Peter J Goadsby

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi Pathophysiology of migraine
    Peter J Goadsby
    Headache Group, Department of Neurology, University of California, San Francisco, 1635 Divisadero Street, San Francisco, CA 94115, USA
    Neurol Clin 27:335-60. 2009
  2. ncbi Topiramate is likely to act outside of the trigeminocervical complex
    Robin J Storer
    Headache Group, Department of Neurology, UCSF Headache Center, 1701 Divisadero St, San Francisco, CA 94115, USA
    Cephalalgia 33:291-300. 2013
  3. ncbi Trigeminal autonomic cephalalgias
    Peter J Goadsby
    Department of Neurology, UCSF Headache Center, San Francisco, CA, USA
    Continuum (Minneap Minn) 18:883-95. 2012
  4. ncbi A potential nitrergic mechanism of action for indomethacin, but not of other COX inhibitors: relevance to indomethacin-sensitive headaches
    Oliver Summ
    Headache Group, Department of Neurology, University of California, 1701 Divisadero St, Suite 480, San Francisco, CA 94115, USA
    J Headache Pain 11:477-83. 2010
  5. ncbi Acute migraine therapy: new drugs and new approaches
    Teshamae S Monteith
    Department of Neurology, UCSF Headache Center, 1701 Divisadero Street, Suite 480, San Francisco, CA, 94115, USA
    Curr Treat Options Neurol 13:1-14. 2011
  6. ncbi Update on hemicrania continua
    Elisabetta Cittadini
    Functional Magnetic Resonance Imaging of the Brain Centre, PAIN Group, Oxford University, Oxford, UK
    Curr Pain Headache Rep 15:51-6. 2011
  7. ncbi Current practice and future directions in the prevention and acute management of migraine
    Peter J Goadsby
    Department of Neurology, University of California, San Francisco, 94115, USA
    Lancet Neurol 9:285-98. 2010
  8. ncbi Intravenous dihydroergotamine for inpatient management of refractory primary headaches
    Abraham J Nagy
    Department of Neurology, University of California, San Francisco, CA, USA
    Neurology 77:1827-32. 2011
  9. ncbi Inhibition of trigeminovascular dural nociceptive afferents by Ca(2+)-activated K(+) (MaxiK/BK(Ca)) channel opening
    Simon Akerman
    UCSF Headache Group, Department of Neurology, University of California, San Francisco, CA 94115, USA
    Pain 151:128-36. 2010
  10. ncbi Topiramate in the treatment of migraine: a kainate (glutamate) receptor antagonist within the trigeminothalamic pathway
    Anna P Andreou
    Headache Group, University of California, San Francisco, 1701 Divisadero St, San Francisco, CA 94115, USA
    Cephalalgia 31:1343-58. 2011

Collaborators

Detail Information

Publications43

  1. ncbi Pathophysiology of migraine
    Peter J Goadsby
    Headache Group, Department of Neurology, University of California, San Francisco, 1635 Divisadero Street, San Francisco, CA 94115, USA
    Neurol Clin 27:335-60. 2009
    ..The disturbance in the brain is of the subcortical aminergic sensory modulatory systems, and probably includes brainstem, hypothalamic, and thalamic changes that produce the rich clinical presentation seen in practice...
  2. ncbi Topiramate is likely to act outside of the trigeminocervical complex
    Robin J Storer
    Headache Group, Department of Neurology, UCSF Headache Center, 1701 Divisadero St, San Francisco, CA 94115, USA
    Cephalalgia 33:291-300. 2013
    ..To facilitate understanding the locus and mechanism of action of antimigraine preventives, we examined the effect of topiramate on trigeminocervical activation in the cat...
  3. ncbi Trigeminal autonomic cephalalgias
    Peter J Goadsby
    Department of Neurology, UCSF Headache Center, San Francisco, CA, USA
    Continuum (Minneap Minn) 18:883-95. 2012
    ..This article covers the clinical manifestations and differential diagnosis of the trigeminal autonomic cephalalgias (TACs)...
