Neriman Gokden

Summary

Affiliation: University of Arkansas for Medical Sciences
Country: USA

Publications

  1. doi request reprint Loss of heterozygosity of DNA repair gene, hOGG1, in renal cell carcinoma but not in renal papillary adenoma
    Neriman Gokden
    Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
    Pathol Int 58:339-43. 2008
  2. doi request reprint Morphologic heterogeneity of renal light-chain deposition disease
    Neriman Gokden
    Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
    Ultrastruct Pathol 32:17-24. 2008
  3. doi request reprint The utility of PAX-2 in distinguishing metastatic clear cell renal cell carcinoma from its morphologic mimics: an immunohistochemical study with comparison to renal cell carcinoma marker
    Neriman Gokden
    Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    Am J Surg Pathol 32:1462-7. 2008
  4. doi request reprint Renal sclerosing peritubular nodules in a patient with neurofibromatosis type 2: a case report with immunohistochemical and electron microscopic studies
    Neriman Gokden
    University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    Hum Pathol 40:1650-4. 2009
  5. ncbi request reprint Morphologic manifestations of combined light-chain deposition disease and light-chain cast nephropathy
    Neriman Gokden
    Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
    Ultrastruct Pathol 31:141-9. 2007
  6. ncbi request reprint Dermatofibrosarcoma protuberans of the vulva and groin: detection of COL1A1-PDGFB fusion transcripts by RT-PCR
    Neriman Gokden
    Lauren V Ackerman Laboratory of Surgical Pathology, Barnes Jewish Hospital, Washington University Medical Center, St Louis, MO, USA
    J Cutan Pathol 30:190-5. 2003
  7. pmc Development of oxidative stress in the peritubular capillary microenvironment mediates sepsis-induced renal microcirculatory failure and acute kidney injury
    Zhen Wang
    Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    Am J Pathol 180:505-16. 2012
  8. pmc Resveratrol improves renal microcirculation, protects the tubular epithelium, and prolongs survival in a mouse model of sepsis-induced acute kidney injury
    Joseph H Holthoff
    Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
    Kidney Int 81:370-8. 2012
  9. pmc Rolipram improves renal perfusion and function during sepsis in the mouse
    Joseph H Holthoff
    Department of Pharmacology and Toxicology J H H, Z W, N K P, P R M and Pathology N G, University of Arkansas for Medical Sciences, Little Rock, Arkansas
    J Pharmacol Exp Ther 347:357-64. 2013
  10. pmc Hemodynamic changes in the kidney in a pediatric rat model of sepsis-induced acute kidney injury
    Kathryn A Seely
    Dept of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, 4301 West Markham St, 611, Little Rock, AR 72205, USA
    Am J Physiol Renal Physiol 301:F209-17. 2011

