Research Topics
| EDWARD GOETZLSummaryAffiliation: University of California Country: USA Publications
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Detail Information
Publications
Regulation of the roles of sphingosine 1-phosphate and its type 1 G protein-coupled receptor in T cell immunity and autoimmunityEdward J Goetzl
Department of Medicine, University of California Medical Center, San Francisco, CA 94143, USA
Biochim Biophys Acta 1781:503-7. 2008..Such agents have so far been beneficial in the settings of autoimmunity and rejection of transplanted organs, and are likely to become valuable constituents of combined drug programs...- Distinct energy requirements for human memory CD4 T-cell homeostatic functionsDennis D Taub
National Institute on Aging, National Institutes of Health, Baltimore, Maryland, USA
FASEB J 27:342-9. 2013..The sources supplying energy for diverse functions of unactivated T(mem) cells differ from that required for function after immune activation... - Distinctive immunoregulatory effects of adenosine on T cells of older humansCharles S Hesdorffer
National Institute on Aging, National Institutes of Health, Baltimore, Maryland, USA
FASEB J 26:1301-10. 2012..Adenosine is an endogenous T-cell immunosuppressor in older humans, and A(2A) antagonists reverse adenosine-induced T-cell deficiencies of aging... - Gender specificity of altered human immune cytokine profiles in agingEdward J Goetzl
Department of Medicine, University of California, San Francisco, CA 94143 0711, USA
FASEB J 24:3580-9. 2010..38, P<0.05 and 1.62, P<0.01, respectively), whereas ratios of IFN-gamma-evoked IP-10 chemokine were low in all groups. Alterations in immune cytokine profiles with aging show significant gender specificity... 
Hypothesis: VPAC G protein-coupled receptors for vasoactive intestinal peptide constitute a dynamic system for signaling T cells from plasma membrane and nuclear membrane complexesEdward J Goetzl
Departments of Medicine and Immunology, University of California Medical Center, Room UB8B, UC Box 0711, 533 Parnassus Ave at 4th, San Francisco, CA 94143 0711, United States
Regul Pept 137:75-8. 2006..The types of substantial additional proof needed to support this hypothesis are described, as are its advantages for more selective VIP-directed therapies...
Diverse mechanisms and consequences of immunoadoption of neuromediator systemsEdward J Goetzl
Department of Medicine and Microbiology Immunology, University of California, San Francisco, CA 94143 0711, USA
Ann N Y Acad Sci 1144:56-60. 2008..Better understanding of how tissue context establishes the nature of neuroregulation of immunity will improve neuropharmacological and other neurotherapeutic approaches to immune diseases...- Changing paradigms in the immunological science of allergy: 2008Edward J Goetzl
Department of Medicine, University of California, UC Box 0711, 533 Parnassus at 4th Avenue, San Francisco, CA 94143, USA
Curr Allergy Asthma Rep 8:28-31. 2008..Their properties and effects are reviewed from the perspective of novel targets for antiallergic therapy... - Changing paradigms in the immunologic science of allergyEdward J Goetzl
Department of Medicine, University of California, San Francisco 94143-0711, USA
Curr Allergy Asthma Rep 6:1-3. 2006 - Diverse pathways for nuclear signaling by G protein-coupled receptors and their ligandsEdward J Goetzl
Department of Medicine, University of California, San Francisco, California, USA
FASEB J 21:638-42. 2007.... - Defective T cell chemotaxis to sphingosine 1-phosphate and chemokine CCL21 in idiopathic T lymphocytopeniaEdward J Goetzl
Department of Medicine, University of California, Geriatric Research Center, San Francisco, CA 94112, USA
J Clin Immunol 31:744-51. 2011..Defective T cell chemotactic responses to S1P and some chemokines may lead to subset-selective abnormal T cell trafficking and chronic T cell lymphocytopenia... - Sphingosine 1-phosphate as an intracellular messenger and extracellular mediator in immunityEdward J Goetzl
