EDWARD GOETZL

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Regulation of the roles of sphingosine 1-phosphate and its type 1 G protein-coupled receptor in T cell immunity and autoimmunity
    Edward J Goetzl
    Department of Medicine, University of California Medical Center, San Francisco, CA 94143, USA
    Biochim Biophys Acta 1781:503-7. 2008
  2. pmc Aging enhances release of exosomal cytokine mRNAs by Aβ1-42-stimulated macrophages
    Masato Mitsuhashi
    3UCSF Geriatric Research Center, 1719 Broderick Street, San Francisco, CA 94115 2525, USA E mail
    FASEB J 27:5141-50. 2013
  3. pmc Distinct energy requirements for human memory CD4 T-cell homeostatic functions
    Dennis D Taub
    National Institute on Aging, National Institutes of Health, Baltimore, Maryland, USA
    FASEB J 27:342-9. 2013
  4. pmc Distinctive immunoregulatory effects of adenosine on T cells of older humans
    Charles S Hesdorffer
    National Institute on Aging, National Institutes of Health, Baltimore, Maryland, USA
    FASEB J 26:1301-10. 2012
  5. doi request reprint Diverse mechanisms and consequences of immunoadoption of neuromediator systems
    Edward J Goetzl
    Department of Medicine and Microbiology Immunology, University of California, San Francisco, CA 94143 0711, USA
    Ann N Y Acad Sci 1144:56-60. 2008
  6. ncbi request reprint Changing paradigms in the immunological science of allergy
    Edward J Goetzl
    Department of Medicine, University of California, Room UB8B, UC Box 0711, 533 Parnassus Avenue at 4th Avenue, San Francisco, CA 94143 0711, USA
    Curr Allergy Asthma Rep 7:7-10. 2007
  7. ncbi request reprint Sphingosine 1-phosphate as an intracellular messenger and extracellular mediator in immunity
    Edward J Goetzl
    Department of Medicine, University of California, San Francisco, CA 94143 0711, USA
    Acta Paediatr Suppl 96:49-52. 2007
  8. ncbi request reprint Diverse pathways for nuclear signaling by G protein-coupled receptors and their ligands
    Edward J Goetzl
    Department of Medicine, University of California, San Francisco, California, USA
    FASEB J 21:638-42. 2007
  9. ncbi request reprint Hypothesis: VPAC G protein-coupled receptors for vasoactive intestinal peptide constitute a dynamic system for signaling T cells from plasma membrane and nuclear membrane complexes
    Edward J Goetzl
    Departments of Medicine and Immunology, University of California Medical Center, Room UB8B, UC Box 0711, 533 Parnassus Ave at 4th, San Francisco, CA 94143 0711, United States
    Regul Pept 137:75-8. 2006
  10. ncbi request reprint Changing paradigms in the immunologic science of allergy
    Edward J Goetzl
    Department of Medicine, University of California, San Francisco 94143 0711, USA
    Curr Allergy Asthma Rep 6:1-3. 2006

Research Grants

Collaborators

Detail Information

Publications60

  1. pmc Regulation of the roles of sphingosine 1-phosphate and its type 1 G protein-coupled receptor in T cell immunity and autoimmunity
    Edward J Goetzl
    Department of Medicine, University of California Medical Center, San Francisco, CA 94143, USA
    Biochim Biophys Acta 1781:503-7. 2008
    ..Such agents have so far been beneficial in the settings of autoimmunity and rejection of transplanted organs, and are likely to become valuable constituents of combined drug programs...
  2. pmc Aging enhances release of exosomal cytokine mRNAs by Aβ1-42-stimulated macrophages
    Masato Mitsuhashi
    3UCSF Geriatric Research Center, 1719 Broderick Street, San Francisco, CA 94115 2525, USA E mail
    FASEB J 27:5141-50. 2013
    ..An Aβ level relevant to neurodegeneration elicited broad M cytokine and ex-mRNA responses that were significantly greater in the old subjects, but only narrow and age-independent CD4-Tm responses...
