Apollina Goel

Summary

Affiliation: University of Iowa
Country: USA

Publications

  1. doi request reprint Copper-zinc superoxide dismutase-mediated redox regulation of bortezomib resistance in multiple myeloma
    Kelley Salem
    Department of Radiation Oncology, Free Radical and Radiation Biology Program, Iowa City, IA, USA
    Redox Biol 4:23-33. 2015
  2. pmc Interleukin-6 counteracts therapy-induced cellular oxidative stress in multiple myeloma by up-regulating manganese superoxide dismutase
    Charles O Brown
    Free Radical and Radiation Biology Program, Department of Radiation Oncology, University of Iowa, Iowa City, IA 52242, USA
    Biochem J 444:515-27. 2012
  3. pmc Manipulation of cellular redox parameters for improving therapeutic responses in B-cell lymphoma and multiple myeloma
    Apollina Goel
    Free Radical and Radiation Biology Program, Department of Radiation Oncology, The Holden Comprehensive Cancer Center, University of Iowa, Iowa City, Iowa 52242, USA
    J Cell Biochem 113:419-25. 2012
  4. pmc Combination chemotherapy increases cytotoxicity of multiple myeloma cells by modification of nuclear factor (NF)-κB activity
    Kelley Salem
    Free Radical and Radiation Biology Program, Department of Radiation Oncology, The Holden Comprehensive Cancer Center, University of Iowa, Iowa City, IA 52242, USA
    Exp Hematol 41:209-18. 2013
  5. pmc Scavenger receptor class A member 3 (SCARA3) in disease progression and therapy resistance in multiple myeloma
    Charles O Brown
    Free Radical and Radiation Biology Program, Department of Radiation Oncology, USA
    Leuk Res 37:963-9. 2013
  6. pmc Dexamethasone-induced oxidative stress enhances myeloma cell radiosensitization while sparing normal bone marrow hematopoiesis
    Soumen Bera
    Free Radical and Radiation Biology Program, Department of Radiation Oncology, The Holden Comprehensive Cancer Center, University of Iowa, Iowa City, IA 52242 1181, USA
    Neoplasia 12:980-92. 2010
  7. pmc Endothelial cell migration on fibronectin is regulated by syntaxin 6-mediated alpha5beta1 integrin recycling
    Ajit Tiwari
    Department of Anatomy and Cell Biology, University of Iowa, Iowa City, Iowa 52242, USA
    J Biol Chem 286:36749-61. 2011
  8. pmc Secretion of soluble vascular endothelial growth factor receptor 1 (sVEGFR1/sFlt1) requires Arf1, Arf6, and Rab11 GTPases
    Jae Joon Jung
    Departments of Anatomy and Cell Biology, University of Iowa, Iowa City, Iowa, United States of America
    PLoS ONE 7:e44572. 2012
  9. pmc Regulation of vascular endothelial growth factor receptor 2 trafficking and angiogenesis by Golgi localized t-SNARE syntaxin 6
    Venkatraman Manickam
    Department of Anatomy and Cell Biology, University of Iowa, 51 Newton Rd, Iowa City, IA 52242, USA
    Blood 117:1425-35. 2011

Collaborators

  • Fenghuang Zhan
  • Debabrata Mukhopadhyay
  • Resham Bhattacharya
  • Kelley Salem
  • Charles O Brown
  • Ajit Tiwari
  • Amit Choudhury
  • Jae Joon Jung
  • Soumen Bera
  • Jeanine Schibler
  • Neeraj Singh
  • Shivangi M Inamdar
  • Venkatraman Manickam
  • Erik Wendlandt
  • Michael L McCormick
  • Matthew P Fitzgerald
  • Christie P Thomas
  • Brett A Wagner
  • Garry R Buettner
  • Douglas R Spitz
  • Angela Dispenzieri
  • Suzanne Greiner
  • Stephen J Russell