Department of Medicine, University of California, San Francisco, CA 94143 0711, USA
Acta Paediatr Suppl 96:49-52. 2007..Recruitment of this novel, potentially immunosuppressive, function of S1P(1) may be beneficial in some autoimmune diseases and will require application of cell membrane-permeant S1P(1)-specific drugs... - Changing paradigms in the immunological science of allergyEdward J Goetzl
Department of Medicine, University of California, Room UB8B, UC Box 0711, 533 Parnassus Avenue at 4th Avenue, San Francisco, CA 94143 0711, USA
Curr Allergy Asthma Rep 7:7-10. 2007.... - Type 1 sphingosine 1-phosphate G protein-coupled receptor signaling of lymphocyte functions requires sulfation of its extracellular amino-terminal tyrosinesClaudia B Fieger
Department of Anatomy, University of California, San Francisco, California 94143 0711, USA
FASEB J 19:1926-8. 2005..Inhibition of S1P1 tyrosine sulfation or sulfatase removal of S1P1 sulfate in mouse CD4 T cells suppresses immune functional effects of S1P. Tyrosine sulfation of S1P1 may be a major controller of S1P effects on T cell traffic... - Protein kinase C epsilon dependence of the recovery from down-regulation of S1P1 G protein-coupled receptors of T lymphocytesMarkus H Graeler
Department of Medicine, University of California, San Francisco, California 94143 0711, USA
J Biol Chem 278:27737-41. 2003..Biochemical requisites for recovery of down-regulated S1P1 Rs thus differ from those for S1P induction of down-regulation... - Cutting edge: suppression of T cell chemotaxis by sphingosine 1-phosphateMarkus Graeler
Department of Medicine, University of California Medical Center, 533 Parnassus at 4th, San Francisco, CA 94143, USA
J Immunol 169:4084-7. 2002..c. air pouches. The S1P-S1P(1) receptor axis thus controls recruitment of naive T cells by maintaining their response threshold to diverse lymphotactic factors... - Type 4 sphingosine 1-phosphate G protein-coupled receptor (S1P4) transduces S1P effects on T cell proliferation and cytokine secretion without signaling migrationWengang Wang
Department of Medicine, University of California, San Francisco, California 94143 0711, USA
FASEB J 19:1731-3. 2005..1 T cells. Thus, S1P4 mediates immunosuppressive effects of S1P by inhibiting proliferation and secretion of effector cytokines, while enhancing secretion of the suppressive cytokine IL-10... - Transduction of multiple effects of sphingosine 1-phosphate (S1P) on T cell functions by the S1P1 G protein-coupled receptorGlenn Dorsam
Departments of Medicine and Immunology, University of California, San Francisco, CA 94143, USA
J Immunol 171:3500-7. 2003..Thus, S1P(1) signals multiple immune functions of T cells as well as migration and tissue distribution... - Activation-regulated expression and chemotactic function of sphingosine 1-phosphate receptors in mouse splenic T cellsMarkus Graeler
Department of Medicine, University of California, San Francisco, California 94143-0711, USA
FASEB J 16:1874-8. 2002..S1P may be a distinctive contributor to compartmental immunity by attracting naïve and memory T cells preferentially over activated effector T cells... - Cutting edge: Alternative signaling of Th17 cell development by sphingosine 1-phosphateJia Jun Liao
Department of Medicine and Department of Microbiology Immunology, University of California, San Francisco, CA 94143, USA
J Immunol 178:5425-8. 2007..The prevention of S1P augmentation of Th17 cell development by the S1P receptor agonist and down-regulator FTY720 implies that FTY720 immunosuppression is attributable partially to inhibition of Th17-mediated inflammation... - Biochemical regulation of breast cancer cell expression of S1P2 (Edg-5) and S1P3 (Edg-3) G protein-coupled receptors for sphingosine 1-phosphateHana Dolezalova
Department of Medicine, University of California, San Francisco, CA 94143-0711, USA
J Cell Biochem 88:732-43. 2003..Thus two structurally-homologous S1P Rs of BCCs differ in coupling to [Ca(2+)](i) signaling and have opposite effects on protein growth factor-stimulated chemotaxis... - Cutting edge: vasoactive intestinal peptide (VIP) induces differentiation of Th17 cells with a distinctive cytokine profileMahesh Yadav