  3. pmc Distinct energy requirements for human memory CD4 T-cell homeostatic functions
    Dennis D Taub
    National Institute on Aging, National Institutes of Health, Baltimore, Maryland, USA
    FASEB J 27:342-9. 2013
    ..The sources supplying energy for diverse functions of unactivated T(mem) cells differ from that required for function after immune activation...
  4. pmc Distinctive immunoregulatory effects of adenosine on T cells of older humans
    Charles S Hesdorffer
    National Institute on Aging, National Institutes of Health, Baltimore, Maryland, USA
    FASEB J 26:1301-10. 2012
    ..Adenosine is an endogenous T-cell immunosuppressor in older humans, and A(2A) antagonists reverse adenosine-induced T-cell deficiencies of aging...
  5. doi request reprint Diverse mechanisms and consequences of immunoadoption of neuromediator systems
    Edward J Goetzl
    Department of Medicine and Microbiology Immunology, University of California, San Francisco, CA 94143 0711, USA
    Ann N Y Acad Sci 1144:56-60. 2008
    ..Better understanding of how tissue context establishes the nature of neuroregulation of immunity will improve neuropharmacological and other neurotherapeutic approaches to immune diseases...
  6. ncbi request reprint Changing paradigms in the immunological science of allergy
    Edward J Goetzl
    Department of Medicine, University of California, Room UB8B, UC Box 0711, 533 Parnassus Avenue at 4th Avenue, San Francisco, CA 94143 0711, USA
    Curr Allergy Asthma Rep 7:7-10. 2007
    ....
  7. ncbi request reprint Sphingosine 1-phosphate as an intracellular messenger and extracellular mediator in immunity
    Edward J Goetzl
    Department of Medicine, University of California, San Francisco, CA 94143 0711, USA
    Acta Paediatr Suppl 96:49-52. 2007
    ..Effective pharmacological approaches to intracellular, as well as cell surface, S1P-S1P receptor axes will thus require the bioaccessibility of agonists and antagonists to the nuclear domain of relevant target cells...
  8. ncbi request reprint Diverse pathways for nuclear signaling by G protein-coupled receptors and their ligands
    Edward J Goetzl
    Department of Medicine, University of California, San Francisco, California, USA
    FASEB J 21:638-42. 2007
    ....
  9. ncbi request reprint Hypothesis: VPAC G protein-coupled receptors for vasoactive intestinal peptide constitute a dynamic system for signaling T cells from plasma membrane and nuclear membrane complexes
    Edward J Goetzl
    Departments of Medicine and Immunology, University of California Medical Center, Room UB8B, UC Box 0711, 533 Parnassus Ave at 4th, San Francisco, CA 94143 0711, United States
    Regul Pept 137:75-8. 2006
    ..The types of substantial additional proof needed to support this hypothesis are described, as are its advantages for more selective VIP-directed therapies...
  10. ncbi request reprint Changing paradigms in the immunologic science of allergy
    Edward J Goetzl
    Department of Medicine, University of California, San Francisco 94143 0711, USA
    Curr Allergy Asthma Rep 6:1-3. 2006
  11. pmc Gender specificity of altered human immune cytokine profiles in aging
    Edward J Goetzl
    Department of Medicine, University of California, San Francisco, CA 94143 0711, USA
    FASEB J 24:3580-9. 2010
    ..38, P<0.05 and 1.62, P<0.01, respectively), whereas ratios of IFN-gamma-evoked IP-10 chemokine were low in all groups. Alterations in immune cytokine profiles with aging show significant gender specificity...