  4. ncbi A potential nitrergic mechanism of action for indomethacin, but not of other COX inhibitors: relevance to indomethacin-sensitive headaches
    Oliver Summ
    Headache Group, Department of Neurology, University of California, 1701 Divisadero St, Suite 480, San Francisco, CA 94115, USA
    J Headache Pain 11:477-83. 2010
    ....
  5. ncbi Acute migraine therapy: new drugs and new approaches
    Teshamae S Monteith
    Department of Neurology, UCSF Headache Center, 1701 Divisadero Street, Suite 480, San Francisco, CA, 94115, USA
    Curr Treat Options Neurol 13:1-14. 2011
    ..Other targets under investigation include glutamate (AMPA/kainate), TRPV1, prostanoid EP4, and nitric oxide synthase. With new neural targets and the potential for therapeutic advances, the next era of antimigraine medications is near...
  6. ncbi Update on hemicrania continua
    Elisabetta Cittadini
    Functional Magnetic Resonance Imaging of the Brain Centre, PAIN Group, Oxford University, Oxford, UK
    Curr Pain Headache Rep 15:51-6. 2011
    ..Increasing the awareness of this primary headache form among clinicians will aid in its diagnosis while further work is being undertaken to characterize the syndrome...
  7. ncbi Current practice and future directions in the prevention and acute management of migraine
    Peter J Goadsby
    Department of Neurology, University of California, San Francisco, 94115, USA
    Lancet Neurol 9:285-98. 2010
    ....
  8. ncbi Intravenous dihydroergotamine for inpatient management of refractory primary headaches
    Abraham J Nagy
    Department of Neurology, University of California, San Francisco, CA, USA
    Neurology 77:1827-32. 2011
    ..To determine dosing and side effects of dihydroergotamine as they affect outcomes in primary headache disorders...
  9. ncbi Inhibition of trigeminovascular dural nociceptive afferents by Ca(2+)-activated K(+) (MaxiK/BK(Ca)) channel opening
    Simon Akerman
    UCSF Headache Group, Department of Neurology, University of California, San Francisco, CA 94115, USA
    Pain 151:128-36. 2010
    ..06, P<0.05). The data taken together indicate that the MaxiK/BK(Ca) channel may represent a novel therapeutic target in migraine...
  10. ncbi Topiramate in the treatment of migraine: a kainate (glutamate) receptor antagonist within the trigeminothalamic pathway
    Anna P Andreou
    Headache Group, University of California, San Francisco, 1701 Divisadero St, San Francisco, CA 94115, USA
    Cephalalgia 31:1343-58. 2011
    ..Since glutamate plays a major role in migraine pathophysiology, the potential action of topiramate through glutamatergic mechanisms is of considerable interest...
  11. ncbi Modulation of nocioceptive transmission with calcitonin gene-related peptide receptor antagonists in the thalamus
    Oliver Summ
    Headache Group Department of Neurology, University of California San Francisco, 1701 Divisadero St, San Francisco, CA 94115, USA
    Brain 133:2540-8. 2010
    ....
  12. ncbi Dopamine: what's new in migraine?
    Annabelle R Charbit
    Headache Group Department of Neurology, University of California, San Francisco, San Francisco, California 94115, USA
    Curr Opin Neurol 23:275-81. 2010
    ..Recent data offer some new perspective on a possible role for dopaminergic mechanisms in migraine. This review aims to summarize our current understanding of dopamine in migraine...
  13. ncbi TRPV1 receptor blockade is ineffective in different in vivo models of migraine
    Oliver Summ
    University of California, USA
    Cephalalgia 31:172-80. 2011
    ..Due to a possible role of TRPV1 receptors in cortical spreading depression (CSD), an experimental phenomenon sharing many features with migraine aura, we also utilized a model of mechanically induced CSD...