Department of Medicine, University of California Medical Center, San Francisco, CA 94143, USA
J Immunol 180:2772-6. 2008..The ability of VIP-VPAC1 axis signals to evoke development of a novel type of Th17 cells demonstrates the unique specificity of neuroregulatory mechanisms in the immunological environment... - Distinctive T cell-suppressive signals from nuclearized type 1 sphingosine 1-phosphate G protein-coupled receptorsJia Jun Liao
Department of Medicine, University of California, San Francisco, California 94143, USA
J Biol Chem 282:1964-72. 2007.... - Lysophospholipid growth factors and their G protein-coupled receptors in immunity, coronary artery disease, and cancerEdward J Goetzl
Department of Medicine, University of California, UB8B, 533 Parnassus at 4th, San Francisco, CA 94143-0711, USA
ScientificWorldJournal 2:324-38. 2002..The breadth of physiologic and pathologic activities of LPLs emphasizes the importance of developing bioavailable nonlipid agonists and antagonists of the LPA/S1P receptors for diverse therapeutic applications... - Immunosuppressive human anti-lymphocyte autoantibodies specific for the type 1 sphingosine 1-phosphate receptorJia Jun Liao
Department of Medicine, University of California San Francisco, San Francisco, California, USA
FASEB J 23:1786-96. 2009..Human Abs to the amino terminus of S1P(1) suppress T-cell trafficking sufficiently to impair host defense and provide therapeutic immunosuppression... - A natural variant type II G protein-coupled receptor for vasoactive intestinal peptide with altered functionCarola Grinninger
Department of Medicine, University of California, San Francisco, California 94143 0711, USA
J Biol Chem 279:40259-62. 2004..Natural deletion of part of the last transmembrane domain of VPAC2 thus abrogates signaling functions without apparent alterations of expression or ligand binding... - Th17 augmentation in OTII TCR plus T cell-selective type 1 sphingosine 1-phosphate receptor double transgenic miceMei Chuan Huang
Department of Medicine and Department of Microbiology Immunology, University of California, San Francisco, CA 94143, USA
J Immunol 178:6806-13. 2007..Augmentation of the number and activity of Th17 cells by the S1P-S1P(1) axis may thus enhance host defense against microbes and in other settings increase host susceptibility to autoimmune diseases... - Physiological sphingosine 1-phosphate requirement for optimal activity of mouse CD4+ regulatory T CellsWengang Wang
Department of Medicine, University of California, San Francisco, California 94143-0711, USA
FASEB J 18:1043-5. 2004..Extracellular fluid S1P thus is required for optimal activity of CD4+25+ T cells... - Lysophospholipids and their G protein-coupled receptors in inflammation and immunityMarkus H Gräler
Room UB 8B, UC Box 0711, Department of Medicine, University of California Medical Center, 533 Parnassus Avenue, San Francisco, CA 94143 0711, USA
Biochim Biophys Acta 1582:168-74. 2002..These observations suggest that agonists and antagonists for lysophospholipid receptors may influence immune responses... - Nuclear factor-kappaB-dependent reversal of aging-induced alterations in T cell cytokinesMei Chuan Huang
Department of Medicine, University of California, San Francisco, California, USA
FASEB J 22:2142-50. 2008..Pharmacological correction of altered generation of Th17 cell cytokines in immunosenescence represents a novel therapeutic approach to aging-induced inflammatory diseases... - An IgM-kappa rat monoclonal antibody specific for the type 1 sphingosine 1-phosphate G protein-coupled receptor with antagonist and agonist activitiesEdward J Goetzl
Departments of Medicine and Microbiology Immunology, University of California Medical Center, Room UB8B, 533 Parnassus at 4th Avenue, San Francisco, CA 94143 0711, USA