  12. doi request reprint Defective T cell chemotaxis to sphingosine 1-phosphate and chemokine CCL21 in idiopathic T lymphocytopenia
    Edward J Goetzl
    Department of Medicine, University of California, Geriatric Research Center, San Francisco, CA 94112, USA
    J Clin Immunol 31:744-51. 2011
    ..Defective T cell chemotactic responses to S1P and some chemokines may lead to subset-selective abnormal T cell trafficking and chronic T cell lymphocytopenia...
  13. ncbi request reprint Changing paradigms in the immunological science of allergy: 2008
    Edward J Goetzl
    Department of Medicine, University of California, UC Box 0711, 533 Parnassus at 4th Avenue, San Francisco, CA 94143, USA
    Curr Allergy Asthma Rep 8:28-31. 2008
    ..Their properties and effects are reviewed from the perspective of novel targets for antiallergic therapy...
  14. pmc Type 1 sphingosine 1-phosphate G protein-coupled receptor signaling of lymphocyte functions requires sulfation of its extracellular amino-terminal tyrosines
    Claudia B Fieger
    Department of Anatomy, University of California, San Francisco, California 94143 0711, USA
    FASEB J 19:1926-8. 2005
    ..Inhibition of S1P1 tyrosine sulfation or sulfatase removal of S1P1 sulfate in mouse CD4 T cells suppresses immune functional effects of S1P. Tyrosine sulfation of S1P1 may be a major controller of S1P effects on T cell traffic...
  15. ncbi request reprint Protein kinase C epsilon dependence of the recovery from down-regulation of S1P1 G protein-coupled receptors of T lymphocytes
    Markus H Graeler
    Department of Medicine, University of California, San Francisco, California 94143 0711, USA
    J Biol Chem 278:27737-41. 2003
    ..Biochemical requisites for recovery of down-regulated S1P1 Rs thus differ from those for S1P induction of down-regulation...
  16. ncbi request reprint Cutting edge: suppression of T cell chemotaxis by sphingosine 1-phosphate
    Markus Graeler
    Department of Medicine, University of California Medical Center, 533 Parnassus at 4th, San Francisco, CA 94143, USA
    J Immunol 169:4084-7. 2002
    ..c. air pouches. The S1P-S1P(1) receptor axis thus controls recruitment of naive T cells by maintaining their response threshold to diverse lymphotactic factors...
  17. ncbi request reprint Type 4 sphingosine 1-phosphate G protein-coupled receptor (S1P4) transduces S1P effects on T cell proliferation and cytokine secretion without signaling migration
    Wengang Wang
    Department of Medicine, University of California, San Francisco, California 94143 0711, USA
    FASEB J 19:1731-3. 2005
    ..1 T cells. Thus, S1P4 mediates immunosuppressive effects of S1P by inhibiting proliferation and secretion of effector cytokines, while enhancing secretion of the suppressive cytokine IL-10...
  18. ncbi request reprint Transduction of multiple effects of sphingosine 1-phosphate (S1P) on T cell functions by the S1P1 G protein-coupled receptor
    Glenn Dorsam
    Departments of Medicine and Immunology, University of California, San Francisco, CA 94143, USA
    J Immunol 171:3500-7. 2003
    ..Thus, S1P(1) signals multiple immune functions of T cells as well as migration and tissue distribution...
  19. ncbi request reprint Activation-regulated expression and chemotactic function of sphingosine 1-phosphate receptors in mouse splenic T cells
    Markus Graeler
    Department of Medicine, University of California, San Francisco, California 94143 0711, USA
    FASEB J 16:1874-8. 2002
    ..S1P may be a distinctive contributor to compartmental immunity by attracting naïve and memory T cells preferentially over activated effector T cells...
  20. ncbi request reprint Biochemical regulation of breast cancer cell expression of S1P2 (Edg-5) and S1P3 (Edg-3) G protein-coupled receptors for sphingosine 1-phosphate
    Hana Dolezalova
    Department of Medicine, University of California, San Francisco, CA 94143 0711, USA
    J Cell Biochem 88:732-43. 2003
    ..Thus two structurally-homologous S1P Rs of BCCs differ in coupling to [Ca(2+)](i) signaling and have opposite effects on protein growth factor-stimulated chemotaxis...