Detail Information

Publications9

  1. doi request reprint Copper-zinc superoxide dismutase-mediated redox regulation of bortezomib resistance in multiple myeloma
    Kelley Salem
    Department of Radiation Oncology, Free Radical and Radiation Biology Program, Iowa City, IA, USA
    Redox Biol 4:23-33. 2015
    ..Our data validates CuZnSOD as a novel therapeutic target in MM. We propose DSF as an adjuvant to BTZ in MM that is expected to overcome intrinsic and acquired BTZ resistance as well as augment BTZ cytotoxicity. ..
  2. pmc Interleukin-6 counteracts therapy-induced cellular oxidative stress in multiple myeloma by up-regulating manganese superoxide dismutase
    Charles O Brown
    Free Radical and Radiation Biology Program, Department of Radiation Oncology, University of Iowa, Iowa City, IA 52242, USA
    Biochem J 444:515-27. 2012
    ..The results of the present study indicate that inhibition of antioxidant pathways could enhance myeloma cell responses to radiotherapy and/or chemotherapy...
  3. pmc Manipulation of cellular redox parameters for improving therapeutic responses in B-cell lymphoma and multiple myeloma
    Apollina Goel
    Free Radical and Radiation Biology Program, Department of Radiation Oncology, The Holden Comprehensive Cancer Center, University of Iowa, Iowa City, Iowa 52242, USA
    J Cell Biochem 113:419-25. 2012
    ..Besides providing potential curative benefit, such novel therapies could also selectively target and inhibit the emergence of drug-resistance in tumor cells, which is a major determinant of treatment failure in many B-cell malignancies...
  4. pmc Combination chemotherapy increases cytotoxicity of multiple myeloma cells by modification of nuclear factor (NF)-κB activity
    Kelley Salem
    Free Radical and Radiation Biology Program, Department of Radiation Oncology, The Holden Comprehensive Cancer Center, University of Iowa, Iowa City, IA 52242, USA
    Exp Hematol 41:209-18. 2013
    ....
  5. pmc Scavenger receptor class A member 3 (SCARA3) in disease progression and therapy resistance in multiple myeloma
    Charles O Brown
    Free Radical and Radiation Biology Program, Department of Radiation Oncology, USA
    Leuk Res 37:963-9. 2013
    ..In MM, SCARA3 protects against oxidative stress-induced cell killing and can serve as predictor of MM progression and therapeutic response. ..
  6. pmc Dexamethasone-induced oxidative stress enhances myeloma cell radiosensitization while sparing normal bone marrow hematopoiesis
    Soumen Bera
    Free Radical and Radiation Biology Program, Department of Radiation Oncology, The Holden Comprehensive Cancer Center, University of Iowa, Iowa City, IA 52242 1181, USA
    Neoplasia 12:980-92. 2010
    ....
  7. pmc Endothelial cell migration on fibronectin is regulated by syntaxin 6-mediated alpha5beta1 integrin recycling
    Ajit Tiwari
    Department of Anatomy and Cell Biology, University of Iowa, Iowa City, Iowa 52242, USA
    J Biol Chem 286:36749-61. 2011
    ..These syntaxin 6-regulated membrane trafficking events control outside-in signaling via haptotactic and chemotactic mechanisms...
  8. pmc Secretion of soluble vascular endothelial growth factor receptor 1 (sVEGFR1/sFlt1) requires Arf1, Arf6, and Rab11 GTPases
    Jae Joon Jung
    Departments of Anatomy and Cell Biology, University of Iowa, Iowa City, Iowa, United States of America
    PLoS ONE 7:e44572. 2012
    ....
  9. pmc Regulation of vascular endothelial growth factor receptor 2 trafficking and angiogenesis by Golgi localized t-SNARE syntaxin 6
    Venkatraman Manickam
    Department of Anatomy and Cell Biology, University of Iowa, 51 Newton Rd, Iowa City, IA 52242, USA
    Blood 117:1425-35. 2011
    ..Our data demonstrate the importance of syntaxin 6 in the maintenance of cellular VEGFR2 levels, and suggest that the inhibitory form of syntaxin 6 has good potential as an antiangiogenic agent...