  14. ncbi Animal models of headache: from bedside to bench and back to bedside
    Anna P Andreou
    Headache Group Department of Neurology, University of California, San Francisco, San Francisco, CA 94115, USA
    Expert Rev Neurother 10:389-411. 2010
    ..Moreover, although useful in many regards, migraine models are yet to provide a more complete picture of the disorder...
  15. ncbi GABA and valproate modulate trigeminovascular nociceptive transmission in the thalamus
    Anna P Andreou
    Headache Group Department of Neurology, University of California, San Francisco, San Francisco, CA 94115, USA
    Neurobiol Dis 37:314-23. 2010
    ....
  16. ncbi Triptans attenuate capsaicin-induced CREB phosphorylation within the trigeminal nucleus caudalis: a mechanism to prevent central sensitization?
    Dimos D Mitsikostas
    Headache Group, Department of Neurology, University of California, San Francisco, San Francisco, CA, USA
    J Headache Pain 12:411-7. 2011
    ..P-CREB may serve as a new marker for post-synaptic neuronal activation within Sp5C in animal models relevant to migraine...
  17. ncbi Neurons of the dopaminergic/calcitonin gene-related peptide A11 cell group modulate neuronal firing in the trigeminocervical complex: an electrophysiological and immunohistochemical study
    Annabelle R Charbit
    Department of Neurology, University of California, San Francisco, CA 94143, USA
    J Neurosci 29:12532-41. 2009
    ..Exploration of dopaminergic influences and mechanisms in migraine may open up an almost untapped opportunity to pursue potential new therapeutic options for the disorder...
  18. ncbi Diencephalic and brainstem mechanisms in migraine
    Simon Akerman
    Headache Group, Department of Neurology, University of California, San Francisco, California 94115, USA
    Nat Rev Neurosci 12:570-84. 2011
    ....
  19. ncbi Trigeminal autonomic cephalalgias: diagnostic and therapeutic developments
    Peter J Goadsby
    Headache Group, Department of Neurology, University of California, San Francisco, San Francisco California 94143 0114, USA
    Curr Opin Neurol 21:323-30. 2008
    ..Hemicrania continua is included for completeness...
  20. ncbi Child neurology: Migraine with aura in children
    Amy A Gelfand
    Division of Child Neurology, UCSF Department of Neurology, Box 0114, 505 Parnassus Ave, M 798, San Francisco, CA 94143 0114, USA
    Neurology 75:e16-9. 2010
    ..An approach to the prophylactic and acute treatment for children with migraine with aura is offered...
  21. ncbi Migraine in pregnancy
    Peter J Goadsby
    Headache Group, Department of Neurology, University of California, San Francisco, CA 94143-0114, USA
    BMJ 336:1502-4. 2008
  22. ncbi Immunohistochemical characterization of calcitonin gene-related peptide in the trigeminal system of the familial hemiplegic migraine 1 knock-in mouse
    Rammya Mathew
    University of California San Francisco, San Francisco, 1701 Divisadero St, San Francisco, CA 94115, USA
    Cephalalgia 31:1368-80. 2011
    ..Elevated calcitonin gene-related peptide (CGRP) levels in acute migraine and clinical trials using CGRP receptor antagonists suggest CGRP-related mechanisms are important in migraine...
  23. ncbi Oxygen inhibits neuronal activation in the trigeminocervical complex after stimulation of trigeminal autonomic reflex, but not during direct dural activation of trigeminal afferents
    Simon Akerman
    Headache Group, Department of Neurology, University of California, San Francisco, San Francisco, CA 94143 0114, USA
    Headache 49:1131-43. 2009
    ..To understand the mechanism of action of oxygen treatment in cluster headache...
  24. ncbi What has functional neuroimaging done for primary headache ... and for the clinical neurologist?
