Hira Lal Goel

Summary

Affiliation: University of Massachusetts Medical School
Country: USA

Publications

  1. pmc GLI1 regulates a novel neuropilin-2/α6β1 integrin based autocrine pathway that contributes to breast cancer initiation
    Hira Lal Goel
    Department of Cancer Biology, University of Massachusetts Medical School, Worcester, MA, USA
    EMBO Mol Med 5:488-508. 2013
  2. ncbi request reprint VEGF/neuropilin-2 regulation of Bmi-1 and consequent repression of IGF-IR define a novel mechanism of aggressive prostate cancer
    Hira Lal Goel
    Department of Cancer Biology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Cancer Discov 2:906-21. 2012
  3. pmc Neuropilin-2 regulates α6β1 integrin in the formation of focal adhesions and signaling
    Hira Lal Goel
    Department of Cancer Biology, University of Massachusetts Medical School Worcester, MA 01605, USA
    J Cell Sci 125:497-506. 2012
  4. pmc Beta1 integrins mediate cell proliferation in three-dimensional cultures by regulating expression of the sonic hedgehog effector protein, GLI1
    Hira Lal Goel
    Department of Cancer Biology, Prostate Cancer Discovery and Development Program, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    J Cell Physiol 224:210-7. 2010
  5. ncbi request reprint Beta1 integrins modulate cell adhesion by regulating insulin-like growth factor-II levels in the microenvironment
    Hira Lal Goel
    Department of Cancer Biology and the Cancer Center, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Cancer Res 66:331-42. 2006
  6. pmc β1 integrins mediate resistance to ionizing radiation in vivo by inhibiting c-Jun amino terminal kinase 1
    Hira Lal Goel
    Department of Cancer Biology, University of Massachusetts Medical School, Worcester, Massachusetts, USA
    J Cell Physiol 228:1601-9. 2013
  7. pmc Beta1 integrin cytoplasmic variants differentially regulate expression of the antiangiogenic extracellular matrix protein thrombospondin 1
    Hira Lal Goel
    Department of Cancer Biology, Prostate Cancer Discovery and Development Program, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Cancer Res 69:5374-82. 2009
  8. pmc Cytoprotective mitochondrial chaperone TRAP-1 as a novel molecular target in localized and metastatic prostate cancer
    Irwin Leav
    Prostate Cancer Discovery and Development Program, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Am J Pathol 176:393-401. 2010
  9. pmc Enhancing integrin function by VEGF/neuropilin signaling: implications for tumor biology
    Hira Lal Goel
    Department of Cancer Biology University of Massachusetts Medical School Worcester, MA, USA
    Cell Adh Migr 6:554-60. 2012
  10. ncbi request reprint Regulated Splicing of the α6 Integrin Cytoplasmic Domain Determines the Fate of Breast Cancer Stem Cells
    Hira Lal Goel
    Department of Cancer Biology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Cell Rep 7:747-61. 2014

