Research Topics
| Neriman GokdenSummaryAffiliation: University of Arkansas for Medical Sciences Country: USA Publications
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Detail Information
Publications
Morphologic heterogeneity of renal light-chain deposition diseaseNeriman Gokden
Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
Ultrastruct Pathol 32:17-24. 2008..Immunofluorescence is more sensitive than EM for detection of LC for the definitive diagnosis of LCDD. This study supports the importance of utilizing kappa and lambda stains in the routine IF panel for diagnosis of LCDD...- Renal sclerosing peritubular nodules in a patient with neurofibromatosis type 2: a case report with immunohistochemical and electron microscopic studiesNeriman Gokden
University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
Hum Pathol 40:1650-4. 2009..We examined these peritubular proliferations with immunohistochemistry, histochemistry, and electron microscopy and compared our findings with the previous report in the literature... - Loss of heterozygosity of DNA repair gene, hOGG1, in renal cell carcinoma but not in renal papillary adenomaNeriman Gokden
Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
Pathol Int 58:339-43. 2008..It is concluded that deletion of hOGG1 gene occurs commonly in PRCC and CC-RCC but not in renal cortical PA. Further studies are warranted to further explore the exact roles of hOGG1 gene in the development and progression of RCC... 
Morphologic manifestations of combined light-chain deposition disease and light-chain cast nephropathyNeriman Gokden
Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
Ultrastruct Pathol 31:141-9. 2007..There were minimal or no glomerular changes by LM. This study shows the lack of characteristic LM findings of LCDD in combined cases of LCDD and LCCN and emphasizes the difficulty for-definitive diagnosis-without IF and EM...- The utility of PAX-2 in distinguishing metastatic clear cell renal cell carcinoma from its morphologic mimics: an immunohistochemical study with comparison to renal cell carcinoma markerNeriman Gokden
Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
Am J Surg Pathol 32:1462-7. 2008.... - Dermatofibrosarcoma protuberans of the vulva and groin: detection of COL1A1-PDGFB fusion transcripts by RT-PCRNeriman Gokden
Lauren V Ackerman Laboratory of Surgical Pathology, Barnes Jewish Hospital, Washington University Medical Center, St Louis, MO, USA
J Cutan Pathol 30:190-5. 2003..The trunk and extremities are the anatomic sites of predilection for DFSP, whereas the vulva and groin are quite uncommon sites of involvement... 
Development of oxidative stress in the peritubular capillary microenvironment mediates sepsis-induced renal microcirculatory failure and acute kidney injuryZhen Wang
Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
Am J Pathol 180:505-16. 2012..These data demonstrate that renal hemodynamic changes occur early after sepsis and that targeting the later oxidant generation can break the cycle of injury and enable the microcirculation and renal function to recover...- Resveratrol improves renal microcirculation, protects the tubular epithelium, and prolongs survival in a mouse model of sepsis-induced acute kidney injuryJoseph H Holthoff
Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
Kidney Int 81:370-8. 2012..Hence, resveratrol may have a dual mechanism of action to restore the renal microcirculation and scavenge reactive nitrogen species, thus protecting the tubular epithelium even when administered after the onset of sepsis... - Hemodynamic changes in the kidney in a pediatric rat model of sepsis-induced acute kidney injuryKathryn A Seely
Dept of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, 4301 West Markham St, 611, Little Rock, AR 72205, USA
Am J Physiol Renal Physiol 301:F209-17. 2011..Lower RBF and reduced peritubular capillary perfusion in the pup suggest the pediatric kidney may be more susceptible to AKI than would be predicted using adults models... - Evidence for the role of reactive nitrogen species in polymicrobial sepsis-induced renal peritubular capillary dysfunction and tubular injuryLiping Wu
Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, 4301 West Markham Street 611, Little Rock, AR 72205, USA
J Am Soc Nephrol 18:1807-15. 2007..These data show that capillary dysfunction and RNS generation contribute to tubular injury and suggest that RNS should be considered a potential therapeutic target in the treatment of sepsis-induced AKI... - The utility of PAX-2 and renal cell carcinoma marker immunohistochemistry in distinguishing papillary renal cell carcinoma from nonrenal cell neoplasms with papillary featuresShree G Sharma
Department of Pathology, University of Arkansas for Medical Sciences, 4301 West Markham Street 517, Little Rock, AR 72205, USA