Immunol Lett 93:63-9. 2004..2 in vivo may alter immune responses as distinctively as the available poly-S1P GPCR-directed pharmacological agents, without the undesirable side-effects attributable to actions of these agents on other S1P GPCRs... - Immunoregulatory lysophospholipids: new stars in the mast cell constellationEdward J Goetzl
Department of Medicine, University of California Medical Center, San Francisco, 94143-0711, USA
Curr Allergy Asthma Rep 4:175-7. 2004 - Regulation of immunity by lysosphingolipids and their G protein-coupled receptorsEdward J Goetzl
Department of Medicine, UCSF, San Francisco, California, USA
J Clin Invest 114:1531-7. 2004.... - Vasoactive intestinal peptide-mediated Th17 differentiation: an expanding spectrum of vasoactive intestinal peptide effects in immunity and autoimmunityMahesh Yadav
Department of Medicine and Microbiology Immunology, University of California, San Francisco, CA 94143 0711, USA
Ann N Y Acad Sci 1144:83-9. 2008.... - Sphingosine 1-phosphate and its G protein-coupled receptors constitute a multifunctional immunoregulatory systemEdward J Goetzl
Department of Medicine, University of California Medical Center, San Francisco, California 94143 0711, USA
J Cell Biochem 92:1104-14. 2004..Lysophospholipids and their GPCRs thus constitute an immunoregulatory system of sufficient prominence for pharmacological targeting in transplantation, autoimmunity and immunodeficiency... - The immunosuppressant FTY720 down-regulates sphingosine 1-phosphate G-protein-coupled receptorsMarkus H Gräler
University of California, Room UB 8B, UC Box 0711, 533 Parnassus Ave, San Francisco, CA 94143 0711, USA
FASEB J 18:551-3. 2004..The timing and extent of S1P-R internalization are highly dependent on FTY720 concentration. FTY720 is therefore an S1P-GPCR-selective and noncompetitive inhibitor with a unique mechanism of action... - Sphingosine 1-phosphate and its type 1 G protein-coupled receptor: trophic support and functional regulation of T lymphocytesEdward J Goetzl
University of California, 533 Parnassus Ave, Room UB8B, San Francisco, CA 94143 0711
J Leukoc Biol 76:30-5. 2004..LPLs and their GPCRs thus constitute an immunoregulatory system of sufficient prominence for pharmacological targeting in transplantation, autoimmunity, and immunodeficiency... - VPAC1 (vasoactive intestinal peptide (VIP) receptor type 1) G protein-coupled receptor mediation of VIP enhancement of murine experimental colitisMahesh Yadav
Department of Medicine, University of California Medical Center, San Francisco, CA 94143, USA
Cell Immunol 267:124-32. 2011..Thus VIP enhancement of the severity of DSS-induced colitis is mediated solely by VPAC1 receptors... - Vasoactive intestinal peptide receptor-1 (VPAC-1) is a novel gene target of the hemolymphopoietic transcription factor IkarosGlenn Dorsam
Department of Medicine, University of California Medical Center, San Francisco, California 94143 0711, USA
J Biol Chem 277:13488-93. 2002..As both Ikaros and its novel target VPAC-1 are highly expressed in T cells, this system may be a dominant determinant of the VPAC-1 expression in immune responses... - Roles of vasoactive intestinal peptide (VIP) in the expression of different immune phenotypes by wild-type mice and T cell-targeted type II VIP receptor transgenic miceJulia K Voice
Department of Medicine, University of California Medical Center, San Francisco, CA 94143, USA
J Immunol 170:308-14. 2003..The level of VIP recognized by CD4 T cells thus is a major determinant of the relative contributions of Th subsets to the immune effector phenotype... - Differential signaling of T cell generation of IL-4 by wild-type and short-deletion variant of type 2 G protein-coupled receptor for vasoactive intestinal peptide (VPAC2)Mei Chuan Huang
Department of Medicine and Microbiology Immunology, University of California, San Francisco, CA 94143, USA
J Immunol 176:6640-6. 2006..Thus the ratio of two forms of T cell VPAC2 determines the net effect of VIP on IL-4 generation by activated Th2 cells... - Sphingolipid signaling and treatment during remodeling of the uninfarcted ventricular wall after myocardial infarctionChe Chung Yeh