  21. ncbi request reprint Cutting edge: Alternative signaling of Th17 cell development by sphingosine 1-phosphate
    Jia Jun Liao
    Department of Medicine and Department of Microbiology Immunology, University of California, San Francisco, CA 94143, USA
    J Immunol 178:5425-8. 2007
    ..The prevention of S1P augmentation of Th17 cell development by the S1P receptor agonist and down-regulator FTY720 implies that FTY720 immunosuppression is attributable partially to inhibition of Th17-mediated inflammation...
  22. ncbi request reprint Distinctive T cell-suppressive signals from nuclearized type 1 sphingosine 1-phosphate G protein-coupled receptors
    Jia Jun Liao
    Department of Medicine, University of California, San Francisco, California 94143, USA
    J Biol Chem 282:1964-72. 2007
    ....
  23. ncbi request reprint Cutting edge: vasoactive intestinal peptide (VIP) induces differentiation of Th17 cells with a distinctive cytokine profile
    Mahesh Yadav
    Department of Medicine, University of California Medical Center, San Francisco, CA 94143, USA
    J Immunol 180:2772-6. 2008
    ..The ability of VIP-VPAC1 axis signals to evoke development of a novel type of Th17 cells demonstrates the unique specificity of neuroregulatory mechanisms in the immunological environment...
  24. ncbi request reprint Physiological sphingosine 1-phosphate requirement for optimal activity of mouse CD4+ regulatory T Cells
    Wengang Wang
    Department of Medicine, University of California, San Francisco, California 94143 0711, USA
    FASEB J 18:1043-5. 2004
    ..Extracellular fluid S1P thus is required for optimal activity of CD4+25+ T cells...
  25. ncbi request reprint Th17 augmentation in OTII TCR plus T cell-selective type 1 sphingosine 1-phosphate receptor double transgenic mice
    Mei Chuan Huang
    Department of Medicine and Department of Microbiology Immunology, University of California, San Francisco, CA 94143, USA
    J Immunol 178:6806-13. 2007
    ..Augmentation of the number and activity of Th17 cells by the S1P-S1P(1) axis may thus enhance host defense against microbes and in other settings increase host susceptibility to autoimmune diseases...
  26. ncbi request reprint A natural variant type II G protein-coupled receptor for vasoactive intestinal peptide with altered function
    Carola Grinninger
    Department of Medicine, University of California, San Francisco, California 94143 0711, USA
    J Biol Chem 279:40259-62. 2004
    ..Natural deletion of part of the last transmembrane domain of VPAC2 thus abrogates signaling functions without apparent alterations of expression or ligand binding...
  27. pmc Immunosuppressive human anti-lymphocyte autoantibodies specific for the type 1 sphingosine 1-phosphate receptor
    Jia Jun Liao
    Department of Medicine, University of California San Francisco, San Francisco, California, USA
    FASEB J 23:1786-96. 2009
    ..Human Abs to the amino terminus of S1P(1) suppress T-cell trafficking sufficiently to impair host defense and provide therapeutic immunosuppression...
  28. ncbi request reprint Lysophospholipid growth factors and their G protein-coupled receptors in immunity, coronary artery disease, and cancer
    Edward J Goetzl
    Department of Medicine, University of California, UB8B, 533 Parnassus at 4th, San Francisco, CA 94143 0711, USA
    ScientificWorldJournal 2:324-38. 2002
    ..The breadth of physiologic and pathologic activities of LPLs emphasizes the importance of developing bioavailable nonlipid agonists and antagonists of the LPA/S1P receptors for diverse therapeutic applications...