Collaborators

Detail Information

Publications36

  1. doi request reprint Loss of heterozygosity of DNA repair gene, hOGG1, in renal cell carcinoma but not in renal papillary adenoma
    Neriman Gokden
    Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
    Pathol Int 58:339-43. 2008
    ..It is concluded that deletion of hOGG1 gene occurs commonly in PRCC and CC-RCC but not in renal cortical PA. Further studies are warranted to further explore the exact roles of hOGG1 gene in the development and progression of RCC...
  2. doi request reprint Morphologic heterogeneity of renal light-chain deposition disease
    Neriman Gokden
    Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
    Ultrastruct Pathol 32:17-24. 2008
    ..Immunofluorescence is more sensitive than EM for detection of LC for the definitive diagnosis of LCDD. This study supports the importance of utilizing kappa and lambda stains in the routine IF panel for diagnosis of LCDD...
  3. doi request reprint The utility of PAX-2 in distinguishing metastatic clear cell renal cell carcinoma from its morphologic mimics: an immunohistochemical study with comparison to renal cell carcinoma marker
    Neriman Gokden
    Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    Am J Surg Pathol 32:1462-7. 2008
    ....
  4. doi request reprint Renal sclerosing peritubular nodules in a patient with neurofibromatosis type 2: a case report with immunohistochemical and electron microscopic studies
    Neriman Gokden
    University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    Hum Pathol 40:1650-4. 2009
    ..We examined these peritubular proliferations with immunohistochemistry, histochemistry, and electron microscopy and compared our findings with the previous report in the literature...
  5. ncbi request reprint Morphologic manifestations of combined light-chain deposition disease and light-chain cast nephropathy
    Neriman Gokden
    Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
    Ultrastruct Pathol 31:141-9. 2007
    ..There were minimal or no glomerular changes by LM. This study shows the lack of characteristic LM findings of LCDD in combined cases of LCDD and LCCN and emphasizes the difficulty for-definitive diagnosis-without IF and EM...
  6. ncbi request reprint Dermatofibrosarcoma protuberans of the vulva and groin: detection of COL1A1-PDGFB fusion transcripts by RT-PCR
    Neriman Gokden
    Lauren V Ackerman Laboratory of Surgical Pathology, Barnes Jewish Hospital, Washington University Medical Center, St Louis, MO, USA
    J Cutan Pathol 30:190-5. 2003
    ..The trunk and extremities are the anatomic sites of predilection for DFSP, whereas the vulva and groin are quite uncommon sites of involvement...
  7. pmc Development of oxidative stress in the peritubular capillary microenvironment mediates sepsis-induced renal microcirculatory failure and acute kidney injury
    Zhen Wang
    Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    Am J Pathol 180:505-16. 2012
    ..These data demonstrate that renal hemodynamic changes occur early after sepsis and that targeting the later oxidant generation can break the cycle of injury and enable the microcirculation and renal function to recover...
  8. pmc Resveratrol improves renal microcirculation, protects the tubular epithelium, and prolongs survival in a mouse model of sepsis-induced acute kidney injury
    Joseph H Holthoff
    Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
    Kidney Int 81:370-8. 2012
    ..Hence, resveratrol may have a dual mechanism of action to restore the renal microcirculation and scavenge reactive nitrogen species, thus protecting the tubular epithelium even when administered after the onset of sepsis...
  9. pmc Rolipram improves renal perfusion and function during sepsis in the mouse
    Joseph H Holthoff
    Department of Pharmacology and Toxicology J H H, Z W, N K P, P R M and Pathology N G, University of Arkansas for Medical Sciences, Little Rock, Arkansas
    J Pharmacol Exp Ther 347:357-64. 2013
    ....
  10. pmc Hemodynamic changes in the kidney in a pediatric rat model of sepsis-induced acute kidney injury
    Kathryn A Seely
    Dept of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, 4301 West Markham St, 611, Little Rock, AR 72205, USA
    Am J Physiol Renal Physiol 301:F209-17. 2011
    ..Lower RBF and reduced peritubular capillary perfusion in the pup suggest the pediatric kidney may be more susceptible to AKI than would be predicted using adults models...
  11. ncbi request reprint Histopathology, ultrastructure, and clinical phenotypes in thin glomerular basement membrane disease variants
    Helen Liapis
    Department of Pathology, Renal Division and Cell Biology, Washington University School of Medicine, St Louis, MO 63110, USA
    Hum Pathol 33:836-45. 2002
    ..These patients have a TMD variant, but an Alport variant with a potentially transmissible severe defect different from benign hematuria cannot be excluded...
  12. doi request reprint The utility of PAX-2 and renal cell carcinoma marker immunohistochemistry in distinguishing papillary renal cell carcinoma from nonrenal cell neoplasms with papillary features
    Shree G Sharma
    Department of Pathology, University of Arkansas for Medical Sciences, 4301 West Markham Street 517, Little Rock, AR 72205, USA
    Appl Immunohistochem Mol Morphol 18:494-8. 2010