Cardiothoracic Surgery, 4150 Clement St, 112D, San Francisco, CA 94121, USA
Am J Physiol Heart Circ Physiol 296:H1193-9. 2009.... - Human CD4- 8- T cells are a distinctive immunoregulatory subsetMei Chuan Huang
Department of Medicine, University of California, San Francisco, California, USA
FASEB J 24:2558-66. 2010..Decreases in CD4(-)8(-) T cell effects may diminish protective immunity in aging, whereas increases may augment the severity of autoimmune diseases... - Immunoeffector and immunoregulatory activities of vasoactive intestinal peptideJulia K Voice
Department of Medicine, University of California, San Francisco, CA 94143, USA
Regul Pept 109:199-208. 2002..VPAC2R antagonists are being developed to alleviate allergic diseases and strengthen effector Th1 cell-mediated immunoprotection... - Type 1 sphingosine 1-phosphate G protein-coupled receptor (S1P1) mediation of enhanced IL-4 generation by CD4 T cells from S1P1 transgenic miceWengang Wang
Department of Medicine and Department of Microbiology Immunology, University of California, San Francisco, CA 94143
J Immunol 178:4885-90. 2007..Thus, the S1P-S1P(1) axis specifically up-regulates c-Maf, Jun B, and Gata3, which consequently enhance IL-4 production that may lead to a Th2 phenotype... - Cardioprotection mediated by sphingosine-1-phosphate and ganglioside GM-1 in wild-type and PKC epsilon knockout mouse heartsZhu Qiu Jin
Cardiology Section, Veterans Affairs Medical Center, San Francisco, California 94121, USA
Am J Physiol Heart Circ Physiol 282:H1970-7. 2002..In contrast, extracellular S1P induces equivalent cardioprotection through PKC epsilon-independent signaling pathways... - Lysophospholipid mediators of immunity and neoplasiaMei Chuan Huang
UB8B, UC Box 0711, Department of Medicine, University of California Medical Center, 533 Parnassus at 4th Avenue, San Francisco, CA 94143-0711, USA
Biochim Biophys Acta 1582:161-7. 2002.... - c-Maf and JunB mediation of Th2 differentiation induced by the type 2 G protein-coupled receptor (VPAC2) for vasoactive intestinal peptideJulia Voice
Departments of Medicine and Microbiology Immunology, Medical Center, University of California San Francisco, 533 Parnassus at 4th, San Francisco, CA 94143, USA
J Immunol 172:7289-96. 2004.... - Induction of protein growth factor systems in the ovaries of transgenic mice overexpressing human type 2 lysophosphatidic acid G protein-coupled receptor (LPA2)Mei-Chuan Huang
Department of Medicine and Microbiology-Immunology, University of California, San Francisco, CA 94143-0711, USA
Oncogene 23:122-9. 2004..Thus, the LPA-LPA(2) circuit regulates ovarian cells both directly and through increases in protein growth factor systems... - Sphingosine kinase activation mediates ischemic preconditioning in murine heartZhu Qiu Jin
Cardiology Section, VA Medical Center and Department of Medicine, University of California, San Francisco, USA
Circulation 110:1980-9. 2004..Because protein kinase C (PKC)epsilon activation is necessary for myocardial ischemic preconditioning (IPC) and PKC activators increase SK activity, we tested the hypothesis that SK may be a central mediator of IPC... - Signals from type 1 sphingosine 1-phosphate receptors enhance adult mouse cardiac myocyte survival during hypoxiaJianqing Zhang
Medical Service and Cardiology Section, Veterans Affairs Medical Center, San Francisco, CA, USA
Am J Physiol Heart Circ Physiol 293:H3150-8. 2007..These observations highlight the importance of S1P(1) receptors on ventricular myocytes as mediators of inducible resistance against cellular injury during severe hypoxic stress... - Functional splice variants of the type II G protein-coupled receptor (VPAC2) for vasoactive intestinal peptide in mouse and human lymphocytesAllison L Miller
Department of Medicine, University of California Medical Center, Room UB8B, UC Box 0711, 533 Parnassus at 4th, San Francisco, CA 94143 0711, USA