  29. pmc Sphingosine 1-phosphate and its G protein-coupled receptors constitute a multifunctional immunoregulatory system
    Edward J Goetzl
    Department of Medicine, University of California Medical Center, San Francisco, California 94143 0711, USA
    J Cell Biochem 92:1104-14. 2004
    ..Lysophospholipids and their GPCRs thus constitute an immunoregulatory system of sufficient prominence for pharmacological targeting in transplantation, autoimmunity and immunodeficiency...
  30. doi request reprint Vasoactive intestinal peptide-mediated Th17 differentiation: an expanding spectrum of vasoactive intestinal peptide effects in immunity and autoimmunity
    Mahesh Yadav
    Department of Medicine and Microbiology Immunology, University of California, San Francisco, CA 94143 0711, USA
    Ann N Y Acad Sci 1144:83-9. 2008
    ....
  31. doi request reprint Nuclear factor-kappaB-dependent reversal of aging-induced alterations in T cell cytokines
    Mei Chuan Huang
    Department of Medicine, University of California, San Francisco, California, USA
    FASEB J 22:2142-50. 2008
    ..Pharmacological correction of altered generation of Th17 cell cytokines in immunosenescence represents a novel therapeutic approach to aging-induced inflammatory diseases...
  32. ncbi request reprint The immunosuppressant FTY720 down-regulates sphingosine 1-phosphate G-protein-coupled receptors
    Markus H Gräler
    University of California, Room UB 8B, UC Box 0711, 533 Parnassus Ave, San Francisco, CA 94143 0711, USA
    FASEB J 18:551-3. 2004
    ..The timing and extent of S1P-R internalization are highly dependent on FTY720 concentration. FTY720 is therefore an S1P-GPCR-selective and noncompetitive inhibitor with a unique mechanism of action...
  33. ncbi request reprint Immunoregulatory lysophospholipids: new stars in the mast cell constellation
    Edward J Goetzl
    Department of Medicine, University of California Medical Center, San Francisco, 94143 0711, USA
    Curr Allergy Asthma Rep 4:175-7. 2004
  34. ncbi request reprint An IgM-kappa rat monoclonal antibody specific for the type 1 sphingosine 1-phosphate G protein-coupled receptor with antagonist and agonist activities
    Edward J Goetzl
    Departments of Medicine and Microbiology Immunology, University of California Medical Center, Room UB8B, 533 Parnassus at 4th Avenue, San Francisco, CA 94143 0711, USA
    Immunol Lett 93:63-9. 2004
    ..2 in vivo may alter immune responses as distinctively as the available poly-S1P GPCR-directed pharmacological agents, without the undesirable side-effects attributable to actions of these agents on other S1P GPCRs...
  35. ncbi request reprint Lysophospholipids and their G protein-coupled receptors in inflammation and immunity
    Markus H Gräler
    Room UB 8B, UC Box 0711, Department of Medicine, University of California Medical Center, 533 Parnassus Avenue, San Francisco, CA 94143 0711, USA
    Biochim Biophys Acta 1582:168-74. 2002
    ..These observations suggest that agonists and antagonists for lysophospholipid receptors may influence immune responses...
  36. ncbi request reprint Sphingosine 1-phosphate and its type 1 G protein-coupled receptor: trophic support and functional regulation of T lymphocytes
    Edward J Goetzl
    University of California, 533 Parnassus Ave, Room UB8B, San Francisco, CA 94143 0711
    J Leukoc Biol 76:30-5. 2004
    ..LPLs and their GPCRs thus constitute an immunoregulatory system of sufficient prominence for pharmacological targeting in transplantation, autoimmunity, and immunodeficiency...
  37. pmc Regulation of immunity by lysosphingolipids and their G protein-coupled receptors
    Edward J Goetzl
    Department of Medicine, UCSF, San Francisco, California, USA
    J Clin Invest 114:1531-7. 2004
    ....
