G T Gobbel
Affiliation: University of Pittsburgh
- Neuronal death is an active, caspase-dependent process after moderate but not severe DNA damageG T Gobbel
Department of Neurological Surgery, University of Pittsburgh, Pennsylvania 15238, USA
J Neurochem 76:520-31. 2001..These data suggest that cell death after high dose irradiation and severe DNA damage can occur by non apoptotic mechanisms and that blocking apoptotic pathways may not prevent death after severe damage...
- Long-term cultivation of multipotential neural stem cells from adult rat subependymaGlenn T Gobbel
Department of Neurological Surgery, Walter F Copeland Laboratory for Neurosurgical Research, University of Pittsburgh, 200 Lothrop Street, Suite B400, PUH, Pittsburgh, PA 15213, USA
Brain Res 980:221-32. 2003..The optimization of methods to grow adult RNSCs and identification of characteristics that limit their growth should prove useful in increasing the use of RNSCs for studies of their potential role in brain health and disease...
- Sensitivity to radiation-induced apoptosis and neuron loss declines rapidly in the postnatal mouse neocortexK Nakaya
Department of Neurological Surgery, University of Pittsburgh, PA 15213, USA
Int J Radiat Biol 81:545-54. 2005..However, this sensitivity decreases rapidly after birth. By P14, acute cell loss due to radiation occurs primarily in non-neuronal populations...
- Survival of transplanted neural progenitor cells enhanced by brain irradiationAjay Niranjan
Department of Neurological Surgery, University of Pittsburgh, Pennsylvania 15213, USA
J Neurosurg 107:383-91. 2007..In this study, the authors evaluated survival and integration of adult rat-derived NPCs after transplantation and explored the potential impact on transplant survival of various mechanical and biological factors of clinical importance...