Detail Information

Publications19

  1. pmc GLI1 regulates a novel neuropilin-2/α6β1 integrin based autocrine pathway that contributes to breast cancer initiation
    Hira Lal Goel
    Department of Cancer Biology, University of Massachusetts Medical School, Worcester, MA, USA
    EMBO Mol Med 5:488-508. 2013
    ..They also support the feasibility of NRP2-based therapy for the treatment of TNBC that targets and impedes the function of TICs...
  2. ncbi request reprint VEGF/neuropilin-2 regulation of Bmi-1 and consequent repression of IGF-IR define a novel mechanism of aggressive prostate cancer
    Hira Lal Goel
    Department of Cancer Biology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Cancer Discov 2:906-21. 2012
    ..Conversely, targeting NRP2 is only modestly effective because NRP2 inhibition induces compensatory IGF-IR signaling. Inhibition of both NRP2 and IGF-IR, however, completely blocks tumor growth in vivo...
  3. pmc Neuropilin-2 regulates α6β1 integrin in the formation of focal adhesions and signaling
    Hira Lal Goel
    Department of Cancer Biology, University of Massachusetts Medical School Worcester, MA 01605, USA
    J Cell Sci 125:497-506. 2012
    ..Together, our data reveal a new VEGF-NRP2 signaling pathway that activates the α6β1 integrin and enables it to form focal adhesions and signal. This pathway is important in the pathogenesis of breast cancer...
  4. pmc Beta1 integrins mediate cell proliferation in three-dimensional cultures by regulating expression of the sonic hedgehog effector protein, GLI1
    Hira Lal Goel
    Department of Cancer Biology, Prostate Cancer Discovery and Development Program, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    J Cell Physiol 224:210-7. 2010
    ..Our results indicate that the beta1/IGF-IR complex regulates expression of GLI1, which in turn promotes cancer cell proliferation in 3D cultures...
  5. ncbi request reprint Beta1 integrins modulate cell adhesion by regulating insulin-like growth factor-II levels in the microenvironment
    Hira Lal Goel
    Department of Cancer Biology and the Cancer Center, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Cancer Res 66:331-42. 2006
    ..It is, therefore, conceivable that reexpression of beta1C will be sufficient to revert a neoplastic phenotype to a nonproliferative and highly adherent normal phenotype...
  6. pmc β1 integrins mediate resistance to ionizing radiation in vivo by inhibiting c-Jun amino terminal kinase 1
    Hira Lal Goel
    Department of Cancer Biology, University of Massachusetts Medical School, Worcester, Massachusetts, USA
    J Cell Physiol 228:1601-9. 2013
    ..In conclusion, this study demonstrates that β1 integrins mediate resistance to ionizing radiation through inhibition of JNK1 activation...
  7. pmc Beta1 integrin cytoplasmic variants differentially regulate expression of the antiangiogenic extracellular matrix protein thrombospondin 1
    Hira Lal Goel
    Department of Cancer Biology, Prostate Cancer Discovery and Development Program, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Cancer Res 69:5374-82. 2009
    ..In conclusion, our novel findings indicate that expression of the beta(1C) integrin variant in prostate glands prevents cancer progression by up-regulation of TSP1 levels and inhibition of angiogenesis...
  8. pmc Cytoprotective mitochondrial chaperone TRAP-1 as a novel molecular target in localized and metastatic prostate cancer
    Irwin Leav
    Prostate Cancer Discovery and Development Program, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Am J Pathol 176:393-401. 2010
    ..Targeting this pathway with Gamitrinibs could be explored as novel molecular therapy in patients with advanced prostate cancer...
  9. pmc Enhancing integrin function by VEGF/neuropilin signaling: implications for tumor biology
    Hira Lal Goel
    Department of Cancer Biology University of Massachusetts Medical School Worcester, MA, USA
    Cell Adh Migr 6:554-60. 2012
    ..More specifically, we will discuss how neuropilins (NRPs), a distinct class of VEGF receptors, enable the function of specific integrins that contribute to tumor initiation and progression...
  10. ncbi request reprint Regulated Splicing of the α6 Integrin Cytoplasmic Domain Determines the Fate of Breast Cancer Stem Cells
    Hira Lal Goel
    Department of Cancer Biology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Cell Rep 7:747-61. 2014
    ..These data alter our understanding of how α6β1 contributes to breast cancer, and they resolve ambiguities regarding the use of total α6 (CD49f) expression as a biomarker for CSCs. ..
  11. pmc Bicalutamide inhibits androgen-mediated adhesion of prostate cancer cells exposed to ionizing radiation
    Tao Wang
    Department of Radiation Oncology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Prostate 68:1734-42. 2008
    ..Bicalutamide (Casodex) has been used as an anti-androgen agent for prostate cancer patients during hormone ablation therapy. This study focuses on the effect of Bicalutamide on cell adhesion to fibronectin (FN) in prostate cancer cells...
  12. pmc Integrins in prostate cancer progression
    Hira Lal Goel
    Department of Cancer Biology and Cancer Center, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Endocr Relat Cancer 15:657-64. 2008
    ..Their functions and expression are deregulated in several types of cancer, including prostate cancer. In this article, we review the role of integrins in prostate cancer progression and their potential as therapeutic targets...
  13. ncbi request reprint VEGF targets the tumour cell
    Hira Lal Goel
    Department of Cancer Biology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, Massachusetts 01655, USA
    Nat Rev Cancer 13:871-82. 2013
    ..This has important implications for our understanding of tumour biology and for the development of more effective therapeutic approaches. ..
  14. pmc Neuropilin-2 promotes branching morphogenesis in the mouse mammary gland
    Hira Lal Goel
    Department of Cancer Biology, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Development 138:2969-76. 2011
    ..In a broader context, our data support an emerging hypothesis that directional outgrowth and branching morphogenesis in a variety of tissues are influenced by signals that were identified initially for their role in axon guidance...
  15. ncbi request reprint beta1A integrin expression is required for type 1 insulin-like growth factor receptor mitogenic and transforming activities and localization to focal contacts
    Hira Lal Goel
    Department of Cancer Biology and the Cancer Center, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Cancer Res 65:6692-700. 2005
    ....
  16. pmc Integrin signaling aberrations in prostate cancer
    Hira Lal Goel
    Department of Cancer Biology, Prostate Cancer Discovery and Development Program, Cancer Center, University of Massachusetts Medical School Worcester, MA 01605, USA
    Am J Transl Res 1:211-20. 2009
    ..This review is focused on integrin signaling pathways known to be deregulated in prostate cancer and known to promote prostate cancer progression...
  17. pmc Prostate carcinoma and radiation therapy: therapeutic treatment resistance and strategies for targeted therapeutic intervention
    T J Fitzgerald
    Department of Radiation Oncology, University of Massachusetts Medical School, 55 Lake Avenue North Worcester, MA 01605, USA
    Expert Rev Anticancer Ther 8:967-74. 2008
    ..This paper focuses on future treatment strategies integrating new therapeutic options with traditional management, specifically to pinpoint new radiation therapy strategies...
  18. ncbi request reprint The integrin-growth factor receptor duet
    Naved Alam
    Department of Cancer Biology and Cancer Center, University of Massachusetts Medical School, Worcester, Massachusetts, USA
    J Cell Physiol 213:649-53. 2007
    ..We also examine the reciprocal modulation of integrin functions by GFRs and the mechanisms through which those actions are fine-tuned...
  19. pmc Selective modulation of type 1 insulin-like growth factor receptor signaling and functions by beta1 integrins
    Hira Lal Goel
    Department of Cancer Biology, University of Massachusetts Medical School, 364 Plantation St, Worcester 01605, USA
    J Cell Biol 166:407-18. 2004
    ..This study unravels a novel mechanism mediated by the integrin cytoplasmic domain that differentially regulates cell adhesion to LN and cell proliferation in response to IGF...