Appl Immunohistochem Mol Morphol 18:494-8. 2010..PAX-2 and RCCma immunohistochemistry should be interpreted with caution in papillary neoplasms, with particular attention to the possibility of ovarian and uterine papillary serous carcinomas, which can express both PAX-2 and RCCma... - Membranoproliferative injury pattern in a renal allograftNeriman Gokden
Department of Pathology, Vanderbilt University Medical Center, Nashville, TN 37232 2561, USA
Am J Kidney Dis 46:573-6. 2005 - Expression of CD138 (Syndecan-1) in renal cell carcinoma is reduced with increasing nuclear gradeNeriman Gokden
Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, AR, USA
Appl Immunohistochem Mol Morphol 14:173-7. 2006..2) or local stage (P=0.7). Metastatic foci showed a mild to moderate decrease in intensity compared with primary tumor. Decreased expression of CD138 may have a role in more aggressive behavior of clear-cell RCC... - The utility of Pax-2 as an immunohistochemical marker for renal cell carcinoma in cytopathologyNeriman Gokden
Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
Diagn Cytopathol 36:473-7. 2008.... - The distribution of PAX-2 immunoreactivity in the prostate gland, seminal vesicle, and ejaculatory duct: comparison with prostatic adenocarcinoma and discussion of prostatic zonal embryogenesisCharles M Quick
Department of Pathology, The University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
Hum Pathol 41:1145-9. 2010..In addition, these data add further support to the proposed embryogenesis of the prostatic central zone, seminal vesicle, and ejaculatory ducts from the wolffian system... - Diagnostic utility of renal cell carcinoma marker in cytopathologyNeriman Gokden
Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
Appl Immunohistochem Mol Morphol 11:116-9. 2003..RCC antibody has not been studied in hepatocellular carcinoma, and the significance of positivity observed in some of our cases is unclear... - Immunohistochemical distinction of primary adrenal cortical lesions from metastatic clear cell renal cell carcinoma: a study of 248 casesAnkur R Sangoi
Department of Pathology, El Camino Hospital, Mountain View, Palo Alto, CA, USA
Am J Surg Pathol 35:678-86. 2011.... - Actinonin, a meprin A inhibitor, protects the renal microcirculation during sepsisZhen Wang
Department of Pharmacology and Toxicology, Division of Nephrology, University of Arkansas for Medical Sciences, 4301 W Markham Street, Little Rock, AR 72205, USA
Shock 35:141-7. 2011.... - A clonal reciprocal t(2;7)(p13;p13) in plantar fibromatosisJeffrey R Sawyer
Department of Pathology, Cytogenetics Laboratory, University of Arkansas for Medical Sciences, Freeway Medical, Suite 200, 5800 West 10th Street, Little Rock, AR 72204, USA
Cancer Genet Cytogenet 158:67-9. 2005..We report a case of plantar fibromatosis with the novel finding of a t(2;7)(p13;p13) balanced reciprocal translocation as the sole cytogenetic abnormality... - Sirolimus-induced thrombotic microangiopathy in a renal transplant recipientGary W Barone
Department of Surgery, University of Arkansas for Medical Sciences, Little Rock, AK 72205, USA
Am J Kidney Dis 42:202-6. 2003..With recent animal data showing that sirolmus can be nephrotoxic in a renal ischemic-reperfusion model (similar to what happens with a renal transplant), the authors speculate on a mechanism for this adverse reaction... - A reciprocal t(4;9)(q31;p22) in a solitary neurofibromaJeffrey R Sawyer
Department of Pathology, University of Arkansas for Medical Sciences, 4301 West Markham Street, Little Rock, AR 72205, USA
Cancer Genet Cytogenet 156:172-4. 2005..We report the first case of a solitary circumscribed neurofibroma with a (4;9)(q31;p22) balanced reciprocal translocation as the sole cytogenetic abnormality... - Human Papillomavirus DNA and P16INK4A are not detected in renal tumors with immunohistochemistry and signal-amplified in situ hybridization in paraffin-embedded tissueAnissa Hodges
Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
Appl Immunohistochem Mol Morphol 14:432-5. 2006..No staining for HPV DNA and P16 was found in any type of renal tumors. Our results support that HPV does not seem to play a role in the development of benign and malignant renal tumors... - Reduced kidney lipoprotein lipase and renal tubule triglyceride accumulation in cisplatin-mediated acute kidney injuryShenyang Li
Division of Nephrology, Department of Internal Medicine, University of Arkansas for Medical Sciences and Central Arkansas Veterans Healthcare System, Little Rock, AR 72205, USA
Am J Physiol Renal Physiol 303:F437-48. 2012..In summary, a PPARĪ± ligand ameliorates CP-mediated nephrotoxicity by increasing LPL activity via increased expression of GPHBP1 and Lmf1 and by reducing expression of Angptl4 protein in the proximal tubule... - Plasmacytoid carcinoma of the bladder: a urothelial carcinoma variant with a predilection for intraperitoneal spreadRoberto Rafael Ricardo-Gonzalez