    ..PAX-2 and RCCma immunohistochemistry should be interpreted with caution in papillary neoplasms, with particular attention to the possibility of ovarian and uterine papillary serous carcinomas, which can express both PAX-2 and RCCma...
  13. ncbi request reprint Evidence for the role of reactive nitrogen species in polymicrobial sepsis-induced renal peritubular capillary dysfunction and tubular injury
    Liping Wu
    Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, 4301 West Markham Street 611, Little Rock, AR 72205, USA
    J Am Soc Nephrol 18:1807-15. 2007
    ..These data show that capillary dysfunction and RNS generation contribute to tubular injury and suggest that RNS should be considered a potential therapeutic target in the treatment of sepsis-induced AKI...
  14. ncbi request reprint Membranoproliferative injury pattern in a renal allograft
    Neriman Gokden
    Department of Pathology, Vanderbilt University Medical Center, Nashville, TN 37232 2561, USA
    Am J Kidney Dis 46:573-6. 2005
  15. ncbi request reprint Expression of CD138 (Syndecan-1) in renal cell carcinoma is reduced with increasing nuclear grade
    Neriman Gokden
    Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, AR, USA
    Appl Immunohistochem Mol Morphol 14:173-7. 2006
    ..2) or local stage (P=0.7). Metastatic foci showed a mild to moderate decrease in intensity compared with primary tumor. Decreased expression of CD138 may have a role in more aggressive behavior of clear-cell RCC...
  16. doi request reprint The distribution of PAX-2 immunoreactivity in the prostate gland, seminal vesicle, and ejaculatory duct: comparison with prostatic adenocarcinoma and discussion of prostatic zonal embryogenesis
    Charles M Quick
    Department of Pathology, The University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    Hum Pathol 41:1145-9. 2010
    ..In addition, these data add further support to the proposed embryogenesis of the prostatic central zone, seminal vesicle, and ejaculatory ducts from the wolffian system...
  17. doi request reprint Immunohistochemical distinction of primary adrenal cortical lesions from metastatic clear cell renal cell carcinoma: a study of 248 cases
    Ankur R Sangoi
    Department of Pathology, El Camino Hospital, Mountain View, Palo Alto, CA, USA
    Am J Surg Pathol 35:678-86. 2011
    ....
  18. doi request reprint The utility of Pax-2 as an immunohistochemical marker for renal cell carcinoma in cytopathology
    Neriman Gokden
    Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
    Diagn Cytopathol 36:473-7. 2008
    ....
  19. pmc Actinonin, a meprin A inhibitor, protects the renal microcirculation during sepsis
    Zhen Wang
    Department of Pharmacology and Toxicology, Division of Nephrology, University of Arkansas for Medical Sciences, 4301 W Markham Street, Little Rock, AR 72205, USA
    Shock 35:141-7. 2011
    ....
  20. ncbi request reprint Diagnostic utility of renal cell carcinoma marker in cytopathology
    Neriman Gokden
    Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
    Appl Immunohistochem Mol Morphol 11:116-9. 2003
    ..RCC antibody has not been studied in hepatocellular carcinoma, and the significance of positivity observed in some of our cases is unclear...
  21. ncbi request reprint Sirolimus-induced thrombotic microangiopathy in a renal transplant recipient
    Gary W Barone
    Department of Surgery, University of Arkansas for Medical Sciences, Little Rock, AK 72205, USA
    Am J Kidney Dis 42:202-6. 2003
    ..With recent animal data showing that sirolmus can be nephrotoxic in a renal ischemic-reperfusion model (similar to what happens with a renal transplant), the authors speculate on a mechanism for this adverse reaction...
  22. ncbi request reprint A reciprocal t(4;9)(q31;p22) in a solitary neurofibroma
    Jeffrey R Sawyer
    Department of Pathology, University of Arkansas for Medical Sciences, 4301 West Markham Street, Little Rock, AR 72205, USA
    Cancer Genet Cytogenet 156:172-4. 2005
    ..We report the first case of a solitary circumscribed neurofibroma with a (4;9)(q31;p22) balanced reciprocal translocation as the sole cytogenetic abnormality...
  23. ncbi request reprint A clonal reciprocal t(2;7)(p13;p13) in plantar fibromatosis
    Jeffrey R Sawyer
    Department of Pathology, Cytogenetics Laboratory, University of Arkansas for Medical Sciences, Freeway Medical, Suite 200, 5800 West 10th Street, Little Rock, AR 72204, USA
    Cancer Genet Cytogenet 158:67-9. 2005
    ..We report a case of plantar fibromatosis with the novel finding of a t(2;7)(p13;p13) balanced reciprocal translocation as the sole cytogenetic abnormality...
  24. ncbi request reprint Human Papillomavirus DNA and P16INK4A are not detected in renal tumors with immunohistochemistry and signal-amplified in situ hybridization in paraffin-embedded tissue
    Anissa Hodges
    Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    Appl Immunohistochem Mol Morphol 14:432-5. 2006
    ..No staining for HPV DNA and P16 was found in any type of renal tumors. Our results support that HPV does not seem to play a role in the development of benign and malignant renal tumors...
  25. pmc Reduced kidney lipoprotein lipase and renal tubule triglyceride accumulation in cisplatin-mediated acute kidney injury
    Shenyang Li