Ann N Y Acad Sci 1070:422-6. 2006..These splice variants may modify the immunoregulatory contributions of the VIP-VPAC2 axis... - Immunological effects of transgenic constitutive expression of the type 1 sphingosine 1-phosphate receptor by mouse lymphocytesMarkus H Gräler
Institute for Immunology, Hannover Medical School, Hannover, Germany
J Immunol 174:1997-2003. 2005.... - Nitric oxide signaling via nuclearized endothelial nitric-oxide synthase modulates expression of the immediate early genes iNOS and mPGES-1Fernand Gobeil
Department of Pharmacology, Universite de Sherbrooke, Sherbrooke, Quebec J1H 5N4, Canada
J Biol Chem 281:16058-67. 2006..Moreover, our findings strongly support the concept of the nucleus as an autonomous signaling compartment... - Modulation of pro-inflammatory gene expression by nuclear lysophosphatidic acid receptor type-1Fernand Gobeil
Departments of Pediatrics, Ophthalmology and Pharmacology, Research Center of Hôpital Sainte Justine, Montreal, Quebec H3T 1C5, Canada
J Biol Chem 278:38875-83. 2003..This study describes for the first time the nucleus as a potential organelle for LPA intracrine signaling in the regulation of pro-inflammatory gene expression... - Sphingosine 1-phosphate and its receptors: an autocrine and paracrine networkHugh Rosen
Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
Nat Rev Immunol 5:560-70. 2005..S1P-S1P-receptor regulatory systems might therefore be novel targets for the therapy of diverse immunological diseases... - International Union of Pharmacology. XXXIV. Lysophospholipid receptor nomenclatureJerold Chun
Merck Research Laboratories, La Jolla, California 92037, USA
Pharmacol Rev 54:265-9. 2002..Herein, the molecular pharmacology of the lysophospholipid receptors is reviewed briefly, and a rational nomenclature for LPA and S1P receptors that is consistent with the International Union of Pharmacology guidelines is proposed... - Lysophospholipid regulation of mononuclear phagocytesHsinyu Lee
Department of Zoology, National Taiwan University, Taipei, Taiwan, ROC
Biochim Biophys Acta 1582:175-7. 2002..This section summarizes our recent observations of the effects of lysophospholipids on mononuclear phagocytes... - A lymphocyte-generated fragment of vasoactive intestinal peptide with VPAC1 agonist activity and VPAC2 antagonist effectsMonica A Summers
Depaertment of Pediatrics, University of Iowa City, Iowa City, Iowa 52242, USA
J Pharmacol Exp Ther 306:638-45. 2003..Lymphoblasts did not hydrolyze VIP4-28 to a form with VPAC1 antagonist activity. VIP4-28 thus is a lymphocyte-generated VIP fragment with potent agonist activity for VPAC1 and potent antagonist activity for VPAC2... - Lysophospholipids and their G protein-coupled receptors in biology and diseasesEdward J Goetzl
J Cell Biochem 92:867-8. 2004
Research Grants
- LEUKOTRIENE MODULATION OF LEUKOCYTE FUNCTIONEDWARD GOETZL; Fiscal Year: 1993....
- LEUKOTRIENE MODULATION OF LEUKOCYTE FUNCTIONEDWARD GOETZL; Fiscal Year: 1999....
- LYSOLIPID PHOSPHATE REGULATION OF LYMPHOCYTE FUNCTIONSEDWARD GOETZL; Fiscal Year: 2003..A greater knowledge of Edg R expression and functions in T cells will reveal specific mechanisms of lysolipid phosphate immunoregulation and identify new targets for correcting immune disorders. ..
- LYMPHOCYTE RECEPTORS FOR VASOACTIVE INTESTINAL PEPTIDEEDWARD GOETZL; Fiscal Year: 2007..abstract_text> ..
- LYSOLIPID PHOSPHATE REGULATION OF LYMPHOCYTE FUNCTIONSEDWARD GOETZL; Fiscal Year: 2007....
- LEUKOTRIENE MODULATION OF LEUKOCYTE FUNCTIONEDWARD GOETZL; Fiscal Year: 1990..Biochemical and immunochemical methods will be applied to the evaluation of the receptor-associated proteins and cellular events critical for the coupling of receptor stimulation to leukocyte activation...
- LYMPHOCYTE RECEPTORS FOR VASOACTIVE INTESTINAL PEPTIDEEDWARD GOETZL; Fiscal Year: 1993..A greater knowledge of cellular receptors for VIP may elucidate neural controls of immune, enteric, and endocrine functions and provide useful new approaches to some neuroendocrine and autoimmune diseases...