Department of Pathology, Stanford University Medical Center, Stanford, California 94305, USA
J Urol 187:852-5. 2012..Our experience suggests frequent intraperitoneal spread that is not typical of conventional urothelial carcinoma... - Invasive urothelial carcinoma with chordoid features: a report of 12 distinct cases characterized by prominent myxoid stroma and cordlike epithelial architectureRoni M Cox
Department of Pathology, The University of Arkansas for Medical Sciences, Little Rock, AR, USA
Am J Surg Pathol 33:1213-9. 2009..These carcinomas maintain an immunophenotype characteristic of urothelial carcinoma and usually present with high stage disease... - Peritubular capillary dysfunction and renal tubular epithelial cell stress following lipopolysaccharide administration in miceLiping Wu
Dept of Pharmacology and Toxicology, Univ of Arkansas for Medical Sciences, 4301 West Markham St, 611, Little Rock, AR 72205, USA
Am J Physiol Renal Physiol 292:F261-8. 2007..8951, P < 0.0001). These data show that peritubular capillary dysfunction is an early event that contributes to tubular stress and renal injury... - Metastatic renal cell carcinoma to prostateGraham F Greene
Department of Urology, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72005, USA
Urology 65:1227. 2005..We present a case of metachronous renal cell carcinoma found only in the prostate with the longest reported interval of 9 years between radical nephrectomy and clinically apparent disease... - Acute interstitial nephritis due to deferasirox: a case reportGodela Brosnahan
Division of Nephrology, Department of Internal Medicine, University of Arkansas for Medical Sciences, 4301 W Markham, Slot 501, Little Rock, AR 72205, USA
Nephrol Dial Transplant 23:3356-8. 2008..Deferasirox was discontinued and renal function returned to baseline. This is the first pathological description of deferasirox-related acute kidney injury in humans, which differs from tubular vacuolization observed in animals... - The significance of foot process effacement in immunoglobulin a nephropathy: clinicopathologic study of 161 cases with light, immunofluorescence and electron microscopic studiesShree G Sharma
University of Arkansas for Medical Sciences, Department of Pathology, Little Rock, AR, USA
Ultrastruct Pathol 34:269-72. 2010..42) or proteinuria group and IGAN subclass (p=.10) is present. Whether FPE is simply a reflection of other pathologic mechanisms and its significance in the pathophysiology of IGAN requires further investigation... - Histopathology, ultrastructure, and clinical phenotypes in thin glomerular basement membrane disease variantsHelen Liapis
Department of Pathology, Renal Division and Cell Biology, Washington University School of Medicine, St. Louis, MO 63110, USA
Hum Pathol 33:836-45. 2002..These patients have a TMD variant, but an Alport variant with a potentially transmissible severe defect different from benign hematuria cannot be excluded... - PPAR-alpha ligand ameliorates acute renal failure by reducing cisplatin-induced increased expression of renal endonuclease GShenyang Li
Dept. of Medicine, University of Arkansas for Medical Sciences, Slot 501, 4301 W. Markham Street, Little Rock, AR 72205, USA
Am J Physiol Renal Physiol 287:F990-8. 2004.... - High-grade prostatic intraepithelial neoplasia in needle biopsy as risk factor for detection of adenocarcinoma: current level of risk in screening populationNeriman Gokden
Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
Urology 65:538-42. 2005..The data presented here should prompt reconsideration of repeat biopsy strategies for HG-PIN, and re-evaluation of the absolute necessity of repeat biopsy for all patients with HG-PIN... - Extensive somatic mitochondrial mutations in primary prostate cancer using laser capture microdissectionJunjian Z Chen
Division of Molecular Epidemiology, National Center for Toxicological Research, Food and Drug Administration, Jefferson, Arkansas 72079, USA
Cancer Res 62:6470-4. 2002..Inspection of these mutations provides new insights into prostate cancer genetics and reveals unique patterns of somatic mutations in prostatic neoplastic lesions... - Simultaneous generation of multiple mitochondrial DNA mutations in human prostate tumors suggests mitochondrial hyper-mutagenesisJunjian Z Chen
Division of Molecular Epidemiology, National Center for Toxicological Research, Jefferson, AR 72079, USA
Carcinogenesis 24:1481-7. 2003..On the basis of prostate tumor cell kinetics, we propose a unique process of mitochondrial hyper-mutagenesis, probably mediated by cellular oxidative stress, to account for a burst of multiple mtDNA mutations in human prostate tumors...