    Till Sprenger
    UCSF Headache Centre, Department of Neurology, University of California, 1701 Divisadero St, Suite 480, San Francisco, CA 94115, USA
    J Clin Neurosci 17:547-53. 2010
    ..We will further outline future research directions and the clinical applicability of functional imaging in headache patients...
  25. ncbi Cluster headache, hypothalamus, and orexin
    Philip R Holland
    Headache Research Group, Department of Neurology, University of California, San Francisco, Box 0114, 505 Parnassus Avenue, San Francisco, CA 94143, USA
    Curr Pain Headache Rep 13:147-54. 2009
    ..We discuss the hypothalamic involvement in CH and modulation of trigeminovascular processing and examine the emerging involvement of the hypothalamic orexinergic system as a possible key pathway in CH pathophysiology...
  26. ncbi Therapeutic potential of novel glutamate receptor antagonists in migraine
    Anna P Andreou
    Headache Group, Department of Neurology, University of California San Francisco, 1635 Divisadero St, San Francisco, CA 94115, USA
    Expert Opin Investig Drugs 18:789-803. 2009
    ..Glutamate, the major excitatory neurotransmitter in the CNS, is implicated in elements of the pathophysiology of the disorder, including trigeminovascular activation, central sensitization and cortical spreading depression...
  27. ncbi Trigeminocervical complex responses after lesioning dopaminergic A11 nucleus are modified by dopamine and serotonin mechanisms
    Annabelle R Charbit
    Headache Group Department of Neurology, University of California San Francisco, San Francisco, CA 94115, USA
    Pain 152:2365-76. 2011
    ..The data suggest that the serotonergic and dopaminergic antinociceptive pathways act simultaneously on neurons in the trigeminocervical complex, and both amine systems need to be functioning for trigeminal sensitization to be reversed...
  28. ncbi A randomized controlled trial of intranasal ketamine in migraine with prolonged aura
    Shazia K Afridi
    Headache Group, Department of Neurology, University of California, San Francisco, USA
    Neurology 80:642-7. 2013
    ..The aim of our study was to test the hypothesis that ketamine would affect aura in a randomized controlled double-blind trial, and thus to provide direct evidence for the role of glutamatergic transmission in human aura...
  29. ncbi A translational in vivo model of trigeminal autonomic cephalalgias: therapeutic characterization
    Simon Akerman
    Headache Group, Department of Neurology, University of California, San Francisco, 675 Nelson Rising Lane, San Francisco, CA 94158, USA
    Brain 135:3664-75. 2012
    ....
  30. ncbi Before the headache: infant colic as an early life expression of migraine
    Amy A Gelfand
    Division of Child Neurology, Department of Neurology, University of California, San Francisco, CA, USA
    Neurology 79:1392-6. 2012
    ..The objective of this study was to determine whether maternal migraine is associated with an increased risk of infant colic, because this may indicate that colic is a childhood periodic syndrome...
  31. ncbi Treatment of pediatric migraine in the emergency room
    Amy A Gelfand
    Division of Child Neurology, Department of Neurology, University of California, San Francisco, San Francisco, California, USA
    Pediatr Neurol 47:233-41. 2012
    ..We review current knowledge about pediatric migraineurs presenting at the emergency room and their management, and summarize the best evidence available to guide clinical decision-making...
  32. ncbi Trigeminal autonomic cephalalgias: paroxysmal hemicrania, SUNCT/SUNA, and hemicrania continua
    Peter J Goadsby
    Headache Group, Department of Neurology, University of California San Francisco, San Francisco, California, USA
    Semin Neurol 30:186-91. 2010
    ..The syndromes share much in their pathophysiology and investigation paths; however, their treatment is distinct, so that the accurate differentiation is important for optimal management...