  38. doi request reprint VPAC1 (vasoactive intestinal peptide (VIP) receptor type 1) G protein-coupled receptor mediation of VIP enhancement of murine experimental colitis
    Mahesh Yadav
    Department of Medicine, University of California Medical Center, San Francisco, CA 94143, USA
    Cell Immunol 267:124-32. 2011
    ..Thus VIP enhancement of the severity of DSS-induced colitis is mediated solely by VPAC1 receptors...
  39. pmc Differential signaling of T cell generation of IL-4 by wild-type and short-deletion variant of type 2 G protein-coupled receptor for vasoactive intestinal peptide (VPAC2)
    Mei Chuan Huang
    Department of Medicine and Microbiology Immunology, University of California, San Francisco, CA 94143, USA
    J Immunol 176:6640-6. 2006
    ..Thus the ratio of two forms of T cell VPAC2 determines the net effect of VIP on IL-4 generation by activated Th2 cells...
  40. ncbi request reprint Roles of vasoactive intestinal peptide (VIP) in the expression of different immune phenotypes by wild-type mice and T cell-targeted type II VIP receptor transgenic mice
    Julia K Voice
    Department of Medicine, University of California Medical Center, San Francisco, CA 94143, USA
    J Immunol 170:308-14. 2003
    ..The level of VIP recognized by CD4 T cells thus is a major determinant of the relative contributions of Th subsets to the immune effector phenotype...
  41. ncbi request reprint Vasoactive intestinal peptide receptor-1 (VPAC-1) is a novel gene target of the hemolymphopoietic transcription factor Ikaros
    Glenn Dorsam
    Department of Medicine, University of California Medical Center, San Francisco, California 94143 0711, USA
    J Biol Chem 277:13488-93. 2002
    ..As both Ikaros and its novel target VPAC-1 are highly expressed in T cells, this system may be a dominant determinant of the VPAC-1 expression in immune responses...
  42. pmc Human CD4- 8- T cells are a distinctive immunoregulatory subset
    Mei Chuan Huang
    Department of Medicine, University of California, San Francisco, California, USA
    FASEB J 24:2558-66. 2010
    ..Decreases in CD4(-)8(-) T cell effects may diminish protective immunity in aging, whereas increases may augment the severity of autoimmune diseases...
  43. pmc Sphingolipid signaling and treatment during remodeling of the uninfarcted ventricular wall after myocardial infarction
    Che Chung Yeh
    Cardiothoracic Surgery, 4150 Clement St, 112D, San Francisco, CA 94121, USA
    Am J Physiol Heart Circ Physiol 296:H1193-9. 2009
    ....
  44. ncbi request reprint Immunoeffector and immunoregulatory activities of vasoactive intestinal peptide
    Julia K Voice
    Department of Medicine, University of California, San Francisco, CA 94143, USA
    Regul Pept 109:199-208. 2002
    ..VPAC2R antagonists are being developed to alleviate allergic diseases and strengthen effector Th1 cell-mediated immunoprotection...
  45. ncbi request reprint Sphingosine kinase activation mediates ischemic preconditioning in murine heart
    Zhu Qiu Jin
    Cardiology Section, VA Medical Center and Department of Medicine, University of California, San Francisco, USA
    Circulation 110:1980-9. 2004
    ..Because protein kinase C (PKC)epsilon activation is necessary for myocardial ischemic preconditioning (IPC) and PKC activators increase SK activity, we tested the hypothesis that SK may be a central mediator of IPC...
  46. ncbi request reprint Type 1 sphingosine 1-phosphate G protein-coupled receptor (S1P1) mediation of enhanced IL-4 generation by CD4 T cells from S1P1 transgenic mice
    Wengang Wang
    Department of Medicine and Department of Microbiology Immunology, University of California, San Francisco, CA 94143
    J Immunol 178:4885-90. 2007
    ..Thus, the S1P-S1P(1) axis specifically up-regulates c-Maf, Jun B, and Gata3, which consequently enhance IL-4 production that may lead to a Th2 phenotype...