    Division of Nephrology, Department of Internal Medicine, University of Arkansas for Medical Sciences and Central Arkansas Veterans Healthcare System, Little Rock, AR 72205, USA
    Am J Physiol Renal Physiol 303:F437-48. 2012
    ..In summary, a PPARĪ± ligand ameliorates CP-mediated nephrotoxicity by increasing LPL activity via increased expression of GPHBP1 and Lmf1 and by reducing expression of Angptl4 protein in the proximal tubule...
  26. doi request reprint Plasmacytoid carcinoma of the bladder: a urothelial carcinoma variant with a predilection for intraperitoneal spread
    Roberto Rafael Ricardo-Gonzalez
    Department of Pathology, Stanford University Medical Center, Stanford, California 94305, USA
    J Urol 187:852-5. 2012
    ..Our experience suggests frequent intraperitoneal spread that is not typical of conventional urothelial carcinoma...
  27. doi request reprint Invasive urothelial carcinoma with chordoid features: a report of 12 distinct cases characterized by prominent myxoid stroma and cordlike epithelial architecture
    Roni M Cox
    Department of Pathology, The University of Arkansas for Medical Sciences, Little Rock, AR, USA
    Am J Surg Pathol 33:1213-9. 2009
    ..These carcinomas maintain an immunophenotype characteristic of urothelial carcinoma and usually present with high stage disease...
  28. ncbi request reprint Peritubular capillary dysfunction and renal tubular epithelial cell stress following lipopolysaccharide administration in mice
    Liping Wu
    Dept of Pharmacology and Toxicology, Univ of Arkansas for Medical Sciences, 4301 West Markham St, 611, Little Rock, AR 72205, USA
    Am J Physiol Renal Physiol 292:F261-8. 2007
    ..8951, P < 0.0001). These data show that peritubular capillary dysfunction is an early event that contributes to tubular stress and renal injury...
  29. ncbi request reprint Metastatic renal cell carcinoma to prostate
    Graham F Greene
    Department of Urology, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72005, USA
    Urology 65:1227. 2005
    ..We present a case of metachronous renal cell carcinoma found only in the prostate with the longest reported interval of 9 years between radical nephrectomy and clinically apparent disease...
  30. ncbi request reprint Progressive kidney failure as the sole manifestation of extrapulmonary sarcoidosis
    Supreet Sethi
    Division of Nephrology, University of Arkansas for Medical Sciences, USA
    J Ark Med Soc 110:64-6. 2013
    ..A systematic diagnostic approach with pertinent laboratory studies, imaging and renal biopsy elucidated the diagnosis of renal sarcoidosis without any evidence of systemic involvement...
  31. doi request reprint The significance of foot process effacement in immunoglobulin a nephropathy: clinicopathologic study of 161 cases with light, immunofluorescence and electron microscopic studies
    Shree G Sharma
    University of Arkansas for Medical Sciences, Department of Pathology, Little Rock, AR, USA
    Ultrastruct Pathol 34:269-72. 2010
    ..42) or proteinuria group and IGAN subclass (p=.10) is present. Whether FPE is simply a reflection of other pathologic mechanisms and its significance in the pathophysiology of IGAN requires further investigation...
  32. doi request reprint Acute interstitial nephritis due to deferasirox: a case report
    Godela Brosnahan
    Division of Nephrology, Department of Internal Medicine, University of Arkansas for Medical Sciences, 4301 W Markham, Slot 501, Little Rock, AR 72205, USA
    Nephrol Dial Transplant 23:3356-8. 2008
    ..Deferasirox was discontinued and renal function returned to baseline. This is the first pathological description of deferasirox-related acute kidney injury in humans, which differs from tubular vacuolization observed in animals...
  33. ncbi request reprint PPAR-alpha ligand ameliorates acute renal failure by reducing cisplatin-induced increased expression of renal endonuclease G
    Shenyang Li
    Dept of Medicine, University of Arkansas for Medical Sciences, Slot 501, 4301 W Markham Street, Little Rock, AR 72205, USA
    Am J Physiol Renal Physiol 287:F990-8. 2004
    ....
  34. ncbi request reprint High-grade prostatic intraepithelial neoplasia in needle biopsy as risk factor for detection of adenocarcinoma: current level of risk in screening population
    Neriman Gokden
    Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
    Urology 65:538-42. 2005
    ....
  35. ncbi request reprint Extensive somatic mitochondrial mutations in primary prostate cancer using laser capture microdissection
    Junjian Z Chen
    Division of Molecular Epidemiology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, Arkansas 72079, USA
    Cancer Res 62:6470-4. 2002
    ..Inspection of these mutations provides new insights into prostate cancer genetics and reveals unique patterns of somatic mutations in prostatic neoplastic lesions...
  36. ncbi request reprint Simultaneous generation of multiple mitochondrial DNA mutations in human prostate tumors suggests mitochondrial hyper-mutagenesis
    Junjian Z Chen
    Division of Molecular Epidemiology, National Center for Toxicological Research, Jefferson, AR 72079, USA
    Carcinogenesis 24:1481-7. 2003
    ..On the basis of prostate tumor cell kinetics, we propose a unique process of mitochondrial hyper-mutagenesis, probably mediated by cellular oxidative stress, to account for a burst of multiple mtDNA mutations in human prostate tumors...