Andrei Goga

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Therapeutic potential of a synthetic lethal interaction between the MYC proto-oncogene and inhibition of aurora-B kinase
    Dun Yang
    Department of Microbiology and Immunology, G W Hooper Research Foundation, University of California, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 107:13836-41. 2010
  2. pmc MYC pathway activation in triple-negative breast cancer is synthetic lethal with CDK inhibition
    Dai Horiuchi
    Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA
    J Exp Med 209:679-96. 2012
  3. ncbi request reprint Inhibition of CDK1 as a potential therapy for tumors over-expressing MYC
    Andrei Goga
    Department of Medicine, Division of Hematology Oncology, University of California, San Francisco, San Francisco, California 94143 0552, USA
    Nat Med 13:820-7. 2007
  4. ncbi request reprint Anti-oncomir suppression of tumor phenotypes
    Andrei Goga
    Department of Medicine, University of California, San Francisco, CA 94143, USA
    Mol Interv 7:199-202, 180. 2007
  5. pmc Nuclear entry of a cGMP-dependent kinase converts transient into long-lasting olfactory adaptation
    JIN I LEE
    Center for Neuroscience, University of California, Davis, CA 95618, USA
    Proc Natl Acad Sci U S A 107:6016-21. 2010
  6. pmc Investigating tumor perfusion and metabolism using multiple hyperpolarized (13)C compounds: HP001, pyruvate and urea
    Cornelius Von Morze
    Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA 94158, USA
    Magn Reson Imaging 30:305-11. 2012
  7. ncbi request reprint Endogenous nuclear RNAi mediates behavioral adaptation to odor
    Bi Tzen Juang
    Departments of Cell and Tissue Biology and Medicine, University of California, San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143 0512, USA
    Cell 154:1010-22. 2013
  8. ncbi request reprint RNA interference (RNAi) with RNase III-prepared siRNAs
    Dun Yang
    G W Hooper Foundation, Department of Microbiology and Immunology, University of California, San Francisco, USA
    Methods Mol Biol 252:471-82. 2004
  9. pmc Quantitative measurement of cancer metabolism using stimulated echo hyperpolarized carbon-13 MRS
    Christine Leon Swisher
    Department of Radiology and Biomedical Imaging, University of California, San Francisco, California, USA UC Berkeley UCSF Graduate Program in Bioengineering, University of California, San Francisco and University of California, Berkeley, California, USA
    Magn Reson Med 71:1-11. 2014
  10. pmc IRE1α cleaves select microRNAs during ER stress to derepress translation of proapoptotic Caspase-2
    John Paul Upton
    Department of Pathology, University of California, San Francisco, San Francisco, CA 94143, USA
    Science 338:818-22. 2012

Research Grants

  1. CDK Inhibition in Cancer
    Andrei Goga; Fiscal Year: 2007
  2. Targeting the MYC Oncogene with CDK Inhibitors
    Andrei Goga; Fiscal Year: 2010