  47. ncbi request reprint Induction of protein growth factor systems in the ovaries of transgenic mice overexpressing human type 2 lysophosphatidic acid G protein-coupled receptor (LPA2)
    Mei Chuan Huang
    Department of Medicine and Microbiology Immunology, University of California, San Francisco, CA 94143 0711, USA
    Oncogene 23:122-9. 2004
    ..Thus, the LPA-LPA(2) circuit regulates ovarian cells both directly and through increases in protein growth factor systems...
  48. ncbi request reprint Cardioprotection mediated by sphingosine-1-phosphate and ganglioside GM-1 in wild-type and PKC epsilon knockout mouse hearts
    Zhu Qiu Jin
    Cardiology Section, Veterans Affairs Medical Center, San Francisco, California 94121, USA
    Am J Physiol Heart Circ Physiol 282:H1970-7. 2002
    ..In contrast, extracellular S1P induces equivalent cardioprotection through PKC epsilon-independent signaling pathways...
  49. ncbi request reprint Lysophospholipid mediators of immunity and neoplasia
    Mei Chuan Huang
    UB8B, UC Box 0711, Department of Medicine, University of California Medical Center, 533 Parnassus at 4th Avenue, San Francisco, CA 94143 0711, USA
    Biochim Biophys Acta 1582:161-7. 2002
    ....
  50. ncbi request reprint c-Maf and JunB mediation of Th2 differentiation induced by the type 2 G protein-coupled receptor (VPAC2) for vasoactive intestinal peptide
    Julia Voice
    Departments of Medicine and Microbiology Immunology, Medical Center, University of California San Francisco, 533 Parnassus at 4th, San Francisco, CA 94143, USA
    J Immunol 172:7289-96. 2004
    ....
  51. pmc Functional splice variants of the type II G protein-coupled receptor (VPAC2) for vasoactive intestinal peptide in mouse and human lymphocytes
    Allison L Miller
    Department of Medicine, University of California Medical Center, Room UB8B, UC Box 0711, 533 Parnassus at 4th, San Francisco, CA 94143 0711, USA
    Ann N Y Acad Sci 1070:422-6. 2006
    ..These splice variants may modify the immunoregulatory contributions of the VIP-VPAC2 axis...
  52. ncbi request reprint Signals from type 1 sphingosine 1-phosphate receptors enhance adult mouse cardiac myocyte survival during hypoxia
    Jianqing Zhang
    Medical Service and Cardiology Section, Veterans Affairs Medical Center, San Francisco, CA, USA
    Am J Physiol Heart Circ Physiol 293:H3150-8. 2007
    ..These observations highlight the importance of S1P(1) receptors on ventricular myocytes as mediators of inducible resistance against cellular injury during severe hypoxic stress...
  53. ncbi request reprint Nitric oxide signaling via nuclearized endothelial nitric-oxide synthase modulates expression of the immediate early genes iNOS and mPGES-1
    Fernand Gobeil
    Department of Pharmacology, Universite de Sherbrooke, Sherbrooke, Quebec J1H 5N4, Canada
    J Biol Chem 281:16058-67. 2006
    ..Moreover, our findings strongly support the concept of the nucleus as an autonomous signaling compartment...
  54. ncbi request reprint International Union of Pharmacology. XXXIV. Lysophospholipid receptor nomenclature
    Jerold Chun
    Merck Research Laboratories, La Jolla, California 92037, USA
    Pharmacol Rev 54:265-9. 2002
    ..Herein, the molecular pharmacology of the lysophospholipid receptors is reviewed briefly, and a rational nomenclature for LPA and S1P receptors that is consistent with the International Union of Pharmacology guidelines is proposed...
