuroscience of Attention in Schizophrenia
    James Gold; Fiscal Year: 2002
    ....
  14. WORK OUTCOME IN SCHIZOPHRENIA--BRAIN FUNCTION/STRUCTURE
    James Gold; Fiscal Year: 2002
    ..Abnormalities present in both good and poor outcome groups are arguably fundamental features of the illness. ..
  15. Cognitive Neuroscience of Attention in Schizophrenia
    James Gold; Fiscal Year: 2003
    ....
  16. Cognitive Neuroscience of Attention in Schizophrenia
    James Gold; Fiscal Year: 2004
    ....
  17. 4/5-Cognitive Neuroscience Task Reliability & Clinical Applications Consortium
    James M Gold; Fiscal Year: 2010
    ..Thus, we need to improve our methods for detecting and enhancing cognitive function in schizophrenia in order to help individuals with this illness lead more productive and fulfilling lives. ..