Collaborators

Detail Information

Publications21

  1. pmc Therapeutic potential of a synthetic lethal interaction between the MYC proto-oncogene and inhibition of aurora-B kinase
    Dun Yang
    Department of Microbiology and Immunology, G W Hooper Research Foundation, University of California, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 107:13836-41. 2010
    ....
  2. pmc MYC pathway activation in triple-negative breast cancer is synthetic lethal with CDK inhibition
    Dai Horiuchi
    Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA
    J Exp Med 209:679-96. 2012
    ..These results indicate that aggressive breast tumors with elevated MYC are uniquely sensitive to CDK inhibitors...
  3. ncbi request reprint Inhibition of CDK1 as a potential therapy for tumors over-expressing MYC
    Andrei Goga
    Department of Medicine, Division of Hematology Oncology, University of California, San Francisco, San Francisco, California 94143 0552, USA
    Nat Med 13:820-7. 2007
    ..As there are no effective small-molecule inhibitors that selectively target the MYC pathway, we propose that CDK1 inhibition might therefore be useful in the treatment of human malignancies that overexpress MYC...
  4. ncbi request reprint Anti-oncomir suppression of tumor phenotypes
    Andrei Goga
    Department of Medicine, University of California, San Francisco, CA 94143, USA
    Mol Interv 7:199-202, 180. 2007
    ..These miRNAs, or "anti-oncomirs," can act as natural inhibitors of oncogene function, indicating the possibility that they might be developed as novel therapeutics...
  5. pmc Nuclear entry of a cGMP-dependent kinase converts transient into long-lasting olfactory adaptation
    JIN I LEE
    Center for Neuroscience, University of California, Davis, CA 95618, USA
    Proc Natl Acad Sci U S A 107:6016-21. 2010
    ..Thus, the EGL-4 protein kinase acts as a sensor that integrates odor signaling over time, and its nuclear translocation is an instructive switch that allows the animal to ignore persistent odors...
  6. pmc Investigating tumor perfusion and metabolism using multiple hyperpolarized (13)C compounds: HP001, pyruvate and urea
    Cornelius Von Morze
    Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA 94158, USA
    Magn Reson Imaging 30:305-11. 2012
    ..A strong and significant correlation (R=0.73, P=.02) detected between the urea and HP001 data confirmed the value of copolarizing urea with pyruvate for simultaneous assessment of perfusion and metabolism...
  7. ncbi request reprint Endogenous nuclear RNAi mediates behavioral adaptation to odor
    Bi Tzen Juang
    Departments of Cell and Tissue Biology and Medicine, University of California, San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143 0512, USA
    Cell 154:1010-22. 2013
    ..This class of siRNA may act broadly as a rheostat allowing prolonged stimulation to dampen gene expression and promote cellular memory formation. PAPERFLICK: ..
  8. ncbi request reprint RNA interference (RNAi) with RNase III-prepared siRNAs
    Dun Yang
    G W Hooper Foundation, Department of Microbiology and Immunology, University of California, San Francisco, USA
    Methods Mol Biol 252:471-82. 2004
    ..Since the whole gene can be used at once, screening for an active siRNA for an individual gene is eliminated. Because of its simplicity and potency, this approach is useful for large-scale analysis of mammalian gene function...
  9. pmc Quantitative measurement of cancer metabolism using stimulated echo hyperpolarized carbon-13 MRS
    Christine Leon Swisher
    Department of Radiology and Biomedical Imaging, University of California, San Francisco, California, USA UC Berkeley UCSF Graduate Program in Bioengineering, University of California, San Francisco and University of California, Berkeley, California, USA
    Magn Reson Med 71:1-11. 2014
    ..However, the accuracy of current methods to calculate kinetic parameters has been limited by T1 relaxation effects, extracellular signal contributions, and reduced precision at lower signal-to-noise ratio...
  10. pmc IRE1α cleaves select microRNAs during ER stress to derepress translation of proapoptotic Caspase-2
    John Paul Upton
    Department of Pathology, University of California, San Francisco, San Francisco, CA 94143, USA
    Science 338:818-22. 2012
    ..Thus, IRE1α regulates translation of a proapoptotic protein through terminating microRNA biogenesis, and noncoding RNAs are part of the ER stress response...
  11. pmc Chemical-genetic analysis of cyclin dependent kinase 2 function reveals an important role in cellular transformation by multiple oncogenic pathways
    Dai Horiuchi
    Department of Medicine, University of California, San Francisco, CA 94143, USA
    Proc Natl Acad Sci U S A 109:E1019-27. 2012
    ..Our results establish that CDK2 activity is necessary for normal mammalian cell cycle progression and suggest that it might be a useful therapeutic target for treating cancer...