  55. ncbi request reprint Modulation of pro-inflammatory gene expression by nuclear lysophosphatidic acid receptor type-1
    Fernand Gobeil
    Departments of Pediatrics, Ophthalmology and Pharmacology, Research Center of Hôpital Sainte Justine, Montreal, Quebec H3T 1C5, Canada
    J Biol Chem 278:38875-83. 2003
    ..This study describes for the first time the nucleus as a potential organelle for LPA intracrine signaling in the regulation of pro-inflammatory gene expression...
  56. ncbi request reprint Immunological effects of transgenic constitutive expression of the type 1 sphingosine 1-phosphate receptor by mouse lymphocytes
    Markus H Gräler
    Institute for Immunology, Hannover Medical School, Hannover, Germany
    J Immunol 174:1997-2003. 2005
    ....
  57. ncbi request reprint Sphingosine 1-phosphate and its receptors: an autocrine and paracrine network
    Hugh Rosen
    Department of Immunology, The Scripps Research Institute, La Jolla, CA 92037, USA
    Nat Rev Immunol 5:560-70. 2005
    ..S1P-S1P-receptor regulatory systems might therefore be novel targets for the therapy of diverse immunological diseases...
  58. ncbi request reprint Lysophospholipids and their G protein-coupled receptors in biology and diseases
    Edward J Goetzl
    J Cell Biochem 92:867-8. 2004
  59. ncbi request reprint Lysophospholipid regulation of mononuclear phagocytes
    Hsinyu Lee
    Department of Zoology, National Taiwan University, Taipei, Taiwan, ROC
    Biochim Biophys Acta 1582:175-7. 2002
    ..This section summarizes our recent observations of the effects of lysophospholipids on mononuclear phagocytes...
  60. ncbi request reprint A lymphocyte-generated fragment of vasoactive intestinal peptide with VPAC1 agonist activity and VPAC2 antagonist effects
    Monica A Summers
    Depaertment of Pediatrics, University of Iowa City, Iowa City, Iowa 52242, USA
    J Pharmacol Exp Ther 306:638-45. 2003
    ..Lymphoblasts did not hydrolyze VIP4-28 to a form with VPAC1 antagonist activity. VIP4-28 thus is a lymphocyte-generated VIP fragment with potent agonist activity for VPAC1 and potent antagonist activity for VPAC2...

Research Grants34

  1. LEUKOTRIENE MODULATION OF LEUKOCYTE FUNCTION
    EDWARD GOETZL; Fiscal Year: 1993
    ....
  2. LEUKOTRIENE MODULATION OF LEUKOCYTE FUNCTION
    EDWARD GOETZL; Fiscal Year: 1999
    ....
  3. LYSOLIPID PHOSPHATE REGULATION OF LYMPHOCYTE FUNCTIONS
    EDWARD GOETZL; Fiscal Year: 2003
    ..A greater knowledge of Edg R expression and functions in T cells will reveal specific mechanisms of lysolipid phosphate immunoregulation and identify new targets for correcting immune disorders. ..
  4. LYMPHOCYTE RECEPTORS FOR VASOACTIVE INTESTINAL PEPTIDE
    EDWARD GOETZL; Fiscal Year: 2007
    ..abstract_text> ..
  5. LYSOLIPID PHOSPHATE REGULATION OF LYMPHOCYTE FUNCTIONS
    EDWARD GOETZL; Fiscal Year: 2007
    ....
  6. LEUKOTRIENE MODULATION OF LEUKOCYTE FUNCTION
    EDWARD GOETZL; Fiscal Year: 1990
    ..Biochemical and immunochemical methods will be applied to the evaluation of the receptor-associated proteins and cellular events critical for the coupling of receptor stimulation to leukocyte activation...
  7. LYMPHOCYTE RECEPTORS FOR VASOACTIVE INTESTINAL PEPTIDE
    EDWARD GOETZL; Fiscal Year: 1993
    ..A greater knowledge of cellular receptors for VIP may elucidate neural controls of immune, enteric, and endocrine functions and provide useful new approaches to some neuroendocrine and autoimmune diseases...