  33. ncbi Trigeminal neuropathic pain in a patient with progressive facial hemiatrophy (parry-romberg syndrome)
    Michele Viana
    Headache Group, Department of Neurology, University of California, San Francisco, San Francisco, CA 94143 1675, USA
    Arch Neurol 68:938-43. 2011
    ..We reviewed the literature on published cases of progressive facial hemiatrophy (Parry-Romberg syndrome) to identify possible pathophysiological mechanisms of the syndrome...
  34. ncbi Single-pulse transcranial magnetic stimulation for acute treatment of migraine with aura: a randomised, double-blind, parallel-group, sham-controlled trial
    Richard B Lipton
    Department of Neurology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Lancet Neurol 9:373-80. 2010
    ..We aimed to assess the efficacy and safety of a new portable sTMS device for acute treatment of migraine with aura...
  35. ncbi Migraine pathogenesis and state of pharmacological treatment options
    Till Sprenger
    UCSF Headache Group Department of Neurology, University of California, San Francisco, CA, USA
    BMC Med 7:71. 2009
    ..The prospects of this research are exciting and are likely to improve patient care...
  36. ncbi Treatment of intractable chronic cluster headache by occipital nerve stimulation in 14 patients
    Brian Burns
    Headache Group, Department of Neurology, University of California San Francisco, San Francisco, CA 19143 0114, USA
    Neurology 72:341-5. 2009
    ..Most patients with chronic cluster headache (CCH) have an unremitting illness requiring daily preventive therapy for years...
  37. ncbi Predictors of migraine headache recurrence: a pooled analysis from the eletriptan database
    David W Dodick
    Department of Neurology, Mayo Clinic, Scottsdale, AZ 85259, USA
    Headache 48:184-93. 2008
    ....
  38. ncbi Consensus statement: cardiovascular safety profile of triptans (5-HT agonists) in the acute treatment of migraine
    David Dodick
    Department of Neurology, Mayo Clinic Scottsdale, AZ 85259, USA
    Headache 44:414-25. 2004
    ..4) The cardiovascular risk-benefit profile of triptans favors their use in the absence of contraindications...
  39. ncbi Priorities for triptan treatment attributes and the implications for selecting an oral triptan for acute migraine: a study of US primary care physicians (the TRIPSTAR Project)
    F Michael Cutrer
    Department of Neurology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Clin Ther 26:1533-45. 2004
    ..Physicians treating patients with migraine can now choose from among 7 triptans, which differ on a range of attributes that may be important for treatment selection...
  40. ncbi Obesity, migraine, and chronic migraine: possible mechanisms of interaction
    Marcelo E Bigal
    Department of Neurology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Neurology 68:1851-61. 2007
    ..Dysfunction in the orexins pathways seems to be a risk factor for both conditions. Finally, conditions that are comorbid to both states (e.g., depression, sleep apnea) may also make the relationship between both diseases more complex...
  41. ncbi Prioritizing treatment attributes and their impact on selecting an oral triptan: results from the TRIPSTAR Project
    David W Dodick
    Department of Neurology, Mayo Clinic Scottsdale, AZ 85259, USA
    Curr Pain Headache Rep 8:435-42. 2004
    ..Using a multiattribute decision model, we combined these data on the importance of treatment attributes with information on the relative performance of the oral triptans derived from a recent meta-analysis of controlled clinical trials...
  42. ncbi Short-lasting unilateral neuralgiform headache with conjunctival injection and tearing syndrome: a review
    Manjit S Matharu
    Mayo Clinic, Department of Neurology, Rochester, MN, USA
    Curr Pain Headache Rep 7:308-18. 2003
    ..These results offer the promise of better treatments for this syndrome, but require validation in controlled trials...
  43. ncbi Mechanically-induced cortical spreading depression associated regional cerebral blood flow changes are blocked by Na+ ion channel blockade
    Simon Akerman
    Department of Neurology, University of California, San Francisco, 505 Parnassus Avenue, San Francisco CA 94143 0114, USA
    Brain Res 1229:27-36. 2008
    ....