  12. pmc 13C-pyruvate imaging reveals alterations in glycolysis that precede c-Myc-induced tumor formation and regression
    Simon Hu
    Department of Radiology and Biomedical Imaging, University of California San Francisco, CA 94143, USA
    Cell Metab 14:131-42. 2011
    ..These results demonstrate that metabolic changes precede tumor formation and regression and are directly linked to the activity of a single oncogene...
  13. pmc Up-regulation of miR-21 by HER2/neu signaling promotes cell invasion
    Tzu Hsuan Huang
    Department of Microbiology and Immunology, University of California, San Francisco, California 94143, USA
    J Biol Chem 284:18515-24. 2009
    ..Our data reveal a mechanism for HER2/neu-induced cancer cell invasion via miRNA deregulation. In addition, our results identify miR-21 as a potential therapeutic target for the prevention of breast cancer invasion and metastasis...
  14. pmc MicroRNA-494 within an oncogenic microRNA megacluster regulates G1/S transition in liver tumorigenesis through suppression of mutated in colorectal cancer
    Lionel Lim
    Department of Cell and Tissue Biology, University of California San Francisco, San Francisco, CA Department of Medicine, University of California San Francisco, San Francisco, CA
    Hepatology 59:202-15. 2014
    ..miR-494 inhibition in human HCC cell lines decreases cellular transformation, and anti-miR-494 treatment of primary MYC-driven liver tumor formation significantly diminishes tumor size...
  15. ncbi request reprint Taking on Challenging Targets: Making MYC Druggable
    Dai Horiuchi
    From the Department of Cell and Tissue Biology, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA the Department of Cell and Tissue Biology and Biomedical Sciences Graduate Program, University of California, San Francisco, San Francisco, CA and the Department of Cell and Tissue Biology, Department of Medicine, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA
    Am Soc Clin Oncol Educ Book 34:e497-502. 2014
    ..This article summarizes the progresses being made to discover and implement new therapies to kill MYC over-expressing tumors-a target that was once deemed undruggable. ..
  16. pmc Imaging of blood flow using hyperpolarized [(13)C]urea in preclinical cancer models
    Cornelius Von Morze
    Department of Radiology and Biomedical Imaging, University of California, San Francisco, California 94158 2512, USA
    J Magn Reson Imaging 33:692-7. 2011
    ..To demonstrate dynamic imaging of a diffusible perfusion tracer, hyperpolarized [(13)C]urea, for regional measurement of blood flow in preclinical cancer models...
  17. pmc HER3 signalling is regulated through a multitude of redundant mechanisms in HER2-driven tumour cells
    Dhara N Amin
    Department of Medicine and Helen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, CA 94143, USA
    Biochem J 447:417-25. 2012
    ....
  18. doi request reprint Nanodiamond therapeutic delivery agents mediate enhanced chemoresistant tumor treatment
    Edward K Chow
    George Williams Hooper Foundation, University of California, San Francisco, CA 94143, USA
    Sci Transl Med 3:73ra21. 2011
    ..Thus, ND-conjugated chemotherapy represents a promising, biocompatible strategy for overcoming chemoresistance and enhancing chemotherapy efficacy and safety...
  19. ncbi request reprint A 3'UTR pumilio-binding element directs translational activation in olfactory sensory neurons
    Julia A Kaye
    Cellular and Developmental Biology Program, 1 Shields Drive, University of California, Davis, Davis, CA 95616, USA
    Neuron 61:57-70. 2009
    ....
  20. pmc Short RNA duplexes produced by hydrolysis with Escherichia coli RNase III mediate effective RNA interference in mammalian cells
    Dun Yang
    G W Hooper Foundation and Department of Microbiology and Immunology, University of California, San Francisco, CA 94143 0552, USA
    Proc Natl Acad Sci U S A 99:9942-7. 2002
    ..esiRNA works by eliciting the destruction of its cognate mRNA. Because of its simplicity and potency, this approach is useful for analysis of mammalian gene functions...
  21. ncbi request reprint Coordinate suppression of ERBB2 and ERBB3 by enforced expression of micro-RNA miR-125a or miR-125b
    Gary K Scott
    Buck Institute for Age Research, Novato, California 94945, USA
    J Biol Chem 282:1479-86. 2007
    ..These results illustrate the feasibility of using miRNAs as a therapeutic strategy to suppress oncogene expression and function...

Research Grants3

  1. CDK Inhibition in Cancer
    Andrei Goga; Fiscal Year: 2007
    ..The proposed training program is designed with the goal of preparing this applicant to establish an independent laboratory in an academic oncology department. ..
  2. Targeting the MYC Oncogene with CDK Inhibitors
    Andrei Goga; Fiscal Year: 2010
    ..The knowledge gained from these studies will facilitate the development of new therapeutics that target tumor cells with particular genetic changes by precisely inhibiting the cell division cycle. ..